Ukuvelisa i-Hydroxypropyl Methylcellulose (HPMC) ibandakanya amanyathelo amaninzi antsonkothileyo aguqula i-cellulose ibe yipolymer eguquguqukayo enoluhlu olubanzi lwezicelo kumashishini ahlukeneyo. Le nkqubo iqala ngokutsalwa kweselulosi kwimithombo esekwe kwizityalo, ilandelwa lutshintsho lweekhemikhali ukwazisa amaqela e-hydroxypropyl kunye ne-methyl kwi-cellulose backbone. Iziphumo zepolymer zeHPMC zibonelela ngeempawu ezizodwa ezinjengokuqina, ukubopha, ukwenza ifilimu, kunye nokugcinwa kwamanzi. Makhe sihlolisise inkqubo eneenkcukacha yemveliso ye-HPMC.
1. Ukufumana iMathiriyeli ekrwada:
Eyona mathiriyeli ekrwada yokuqala yemveliso ye-HPMC yiselulosi, ephuma kwimithombo esekwe kwizityalo efana nentlaka yeenkuni, iilitha zomqhaphu, okanye ezinye izityalo ezineefayibha. Le mithombo ikhethwa ngokusekelwe kwizinto ezinjengobunyulu, umxholo we-cellulose, kunye nokuzinza.
2. Ukutsalwa kweSelulosi:
I-cellulose ikhutshwe kwimithombo ekhethiweyo yezityalo ngokusebenzisa uchungechunge lweenkqubo zoomatshini kunye neekhemikhali. Ekuqaleni, loo nto ikrwada ilungiswa kwangaphambili, nto leyo esenokuquka ukuhlanjwa, ukugraya, nokomiswa ukuze kususwe ukungcola nokufuma. Emva koko, i-cellulose iphathwa ngeekhemikhali ezifana ne-alkalis okanye i-acids ukudiliza i-lignin kunye ne-hemicellulose, ishiya ngasemva imicu ye-cellulose ecocekileyo.
3. Etherification:
I-Etherification yinkqubo ephambili yeekhemikhali kwimveliso ye-HPMC, apho i-hydroxypropyl kunye namaqela e-methyl aziswa kwi-cellulose backbone. Eli nyathelo libalulekile ekulungiseni iipropati zeselulosi ukufezekisa imisebenzi efunekayo ye-HPMC. I-Etherification ngokuqhelekileyo iqhutyelwa ngokusabela kweselulosi ngepropylene oxide (yamaqela e-hydroxypropyl) kunye ne-methyl chloride (yamaqela e-methyl) phambi kwee-catalysts ze-alkali phantsi kweemeko ezilawulwayo zobushushu kunye noxinzelelo.
4. Ukungathathi hlangothi kunye nokuHlanjwa:
Emva kwe-etherification, umxube wokuphendula awuthathi hlangothi ukuze ususe nayiphi na i-alkali catalysts eseleyo kwaye ulungelelanise inqanaba le-pH. Oku kuqhele ukwenziwa ngokudibanisa iasidi okanye isiseko ngokuxhomekeke kwiimeko ezithile zokusabela. I-Neutralization ilandelwa kukuhlanjwa ngokucokisekileyo ukususa iimveliso, iikhemikhali ezingaphendulwanga, kunye nokungcola kwimveliso ye-HPMC.
5. Ukuhluza kunye nokomisa:
Isisombululo se-HPMC esingathathi hlangothi kwaye sihlanjwe sihlanjululwa ukuze sihlukanise amaqhekeza aqinileyo kwaye sifezekise isisombululo esicacileyo. Ukuhluza kunokubandakanya iindlela ezahlukeneyo ezinje ngokucoca ivacuum okanye i-centrifugation. Emva kokuba isisombululo sicacisiwe, somiswa ukususa amanzi kwaye sifumane i-HPMC kwifom yomgubo. Iindlela zokomisa zingabandakanya ukomisa isitshizi, ukomisa umandlalo omanzi, okanye ukomisa igubu, kuxhomekeke kubungakanani besuntswana elifunekayo kunye neempawu zemveliso yokugqibela.
6. Ukusila kunye nokuhluzwa (Ngokuzithandela):
Kwezinye iimeko, i-powder ye-HPMC eyomileyo inokuqhubela phambili ukuqhutyelwa phambili njengokugaya kunye ne-sieving ukufezekisa ubungakanani obuthile kunye nokuphucula ukuhamba. Eli nyathelo linceda ukufumana i-HPMC eneempawu zomzimba ezihambelanayo ezifanelekileyo kwizicelo ezahlukeneyo.
