I-Hydroxypropyl Methylcellulose (HPMC) iyinto ebalulekile enezicelo eziningi ezahlukahlukene embonini yezemithi kanye nezinye izimboni ezinjengokudla, izimonyo nokwakha. Isidingo se-HPMC besikhule ngokuqinile eminyakeni edlule ngenxa yezakhiwo zayo ezihlukile njengokuqina, ukubopha, ukushaya ifilimu nokugcinwa kwamanzi. Kulesi sihloko, sizoxoxa ngendlela yokukhiqiza ye-Alkaline Leashing ye-Hydroxypropylylylylyllose (HPMC).
Indlela yokukhiqiza ye-Alkali Leashing ye-Hydroxypropyllylylylylyl (HPMC) yinqubo lapho iselula ahlangana khona ne-propelene oxide ne-methyl chloride phambi kwe-Alkali. Inqubo yenzeka ngaphansi kokushisa, ingcindezi kanye nezimo ezilawulwa isikhathi ukukhiqiza imikhiqizo ephezulu ye-HPMC.
Isinyathelo sokuqala sokukhiqiza i-HPMC usebenzisa indlela yokukhiqiza i-Alkaline Leashing ukulungiswa kwezinto ezibonakalayo ezivuthiwe. I-cellulose ihlanjululwa okokuqala ngokususa noma yikuphi ukungcola bese iguqulwa ibe yi-Alkali Cellulose ngokwelashwa nge-alkali enjenge-sodium hydroxide. Lesi sinyathelo sibucayi ngoba sandisa ukuvumelanisa kwe-cellulose nge-reagents esetshenziswa ezitebhisini ezalandela.
I-Alkali Cellulose iphathwa ngengxube ye-propylene oxide ne-methyl chloride ngaphansi kokushisa okulawulwayo kanye nengcindezi. Ukusabela phakathi kwe-Alkali Cellulose kanye ne-Reagent kuphumela ekwakhekeni komkhiqizo, okuyingxube ye-hydroxypropylylylylylylylykyl methylcellulose neminye yemikhiqizo.
Inhlanganisela iyagezwa, ingathathi hlangothi futhi ihlungwa ukususa ukungcola okufana nama-reagents angavuliwe kanye nemikhiqizo. Isixazululo esivelayo sibe sesigxilwe ngokuhwamuka ukuze sithole umkhiqizo we-HPMC ophakeme.
Indlela yokukhiqiza ye-Alkali Leashing ye-Hydroxypropyllylylylylyl (HPMC) inezinzuzo eziningi ngokuqhathaniswa nezinye izindlela zokukhiqiza ezifana nokuthezeka. Enye yezinzuzo ukuthi inqubo enobungani bemvelo. Ngokungafani nezinye izinqubo, indlela yokukhiqiza i-Alkali Leashing ayisebenzisi ama-solvents anenkani eyingozi emvelweni nasempilweni yomuntu.
Enye inzuzo yale ndlela ukukhiqizwa kwemikhiqizo ye-HPMC ephakeme. Izimo zokuphendula ezilawulwayo ziqinisekisa umkhiqizo wokugcina ungekhwalithi engaguquki futhi ulungele izinhlelo ezahlukahlukene ezahlukahlukene.
Ukusetshenziswa kwe-HPMC embonini yezemithi kubalulekile ukukhiqizwa kwamathebulethi, ama-caplule namanye amafomu dosage. I-HPMC ingasetshenziswa njenge-binder, ukuqhelelana, i-ejenti, njll. Ukusetshenziswa kwe-HPMC kulezi zicelo kuqinisekisa ukuthi ifomu lomthamo lingekhwalithi ephezulu futhi lihlangabezana namazinga adingekayo.
I-HPMC nayo isetshenziswa njenge-mkhulu, i-emulsifier ne-stabilizer embonini yokudla. Ukusetshenziswa kwe-HPMC emikhiqizweni yokudla kuqinisekisa ukuthungwa okungaguquki, ukubonakala kanye nekhwalithi.
Embonini yezokwakha, i-HPMC isetshenziswa njengesengezo sesimende ukwenza ngcono ukuwenza, ukugcinwa kwamanzi kanye nezindawo zokubopha izibopho zikasimende. Ukusetshenziswa kwe-HPMC kuqinisekisa ukuthi imikhiqizo yokwakha ingekhwalithi ephezulu futhi ihlangabezana namazinga adingekayo.
Ngokufundwa, indlela yokukhiqiza ye-Alkali Leashing ye-Hydroxypropylllylylylylylylyl (HPMC) yinqubo yokukhiqiza imikhiqizo esezingeni eliphakeme ye-HPMC futhi isetshenziswa kabanzi kwizimboni ezahlukahlukene ezinjengemithi, ukudla, kanye nokwakha. Ukusetshenziswa kwe-HPMC kulezi zicelo kuqinisekisa ukuthi umkhiqizo wekhwalithi ephezulu futhi uhlangabezana namazinga adingekayo. Le ndlela yokukhiqiza nayo inobungani bemvelo futhi ikhiqiza umkhiqizo we-HPMC ophakeme we-HPMC.
Isikhathi sePosi: Sep-15-2023