Yeyiphi eyona nto iphambili ye-hydroxypropyl methylcelcelgalose?

I-HydroxyPOpyl Methylcelcelsele (i-HPMC) yi-polymer eguquguqukayo ngoluhlu olubanzi lwezicelo kumashishini ahlukeneyo kubandakanya i-submerceuticals, ukutya, ukwakhiwa kunye ne-cosmetics. Ezona zinto zibalulekileyo eziluhlaza ezisetyenziselwa ukuqesha i-HPMC yi-selululose kunye ne-propylene oxide.

1. I-Selelose: isiseko se-HPMC

1.1 Amagqabantshintshi eSeluplose

I-seluplose yi-carbohydrate enento eyinxalenye ephambili yolwakhiwo lweendonga zeseli eziluhlaza. Inamathele imixokelelwane yomgca we-glucose molecus edityaniswe kunye β-1,4-Glycosidic Bonds. Ubuninzi bamaqela e-hydroxyl kwi-sellulose yenza ukuba ibe yinto efanelekileyo yokuqalisa ye-synthesis ye-synthesives eyahlukeneyo yeselfowuni, kubandakanya i-HPMC.

1.2 Ukuthengwa kweSeluplose

I-seluplose inokufumaneka kwizinto ezahlukeneyo zezityalo, ezinjengeenkuni zenkuni, ii-cotton ezinemithi, okanye ezinye izityalo ezinamaqhina. IPubp yeWood ngumthombo oqhelekileyo ngenxa yentabalala yayo, ukusebenza kweendleko, kunye nokuzinza. Ukukhutshwa kwesellulose kudla ngokubandakanya ukwahlukana kweentsinga zezityalo ngothotho lweenkqubo zoomatshini kunye neekhemikhali.

1.3 Ukucoceka kunye neempawu

Umgangatho kunye nokucoceka kweselselose kubalulekile ekumiseleni iimpawu zemveliso yokugqibela ye-HPMC. Ukucoceka okucocekileyo kuqinisekisa ukuba i-HPMC iveliswa ngeempawu ezingaguqukiyo ezinje nge-viscofity, isoba kunye nokuzinza komzimba.

I-2. I-propylene oxide: Intshayelelo yeQela le-hydroxypropy

2.1 Intshayelelo kwi-propylene oxide

I-propylene oxide (PO) i-organic ye-organic ngefomula yekhemikhali c3h6o. Yinto e-Epoxide, intsingiselo iqulethe i-shopygen atom ibotshwe kwiiathom ezikufuphi ezimbini. I-propylene oxide yeyona nto iphambili kwi-synthesis ye-hydroxdpropyl yeseluplose, enendawo ephakathi kwimveliso ye-HPMC.

2.2 Inkqubo ye-hydroxy

Inkqubo ye-hydroxyprocypropy iquka impendulo yesellulose nge-propylene oxide ukwazisa amaqela e-hydroxypropy kwi-selsulose i-sellenene. Le mpendulo idla ngokuqhutywa phambi komgangatho osisiseko. Amaqela e-hydroxyproplopy adlulisela ukuphuculwa kokuphucula amandla kunye nezinye iipropathi ezinqwenelekayo kwi-seluplose, ekhokelela ekumiselweni kwe-hydroxdpropyl yeseluplose.

I-3. I-MethyItrance: Yongeza amaqela e-methyl

3.1 Inkqubo ye-methylid

Emva kwe-hydroxyypropypy, inyathelo elilandelayo kwi-HPMC Synthesis yiMethysity. Inkqubo ibandakanya ukwenziwa kwamaqela e-methyl kwi-selsulose plarbone. I-methyl chloride yinkqubo esetyenziswayo isetyenziselwa le mpendulo. Inqanaba le-methysity lichaphazela iipropathi zemveliso ye-HPMC yokugqibela, kubandakanya nokuziphatha kwalo kunye ne-gel.

I-3.2 isidanga sokufaka

Inqanaba lokufakwa endaweni (DS) yiparamitha ephambili yokutshintsha inani lezinto ezithengisa izinto (i-methyl kunye ne-hydroxypropy) ngeyunithi ye-anhydroglucose kwikhonkco. Inkqubo yokwenziwa ilawulwa ngononophelo ukufezekisa intsebenzo oyifunayo yeemveliso ze-HPMC.

4. Ukucocwa kunye nokulawulwa komgangatho

4.1 Ukususwa kweemveliso ze-2

I-Synthesis ye-HPMC inokubangela ukumiswa kweemveliso ezinjengeetyus okanye iirejista ezingahoywanga. Amanyathelo okucoca kubandakanya ukuhlamba kunye nokufakelwa kusetyenziswa ukususa ezi zinto ziphangeleyo kunye nokunyusa ubunyulu bemveliso yokugqibela.

Amanyathelo olawulo lomgangatho

Amanyathelo olawulo olungqongqo aphunyezwe kuyo yonke inkqubo yokuqinisekisa ukuqinisekisa ukungqinelana kunye nomgangatho we-HPMC. Iindlela zohlalutyo ezifana ne-spectrascopy, i-chromatography kunye ne-romaology zisetyenziselwa ukuvavanya iiparameter ezifana nobunzima bemolekyuli, isidanga sokufaka kunye novimba.

