I-Hydroxypropyl cellulose, i-excipietieutietical yekhemisi, ihlukaniswe nge-hydroxyproppropyllopyllopylls (L-HPC) ne-HYDROXYproses ephansi (H-HPC) ngokuya ngokuqukethwe kwe-hydroxypropopoxyPropoxy yayo engaphansi. I-L-HPC ivuvukala kusisombululo se-colloidal emanzini, inazo izakhiwo zokunamathela, ukwakheka kwamafilimu, i-emulsation, njll. Ngenkathi i-H-HPC incane emanzini kanye nezinhlelo ezahlukahlukene ze-organic emazingeni okushisa asekamelweni, futhi ine-thermoplasticity enhle. , Ukubumbana kanye nezakhiwo ezenziwe ngefilimu, ifilimu eyakhekile inzima, icwebezelayo, futhi igcwele ngokuphelele, futhi isetshenziswa ikakhulukazi njengezinto ezakhayo zefilimu nezinto zokuhlanganisa. Kusetshenziswa isicelo esithile se-hydroxypropylllulose kumalungiselelo aqinile manje seyethulwa.
1. Njengokuqhekeka kwamalungiselelo aqinile njengamathebulethi
Ingaphezulu lezinhlayiya ze-hydroxypropproppropyllopyllopylls crystallose eziphansi azilingani, ngesakhiwo esibonisa esibonisa isimo sezulu. Lesi sakhiwo esibi esibi asisona nje senza kube nendawo enkulu yobuso, kepha futhi lapho icindezelwa kwithebhulethi kanye nezidakamizwa nakwamanye ama-excipie, ukuze kusungulwe ama-ports kanye ne-tablet core kungangezela umswakama Izinga lokutholwa nokumunca amanzi kukhulisa ukuvuvukala. UkusebenzisaL-hpcNjenge-ecesicient kungenza ukuthi ithebhulethi ihlukaniswe ngokushesha ibe yi-powder efanayo, futhi ithuthukise kakhulu ukuhlukaniswa, ukuchitheka kanye ne-bioavailability yethebhulethi. Isibonelo, ukusetshenziswa kwe-L-HPC kungasheshisa ukuhlukaniswa kwamathebulethi e-paracetamol, amaphilisi we-aspirin, namaphilisi we-chlorpheniramine, futhi athuthukise izinga lokuchitheka. Ukuhlukaniswa kanye nokuchithwa kwezidakamizwa ezingenampilo ezingezincishayo ezifana namathebulethi we-FPC ane-L-HPC njengoba kungcono kakhulu kunaleso axhumene ne-PVPP exhumene ne-CMC-NA kanye ne-CMS-NE njengokuhlukaniswa. Usebenzisa i-L-HPC njengokuqhekeka kwangaphakathi kwama-granures kuma-capsule anenzuzo ekuqhekekeni kwama-granugres, kwandisa indawo yokuxhumana phakathi kwesidakamizwa kanye nokuchithwa kwemithi, futhi kuthuthukisa ukuchithwa komuthi, futhi kuthuthukisa ukubizelwa kwe-bioavailability. Ukulungiswa okuqinile okukudelwe ngokushesha okumelwe amalungiselelo aqinile ashukumisayo kanye namalungiselelo aqinile asuswa ngokushesha, ukuncibilika okusheshayo, imiphumela esebenza ngokushesha, ukucasulwa kwezidakamizwa kuya e-esophagus kanye nepheshana lesisu, futhi kulula ukuthatha futhi uhambisane kahle. kanye nezinye izinzuzo, kuthatha isikhundla esibalulekile emkhakheni wekhemisi. I-L-HPC isibe ngenye ye-Excipients ebaluleke kakhulu yamalungiselelo aqinile avele ngokushesha ngenxa ye-hydrophicity yayo eqinile, i-hygroscopicity, isikhathi sokuphuma, isikhathi esifushane sokutholwa kwamanzi, kanye nokugcotshwa kwamanzi okusheshayo. Kuyindlela ekahle yokuqhekeka ngenxa yamathebulethi ahlukaniswe ngomlomo. I-paracetamol ngomlomo amaphilisi aqhekeka alungiswa nge-L-HPC njengokuqhekeka, kanti amaphilisi ahlukaniswe ngokushesha phakathi kwama-20s. I-L-HPC isetshenziswa njengokuqhekeka kwamathebulethi, futhi umthamo wayo ojwayelekile ngu-2% kuya ku-10%, ikakhulukazi ama-5%.
