Hydroxypropyl methylcelculose (hpmc)Ngaba i-polymer ye-polymer ye-polymer esetyenziswe ngokubanzi kwi-pharmaceutical, yokwakha, ukutya, i-cosmetics kunye namanye amasimi. Ipropathi yayo yokufakwa kwe-viscosity yiparamitha ebalulekileyo yokulinganisa indlela yokuziphatha yengqolowa phantsi kweemeko ezahlukeneyo. Ukuqonda ipropathi yokufakwa kwe-HPMC ye-HPMC ixhaka kakuhle ukuba siqonde indlela yokuziphatha kunye nokusebenza kwezicelo ezahlukeneyo.
1. Isakhiwo semichiza kunye neepropathi ze-HPMC
I-HPMC ifunyanwa ngokulungiswa kweekhemikhali zeselutase yendalo, ikakhulu yenziwa ikakhulu yi-hydroxyypropy kunye ne-methylid yeemolekyuli zeselfowuni. Kwimo yemichiza ye-HPMC, ukungeniswa kwe-methyl (-och₃) kunye ne-hydroxypropyl (-och₂okhchch₃) amaqela enza ukuba inyibilike inyibilike kwaye isebenze kakuhle amandla. Ukusebenza kwe-viscosity yesisombululo sayo sobuchwephesha kunye namaqondo obushushu achaphazeleka zizinto ezininzi ezinje ngobunzima bemolekyuli, isidanga sokufaka endaweni, ukugxila kwesisombululo, njl.
2. Ubudlelwane phakathi kwe-viscofity kunye noxinzelelo
I-viscosity ye-viscosity ye-diance chpm®hpmc acteract ihlala inyuka ngokukhulisa uxinzelelo. Kungenxa yokuba kumaxesha aphezulu, ukusebenzisana phakathi kweeMolekyuli kuyaphuculwa, kukhokelela ekunyukeni kokunganyangeki. Nangona kunjalo, ukwahlulahlula kunye neempawu ze-viscosity ze-HPMC emanzini kuyachaphazeleka kukuqina kwemolekyuli. I-HPMC enezisindo eziphakamileyo zemolekyuli zihlala zibonisa i-viscofity ephezulu, ngelixa ubunzima bemolekyuli ephantsi busezantsi.
Ukugxininisa okuphantsi: ISisombululo se-HPMC sibonisa i-viscofity esezantsi kwiingcinezelo ezisezantsi (ezinje nge-0.5%). Ngeli xesha, unxibelelwano phakathi kweemolekyuli lubuthathaka kwaye ubulwele bulungile. Ihlala isetyenziswa kwizicelo ezifana nengubo yangaphantsi kunye nokukhululwa kwezichiza.
Ukugxila okuphezulu: Ngeengxoxo eziphezulu (ezinje nge-2% okanye ngaphezulu), ukubonwa kwesisombululo se-HPMC AMARANI EYUYELA EKUGQIBELENI, ebonisa iipropathi ezifanayo nezisombululo zeColoidal. Ngeli xesha, ulwelo lwesisombululo luxhomekeke ekuchaseni kakhulu.
3. Ubudlelwane phakathi kwe-viscofity kunye neqondo lobushushu
Uhlobo lwe-viscosity ye-HPMC ACTEAUROOOOOOOOOOOOOR ITSHINTSHO KAKHULU NGOKUGQIBELA. Njengoko iqondo lobushushu liyanda, intshukumo phakathi kweemolekyuli zamanzi iyanda, kwaye unxibelelwano phakathi kweemolekyuli ze-HPMC luba buthathaka, lukhokelela ekunciphiseni kwe-viscofity. Olu phawu lwenza ukuba ukusetyenziswa kwe-HPMC kubushushu obahlukeneyo kubonisa uhlengahlengiso oluqinileyo. Umzekelo, phantsi kweemeko zobushushu obuphezulu, i-viscosity ye-HPMC ihlala incipha, ebaluleke ngakumbi kwinkqubo yokukhululwa kwamayeza, ngakumbi kwiifom zokukhululwa kwamachiza, apho utshintsho lobushushu lunokuchaphazela uzinzo kunye nesiphumo sesisombululo.
