Yintoni i-HPMC kwishishini lamayeza?

IHydroxypropylmethylcellulose (HPMC) yipolymer esebenzayo esetyenziswa kakhulu kwishishini lamayeza. Yeyodidi lwe-cellulose ether kwaye iphuma kwi-cellulose yendalo. I-HPMC yenziwe ngokuphatha i-cellulose nge-propylene oxide kunye ne-methyl chloride, okukhokelela kwiikhompawundi ezinokuphucula ukunyibilika kunye nezinye izinto ezinqwenelekayo. Lo mxhasi woxubo mayeza usetyenziswa ngokubanzi kuphuhliso kunye nokwenziwa kweefom ezahlukeneyo zedosi, kubandakanywa iipilisi, iicapsules, amalungiselelo e-ophthalmic kunye neenkqubo zokuhanjiswa kweziyobisi ezilawulwayo.

Intshayelelo ye-hydroxypropyl methylcellulose:

Ubume bekhemikhali kunye neempawu:

IHydroxypropyl methylcellulose yi-semi-synthetic, inert, i-polymer enyibilikayo emanzini. Ubume bayo beekhemikhali bubandakanya i-hydroxypropyl kunye namaqela e-methoxy afakwe kwi-backbone ye-cellulose. Ubungakanani bala maqela bunokwahluka, okukhokelela kumabakala ahlukeneyo e-HPMC eneempawu ezahlukeneyo. Ipateni yokutshintsha ichaphazela iiparameters ezifana ne-viscosity, i-solubility, kunye neempawu ze-gel.

Inkqubo yokwenziwa kwemveliso:

Ukuveliswa kwe-HPMC kubandakanya i-etherification ye-cellulose nge-propylene oxide kunye ne-methyl chloride. Iqondo lokutshintshwa (DS) lwe-hydroxypropyl kunye namaqela e-methoxy anokulawulwa ngexesha lokudibanisa, ukuvumela ukulungelelaniswa kweepropati ze-HPMC kwiimfuno ezithile zokuqulunqa ichiza.

Izicelo kwishishini lamayeza:

Izibophelelo kukwenziwa kwethebhulethi:

I-HPMC isetyenziswa ngokubanzi njengesibophelelo kwiinkqubo zethebhulethi. Iipropati zayo ezibophelelayo zinceda ekuxinzeleleni umgubo kwiipilisi eziqinileyo. Ukukhutshwa okulawulwayo kwezithako ezisebenzayo zamachiza (APIs) kunokufezekiswa ngokusebenzisa amabakala athile e-HPMC kunye ne-viscosity efanelekileyo kunye namanqanaba okutshintshwa.

I-arhente yokugquma ifilimu:

I-HPMC isetyenziswa njenge-arhente yokugquma ifilimu kwiipilisi kunye neegranules. Inika isambatho esifanayo sokukhusela esiphucula ukubonakala, ukufihla ukunambitha kunye nokuzinza kweefom zedosi. Ngaphaya koko, iingubo ezisekwe kwi-HPMC zinokumodareyitha iiprofayili zokukhupha ichiza.

Ukukhululwa okuzinzileyo nokulawulwayo:

Ubume be-hydrophilic bale polymer buyenza ilungele ukusetyenziswa kwimiqulu ezinzileyo kunye nelawulwayo yokukhutshwa. I-matrix ye-HPMC ivumela ukukhutshwa kwechiza elilawulwayo kwithuba elide lexesha, ukuphucula ukuthotyelwa kwesigulane kunye nokunciphisa ukuphindaphinda kwedosi.

Amalungiselelo e-Ophthalmic:

Kwi-ophthalmic formulations, i-HPMC isetyenziselwa ukunyusa i-viscosity ye-eye drops, ngaloo ndlela inikezela ixesha elide lokuhlala kwindawo ye-ocular. Oku konyusa ukubakho kwendalo kunye nonyango olusebenzayo.

