I-Hydroxypropyl Methylcelceltulose ye-HOTMELCE (HPMC) yindawo esetyenziswa kakhulu kwi-chitary kunye ne-dieric eyongezelelekileyo kwimizi-mveliso, idla ngokufumaneka ngeendlela ezahlukeneyo zeevithamini kunye nezinye izongezo. Ukubandakanywa kwayo kusebenza ngeenjongo ezininzi, ukusukela kwindima yayo njengendawo yokubhabha, kukwazi kwayo ukwenza njenge-arhente elawulwayo, kwaye nezibonelelo zayo ezinokubakho ekuphuculeni izibonelelo ezisebenzayo.
1. Intshayelelo kwi-hydroxypropyl methylcelcelce
I-Hydroxypropyl Methylcelcelculose i-semi-synthetic, i-InErt, kunye ne-villsmelastic polymer ethathwe kwi-sellulose. Ngokucacileyo, yi-methyl ekutyuntshela kwi-sellyulose apho amanye amaqela e-hydroxyl kwiyunithi ephindayo ephindaphindayo afakwa kwi-Acpussit kunye namaqela e-hydroxypropy. Oku kuguqulwa kutshintsha iipropathi zayo zomsebenzi, ukubonelela ngenyibilikisi emanzini kwaye zisinika ngokwemisebenzi eyahlukeneyo esebenzayo eyenza ilungele uluhlu olubanzi lwezicelo, kubandakanya amayeza kunye nezondlo.
I-2. Imisebenzi ye-HPMC kwiivithamini kunye nezongezo zokutya
a. I-binder
I-HPMC isebenza njengombophelelo osebenzayo ekuvelisweni kweetafile zevithamimin kunye ne-capsules. Iipropathi zayo zokunamathela zivumela ukuba zibophelelene izithako ezahlukeneyo ezikhoyo kwindawo yokuqulunqwa, kuqinisekisa ukusasazwa iyunifomu kunye nokwenza lula inkqubo yokuphucula.
b. Iarhente yokukhupha
Omnye wemisebenzi ephambili ye-HPMC kwizongezelelo kukukwazi ukwenza amandla ayo njengearhente yokukhupha. Ngokwenza i-gel matrix xa i-hydrated, i-HPMC inokulawula ukukhululwa kwezithako ezisebenzayo, enyusa ukuchithwa kwabo kunye nokuthathwa kwi-gastrointenal phecanal. Le ndlela yokukhutshwa kwe-imeyile inceda ekuncedeni i-bioaaaais yeevithamini kunye nezinye izondlo, ukuqinisekisa ukukhutshwa okuzinzileyo ixesha elide.
c. Ifilimu yangaphambili kunye ne-commatiler
I-HPMC ikwasetyenziswa njengefilimu yangaphambili kunye ne-cariting kwimveliso yamacwecwe ahlanganisiweyo kunye ne-capsules. Ipropathi yayo yokwenza ifilimu yenza isithintelo esikhuselayo malunga nezithako ezisebenzayo, zikhusela kwizinto ezikhoyo, zikhusela izinto ezifana nokufuma, ukukhanya, kunye nokuzinza.
d. I-thickener kunye ne-stibilizer
Kwimigaqo engamanzi njengokumiswa, isiraphu, kunye nokuvela, i-HPMC isebenza njenge-thi checker kunye nokuzinzisa. Ukukwazi kwayo ukwandisa i-viscosity idlulisela isiphumo esinqwenelekayo kwimveliso, ngelixa iipropathi zayo zizinzi zithintela ukuhlawula amasuntswana kwaye kuqinisekiswe ukusasazeka kwezithako ezisebenzayo kulo lonke izithako ezisebenzayo kulo lonke izithako ezisebenzayo kulo lonke izithako ezisebenzayo kulo lonke izithako ezisebenzayo kulo lonke izithako ezisebenzayo kulo lonke izithako ezisebenzayo kulo lonke izithako ezisebenzayo ngalo lonke izithako ezisebenzayo kulo lonke izithako ezisebenzayo ngalo lonke izithako ezisebenzayo kulo lonke izithako ezisebenzayo ngalo lonke izithako ezisebenzayo kulo lonke izithako ezisebenzayo kulo lonke izithako ezifanelekileyo.
I-3. Ukusetyenziswa kwe-HPMC kwi-vitamin fomulations
a. I-Multivitamins
Izongezo ze-Mulvitamin zihlala ziqulunqa uluhlu olubanzi lweevithamini kunye neeminerali, zifuna ukusetyenziswa kweembiza, ezisasazekileyo, kunye nezinye iziqu zokuqinisekisa ukuthembeka kunye nokusebenza kwemveliso yokugqibela. I-HPMC idlala indima ebalulekileyo kwinkqubo enjalo ngokwenza lula ukunyanzelwa kwezithako kwiitafile okanye ezingezo ze-powders kwiicapsules.
b. Iitafile zeVitamin kunye ne-capsules
I-HPMC isetyenziselwa ukuveliswa kweepilisi zevithamini kunye ne-capsules ngenxa yokungaguqukiyo njenge-binder, intsholongwane, kunye ne-arhente yokukhupha i-Arhente. Imo yayo ye-Interter yenza ukuba ihambelane noluhlu olwahlukileyo lwezithako ezisebenzayo, zivumela ukwenziwa kweemveliso ezenziwe ngokwezifiso zilungiselelwe iimfuno ezithile zesondlo.
