IHydroxypropyl methylcellulose (HPMC)yinto eqhelekileyo yeekhemikhali esetyenziswa ngokubanzi kumashishini amaninzi afana nokwakha, amayeza, ukutya kunye nezithambiso. Nangona kunjalo, nangona i-HPMC ineempawu ezininzi ezigqwesileyo, ezinje ngokutyeba, i-emulsification, ukwakheka kweefilim, kunye neenkqubo zokunqunyanyiswa ezizinzileyo, ikwanazo ezinye izinto ezingeloncedo kunye nezithintelo.
1. Imiba yokunyibilika
Nangona i-HPMC inokunyibilika emanzini kunye nezinye izinyibilikisi eziphilayo, ukunyibilika kwayo kuchatshazelwa bubushushu. Inyibilika ngokucothayo emanzini abandayo kwaye ifuna ukushukunyiswa okwaneleyo ukuze inyibilike ngokupheleleyo, ngelixa inokwenza ijeli kumanzi obushushu obuphezulu, iyenze ihlakazeke ngokungalinganiyo. Olu phawu lusenokuzisa iziphazamiso ezithile kwiimeko ezithile zezicelo (ezifana nemathiriyeli yokwakha kunye namayeza), kwaye iinkqubo ezikhethekileyo zokuchithwa okanye izongezo ziyafuneka ukuze kwandiswe isiphumo sokuchithwa.
2. Iindleko eziphezulu
Xa kuthelekiswa nezinye izityebe zendalo okanye ezenziweyo, ixabiso lemveliso ye-HPMC liphezulu. Ngenxa yenkqubo yayo yokulungiselela eyinkimbinkimbi, ebandakanya amanyathelo amaninzi afana ne-etherification kunye nokucoca, ixabiso layo liphezulu kunezinye i-thickeners, ezifana ne-hydroxyethyl cellulose (HEC) okanye i-carboxymethyl cellulose (CMC). Xa isetyenziswe kumlinganiselo omkhulu, izinto zeendleko zinokuba sisizathu esibalulekileyo sokunciphisa ukusetyenziswa kwayo.
3. Ichatshazelwa lixabiso le-pH
I-HPMC inozinzo oluhle phantsi kweemeko ezahlukeneyo ze-pH, kodwa inokuthotywa phantsi kweemeko ezigqithisileyo ze-pH (ezifana ne-asidi eyomeleleyo okanye isiseko esomeleleyo), echaphazela ukutyeba kwayo nokuzinzisa iziphumo. Ke ngoko, ukusetyenziswa kwe-HPMC kunokuthintelwa kwezinye iimeko zosetyenziso ezifuna iimeko ze-pH ezigqithisileyo (ezifana neenkqubo ezikhethekileyo zokusabela kweekhemikhali).
4. Ubuncinci bezinto eziphilayo
Nangona i-HPMC ithathwa njengesixhobo esihambelana nokusingqongileyo, isathatha ixesha elide ukuba iguqulwe ngokupheleleyo. Kwimo engqongileyo yendalo, izinga lokuthotywa kwe-HPMC liyacotha, elinokuba nempembelelo ethile kubume bendalo. Kwizicelo ezineemfuno eziphezulu zokhuseleko lokusingqongileyo, ukuthotywa kwe-HPMC kusenokungabi lolona khetho lulungileyo.
5. Amandla aphantsi oomatshini
Xa i-HPMC isetyenziswa njengesixhobo sefilimu okanye ijeli, amandla ayo omatshini aphantsi kwaye kulula ukuwaphula okanye ukonakala. Ngokomzekelo, kumashishini amayeza, xa i-HPMC isetyenziselwa ukwenza iipilisi, inobunzima obunzima xa kuthelekiswa ne-gelatin capsules, kwaye ingxaki ye-fragility inokuchaphazela ukuzinza kokuthutha kunye nokugcinwa. Kwishishini lokwakha, xa i-HPMC isetyenziswa njenge-thickener, nangona inokuphucula ukunamathela kodaka, inegalelo elilinganiselweyo kumandla omatshini wemveliso yokugqibela.
