IHydroxypropyl methylcellulose (HPMC), eyaziwa nangokuthi i-hypromellose, iyi-polymer eguquguqukayo esetshenziswa kabanzi embonini yezemithi. I-semi-synthetic, inert, i-viscoelastic polymer etholakala ku-cellulose, i-polysaccharide yemvelo. I-HPMC ibaluleke kakhulu ngokuncibilika kwayo emanzini, imvelo engenabo ubuthi, kanye nekhono layo lokwenza amafilimu namajeli.
1. I-Binder Ekwakhiweni Kwethebhulethi
Enye yezinhlelo eziyinhloko ze-HPMC kwezemithi injenge-binder ekwenziweni kwethebhulethi. I-HPMC isetshenziswa ukuze kuqinisekiswe ukuthi izithako kuthebhulethi zinamathela ndawonye futhi zihlala zizinzile kuze kube yilapho zingeniswa. Izakhiwo zawo ezibophayo zithuthukisa amandla okusebenza amaphilisi, awenze angajwayele ukuchotshozwa noma ukuphuka ngesikhathi sokupakishwa, ukuthuthwa, kanye nokuphathwa. Ukwengeza, imvelo ye-HPMC engeyona i-ionic iqinisekisa ukuthi ayisabeli nezinye izithako, igcina ukuqina nokusebenza kwezithako ezisebenzayo zemithi (ama-API).
2. I-Matrix Yokukhishwa Okulawulwayo
I-HPMC ibalulekile ekuthuthukisweni kokukhishwa okulawulwayo (CR) kanye nokwakhiwa kokukhululwa okuqinile (SR). Lokhu kwakheka kuklanyelwe ukukhulula umuthi ngenani elinqunywe kusengaphambili, ukugcina amazinga ezidakamizwa angaguquki egazini esikhathini eside. Ikhono lokwakha ijeli le-HPMC lapho ithinta uketshezi lwamathumbu lenza ilungele le njongo. Yakha ungqimba lwejeli ye-viscous ezungeze ithebhulethi, elawula ukusakazeka komuthi. Lesi sici sizuzisa kakhulu izidakamizwa ezinenkomba emincane yokwelapha, njengoba isiza ekugcineni ukugxila kwe-plasma oyifunayo, ngaleyo ndlela kuthuthukise ukusebenza kahle nokunciphisa imiphumela emibi.
3. I-Film Coating
Okunye ukusetshenziswa okubalulekile kwe-HPMC ekwengezeni ifilimu yamaphilisi namaphilisi. Izigqoko ezisekelwe ku-HPMC zivikela ithebhulethi ezicini zemvelo ezifana nomswakama, ukukhanya, nomoya, ezingonakalisa izithako ezisebenzayo. Ukufakwa kwefilimu nakho kuthuthukisa ukukhanga kobuhle kwethebhulethi, kuthuthukisa ukufihla ukunambitheka, futhi kungasetshenziswa ukunikeza ukuvikeleka kwe-enteric, ukuqinisekisa ukuthi umuthi ukhishwa ezindaweni ezithile zepheshana lamathumbu. Ngaphezu kwalokho, ukumbozwa kwe-HPMC kungaklanywa ukuguqula iphrofayili yokukhululwa yomuthi, kusize ezinhlelweni zokulethwa okuhlosiwe.
4. I-ejenti yokujiya
I-HPMC isebenza njenge-ejenti yokuqina esebenzayo ekwakhiweni koketshezi njengamasyrups nokumiswa. Ikhono layo lokwandisa i-viscosity ngaphandle kokuguqula ngokuphawulekayo ezinye izici zokwakheka kunenzuzo ekuqinisekiseni ukusatshalaliswa okufanayo komuthi ngaphakathi koketshezi, ukuvimbela ukuthungwa kwezinhlayiya ezimisiwe, nokunikeza umlomo ofiselekayo. Lesi sakhiwo sibaluleke kakhulu ekwakhiweni kwezingane kanye ne-geriatric, lapho ukulawulwa kalula kubalulekile.