c. I-Vitamin Coyints
Kwiitafile ezidityanisiweyo kunye neecapbules, i-HPMC isebenza njengemiboniso bhanyabhanya yangaphambili kunye neyehlakani, ibonelela ngokugqibezela kwaye igqitywe kwifom yedosi. Oku kukhathazeka akuyiphumi nje isibongozo esihle ngokwemveliso kodwa kukhusela izithako ezisebenzayo kwi-Degrafition, umswakama, kunye nezinye izinto zangaphandle.
d. Ifomu yeVitamin ye-vitamin
Iinkqubo zeVitamin ye-vitamin enjengokuriza, ukunqunyanyiswa, kunye nee-emulssions zixhamla kwizinto zokubambisa kwaye zizimisele iipropathi ze-HPMC. Ngokudlulisela i-viscofity kwaye uthintele ukulungisa amasuntswana, i-HPMC iqinisekisa ukusasazwa kweevithamini kunye neeminerals kulo lonke uhlobo, ukuphucula ukubonakala kwayo kunye nokusebenza kwaso.
I-4. Izibonelelo ze-HPMC kwi-Vitamin
a. Uzinzo oluphuculweyo
Ukusetyenziswa kwe-HPMC kwi-vitamin yeendlela zeVitamin kunegalelo kuzinzo lwemveliso ngokukhusela izithako ezisebenzayo ekuthandeni okubangelwa kukufuma, ukukhanya kunye ne-oxidation. Ukwenza ifilimu kunye nokudibana kwe-HPMC Yenza isithintelo esikhusela iivithamini kwiimpembelelo zangaphandle, ngaloo ndlela igcina i-poling yawo kunye nokusebenza kakuhle kobomi bemveliso.
b. Ukuphuculwa kwebhayili
Indima ye-HPMC njenge-Arhente yokukhupha elawulwayo inceda ekuncedeni i-bioaaaains yevithamini ngokulawula ukukhutshwa kwayo kunye nokuthathwa komzimba. Ngokwandisa ukupheliswa kwezithako ezisebenzayo, i-HPMC iqinisekisa iprofayili yokukhupha okuzinzileyo, ivumela ukuthathwa okungcono kunye nokusetyenziswa kweevithamini kunye neeminerals ngomzimba.
c. Iifomu ezilungiselelwe ngokwezifiso
Ukusetyenziswa kwe-HPMC kuvumela ukwenziwa kwenkqubo ye-vitamin eyenziwe ngokwezifiso elungiselelwe iimfuno ezithile kunye nezinto ozithandayo. Nokuba ihlengahlengise iprofayili yokukhulula izithako ezisebenzayo okanye ezenza iifom ze-dosage ezikhethekileyo ezinjengeetafile ezincitshisiweyo okanye isiza-ntloko ezinamafutha, i-HPMC ibonelela ngeefomu zokuguquguquka kwimakethi yokutya okhuthazayo.
d. Ukuthobela isigulana
Ukusetyenziswa kwe-HPMC kwi-vitamin yokwandisa ukuthotyelwa kwesigulana ngokuphucula iimpawu zemvakalelo. Nokuba yintanda, ukuthungwa, okanye ukulungelwa, ukuqhutywa kwe-HPMC kunokuba negalelo kumava amnandi nabufanabudeni, ukukhuthaza abathengi ukuba balandele irejimeni yongeziimeko.
5. Ukuqwalaselwa kukhuseleko kunye nemeko yolawulo
I-HPMC ithathelwa ingqalelo njengekukhuselekileyo ukuze isetyenziswe kwii-chimeruticals kunye nezongezelelo zokutya xa zisetyenziswa ngokungqinelana neenkqubo zokwenza imveliso (i-GMP) kunye nezikhokelo ezimiselweyo zolawulo. Inembali ende yokusetyenziswa kwishishini kwaye iphononongwe kakhulu ngeprofayili yayo yokhuseleko. Nangona kunjalo, njengaluphi na omnye umqwalasele, kubalulekile ukuqinisekisa ukuba umgangatho, ubunyulu, kunye nokuthotyelwa kweemveliso ze-HPMC ezinemigangatho efanelekileyo yolawulo ukukhusela impilo yabathengi kunye nokhuseleko.
I-HydroxyPOpyl Methylcelcelsulose (HPMC) idlala indima ye-Prousterase (i-HPMC) idlala indima ye-vitamins kunye nezongezo zokutya, ukukhutshwa okulawulwa, ukwenziwa kwefilimu, kunye nokuzinza. Ukusetyenziswa kwendalo kunye nendalo ye-Inter yenze ukuba kubekho ukuba bakhethe iifomula zenjongo ezifuna ukuphucula uzinzo, bhayoloji, kunye nokuthotyelwa komonde kwiimveliso zabo. Njengoko imfuno yongezelelekileyo yesondlo esiphezulu iqhubeka ikhula, i-HPMC ihlala inesithako esixabisekileyo kwifomulators yefomulares, isebenze ukuphuculwa kwendlela yokwenziwa kwe-vitamin kunye ne-vitamin eyiyo yokulungelelanisa iimfuno ezahlukeneyo zabathengi.
Ixesha lokuphumla: Mar-19 ukuya ku-4024