Ukujiyisa ukuzinzisa:

I-HPMC isetyenziswa njenge-thickener kunye ne-stabilizer kulwelo kunye ne-semi-solid formulations efana nejeli, iikhrimu kunye nokuxhonywa. Inika i-viscosity kwezi zakhiwo kunye nokuphucula iimpawu zabo ze-rheological ngokubanzi.

Iimpawu eziphambili zeHPMC:

Ukunyibilika:

I-HPMC iyanyibilika emanzini kwaye yenza isisombululo esicacileyo, esingenambala. Isantya sokuchithwa sichatshazelwa yinqanaba lokutshintshwa kunye nebakala le-viscosity.

Viscosity:

I-viscosity yezisombululo ze-HPMC ibalulekile ekuqinisekiseni ukusebenza kwazo kwizicelo ezahlukeneyo. Amabakala ahlukeneyo akhoyo kunye ne-viscosities eyahlukeneyo, evumela ulawulo oluchanekileyo lweempawu ze-rheological zokuqulunqwa.

I-Thermal Gelation:

Amabanga athile e-HPMC abonisa iipropati ze-thermogelling, ezenza iijeli kumaqondo obushushu aphezulu. Le propati isetyenziselwa ukuphuhlisa imixube evakalelwa kubushushu.

ukuhambelana:

I-HPMC iyahambelana noluhlu olubanzi lwee-excipients zamachiza kunye ne-APIs, okwenza kube yinto yokuqala yokukhetha abaqulunqi. Ayisebenzi okanye ithobe uninzi lwezithako ezisebenzayo.

Imingeni kunye nokuqwalaselwa:

I-Hygroscopicity:

I-HPMC yi-hygroscopic, oku kuthetha ukuba ifunxa ukufuma kokusingqongileyo. Oku kuchaphazela ukuzinza kunye nokubonakala kokuqulunqwa, ngoko ke kufuneka iimeko ezifanelekileyo zokugcina.

Ukuhambelana nabanye abancedisi:

Nangona ngokubanzi iyahambelana, abaqulunqi kufuneka bathathele ingqalelo ukuhambelana kwe-HPMC kunye nabanye abancedisi ukunqanda ukusebenzisana okunokubakho okunokuthi kuchaphazele ukusebenza koqulunqo.

Ifuthe kwijika yonyibiliko:

Ukukhethwa kwebakala le-HPMC kunokuchaphazela kakhulu iprofayili yokupheliswa kwechiza. Umqambi kufuneka akhethe ngononophelo ibakala elifanelekileyo ukuze afikelele kwiimpawu zokukhupha ezinqwenelekayo.

Iingqwalasela zolawulo:

I-HPMC yamkelwe ngokubanzi njengesixhobo esikhuselekileyo nesisebenzayo soxubo-mayeza. Ihlangabezana nemigangatho eyahlukeneyo yokulawula kwaye ifakwe kwi-pharmacopoeias emhlabeni jikelele. Abavelisi kufuneka babambelele kwi-Good Manufacturing Practices (GMP) ukuqinisekisa umgangatho kunye nokuhambelana kweemveliso zamachiza ezine-HPMC.

ukuququmbela:

IHydroxypropylmethylcellulose (HPMC), njengesixhobo esisebenza ngeendlela ezininzi nesisetyenziswa ngokubanzi, idlala indima ebalulekileyo kwishishini loxubo-mayeza. Iimpawu zayo ezikhethekileyo zenza ukuba zilungele ukusetyenziswa kwiifom ezahlukeneyo zokulinganisa, kubandakanywa iipilisi, iipilisi kunye namalungiselelo ophthalmic. Abaqulunqi bayazuza ngokukwazi ukulungisa iipropati ze-HPMC ukuhlangabezana neemfuno ezithile zokuqulunqa, ezifana nokukhululwa okulawulwayo kunye nokuphucula uzinzo. Ngaphandle kwemingeni ethile, i-HPMC ihlala iyisithako esiphambili ekuphuhlisweni kweemveliso zamayeza ezikumgangatho ophezulu, ezinegalelo kukhuseleko kunye nokusebenza kakuhle kokwenziwa kwamachiza amaninzi.