I-HPMC (i-Hydroxypropyl Methylcellulose) yi-ether ye-cellulose e-nonionic esetyenziswa kakhulu kwiyeza, ukutya, ukwakhiwa kunye nezithambiso. Amabanga ahlukeneyo e-HPMC ahlelwa ikakhulu ngokwesakhiwo sawo sekhemikhali, iipropathi zomzimba, i-viscosity, inqanaba lokuthatha indawo kunye nokusetyenziswa okwahlukileyo.
1. Ubume bekhemikhali kunye nenqanaba lokutshintshwa
Ulwakhiwo lwemolekyuli ye-HPMC iqulathe amaqela e-hydroxyl kwitsheyina le-cellulose endaweni yawo ngamaqela e-methoxy kunye ne-hydroxypropoxy. Iimpawu zomzimba kunye neekhemikhali ze-HPMC ziyahluka ngokuxhomekeke kwiqondo lokutshintshwa kwe-methoxy kunye namaqela e-hydroxypropoxy. Iqondo lokutshintsha lichaphazela ngokuthe ngqo ukunyibilika, ukuzinza kwe-thermal kunye nomsebenzi womphezulu we-HPMC. Ngokukodwa:
I-HPMC enomxholo ophezulu we-methoxy ithande ukubonisa ubushushu obuphezulu be-thermal gelation, eyenza ukuba ifaneleke ngakumbi kwizicelo ezinobushushu obufana namalungiselelo eziyobisi ezilawulwayo.
I-HPMC enomxholo ophezulu we-hydroxypropoxy ine-solubility engcono yamanzi, kunye nenkqubo yokuchithwa kwayo ayichatshazelwa kancinci ngubushushu, iyenze ilungele ukusetyenziswa kwiindawo ezibandayo.
2. Ibakala leViscosity
Viscosity yenye yezalathi ezibalulekileyo zebakala HPMC. I-HPMC inoluhlu olubanzi lwee-viscosities, ukusuka kwi-centipoise embalwa ukuya kumashumi amawaka e-centipoise. Ibakala le-viscosity lichaphazela ukusetyenziswa kwayo kwizicelo ezahlukeneyo:
Viscosity Low HPMC (ezifana 10-100 centipoise): Eli bakala HPMC ikakhulu isetyenziswa izicelo ezifuna viscosity esezantsi kunye fluidity eliphezulu, ezifana ifilimu ukutyabeka, zokuncamathelisa tablet, njl. Inokunika iqondo elithile amandla bonding ngaphandle kokuchaphazela ubumanzi bokulungiselela.
I-HPMC ye-viscosity ephakathi (efana ne-100-1000 centipoise): Ngokuqhelekileyo isetyenziselwa ukutya, izimonyo kunye namalungiselelo athile amayeza, inokusebenza njenge-thickener kunye nokuphucula ukuthungwa kunye nokuzinza kwemveliso.
High viscosity HPMC (ezifana ngasentla 1000 centipoise): Eli bakala HPMC ikakhulu isetyenziswa kwizicelo ezifuna viscosity eliphezulu, ezifana glues, ancamathelisi kunye nezinto zokwakha. Zibonelela ngezakhono ezigqwesileyo zokujiya kunye nokuxhoma.
3. Iimpawu ezibonakalayo
Iimpawu ezibonakalayo ze-HPMC, ezifana nokunyibilika, ubushushu be-gelation, kunye nomthamo wokufunxa amanzi, nazo ziyahluka ngokwebakala layo:
Ukunyibilika: Uninzi lwe-HPMC lunokunyibilika okulungileyo kumanzi abandayo, kodwa ukunyibilika kuncipha njengoko umxholo we-methoxy usanda. Amanye amabakala akhethekileyo e-HPMC nawo asenokunyibilikiswa kwizinyibilikisi zendalo kwizicelo ezithile zemizi-mveliso.
Ubushushu beGelation: Ubushushu be-gelation ye-HPMC kwisisombululo esinamanzi siyahluka ngohlobo kunye nomxholo wababambeli. Ngokuqhelekileyo, i-HPMC enomxholo ophezulu we-methoxy ithande ukwenza iijeli kumaqondo obushushu aphezulu, ngelixa i-HPMC enomxholo ophezulu we-hydroxypropoxy ibonisa ubushushu obuphantsi be-gelation.
I-Hygroscopicity: I-HPMC ine-hygroscopicity ephantsi, ngakumbi amabanga afakwe endaweni ephezulu. Oku kuyenza igqwese kwiindawo ezifuna ukuxhathisa ukufuma.
