I-HydroxyPOpyl Methylcelcelsulose (i-HPMC) yiyothusa ibalulekileyo yeekhemikhali, esetyenziswa ngokubanzi kwimimandla emininzi enjengezokwakha, amayeza, ukutya kunye ne-cosmetics. Inesithukuthezi esihle, ukugxeka, ukonakalisa, ukwenza ifilimu, kunye neempawu zefilimu, kunye nokuzinza okuthile kubushushu kunye nePH. Ukunyibilisela i-HPMC yenye yemicimbi ephambili ekusetyenzisweni kwayo. Ukuqonda indlela echanekileyo yokuchithwa kubalulekile ukuqinisekisa ukusebenza kwalo.
1. Iipropathi ezisisiseko zokuchithwa kwe-HPMC
I-Hydroxypropyl Methylcelcelcelose i-ionic ye-ionic ye-ioni ye-ioni ye-Iosey enokuchithwa kumanzi abandayo okanye ashushu ukwenza isisombululo esibonakalayo okanye sokudumisa. Ukuluka kwayo kuchithwa ikakhulu kubushushu. Kulula ukunyibilikisa amanzi abandayo kwaye kulula ukwenza i-colloid emanzini ashushu. I-HPMC inomhlaba othe tyaba, oko kukuthi, inamandla okuhlala kakubi kumaqondo obushushu aphezulu, kodwa inokuchithwa ngokupheleleyo xa iqondo lobushushu lihlisiwe. I-HPMC inee-moleks zahloka kunye nokujonga izinto, ke ngexesha lenkqubo yokutshintsha, imodeli efanelekileyo ye-HPMC kufuneka ikhethwe ngokweemfuno zemveliso.
2. Indlela yokuphelisa i-HPMC
Indlela yokusasazwa kwamanzi ebandayo
Indlela yokusasazwa kwamanzi ebandayo yeyona ndlela isetyenziswayo ye-HPMC yokuNyikisa i-HPMC kwaye ilungele eyona meko isetyenziswayo. Amanyathelo athile alandelayo:
Lungiselela amanzi abandayo: Thela inani elifunekayo lamanzi abandayo kwisitya sokuxuba. Iqondo lobushushu lamanzi lihlala licetyiswa ukuba lingaphantsi kwe-40 ° C ukunqanda i-HPMC ukusuka kwi-tumps kwiqondo lobushushu eliphezulu.
Ngokuthe ngcembe ukongeza i-HPMC: ngokuthe chu yongeza i-HPMC POMDER kwaye uqhubeke nokushukumisa. Ukwenzela ukuthintela ukungasebenzi kakuhle kwe-powder, isantya esifanelekileyo sesantya esifanelekileyo kufuneka sisetyenziselwe ukuqinisekisa ukuba i-HPMC ingasasazeka kakhulu emanzini.
Ukuma kunye nokunyibilika: Emva kokuba i-HPMC ichithwe kumanzi abandayo, kufuneka ime ixesha elithile lokunyibilikisa ngokupheleleyo. Ngokwesiqhelo, ishiywe emi kangangemizuzu engama-30 ukuya kwiiyure ezininzi, kwaye ixesha elithile liyahluka ngokuxhomekeka kwimodeli ye-HPMC kunye neqondo lobushushu lamanzi. Ngexesha lenkqubo yokuma, i-HPMC iya kunyibilikisa ukwenza isisombululo se-viscous.
Indlela eshushu yokuphambuka kwamanzi
Indlela eshushu yokuchithwa kwamanzi eshushu ilungele ezinye zeemodeli ze-HPMC nge-viscofity ephezulu okanye kunzima ukuyinyibilikisa ngokupheleleyo emanzini abandayo. Le ndlela kukuqala ukuxuba i-HPMC Powder enenxalenye yamanzi ashushu ukwenza i-paste, kwaye emva koko udibanise namanzi abandayo ukuze ekugqibeleni afumane isisombululo. Amanyathelo athile alandelayo:
Ukufudumeza Amanzi: Fudumeza inani elithile lamanzi ukuya kuma-80 ° C kwaye ugalele kwisitya sokuxuba.
Ukongeza i-HPMC POMDER: Thululela umgubo we-HPMC kubankcenkceshela ashushu kunye nokuvuselela ngelixa ugalela ukwenza umxube we-paste. Ngamanzi ashushu, i-HPMC iya kunyibilikisa okwethutyana kwaye yenze into efana nejeli.
Ukongeza amanzi abandayo ukuya kwi-DILTE: Emva komxube we-paste upholile phantsi, ngokuthe ngcembe yongeza amanzi abandayo ukuze aphumle kwaye aqhubeke nesisombululo esibonakalayo esibonakalayo okanye esidlule.
Indlela ye-orgation ye-orgation
Ngamanye amaxesha, ukwenzela ukukhawulezisa ukupheliswa kwe-HPMC okanye ukuphucula isiphumo sezicelo ezithile ezikhethekileyo, isinyithi esiphilayo sinokusetyenziselwa ukuxubana namanzi ukunyibilikisa i-HPMC. Umzekelo, izinyibilikisi zendalo ezinje nge-ethanol kunye ne-acetone zingasetyenziselwa ukusasaza i-HPMC kuqala, kwaye ke amanzi angongezwa ukuze ancedise i-HPMC ngokukhawuleza. Le ndlela ihlala isetyenziswa ekuvelisweni kweemveliso ezisekwe kwiSolvent, ezinje ngengubo kunye neepeyinti.