4. Isiphumo se-PH kwi-viscosity
Uhlobo lwesisombululo se-HPMC AMAICOOU ENGAXELELEKILE KUQHUTYWA NOKUXELWA NGEXESHA LESICOLO. Nangona i-HPMC yinto engeyiyo i-ionic, i-hydrophicicity i-hydrophicicy kunye neepropathi zobufazi zichaphazeleka ikakhulu yimo yemolekyuli kunye nemeko yesisombululo. Nangona kunjalo, phantsi kwe-acidic okanye iimeko ze-alkaline, i-smobility kunye nemozulu ye-molecular ye-HPMC inokutshintsha, ngenxa yoko ichaphazela i-viscofity. Umzekelo, phantsi kweemeko ze-acidic, i-sloubing ye-HPMC inokubuthathaka kancinci, ikhokelela ekunyuseni i-viscofity eyandisiweyo; Ngelixa phantsi kwemeko ye-alkaline, i-hydrolysis ye-HPMC inokubangela ukuba ubunzima bayo buye bancipha, ngaloo ndlela kuncitshiswa i-viscofity.
5. Ubunzima bemolekyuli kunye ne-viscofity
Ubunzima bemolekyuli yenye yezinto ezibalulekileyo ezichaphazela i-viscofity yesisombululo se-HPMC. Ubunzima bemolekyuli obuphezulu bunyusa ukungathathi-sulwa kunye nokudibanisa ukudibanisa phakathi kweemolekyuli, okukhokelela kulwandiso lwe-viscosity. Ubunzima obuphantsi kwemolekyuli i-suntrincel®hpmc inolwazi olungcono kakhulu emanzini nasezantsi. Iimfuneko ezahlukeneyo zesicelo zihlala zifuna ukukhetha i-HPMC kunye neemolekyuli ezahlukeneyo zemolekyuli. Umzekelo, kwi-coyings kunye nemihlambi, ubunzima bemolekyuli ephezulu ye-HPMC ihlala ikhethiwe ukuze ibethelele kunye nolwelo; Ngelixa amalungiselelo asechiza, i-HPMC ye-molecular ye moleculart inokusetyenziswa ukulawula inqanaba lokukhupha amachiza.
I-6. Ubudlelwane phakathi kwenqanaba le-Shear kunye ne-viscofity
Uhlobo lwe-viscosity ye-HPMC ACTEAROOR AMANQAKU AYA KUPHELA NGEXESHA LOKUGQIBELA, elibonisa indlela yokuziphatha ye-pseudoplastic. I-pseudoplastic fluid i-fluid i-viscofity ehamba ngokuthe ngcembe incipha ngokunyuka kwenqanaba le-Shear. Olu phawu lwenza ukuba isisombululo se-HPMC ukuze silondoloze i-viscofity ephezulu kwixabiso le-Shearl Shear xa isetyenziswa, kwaye yandise ulwelo kwinqanaba le-Shoarte. Umzekelo, kumzi-mveliso oqengqelekayo, isisombululo se-HPMC hlala kufuneka sibonise i-viscofity ephezulu kwixabiso le-Shearting xa kuqinisekiswa ukuqinisekisa ukuba i-adhesion kunye nenqanaba lenkqubo yokwakha, kuyimfuneko ukwandisa umlinganiso weShear ukuze enze I-fluid ngakumbi.
7. Isicelo kunye neempawu ze-viscosity ze-HPMC
Iimpawu ze-viscosity zeI-HPMCyenza isetyenziswe ngokubanzi kwiindawo ezininzi. Umzekelo, kumzi-mveliso wamayeza, i-HPMC ihlala isetyenziswa njenge-arhente egciniweyo yokukhupha iziyobisi, kwaye umgaqo wayo wokuVangela usetyenziselwa ukulawula inqanaba lokukhutshwa kwechiza; Kumzi-mveliso wokwakha, i-HPMC isetyenziswa njenge-thichoner ukuphucula ukusebenza kunye nokugcwala kodaka kunye nababukeli; Kwishishini lokutya, i-HPMC inokusetyenziswa njenge-thickener, i-eulsifier kunye nokuzinzisa ukuphucula incasa kunye nokubonakala kokutya.
Iimpawu ze-viscosity ye-viscosic ye-chancelcel®hpmc aquous sisitshixo sokufaka isicelo kwimimandla eyahlukeneyo. Ukuqonda ubudlelwane bayo nezinto ezinje ngoxinzelelo, ubushushu, i-PH, isilinganiselo sobunzima bemolekyuli kunye nenqanaba le-Shearl ibaluleke kakhulu ekuphuculeni imveliso yemveliso efanelekile.
IXESHA LOKUQALA: UJAN-27-2025