I-HPMC (Hydroxypropyl Methylcellulose) yikhompawundi yepolymer enyibilikayo emanzini esetyenziswa kakhulu kumayeza, ukutya, ulwakhiwo, izinto zokuthambisa kunye namanye amashishini. I-HPMC yi-semi-synthetic cellulose derivative efunyenwe ngokuguqulwa kweekhemikhali zeselulosi yendalo, kwaye idla ngokusetyenziswa njenge-thickener, stabilizer, emulsifier kunye ne-adhesive.
Iimpawu ezibonakalayo ze-HPMC
Indawo yokunyibilika ye-HPMC intsonkothe ngakumbi kuba indawo yayo yokunyibilika ayicacanga njengaleyo yemathiriyeli eqhelekileyo yekristale. Indawo yayo yokunyibilika ichaphazeleka kubume bemolekyuli, ubunzima bemolekyuli kunye nenqanaba lokutshintshwa kwe-hydroxypropyl kunye namaqela e-methyl, ngoko inokwahluka ngokwemveliso ethile ye-HPMC. Ngokubanzi, njengepolima enyibilikayo emanzini, i-HPMC ayinayo indawo yokunyibilika ecacileyo nefanayo, kodwa iyathamba kwaye ibole phakathi koluhlu oluthile lobushushu.
Uluhlu lwendawo yokunyibilika
Ukuziphatha kwe-thermal ye-AnxinCel®HPMC inzima kakhulu, kwaye ukuziphatha kwayo kokubola kwe-thermal ngokuqhelekileyo kufundwe ngohlalutyo lwe-thermogravimetric (TGA). Ukusuka kuncwadi, kunokufunyanwa ukuba indawo yokunyibilika ye-HPMC iphakathi kwama-200.°C kunye ne-300°C, kodwa olu luhlu alumeli eyona ndawo yokunyibilika yazo zonke iimveliso ze-HPMC. Iindidi ezahlukeneyo zeemveliso ze-HPMC zinokuba namanqaku ahlukeneyo okunyibilika kunye nokuzinza kwe-thermal ngenxa yezinto ezifana nobunzima be-molecular, i-degree of ethoxylation (i-degree of substitution), i-degree of hydroxypropylation (i-degree of substitution).
Ubunzima bemolekyuli esezantsi HPMC: Iqhele ukunyibilika okanye ithambe kumaqondo obushushu asezantsi, kwaye inokuqalisa ukunyibilika okanye ukunyibilika malunga nama-200.°C.
Ubunzima obuphezulu bemolekyuli HPMC: Iipholima zeHPMC ezinobunzima obuphezulu bemolekyuli zinokufuna amaqondo obushushu aphezulu ukuba anyibilike okanye athambe ngenxa yamatyathanga azo amade emolekyuli, kwaye aqhele ukuqala ukubola kunye nokunyibilika phakathi kwama-250.°C kunye ne-300°C.
Izinto ezichaphazela indawo yokunyibilika ye-HPMC
Ubunzima bemolekyuli: Ubunzima bemolekyuli ye-HPMC inempembelelo enkulu kwindawo yayo yokunyibilika. Ubunzima bemolekyuli obusezantsi buhlala buthetha ubushushu obuphantsi bokunyibilika, ngelixa ubunzima obuphezulu bemolekyuli bunokukhokelela kwindawo ephezulu yokunyibilika.
Iqondo lokutshintsha: Iqondo le-hydroxypropylation (okt umlinganiselo wokutshintsha kwe-hydroxypropyl kwi-molecule) kunye neqondo le-methylation (oko kukuthi umlinganiselo wokutshintshwa kwe-methyl kwi-molecule) ye-HPMC nayo ichaphazela indawo yayo yokunyibilika. Ngokubanzi, iqondo eliphezulu lokutshintsha linyusa ukunyibilika kwe-HPMC kwaye kunciphisa indawo yayo yokunyibilika.
Umxholo wokufuma: Njengesixhobo sokunyibilika kwamanzi, indawo yokunyibilika ye-HPMC nayo ichatshazelwa kukufuma kwayo. I-HPMC enomxholo ophezulu wokufuma inokuthi ingene kwi-hydration okanye i-partial dissolution, ekhokelela kutshintsho kwiqondo lokushisa lokubola kwe-thermal.
Uzinzo lwe-Thermal kunye nobushushu bokubola kwe-HPMC
Nangona i-HPMC ingenayo indawo engqongqo yokunyibilika, ukuzinza kwayo kwe-thermal sisalathisi sokusebenza. Ngokohlalutyo lwedatha ye-thermogravimetric (TGA), i-HPMC idla ngokuqala ukubola kuluhlu lobushushu obungama-250.°C ukuya ku-300°C. Ubushushu obuthile bokubola buxhomekeke kubunzima bemolekyuli, iqondo lokuthatha indawo kunye nezinye iipropati zomzimba kunye neekhemikhali ze-HPMC.
unyango Thermal izicelo HPMC
Kwizicelo, indawo yokunyibilika kunye nokuzinza kwe-thermal ye-HPMC kubaluleke kakhulu. Ngokomzekelo, kwishishini lamachiza, i-HPMC isoloko isetyenziswa njengesixhobo se-capsules, i-coatings yefilimu, kunye nabathwali bamachiza akhululwe ngokuqhubekayo. Kwezi zicelo, uzinzo lwe-thermal ye-HPMC kufuneka ihlangabezane neemfuno zokushisa, ngoko ke ukuqonda ukuziphatha kwe-thermal kunye noluhlu lwendawo yokunyibilika kwe-HPMC kubalulekile ekulawuleni inkqubo yemveliso.
Kwintsimi yolwakhiwo, i-AnxinCel®HPMC isoloko isetyenziswa njengento etyebisayo kudaka olomileyo, ukwambathisa kunye nokunamathelisa. Kwezi zicelo, ukuzinza kwe-thermal ye-HPMC kufuneka kwakhona ibe phakathi koluhlu oluthile ukuze kuqinisekiswe ukuba aluboli ngexesha lokwakhiwa.
HPMC, njenge-polymer material, ayinayo indawo edibeneyo yokunyibilika, kodwa ibonisa ukuthambisa kunye neempawu ze-pyrolysis ngaphakathi kwinqanaba elithile lobushushu. Indawo yayo yokunyibilika iphakathi kwama-200°C kunye ne-300°C, kunye neqondo elithile lokunyibilika lixhomekeke kwizinto ezifana nobunzima be-molecular, i-degree of hydroxypropylation, i-degree of methylation, kunye nomxholo womswakama we-HPMC. Kwiimeko ezahlukeneyo zokusetyenziswa, ukuqonda ezi mpawu ze-thermal kubalulekile ekulungiseleleni nasekusetyenzisweni kwayo.
Ixesha lokuposa: Jan-04-2025