Ziziphi iimpawu ze-rheological ze-HPMC?

Ziziphi iimpawu ze-rheologicalHPMC?

IHydroxypropyl methylcellulose (HPMC) yipolymer eguquguqukayo efumana ukusetyenziswa okubanzi kumashishini ahlukeneyo, kubandakanywa amayeza, ulwakhiwo, ukutya, kunye nezithambiso, ngokuyintloko ngenxa yeempawu zayo ezizodwa zerheological. I-Rheology kuphononongo lokuhamba kunye nokuguqulwa kwezinto, kwaye ukuqonda iimpawu ze-rheological ze-HPMC kubalulekile ekuphuculeni ukusebenza kwayo kwizicelo ezahlukeneyo.

I-Viscosity: I-HPMC ibonisa i-pseudoplastic okanye i-shear-thinning behavior, oku kuthetha ukuba i-viscosity yayo iyancipha ngokunyuka kwesantya sokucheba. Le propati iyimfuneko kwizicelo ezifana nokuqulunqwa kwamayeza, apho ivumela ukupompa okulula, ukusabalalisa, kunye nokusetyenziswa. I-Viscosity inokulungiswa ngokuguqula iqondo lokuthatha indawo (DS) kunye nobunzima bemolekyuli ye-HPMC.

Thixotropy: Thixotropy ibhekisela kwinguqu eguqukayo ye-gel-sol eboniswa yizinto ezithile phantsi koxinzelelo lwe-shear. Iijeli ze-HPMC ezenziwe ekuphumleni zinokuqhekeka phantsi kwe-chear kwaye ziphinde zifumane isakhiwo sejeli xa uxinzelelo lususiwe. Le propati inenzuzo kwizicelo ezifana nepeyinti, apho ithintela ukudilika ngexesha lokufaka isicelo kodwa iqinisekisa ukugquma okufanelekileyo xa sele ifakiwe.

I-Hydration: I-HPMC i-hygroscopic kwaye inokufunxa amanzi, ekhokelela ekudumbeni kunye nokwanda kwe-viscosity. Iqondo lokuqukunjelwa kwamanzi lixhomekeke kwizinto ezifana nobushushu, i-pH, kunye namandla e-ionic yesiphakathi esijikelezileyo. I-Hydration idlala indima ebalulekileyo ekulawuleni ukukhutshwa kwamachiza kwimixube yamayeza kunye nokugcina umxholo wokufuma kwiimveliso zokutya.

Uvakalelo lobushushu:HPMCIzisombululo zibonisa i-viscosity exhomekeke kwiqondo lokushisa, kunye ne-viscosity eyancipha njengoko ubushushu bukhula. Nangona kunjalo, oku kuziphatha kunokwahluka ngokuxhomekeke kwizinto ezinje ngoxinaniso lwepolymer kunye nesisombululo pH. Ubuzaza bobushushu bubalulekile kwizicelo ezifana nemathiriyeli yokwakha, apho buchaphazela ukusebenza kunye nexesha lokumisela.

Ukuvakala kweTyuwa: Izisombululo ze-HPMC zinokubonisa ubuntununtunu kwiityuwa, kunye neetyuwa ezithile ezibangela ukuphuculwa kwe-viscosity kunye nezinye ezibangela ukuncipha kwe-viscosity. Le nto ibangelwa kubudlelwane phakathi kweeathomu ze-HPMC kunye ne-ion kwisisombululo. Ubuzaza betyuwa bubalulekile ekuxutyweni kwamayeza kunye neemveliso zokutya apho isiqulatho setyuwa kufuneka silawulwe ngononophelo.

I-Shear Rate Dependence: Iimpawu ze-rheological zezisombululo ze-HPMC zixhomekeke kakhulu kwizinga lokucheba elisetyenzisiweyo. Kumazinga asezantsi okucheba, i-viscosity iphezulu ngenxa yokunyuka kokuphonswa kwemolekyuli, ngelixa kumazinga aphezulu okucheba, i-viscosity iyancipha ngenxa yokuchetywa kwe-chear. Ukuqonda ukuxhomekeka kwesantya sokucheba kubalulekile ekuyileni iimeko zokusetyenzwa kwizicelo ezahlukeneyo.

I-Particle Suspension: I-HPMC inokusebenza njenge-arhente yokumisa amasuntswana kulwelo oluxutywayo ngenxa yokuqina kwayo kunye nokuzinzisa iipropati. Inceda ukuthintela ukuhlaliswa kwamasuntswana aqinileyo, ukuqinisekisa ukuhanjiswa okufanayo kunye nokungaguquguquki kwiimveliso ezinjengepeyinti, i-adhesives, kunye nokumiswa kwamayeza.

Ukwenziwa kweGel:HPMCinokwenza i-gels kwiindawo eziphezulu okanye phambi kwee-agent ezinqamlezayo ezifana ne-divalent cations. Ezi gel zibonisa iimpawu ze-viscoelastic kwaye zisetyenziselwa izicelo ezifana nokuhanjiswa kweziyobisi ezilawulwayo, apho ukukhululwa okuqhubekayo kwezinto ezisebenzayo kuyadingeka.

iipropathi zerheological ze-HPMC, kubandakanya i-viscosity, i-thixotropy, i-hydration, ubushushu kunye nobuntununtunu betyuwa, ukuxhomekeka kwesantya sokucheba, ukunqunyanyiswa kwamasuntswana, kunye nokwakheka kwejeli, kudlala indima ebalulekileyo ekumiseleni ukusebenza kwayo kwizicelo ezahlukeneyo zemizi-mveliso. Ukuqonda nokulawula ezi mpawu zibalulekile ekwandiseni ukuqulunqwa nokusetyenzwa kweemveliso ezisekwe kwiHPMC.