I-Hydroxypropyl Methylcellulose (HPMC), eyaziwa nangokuthi i-Hypromellose, iyinhlangano eguquguqukayo esetshenziswa kabanzi embonini yezemithi. Kuyinto e-semi-zokwenziwa, inert, i-viscoelastic polymer ethathwe ku-cellulose, i-polysaccharide yemvelo. I-HPMC ibaluleke kakhulu nge-solubility yayo emanzini, imvelo engeyona inobuthi, kanye nekhono layo lokukha amafilimu nama-gels.
1. I-Binder ekusungulweni kwethebhulethi
Enye yezinhlelo zokusebenza eziphambili ze-HPMC e-Pharmaceuticals injenge-binder ekusungulweni kwethebhulethi. I-HPMC iqashwa ukuqinisekisa ukuthi izithako ezinamathebhulethi zibambelela ndawonye futhi zihlala zizinzile kuze kube yilapho kufakwa. Izakhiwo zayo ezibophayo zithuthukisa amandla amathebulethi, zibenze bathambekele ekutholeni noma baphuke ngesikhathi sokupakisha, izinto zokuhamba, nokuphatha. Ngokwengeziwe, i-HPMC's Non-Ion-Ionic Imvelo iyaqinisekisa ukuthi ayiphenduli nezinye izithako, ukugcina ukuqina nokusebenza kahle kwezithako ezenziwa ngemithi (API).
2. I-Matrix elawulwayo
I-HPMC ibalulekile ekuthuthukisweni kokuhlinzekwa okulawulwa okulawulwayo (CR) kanye nokwakheka okuqhubekayo (SR). Lezi zinhlaka zenzelwe ukukhipha umuthi ngesilinganiso esinqunyiwe, sigcina amazinga ezidakamizwa angaguquki egazini ngaphezulu kwesikhathi eseluliwe. Amandla e-gel-enziwe yi-gel-enziwe nge-HPMC lapho axhumana noketshezi lwe-gastrointenal kwenza kube kuhle ngale njongo. Kwakha ungqimba lwe-gel olusezingeni eliphansi ezungeze ithebhulethi, elawula ukubekeka kwesidakamizwa. Lesi sici sizuzisa kakhulu izidakamizwa ezinenkomba yokwelapha emincane, ngoba zisiza ekugcineni ukugxila kwe-plasma oyifunayo, ngaleyo ndlela kuthuthukise ukusebenza kahle kanye nokunciphisa imiphumela emibi.
3. I-film coating
Olunye uhlelo lokusebenza olubalulekile lwe-HPMC lusemafulethini amathebulethi nama-caplule. Izambatho ezisuselwa ku-HPMC zivikela ithebhulethi ezicini zezemvelo ezifana nomswakama, ukukhanya nomoya, ezingalimaza izithako ezisebenzayo. I-Film coating nayo ithuthukisa ukudluliswa kwethebulethi, ithuthukisa ukunambitheka, futhi ingasetshenziselwa ukuhlinzeka ngokuvikelwa okufakiwe, ukuqinisekisa ukuthi umuthi ukhishwa ezindaweni ezithile zepheshana lesisu. Ngaphezu kwalokho, izimbobo ze-HPMC zenzelwe ukuguqula iphrofayili yokukhishwa yomuthi, ukusiza ezinhlelweni zokulethwa okuhlosiwe.
4. Ukuqina kwe-ejenti
I-HPMC isebenza njenge-ejenti yokuqina esebenzayo ekusungulweni koketshezi njenge-syrups nokumiswa. Amandla alo okukhulisa ukubonakala ngaphandle kokushintsha kakhulu ezinye izakhiwo zokwakhiwa zizuzisa ukulundla ukwabiwa okufanayo kwezidakamizwa ngaphakathi koketshezi, nokunikeza inkunzi efiselekayo. Le mpahla ibaluleke kakhulu ekwakhekeni kwezingane kanye nokwakhiwa kwama-geriatric, lapho ukulunga kokuphatha kubalulekile.