I-5. Iimpawu ze-HydroxyPOpyl MethylcelcelUlose (HPMC)

5.1 Iipropathi zomzimba

I-HPMC i-white ukuya kwi-white-white emhlophe, i-odol engenasi-odol engenasixhobo sefilimu. I-hygroscopic kwaye icacisa ngokulula ijeli ebonakalayo xa ichithwa emanzini. Ukunyibilisela i-HPMC kuxhomekeka kwinqanaba lokufaka endaweni kwaye ichaphazelekile zizinto ezinje ngamaqondo obushushu kunye ne-pH.

5.2 Ubume bemichiza

Isakhiwo sekhemikhali se-HPMC siqukethe i-selllose yeselfowuni kunye ne-hydroxypropy ye-hydroxyl kunye ne-methyl. Umyinge wale nto, uboniswe kwinqanaba lokufaka endaweni, uthatha isakhiwo semichiza ngokubanzi kwaye ngenxa yoko iipropathi ze-HPMC.

5.3 I-Viscosity kunye neePropathi zeRheOology

I-HPMC iyafumaneka kumabakala ohlukeneyo nge-vingsm ye-vings. UVenkile weZisombululo ze-HPMC yinto ephambili kwizicelo ezinje ngamayeza, apho ichaphazela iprofayili yokukhulula ichiza, kwaye ichaphazela khona ukusebenza kwezifa kunye ne-pastes.

I-5.4 yefilimu yefilimu kunye nezinto ezinamabala

I-HPMC isetyenziswa ngokubanzi njengefilimu yangaphambili kwi-thematoceouticals kunye nearhente yokuthambisa kwiintlobo ezahlukeneyo zefomu. Ukuqulunqwa kwefilimu yefilimu kwenza ukuba ixabiseke kuphuhliso lweenkqubo zokuhambisa iziyobisi ezilawulayo, ngelixa iipropathi zayo zokuthambisa ziya kuphucula ukuthungwa kunye nokuzinza kweemveliso ezininzi.

6. Ukusetyenziswa kwe-hydroxypropyl methylcelcelceluplose

I-6.1 Ishishini lamayeza

Kumzi-mveliso wamayeza, i-HPMC isetyenziselwa ukwenza iifom zomnxeba eziqinileyo zethamo ezifana neetafile kunye neecapsules. Iqhelekile njenge-binder, i-istiongranti kunye nearhente yokuhlambela ifilimu. Ipropathi yokukhutshwa kwe-HPMC iququzelela isicelo sayo kwiifom zokukhupha ezizinzileyo.

6.2 Imveliso yokwakha

Kwicandelo lezokwakha, i-HPMC isetyenziswa njengearhente yokugcina amanzi, i-thi cokener kunye nokunamathela kwiimveliso ezisekwe kwisamente. Iphucula ukusebenza kodaka, kuthintela ukungcungcutheka kwizicelo ezithe nkqo, kwaye kuphucula ukusebenza kwento yokwakha.

6.3 Ishishini lokutya

I-HPMC isetyenziswa kumzi-mveliso wokutya njenge-gickener, i-stabilizer kunye ne-emulsifier. Ukukwazi kwayo ukwenza ii-gels kwiindawo ezigxile kuzo kwenza ilungele iintlobo ezahlukeneyo, kubandakanya iisosi, ukunxiba kunye needessert.

6.4 I-cosmetics kunye neemveliso zononophelo lomntu

Kwizithambiso kunye neemveliso zononophelo lobuqu, i-HPMC ifumaneka kuluhlu lweefom ezahlukeneyo kubandakanya iikhrim, i-lotions kunye ne-shampoos. Inceda ukuphucula ukuthungwa, uzinzo kunye nokusebenza ngokubanzi kwezi mveliso.

6.5 Amanye amashishini

Ukonwaba kwe-HPMC kwanda kwamanye amashishini, kubandakanya iipeyinti, iipeyinti kunye neminyango, apho inokusetyenziswa khona njenge-gemology modifier, iarhente yokugcina amanzi kunye ne-tickener.

7. Ukuqukumbela

I-HydroxyPOpylMethylcelcelcelcelose yi-polymer eguquguqukayo ngezicelo ezininzi. I-synthesi yayo isebenzisa isellulose kunye ne-propylene oxide njengezixhobo eziphambili ze-riw, kwaye i-selsulose ilungisiwe kwi-hydroxyprovypropy kunye neenkqubo zemazithi. Ulawulo olulawulwayo lwezi zinto zingafunekiyo kunye neemeko zokuphendula zinokuvelisa i-HPMC ngeepropathi ezenziwe ngokwezifiso ukufezekisa iimfuno ezithile zeshishini. Ke ngoko, i-HPMC idlala indima ebalulekileyo ekuphuculeni intsebenzo kunye nokusebenza kweemveliso kumashishini. Ukuphononongwa okuqhubekayo kwezicelo ezitsha kunye nokuphuculwa kweenkqubo zokwenza imveliso nceda i-HPMC iyaqhubeka nokudlala indima ebalulekileyo kwintengiso yehlabathi.