I-HPMC (Hydroxypropyl Methylcellulose)yinto eqhelekileyo esetyenziswa ngokuqhelekileyo kwii-capsules ze-gel zamachiza (ii-capsules ezinzima kunye nezithambileyo) kunye neentlobo ezahlukeneyo zeenzuzo ezizodwa.
1. I-Biocompatibility
I-HPMC sisityalo sendalo esiphuma kwiselulosi esine-biocompatibility egqwesileyo emva kokuguqulwa kwemichiza. Iyahambelana kakhulu nemekobume ye-physiological yomzimba womntu kwaye inokunciphisa ngokufanelekileyo umngcipheko wokungaphenduli. Ngoko ke, isetyenziswa rhoqo kumalungiselelo eziyobisi, ngakumbi kumachiza afuna ukuthathwa ixesha elide. Izinto ze-HPMC zinokucaphuka kancinci kwindlela yesisu, ngoko ke inokhuseleko oluphezulu njengenkqubo yokuhanjiswa kweziyobisi, ngakumbi kumalungiselelo okukhutshwa okuzinzileyo kunye nokulawulwa kokukhutshwa kweziyobisi.
2. Iipropati zokukhululwa ezilungisekayo
HPMCinokugcina ukuzinza kwayo kwiindawo ezahlukeneyo (amanzi kunye ne-pH), ngoko kulungele kakhulu ukulawula izinga lokukhululwa kweziyobisi. Kwii-capsules ze-gel ze-pharmaceutical, iipropati ze-HPMC zinokuhlengahlengiswa ngokutshintsha iqondo layo le-polymerization (ubunzima be-molecular) kunye neqondo le-hydroxypropylation, okwenza kube yinto efanelekileyo yokukhetha ukukhululwa okuqhubekayo kunye nokulawulwa-ukukhululwa kwamalungiselelo eziyobisi. Inokulibazisa ukukhutshwa kweziyobisi ngokwenza umaleko we-hydrated gelatinous material, ukuqinisekisa ukuba amachiza anokukhutshwa ngokulinganayo kwaye ngokuqhubekayo kwiindawo ezahlukeneyo zokugaya ukutya, ukunciphisa inani lamayeza kunye nokwandisa ukuthotyelwa kwezigulane.
3. Akukho mvelaphi yezilwanyana, ilungele abantu abatya imifuno
Ngokungafaniyo neecapsules zegelatin zemveli, i-HPMC ithathwe kwisityalo kwaye ke ayiqulathanga izithako zezilwanyana, iyenza ilungele abantu abatya imifuno kunye namaqela iinkolelo zabo zonqulo zine-taboos kwizithako zezilwanyana. Ukongeza, ii-capsules ze-HPMC zikwabonwa njengokhetho oluhambelana nokusingqongileyo kuba inkqubo yabo yokuvelisa ihambelana nokusingqongileyo kwaye ayibandakanyi ukuxhelwa kwezilwanyana.
4. Iipropati ezilungileyo zokwenza ifilimu
HPMCine-solubility efanelekileyo emanzini kwaye inokukhawuleza ukwenza ifilimu yejeli efanayo. Oku kuvumela i-HPMC ukuba idlale indima ebalulekileyo ekubunjweni kwefilimu yangaphandle ye-capsule. Xa kuthelekiswa nezinye izinto, ukubunjwa kwefilimu ye-HPMC igudileyo kwaye izinzile, kwaye ayichatshazelwa lula lutshintsho lokufuma. Inokukhusela ngokufanelekileyo izithako zeziyobisi kwi-capsule ekubeni zichatshazelwa yimeko yangaphandle kunye nokunciphisa ukuthotywa kweziyobisi.
5. Lawula ukuzinza kwechiza
I-HPMC inokumelana nokufuma okulungileyo kwaye inokuthintela ngokufanelekileyo iyeza ekufunxeni ukufuma kwi-capsule, ngaloo ndlela iphucula uzinzo lwechiza kunye nokwandisa ubomi beshelufu yechiza. Xa kuthelekiswa ne-gelatin capsules, ii-capsules ze-HPMC azinakwenzeka ukuba zifunxe amanzi, ngoko ke zinozinzo olungcono, ngakumbi kwiindawo zokufuma eziphezulu.