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Emakwakheni aphezulu afana nokhilimu, ama-gels, kanye namafutha, i-HPMC isebenza njenge-stabilizer ne-emulsifier. Kuyasiza ukugcina ukuvumelana nokuqina kokwakhiwa, ukuqinisekisa ukuthi izithako ezisebenzayo zisatshalaliswa ngokulinganayo. I-HPMC ibuye inikeze ukuthungwa okubushelelezi, ukuthuthukisa uhlelo lokusebenza kanye nokutholwa komkhiqizo esikhunjeni. Imvelo yayo engacasuli yenza kube lula ukusetshenziswa ekwakhiweni kwesikhumba esibucayi.
6. Amalungiselelo we-Ophthalmic
I-HPMC isetshenziswa kabanzi kumalungiselelo we-ophthalmic, njengezinyembezi zokufakelwa kanye nezixazululo zelensi yokuxhumana. Izakhiwo zalo ze-thocoelastic zilingisa ifilimu yemvelo yemvelo, zinikeza ukuthambisa kanye nomswakama emehlweni. Amaconsi e-HPMC asuselwa kuso azuzisa kakhulu abantu abane-eye ye-Eyel Syndrome, enikeza impumuzo ekucasukeni nasekuphatheni. Ngokwengeziwe, i-HPMC isetshenziswa ezinhlelweni zokulethwa kwezidakamizwa ze-ocular, lapho ithola khona ekwamukeleni isikhathi sokuxhumana nesidakamizwa nge-ocular ebusweni, ukuthuthukisa ukusebenza kahle kokwelapha.
7. Ukuqanjwa kwe-capsule
I-HPMC nayo isetshenziswa ekwenziweni kwama-caplule anzima futhi athambile. Isebenza njengenye indlela ye-gelatin, enikeza inketho yemifino yama-capsule amagobolondo. Ama-HPMC capsule akhethwa ngokuqukethwe kwawo komswakama ophansi, okuzuzisa izidakamizwa ezibucayi komswakama. Baphinde banikeze ukuqina okungcono emazingeni ahlukahlukene wezemvelo futhi mancane amathuba okuthi banqamula-isixhumanisi, udaba olujwayelekile ngama-gelatin caplule angathinta amaphrofayili okukhishwa kwezidakamizwa.
8. Ukuthuthukiswa kwe-Bioavailability
Kwezinye izindlela, i-HPMC ingathuthukisa ubuhlakani bezidakamizwa ezingenampilo kabi. Ngokwakha i-matrix ye-gel, i-HPMC ingakhuphula izinga lokuchithwa kwesidakamizwa epheshanasistimu yesisu, lula ukumunqwa okungcono. Lokhu kubaluleke kakhulu ezidakamizweni ezinamanzi aphansi we-solubity, njengoba ukuhlukaniswa okuthuthukile kungathinta kakhulu ukusebenza kwezidakamizwa.
9. Izicelo ze-mucoadhesive
I-HPMC ikhombisa izakhiwo ze-mucoadhesive, okwenza ilungele izinhlelo zokulethwa kwezidakamizwa nezinhlelo zokufuya. Lezi zinhlelo zidinga umuthi ukunamathela ngolwelwesi lwama-mucous, ukuhlinzeka ukukhishwa isikhathi eside kanye nokutholwa ngqo egazini, kudlula umehluko wokuqala we-peapolim. Le ndlela inenzuzo yezidakamizwa ezincipha emvelweni ene-acidic yesisu noma zibe ne-bioavailource empofu yomlomo.
Ukuguquguquka okuhlukahlukene kwe-hydroxypropylm methylcellulose (HPMC) ezinqumweni zezemithi azikwazi ukweqiwa. Izicelo zalo ezivela ku-tablet zibopha kanye ne-film coating ukuze zikhule kanye nokuzinza ama-ejenti ezinhlantesweni ezahlukahlukene. Amandla we-HPMC okuguqula amaphrofayili okukhishwa kwezidakamizwa, athuthukise ama-bioavailability, futhi ahlinzeke nge-mucoadhesion agcizelela ukubaluleka kwayo ekuthuthukisweni kwezinhlelo ezithuthukile zokulethwa kwezidakamizwa. Njengoba imboni yezemithi iyaqhubeka nokuvela, iqhaza le-HPMC lizokhula, liqhutshwe ngemizamo eqhubekayo yokucwaninga nemizamo yentuthuko ehlose ukulungiselela ukulethwa kwezidakamizwa kanye nemiphumela yeziguli.
Isikhathi Sokuthumela: Jun-05-2024