Yintoni i-hypromellose?

Hypromellose (hydroxypropyl Methylcelceltulose: HPMC): Uhlalutyo olubanzi

1. Intshayelelo

Hypromellose, ekwabizwa ngokuba yi-hydroxypropyl methylcelcelsulose (i-HPMC), yi-polylile, i-polymer polymer ethathwe kwi-sellyulose. Isetyenziswe ngokubanzi kwi-Homarmaceuticals, Opthalmology, iimveliso zokutya, iicosmetics, kunye nemizi-mveliso yokwakha. Ngenxa yendalo engatyhefini, ipropati ebalaseleyo yefilimu, kunye nokuhambelana ne-bio, i-Hypromellose iyeyona nto ibaluleke kakhulu kwiifom ezahlukeneyo.

Olu xwebhu lubonelela ngohlalutyo olunzulu lwe-hypromellose, kubandakanya iipropathi zekhemikhali, isifo, izicelo, iprofayili yokhuseleko, kunye nokuqwalaselwa kolawulo.

I-2. Isakhiwo semichiza kunye neepropathi

I-Hypromellose i-selsued ye-cutesid sheet i-herguese i-hergued amaqela e-hydroxyl ithathelwe indawo yi-Manacxy (-och3) kunye ne-hydroxypropyl (-och2ch (oh) amaqela. Ubunzima bemolekyuli buyahluka ngokuxhomekeke kwinqanaba lokufaka kunye ne-polymerization.

• Umoya wobuchule:Ukunyibilika emanzini, ukwenza isisombululo se-viscous; I-Infolble e-ethanol kunye nezinye izinyibilikisi zendalo.
• I-Viskosity:Ifumaneka kuluhlu olubanzi lokuphila, lwenze ukuba kube luncedo kwizicelo ezahlukeneyo.
• Uzinzo lwePH:Izinzile kwi-RE RB Uluhlu lwe-PH (3-11).
• I-Termal:Yenza ijeli kwimfumba, ipropathi ephambili ekusetyenzisweni kweziyobisi.
• Imeko engeyiyo i-ionic:Ihambelana nezithako ezahlukeneyo zamayeza ezisebenzayo (i-APIS) ngaphandle kokunxibelelana kwemichiza.

I-3. Synthesis ye-hypromellose

Ukuveliswa kwe-hypromellose kubandakanya la manyathelo alandelayo:

1. Ukucocwa kweSeluplose:Kuthathwe kwiintsinga zezityalo, ngokuyintloko i-pulp okanye umqhaphu.
2. I-Alkalition:Iphathwe nge-sodium hydroxide (i-nayenzayo) yokuphucula ukuphinda isebenze kwakhona.
3. I-ether:Iphendulwe nge-methyl chloride kwaye i-proplene oxide yokwazisa i-Mactionsy kunye ne-hydroxypropy yamaqela.
4. Ukucocwa kunye nokomisa:Imveliso yokugqibela ihlanjululwe, yomiswe, kwaye ifunelwe kukuyifumana ubungakanani kunye ne-viscosity.

4. Ukusetyenziswa kwe-hypromellose

4.1 Ishishini lamayeza

I-Hypromellose isetyenziswa kakhulu kwifomu yamayeza ngenxa yokuqulunqa ifilimu, i-bioadive, kunye ne-Providencergeties:

• Ithebhulethi yeTafile:Yenza ungqimba okhuselayo ngeenxa zonke kwiitafile ukuphucula uzinzo kunye nokuthotyelwa komonde.
• Ukukhutshwa kweziyobisi nokulawulwa kweziyobisi:Isetyenziswe kwiitafile ze-matrix kunye neenkqubo ze-hydrophilic ges ukulawula ukutshitshiswa kweziyobisi.
• I-Capsule Lull:Isebenza njengenye imifuno kwi-capsules ye-gelatini.
• Inomdla kumahla e-def.Inika i-viscosity kunye nokugcinwa kweziyobisi kwizisombululo ze-opshalmic.