6. I-solubility ephantsi kunye nesantya sokukhululwa kancinci
I-HPMC ine-solubility ephantsi kwi-traintestinal tract, eyenza ukuba inyibilike ngokucothayo kwisisu, ngoko inokuba khona kwisisu ixesha elide, elilungele ukulungiswa kwamachiza okukhululwa okuqhubekayo. Xa kuthelekiswa ne-gelatin capsules, ii-capsules ze-HPMC zinexesha elide lokuchithwa, elinokuqinisekisa ukukhutshwa okuchanekileyo kwamachiza emathunjini amancinci okanye kwezinye iindawo.
7. Isebenza kumalungiselelo ahlukeneyo eziyobisi
I-HPMC iyahambelana neendidi zezithako zamachiza. Nokuba ngamachiza aqinileyo, amachiza angamalwelo, okanye amachiza anganyibiliki kakuhle, anokuthi afakwe ngokufanelekileyo ziicapsules zeHPMC. Ngokukodwa xa i-encapsulating i-oil-soluble drug, ii-capsules ze-HPMC zinokutywinwa okungcono kunye nokukhuselwa, okunokuthi kuthintele ngokufanelekileyo ukuguquguquka kunye nokuthotywa kweziyobisi.
8. Ukuncipha kokungalungi kunye neziphumo ebezingalindelekanga
Xa kuthelekiswa ne-gelatin capsules, i-HPMC inezehlo ezisezantsi zokungaguquki, oko kuyenza ibe lolona khetho lufanelekileyo kubantu abanovelwano kwizithako zamachiza. Ekubeni i-HPMC ingenayo iprotheni yezilwanyana, inciphisa iingxaki ezibangelwa zizilwanyana eziphuma kwizilwanyana kwaye ifaneleke ngokukodwa kwizigulane ezingadibaniyo ne-gelatin.
9. Kulula ukuvelisa kunye nokusebenza
Inkqubo yemveliso ye-HPMC ilula kwaye inokuqhutywa kwiqondo lokushisa kunye noxinzelelo. Xa kuthelekiswa ne-gelatin, inkqubo yokuvelisa ii-capsules ze-HPMC ayifuni ukulawulwa kweqondo lokushisa eliyinkimbinkimbi kunye neenkqubo zokumisa, ukugcina iindleko zokuvelisa. Ukongeza, ii-capsules ze-HPMC zinamandla omatshini kunye nokuqina, kwaye zifanelekile kwimveliso enkulu ezenzekelayo.
10. Ukungafihli kunye nenkangeleko
Iipilisi ze-HPMC zinokucaca kakuhle, ngoko ke imbonakalo yee-capsules intle ngakumbi, ebaluleke kakhulu kumachiza athile afuna ukubonakala okucacileyo. Xa kuthelekiswa ne-gelatin capsules yendabuko, ii-capsules ze-HPMC zinokucaca okuphezulu kwaye zinokubonisa amachiza kwii-capsules, ezivumela izigulane ukuba ziqonde imixholo yamachiza ngakumbi intuitively.
Ukusetyenziswa kweHPMCkwii-capsules zejeli zamachiza zineenzuzo ezininzi, kubandakanywa ne-biocompatibility egqwesileyo, iimpawu zokukhutshwa kweziyobisi ezilungelelanisiweyo, ezifanelekileyo kwimifuno, iimpawu ezintle zokubumba ifilimu, kunye nokuphucula ukuzinza kweziyobisi. Ngoko ke, isetyenziswa ngokubanzi kwishishini lamachiza, ngakumbi ekukhutshweni okuzinzileyo, ukukhutshwa okulawulwayo kwamalungiselelo eziyobisi kunye namalungiselelo asekelwe kwizityalo. Ngokunyuka kwemfuno yabathengi kukhuseleko lwezempilo kunye nokusingqongileyo, ithemba lemarike yee-capsules ze-HPMC liya liba banzi.
Ixesha lokuposa: Nov-28-2024