5. I-Stabilizer ku-Topical Formulations
Ekwakhiweni kwezihloko okufana nokhilimu, amajeli, namafutha okugcoba, i-HPMC isebenza njengesiqinisi nesifanisi. Kuyasiza ukugcina ukuhambisana nokuzinza kokubunjwa, ukuqinisekisa ukuthi izithako ezisebenzayo zisatshalaliswa ngokulinganayo. I-HPMC futhi inikeza ukuthungwa okushelelayo, ithuthukisa ukusetshenziswa nokumuncwa komkhiqizo esikhumbeni. Ukungacunuli kwayo kuyenza ilungele ukusetshenziswa ekwakhiweni kwesikhumba esibucayi.
6. Amalungiselelo e-Ophthalmic
I-HPMC isetshenziswa kakhulu kumalungiselelo e-ophthalmic, njengezinyembezi zokwenziwa kanye nezixazululo zelensi yokuxhumana. Izakhiwo zayo ze-viscoelastic zilingisa ifilimu yezinyembezi zemvelo, ihlinzeka ngokugcoba kanye nomswakama emehlweni. Amaconsi eso asuselwa ku-HPMC azuzisa kakhulu abantu abane-eye syndrome eyomile, enikeza impumuzo ekucasukeni nasekuphatheni kabi. Ukwengeza, i-HPMC isetshenziswa ezinhlelweni zokulethwa kwezidakamizwa ze-ocular, lapho isiza ekwandiseni isikhathi sokuxhumana somuthi ngendawo yamehlo, okuthuthukisa ukusebenza kahle kokwelapha.
7. Ukwakhiwa kwe-Capsule
I-HPMC isetshenziswa futhi ekwenzeni amaphilisi aqinile nathambile. Isebenza njengenye indlela ye-gelatin, ihlinzeka ngenketho yemifino yamagobolondo e-capsule. Amaphilisi e-HPMC akhethwa ngenxa yokuqukethwe kwawo okuphansi komswakama, okunenzuzo emithini engezwani nomswakama. Ziphinde zinikeze ukuzinza okungcono ezimweni ezihlukene zemvelo futhi mancane amathuba okuthi zinqamuke, inkinga evamile ngamaphilisi e-gelatin angathinta amaphrofayili okukhishwa kwezidakamizwa.
8. Ukuthuthukisa I-Bioavailability
Kwezinye izimo, i-HPMC ingathuthukisa i-bioavailability yemithi engancibiliki kahle. Ngokwenza i-matrix yejeli, i-HPMC ingakhuphula izinga lokuqedwa lomuthi epheshaneni lamathumbu, kube lula ukumuncwa okungcono. Lokhu kubaluleke kakhulu ezidakamizweni ezinokuncibilika okuphansi kwamanzi, njengoba ukuncibilika okuthuthukisiwe kungaba nomthelela omkhulu ekwelashweni komuthi.
9. Izicelo ze-Mucoadhesive
I-HPMC ikhombisa izinto zokunamathisela i-mucoadhesive, iyenze ifanelekele izinhlelo zokulethwa kwezidakamizwa ze-buccal nezilimi ezingaphansi. Lezi zinhlelo zidinga ukuthi umuthi unamathele kulwelwesi lwamafinyila, unikeze ukukhululwa isikhathi eside nokumuncwa ngqo egazini, udlule i-first pass metabolism. Le ndlela inenzuzo emithini eyehlisa isithunzi endaweni ene-asidi yesisu noma ene-bioavailability yomlomo engemihle.
Ukuhlukahluka kwe-hydroxypropyl methylcellulose (HPMC) ekwakhekeni kwemithi akukwazi ukweqiwa. Isebenza kusukela ekubopheni amathebulethi kanye nokunamathiswa kwefilimu kuya ekujikeni nasekuzinziseni ekwenziweni okuhlukahlukene. Ikhono le-HPMC lokushintsha amaphrofayili okukhishwa kwezidakamizwa, ukuthuthukisa ukutholakala kwezidakamizwa, kanye nokuhlinzeka nge-mucoadhesion kugcizelela futhi ukubaluleka kwayo ekuthuthukisweni kwezinhlelo ezithuthukisiwe zokulethwa kwezidakamizwa. Njengoba imboni yemithi iqhubeka nokuvela, indima ye-HPMC cishe izokhula, iqhutshwa ucwaningo oluqhubekayo nemizamo yokuthuthukisa okuhloswe ngayo ukuthuthukisa ukulethwa kwezidakamizwa kanye nemiphumela yesiguli.
Isikhathi sokuthumela: Jun-05-2024