4.2 Izicelo ze-Ophthalmic

I-Hypromellose sisithako esiphambili kwiinyembezi ze-artificicial kunye ne-edops yeliso leliso:

• UKUNYANGWA KWE-SMNROMO YOKUGQIBELA:Izenzo njenge-arhente yokugcina umswakama ukukhulula ukomisa iliso kunye nokucaphukisa.
• Nxibelelana nezisombululo zeLensi:Iphucula i-lens intuthuzelo ngokunciphisa ukuxabana kunye nokuphucula i-hydration.

Imveliso yokutya

Njengoosongezelelo lokutya okhulisiweyo (E464), i-Hypromellose isebenza ngeenjongo ezahlukeneyo ekuqhubekeni kokutya:

• Iarhente yokuthambisa:Ukuphucula ukuthungwa kunye nokuzinza kwiisosi, ukunxiba, kunye neemveliso zobisi.
• I-Emoulsifier kunye ne-stibilizer:Gcina ukungqinelana ngokutya okuqhubekekayo kunye neziselo.
• I-Vegallit Telatitutter:Isetyenziswe kwiimveliso ezisekwe kwizityalo kunye nezinto ze-confectionery.

4.4 I-cosmetics kunye nokhathalelo lomntu

I-Hypromellose isetyenziswa ngokubanzi kubuhle kunye neemveliso ze-skeccare:

• Izityholo kunye neekhrim:Isebenza njenge-thi cokener kunye ne-stabilizer.
• I-Shampoos kunye neePisirioners:Iphucula i-viscofity kunye nokuqulunqwa kokuhambelana.
• Iimveliso zokwenza:Ukuphucula ukuthungwa kweMascaras nakwiziseko.

4.5 Izicelo zoKwakha kunye neziSeko zoMveliso

Ngenxa yokugcinwa kwayo amanzi kunye nobuchule bokwenza ifilimu, i-hypromellose isetyenziswa:

• Isamente kunye nokubeka phantsi:Ukuphucula ukusebenza nokunciphisa ukulahleka kwamanzi.
• Iipeyinti kunye neengubo:Imisebenzi njenge-binder kunye ne-stabilizer.
• Iziqwengana:Yandisa i-viscosity kwizicombulo ezingamanzi.

I-5. Ukhuseleko kunye nolawulo

I-Hypromellose ibonwa njengeearhente ezikhuselekileyo (iigrasi) ngeearhente zokulawula, kubandakanya nolawulo lweziyobisi (i-FDA) kunye nogunyaziso lokhuseleko lokutya e-Europe (i-EFSA). Inetyhefu encinci kwaye ayicaphukiyo xa isetyenziswa kwimida ecetyiswayo.

I-6. Iziphumo ezinokubakho kunye nezilumkiso

Ngelixa i-hypromellose ikhuselekile kubasebenzisi abaninzi, ezinye iziphumo ezinokubakho zibandakanya:

• Ukucaphuka kweliso leliso:Kwiimeko ezinqabileyo xa zisetyenziswa ekwehla ngamehlo.
• Ukugaya okungahambi kakuhle:Ukusetyenziswa kakhulu kweemveliso zokutya kunokubangela ukubhloka.
• IIMPENDULO EZIQHELEKILEYO:Inqabile kakhulu kodwa inokwenzeka kubantu abanobuthathaka.

HypromelloseNgaba isithako esibalulekileyo kumashishini amaninzi amaninzi, axabiseke ngenxa yetyhefu yayo engenabungozi, eguquguqukayo, kunye nokuzinzisa iipropathi. Indima yayo kwiindawo zamachiza, ukutya, izixhobo zokuthambisa, kunye nezicelo zemizi-mveliso ziyaqhubeka nokwandisa, zenza ukuba yeyeyona nto isetyenzisiweyo yeselcelosey kwihlabathi jikelele.