4. Iindawo zokufaka izicelo
Ngenxa yokuba amabakala ahlukeneyo e-HPMC aneempawu ezahlukeneyo zomzimba nezekhemikhali, izicelo zabo kwiinkalo ezahlukeneyo nazo zahlukile:
Umzi-mveliso wamachiza: I-HPMC iqhele ukusetyenziswa kwiingubo zokwaleka iipilisi, amalungiselelo okukhululwa okuzinzileyo, izinto zokuncamathelisa, kunye nezityebe. I-HPMC ye-Pharmaceutical grade kufuneka ihlangabezane nemigangatho ethile ye-pharmacopoeia, efana ne-United States Pharmacopoeia (USP), i-European Pharmacopoeia (EP), njl. Amanqanaba ahlukeneyo e-HPMC angasetyenziselwa ukulungelelanisa izinga lokukhululwa kunye nokuzinza kwamachiza.
Ishishini lokutya: I-HPMC isetyenziswa njenge-thickener, i-emulsifier, i-stabilizer kunye nefilimu yangaphambili. Ibakala lokutya i-HPMC idla ngokufuneka ukuba ingabi netyhefu, ingabinancasa, ingabinavumba, kwaye ifune ukuthobela imimiselo yokongezwa kokutya, njengaleyo ye-US Food and Drug Administration (FDA) kunye ne-European Food Safety Authority (EFSA).
Umzi-mveliso wokwakha: Ibakala lokwakha i-HPMC isetyenziswa ikakhulu kwimathiriyeli esekwe kwisamente, kwiimveliso zegypsum kunye nokugquma ukujiya, ukugcina amanzi, ukuthambisa kunye nokuphucula. I-HPMC yamabakala ahlukeneyo e-viscosity inokuchaphazela ukusebenza kwezinto zokwakha kunye nokusebenza kwemveliso yokugqibela.
5. Imigangatho yomgangatho kunye nemimiselo
Amabanga ahlukeneyo e-HPMC aphantsi kwemigangatho eyahlukeneyo kunye nemimiselo yomgangatho:
I-HPMC ye-Pharmaceutical grade: kufuneka ihlangabezane neemfuno ze-pharmacopoeia, ezifana ne-USP, i-EP, njl. Inkqubo yayo yokuvelisa kunye neemfuno zokulawula umgangatho ziphezulu ukuqinisekisa ukhuseleko kunye nokusebenza kakuhle kumalungiselelo amayeza.
I-HPMC yodidi lokutya: Kufuneka ihambelane nemimiselo efanelekileyo kwizongezo zokutya ukuqinisekisa ukhuseleko lwayo ekutyeni. Amazwe ahlukeneyo kunye nemimandla inokuba neenkcukacha ezahlukeneyo ze-HPMC yebakala lokutya.
I-HPMC ye-Industrial-grade: I-HPMC esetyenziswa kulwakhiwo, i-coatings kunye nezinye iindawo ngokuqhelekileyo ayifuni ukuthobela imigangatho yokutya okanye yamachiza, kodwa kusafuneka ihlangabezane nemigangatho yemizi-mveliso ehambelanayo, efana nemigangatho ye-ISO.
6. Ukhuseleko kunye nokukhuselwa kwendalo
I-HPMC yamabanga ahlukeneyo nayo iyahluka kukhuseleko kunye nokhuseleko lokusingqongileyo. I-HPMC yodidi lwamayeza kunye nebakala lokutya luhlala luvavanywa ngokuqatha ukuze kuqinisekiswe ukuba alunabungozi emzimbeni womntu. I-HPMC ye-Industrial-grade, kwelinye icala, ihlawula ingqalelo engakumbi ekukhuselweni kwayo kokusingqongileyo kunye nokonakala ngexesha lokusetyenziswa ukunciphisa impembelelo kokusingqongileyo.
Umahluko phakathi kwamabanga ahlukeneyo we-HPMC ubonakaliswa ikakhulu kwisakhiwo sekhemikhali, i-viscosity, iipropathi ezibonakalayo, iindawo zesicelo, imigangatho yomgangatho kunye nokhuseleko. Ngokweemfuno ezithile zesicelo, ukukhetha ibakala elifanelekileyo le-HPMC kunokuphucula kakhulu ukusebenza kunye nomgangatho wemveliso. Xa kuthengwa i-HPMC, le miba kufuneka iqwalaselwe ngokubanzi ukuqinisekisa ukufaneleka kunye nokusebenza kwemveliso.
Ixesha lokuposa: Aug-20-2024