Yintoni i-hypromellose esetyenziswa kwiipilisi?

IHypromellose, ekwabizwa ngokuba yi-hydroxypropyl methylcellulose (HPMC), iqhele ukusetyenziswa kuqulunqo lwethebhulethi ngeenjongo ezininzi:

1. Isibophelelo: I-HPMC isoloko isetyenziswa njengesibophelelo kuqulunqo lwethebhulethi ukubamba izithako ezisebenzayo zamayeza (APIs) kunye nezinye izinto ezincedisayo kunye. Njenge-binder, i-HPMC inceda ukwenza iipilisi ezidibeneyo kunye namandla aneleyo omatshini, ukuqinisekisa ukuba ithebhulethi igcina ingqibelelo yayo ngexesha lokuphatha, ukupakisha kunye nokugcinwa.
2. I-Disintegrant: Ukongeza kwiipropati zayo zokubopha, i-HPMC inokusebenza njenge-disintegrant kwiipilisi. I-Disintegrants inceda ukukhuthaza ukuphuka ngokukhawuleza okanye ukuchithwa kwethebhulethi xa ifakwe, iququzelele ukukhutshwa kweziyobisi kunye nokufunxa kwi-gastrointestinal tract. I-HPMC idumba ngokukhawuleza xa idibana namanzi, ekhokelela ekuqhekekeni kwethebhulethi ibe ngamasuntswana amancinci kwaye incede ekuchithweni kweziyobisi.
3. Ifilimu yangaphambili / i-Agent ye-Coating: I-HPMC ingasetyenziswa njenge-arhente yokwenza ifilimu okanye i-coating material yamacwecwe. Xa isetyenziswe njengefilimu ebhityileyo kumphezulu wethebhulethi, i-HPMC inceda ukuphucula ukubonakala, ukugwinya, kunye nokuzinza kwethebhulethi. Inokuthi isebenze njengomqobo wokukhusela ithebhulethi kumswakama, ukukhanya, kunye neegesi ze-atmospheric, ngaloo ndlela iphucula ubomi beshelufu kunye nokugcina amandla eyeza.
4. I-Matrix yangaphambili: Ekukhutshweni okulawulwayo okanye ukukhutshwa okuzinzileyo kwe-tablet formulations, i-HPMC isoloko isetyenziswa njenge-matrix yangaphambili. Njenge-matrix yangaphambili, i-HPMC ilawula ukukhutshwa kwechiza ngokwenza i-gel-efana ne-matrix ejikeleze i-API, ilawula izinga lokukhululwa kwayo kwixesha elide. Oku kuvumela ukuhanjiswa kweziyobisi okulawulwayo kunye nokuphuculwa kokuthotyelwa kwesigulane ngokunciphisa ukuphindaphinda kwe-dosing.
5. Umxhasi: I-HPMC isenokusetyenziswa njenge-excipient kwi-tablet formulations ukulungisa iipropathi ze-tablet, ezinje ngokuqina, ukuqina, kunye nesantya sokuchithwa. Iimpawu zayo eziguquguqukayo zenza ukuba zilungele ukusetyenziswa kwimiqulu eyahlukeneyo, kubandakanywa ukukhutshwa ngokukhawuleza, ukulibaziseka-ukukhutshwa, kunye neepilisi zokukhululwa okwandisiweyo.

Lilonke, i-HPMC sisixhobo esisetyenziswa kakhulu kumachiza kuqulunqo lwethebhulethi ngenxa yokuhambelana kwayo nendalo, izinto ezininzi, kunye nokusebenza ngempumelelo ekuphumezeni iipropathi ezinqwenelekayo zethebhulethi. Ubume bayo obusebenzayo buvumela abaqulunqi ukuba balungelelanise iifomyula zethebhulethi ukuhlangabezana neemfuno ezithile zokuhanjiswa kwechiza kunye neemfuno zesigulane.