6. Hygroscopicity
I-HPMC inomlinganiselo othile we-hygroscopicity kwaye ifunxa ngokulula ukufuma kwindawo yokufuma ephezulu, enokuthi ichaphazele ukusebenza kwayo. Umzekelo, ekutyeni okanye ekulungiseleleni iziyobisi, ukufunxa ukufuma kunokubangela ukuthambisa kwethebhulethi kunye notshintsho ekusebenzeni kokuqhekeka, oko kuchaphazela uzinzo lomgangatho wemveliso. Ngoko ke, ngexesha lokugcinwa kunye nokusetyenziswa, umswakama wokusingqongileyo kufuneka ulawulwe ukukhusela ukusebenza kwawo ekuwohlokeni.
7. Impembelelo kwi-bioavailability
Kumashishini axuba amayeza, i-HPMC isoloko isetyenziselwa ukulungiselela ukukhutshwa okuzinzileyo okanye iipilisi ezikhutshwayo ezilawulwayo, kodwa zinokuchaphazela ukuziphatha kokukhululwa kwamachiza athile. Umzekelo, kumachiza e-hydrophobic, ubukho be-HPMC bunokunciphisa izinga lokuchithwa kwechiza emzimbeni, ngaloo ndlela kuchaphazela ukufumaneka kwe-bioavailability. Ke ngoko, xa kuyilwa imixube yamachiza, isiphumo se-HPMC ekukhutshweni kwechiza kufuneka sivavanywe ngononophelo, kwaye abancedisi abongezelelweyo banokufuneka ukongeza ukusebenza kwechiza.
8. Ukuzinza kwe-thermal
I-HPMC inokwehlisa umgangatho okanye itshintshe ukusebenza kumaqondo obushushu aphezulu. Nangona i-HPMC izinzile kuluhlu lweqondo lokushisa eliqhelekileyo, linokuthi linciphise, liguqule umbala, okanye lihlaneke ekusebenzeni kwiqondo lokushisa elingaphezulu kwe-200 ° C, elikhawulela ukusetyenziswa kwayo kwiinkqubo eziphezulu zokushisa. Umzekelo, kwenye iplastiki okanye ukusetyenzwa kwerabha, ukunganyangeki kobushushu kwe-HPMC kunokukhokelela ekwehleni komgangatho wemveliso.
9. Imiba yokuhambelana nezinye izithako
Kwizicelo zokuqulunqa, i-HPMC inokusabela kakubi kunye ne-cationic surfactants ethile okanye ii-ion ezithile zetsimbi, ezikhokelela kwi-turbidity okanye i-coagulation yesisombululo. Lo mbandela wokuhambelana unokuchaphazela umgangatho kunye nokubonakala kwemveliso yokugqibela kwezinye izicelo (ezifana nezithambiso, amayeza okanye izisombululo zekhemikhali), ezifuna uvavanyo lokuhambelana kunye nokuqulunqwa kokulungelelaniswa.
NangonaHPMCyinto esetyenziswa ngokubanzi esebenzayo kunye nefuthe elihle kakhulu, ifilimu yokwenza ifilimu kunye nokuzinzisa iziphumo, nayo inezinto ezingalunganga ezifana nokunyibilika okulinganiselweyo, ixabiso eliphezulu, ukuchithwa kwe-biodegradability, amandla aphantsi omatshini, i-hygroscopicity enamandla, impembelelo ekukhululweni kweziyobisi, kunye nokunganyangeki kobushushu. Le mida inokuchaphazela ukusetyenziswa kwe-HPMC kumashishini athile athile. Ngoko ke, xa ukhetha i-HPMC njengento ekrwada, kuyimfuneko ukuba kuqwalaselwe ngokubanzi iingenelo kunye nobubi kunye nokwandisa ngokudibanisa neemfuno zokwenyani zesicelo.
Ixesha lokuposa: Apr-01-2025