2. Njenge-binder for amalungiselelo anjengamathebulethi kanye nama-granule
Ukwakheka okunzima kwe-L-HPC nakho kwenza kube nomphumela omkhulu kaMose Ngemuva kokucindezelwa kumathebulethi, kukhombisa ubulukhuni ngokwengeziwe futhi ngaleyo ndlela kuthuthukise ikhwalithi yokubukeka kwethebhulethi. Ikakhulu amaphilisi angelula ukwakha, ukukhululeka noma okulula ukuveza, ukwengeza i-L-HPC kungathuthukisa umphumela. Ithebhulethi ye-ciprofloxacin hydrochloride inokuphazamiseka okumpofu, okulula ukuhlukanisa nokunamathela, futhi kulula ukuyithola ngemuva kokungeza i-L-HPC, ngobulukhuni obufanele, futhi izinga lokuchithwa lihlangabezana nezidingo ezijwayelekile zekhwalithi. Ngemuva kokungeza i-L-HPC kwithebhulethi ehlakazekile, ukubukeka kwayo, ukufutheka, ukufana kokuhlakazeka nezinye izici zithuthukiswa kakhulu futhi zithuthukiswa. Ngemuva kokuthi isitashi esinqunyelwe ukuthola ithathelwe indawo yi-L-HPC, ubulukhuni bethebhulethi ehlakazekile le-Azithromycin lwakhushulwa, ukucushwa kwathuthukiswa, nezinkinga zokushoda kwamakhona nemiphetho ebolile yethebhulethi yangempela yaxazululwa. I-L-HPC isetshenziswa njenge-binder yamaphilisi, futhi umthamo jikelele u-5% kuya ku-20%; Ngenkathi i-H-HPC isetshenziswa njenge-tinder yamaphilisi, ama-granules, njll., kanye nomthamo jikelele u-1% kuya ku-5% wokulungiselela.
I-3. Isicelo ku-film coating kanye namalungiselelo wokukhishwa oqinile futhi alawulwayo
Njengamanje, izinto ezincibilikayo zamanzi ezisetshenziswa kakhulu efilimu zifaka i-hydroxypropylmethylcerlelyllelcelcelcellellulose (HPMC), i-hydroxypropylcellulose, i-polyethylene glycol (pogy) glycol (isikhonkwane) nokunye. I-Hydroxypropyllllulose ivame ukusetshenziswa njenge-ejenti eyakha amafilimu ezintweni zokwenziwa zefilimu ze-premixing ngenxa yefilimu yayo enzima, ebanzi neyesicwebezelayo. Uma i-Hydroxypropyllllllllll ixutshwe namanye ama-ejenti amelana namazinga okushisa amelana namazinga, ukusebenza kwama-coating ayo kungathuthukiswa.
Kusetshenziswa amasu namasu afanelekile ukwenza umuthi ube amaphilisi athe xaxa ama-matrix, amaphilisi athambile esiswini, amaphilisi we-multi isidakamizwa egazini. Ukugxila, kunciphisa ukuphendula okuphikisayo, ukunciphisa inani lemithi, futhi ulwele ukukhulisa umphumela olapha ngethamo elincane kunazo zonke, futhi unciphise ukusabela okunzima. I-Hydroxypropylllulose ingenye ye-Excipient enkulu yamalungiselelo anjalo. Ukuchithwa nokukhishwa kwamathebulethi we-DICLOFENAC SODIUM alawulwa ngokusebenzisa i-Hydroxypropyllls kanye ne-ethyl cellulose njengezinto ezihlangene nezamathambo. Ngemuva kokuphathwa ngomlomo kanye nokuxhumana nojusi wesisu, ingaphezulu lama-DICLOFENAC Sodium amaphikisi asatshalaliswa azohlanzwa abe yi-gel. Ngokuchithwa kwejeli kanye nokuvikelwa kwama-molekyuli ezidakamizwa e-gel gap, inhloso yokukhishwa kancane kwama-molecule wezidakamizwa atholakala. I-Hydroxypropplllulose isetshenziswa njenge-matrix ekhishwa ngokulawulwa kwethebhulethi, lapho okuqukethwe kwe-blocker ethyl cellulose kuhlale njalo, okuqukethwe kwayo kwithebhulethi kunquma ngqo isilinganiso somuthi, kanye nesidakamizwa kusuka kuthebulethi Ukukhishwa kwe-hydroxypropyllopylllose kuhamba kancane. Ama-pellets ahlanganisiwe alungiswa ngokusebenzisaL-hpcFuthi ingxenye ethile ye-HPMC njengesixazululo se-coating sokuhlanganiswa njengesendlalelo sokuvuvukala, futhi njengesendlalelo sokukhishwa okulawulwayo sokugoqa nge-ethyl cellulose acassion. Lapho umuthi wokuvuvukala wesendlalelo kanye nomthamo uhleliwe, ngokulawula ubukhulu besendlalelo sokukhishwa esilawulwayo, ama-pellets ahlanganisiwe angakhishwa ngezikhathi ezihlukile ezilindelwe. Izinhlobo eziningana zama-pellets ahlanganisiwe anokuthola isisindo okuhlukile kwesendlalelo sokukhishwa esilawulwayo ahlanganiswa ukwenza ama-shuxiong akhishwe amaphilisi. Emiphakathini yokuqothula, ama-pellets ahlukahlukene ahlanganisiwe angakhipha izidakamizwa ngokulandelana ngezikhathi ezihlukile, ukuze izakhi ezinezici ezihlukile zomzimba nangamakhemikhali ukukhishwa ngasikhathi sinye kutholakale ngasikhathi sinye njengokukhululwa okuqhubekayo
Isikhathi sePosi: APR-25-2024