Indlela yokudibanisa eyomileyo
Indlela yokudibanisa eyomileyo ilungele ukuveliswa kwemveliso enkulu. I-HPMC idla ngokuhlala ixutywe nezinye izinto eziqingqiweyo (ezinje ngesamente, i-gypsum, njl njl), kwaye ke amanzi longezwa ukuxuba xa kusetyenziswa. Le ndlela yenza lula umsebenzi kwaye ithintela ingxaki ye-Ageglomera xa i-HPMC ichithwe yedwa, kodwa ifuna ukuvuselela okwaneleyo emva kokudibanisa ukuba i-HPMC ingayitsiba kwaye idlale indima yokuthambisa.
I-3. Izinto ezichaphazela ukupheliswa kwe-HPMC
Iqondo lokushisa: Ukuzalwa kwe-HPMC kunomdla kakhulu kubushushu. Iqondo lokushisa elisezantsi lilungele ukusasazwa kwayo kunye nokuchithwa kwamanzi, ngelixa ubushushu obuphezulu bubangela i-HPMC ukuba yenze i-colloids, ithintele ukupheliswa kwayo ngokupheleleyo. Ke ngoko, ihlala icetyiswa ukuba isebenzise amanzi abandayo okanye ukulawula amaqondo obushushu amanzi ngezantsi kwe-40 ° C xa inyibilika i-HPMC.
Isantya esishukumisayo: Ukuvuselela okufanelekileyo kunokuphepha ngokufanelekileyo i-HPMCMAME-APGGlelo ye-HPMC, ngaloo ndlela isandula ukutshata kwexabiso lokuchitheka. Nangona kunjalo, isantya esikhawulezayo ngokukhawuleza sinokwazisa inani elikhulu leebhabhu kwaye ichaphazele ukufana kwesisombululo. Ke ngoko, ngokusebenza okuthile, isantya esifanelekileyo sesantya kunye nezixhobo kufuneka zikhethwe.
Umgangatho wamanzi: Ukungcola, ubukhali, ixabiso le-pl, njl. Njl. Ngokukodwa, i-calcium kunye ne-magnesium i-ions emanzini anzima inokuphendula nge-HPMC kwaye ichaphazele isoba. Ke ngoko, ukusebenzisa amanzi acocekileyo okanye amanzi athambileyo anceda ekuphuculeni ukusebenza ngempumelelo kwe-HPMC.
Imodeli ye-HPMC kunye neMolekyuli: Iimodeli ezahlukeneyo ze-HPMC zahlukile kwisantya sokuhlaziya, i-viscofity kunye neqondo lokuhlaselwa. I-HPMC ene-molecular ephezulu yemolekyuli iphosa kancinci, inesisombululo esiphezulu, kwaye ithatha ixesha elide ukunyibilikisa ngokupheleleyo. Ukukhetha imodeli ye-HPMC yasekunene kunokuphucula ukuxhaphaka ngempumelelo nokuhlangabezana neemfuno ezahlukeneyo zesicelo.
4. Iingxaki eziqhelekileyo kunye nezisombululo kwi-HPMC yokuphelisa
Ingxaki ye-Agglomeration: Xa i-HPMC inyibilikisiwe emanzini, i-ageglometions inokwenziwa ukuba umgubo awusasazeki kangako. Ukuthintela le ngxaki, i-HPMC kufuneka yongezelelwa ngexesha lokupheliswa kwaye igcinwe kwisantya esifanelekileyo esishukumisayo, ngelixa sithintela ukongeza i-HPMC POPLER kwiqondo lomdiliya ephezulu.
Isicombululo esingalinganiyo: Ukuba i-stirring ayikwaneli okanye ixesha elimileyo alonelanga, i-HPMC ayinakuchithwa ngokupheleleyo, ikhokelela kwisisombululo esingalinganiyo. Ngeli xesha, ixesha elitshatileyo kufuneka lindiswe okanye ixesha elimisiweyo kufuneka linyuswe ukuqinisekisa ukutshitshiswa ngokupheleleyo.
Ingxaki ye-bubbble: Ukuqina okukhawulezayo okanye ukungcola emanzini kunokwazisa inani elikhulu leebhabhu, kuchaphazele umgangatho wesisombululo. Ngesi sizathu, kucetyiswa ukuba ulawule isantya esitshatileyo xa inyibilikisa i-HPMC ukunqanda amaqamza agqithisileyo, kwaye yongeze i-Defoamer ukuba iyimfuneko.
Ukuchithwa kwe-HPMC luluhlu oluphambili kwisicelo salo. Ukusebenzisana nendlela echanekileyo yokuchitheka kunceda ukuphucula umgangatho wemveliso kunye nokuvelisa ukusebenza. Ngokweentlobo ezahlukeneyo ze-HPMC kunye neemfuno zesicelo, ukusasazeka kwamanzi abandayo, ukuchithwa kwamanzi okushushu, ukusasazeka kwendalo esinyibilikisiweyo okanye ukuxuba komileyo Kwangelo xesha, kufuneka kuthathelwe ingqalelo ekulawuleni izinto ezinje ngeqondo lobushushu, isantya esitshatileyo kunye nomgangatho wamanzi ngexesha lenkqubo yokupheliswa, i-qambles kunye nokuchithwa okungaphelelanga. Ngokwenza ukuba ukuqinisekiswa kweemeko zokuchitha, kunokuqinisekiswa ukuba i-HPMC inokunika umdlalo opheleleyo kwizinto zayo zokuthambisa kunye nefilimu, ukubonelela ngezisombululo ezisemgangathweni ezikumgangatho ophezulu wemizi-mveliso kunye nezicelo ezahlukeneyo zemizi-mveliso.
IXESHA LOKUQALA: UPE-30 ukuya kwi-2024