7. Ulawulo loMgangatho:
Kuyo yonke inkqubo yemveliso, amanyathelo angqongqo olawulo lomgangatho aphunyezwa ukuqinisekisa ubunyulu, ukungaguquguquki, kunye nokusebenza kwemveliso ye-HPMC. Iiparamitha zokulawula umgangatho zingabandakanya i-viscosity, ukusabalalisa ubungakanani be-particle, umxholo womswakama, i-degree of substitution (DS), kunye nezinye iimpawu ezifanelekileyo. Iindlela zokuhlalutya ezifana nemilinganiselo ye-viscosity, i-spectroscopy, i-chromatography, kunye ne-microscopy ziqhelekileyo zisetyenziselwa ukuhlolwa komgangatho.
8. Ukupakishwa kunye noGcino:
Nje ukuba imveliso ye-HPMC iphumelele iimvavanyo zolawulo lomgangatho, ipakishwe kwizikhongozeli ezifanelekileyo ezinjengeengxowa okanye imigqomo kwaye ibhalwe ngokweenkcukacha. Ukupakishwa okufanelekileyo kunceda ukukhusela i-HPMC kumswakama, ungcoliseko, kunye nomonakalo womzimba ngexesha lokugcinwa kunye nokuthutha. I-HPMC epakishweyo igcinwe kwiimeko ezilawulwayo ukugcina uzinzo kunye neshelufu-ubomi de ilungele ukuhanjiswa kunye nokusetyenziswa.
Usetyenziso lwe-HPMC:
IHydroxypropyl Methylcellulose ifumana ukusetyenziswa okubanzi kumashishini ahlukeneyo kubandakanya amayeza, ulwakhiwo, ukutya, izinto zokuthambisa, kunye neemveliso zokhathalelo lomntu. Kumachiza, isetyenziswe njenge-binder, i-disintegrant, ifilimu yangaphambili, kunye ne-ejenti yokukhululwa okuqhubekayo kwi-tablet formulations. Ekwakhiweni, i-HPMC iqeshwe njenge-thickener, i-arhente yokugcina amanzi, kunye ne-rheology modifier kwi-samente-based mortars, i-plasters, kunye ne-adhesives tile. Ekutyeni, isebenza njenge-thickener, stabilizer, kunye ne-emulsifier kwiimveliso ezifana neesosi, isuphu, kunye nezimuncumuncu. Ukongeza, i-HPMC isetyenziswa kwizinto zokuthambisa kunye neemveliso zokhathalelo lomntu ukwenza ifilimu, ukufuma, kunye neempawu zokuguqula ukuthungwa.
Iingqwalasela zokusiNgqongileyo:
Ukuveliswa kweHPMC, njengeenkqubo ezininzi zamashishini, kuneempembelelo zokusingqongileyo. Iinzame ziyenziwa ukuphucula uzinzo lwemveliso ye-HPMC ngamaphulo afana nokusebenzisa imithombo yamandla ahlaziyekayo, ukwandisa ukusetyenziswa kwemathiriyeli ekrwada, ukunciphisa ukuveliswa kwenkunkuma, kunye nokuphumeza ubugcisa bemveliso obulungele indalo. Ukongeza, ukuphuhliswa kwe-bio-based HPMC evela kwimithombo ezinzileyo efana ne-algae okanye i-microbial fermentation ibonisa isithembiso ekunciphiseni indawo yendalo yemveliso ye-HPMC.
ukuveliswa kwe-Hydroxypropyl Methylcellulose kubandakanya uchungechunge lwamanyathelo aqala kwi-cellulose extraction ukuya kukuguqulwa kweekhemikhali, ukuhlanjululwa, kunye nokulawula umgangatho. Isiphumo sepolymer yeHPMC ibonelela ngoluhlu olubanzi lwemisebenzi kwaye ifumana usetyenziso kumashishini ahlukeneyo. Iinzame ezibhekiselele kuzinzo kunye noxanduva lokusingqongileyo ziqhuba izinto ezintsha kwimveliso ye-HPMC, ejolise ekunciphiseni ifuthe layo lokusingqongileyo ngelixa ihlangabezana nemfuno ekhulayo yale polima esebenza ngeendlela ezininzi.
Ixesha lokuposa: Mar-05-2024