Ukusetshenziswa kwe-ethylcellose coating kuma-hydrophilic matric

I-Ethylcelcellose (EC) isetshenziswa kabanzi emikhakheni yamafomu ama-coating umthamo umthamo wama-dosage, ikakhulukazi umatikuletsheni we-hydrophilic, ukufezekisa izinhloso ezahlukahlukene. Nakhu ukuthi i-Ethylcelcwa PACE isetshenziswa kanjani kuma-hydrophilic matric ekwenziweni kwemithi:

1. Ukukhishwa okulawulwayo: Enye yezicelo eziyisisekelo zokuhlanganisa i-ethylcellose kumatikuletsheni we-hydrophilic ukuguqula ukukhishwa kwezidakamizwa. I-Hydrophilic Matric ngokuvamile ikhipha izidakamizwa ngokushesha lapho sixhumana ne-Dislolution Media. Ukusebenzisa i-Ethylcellose Coation kuhlinzeka ngesithiyo esigcina ukungena kwamanzi ku-matrix, kunciphise ukukhishwa kwezidakamizwa. Le phrofayili yokukhishwa elawulwayo ingathuthukisa ukusebenza kwezidakamizwa, idlule imiphumela yokwelapha, futhi inciphise imvamisa ye-dosing.
2. Ukuvikelwa kwezithako ezisebenzayo: Ukuhlanganiswa kwe-Ethylcellose kungavikela izithako ezibucayi noma ezibucayi kakhulu ezisebenzayo ngaphakathi kumatikuletsheni we-hydrophilic. Isithiyo esingenakufinyeleleka esakhiwa yi-Ethylcellose Coating sivikela izithako ezisebenzayo kusuka kumswakama wezemvelo nangomoya-mpilo, kulondolozwa ukuqina kwazo futhi kunweba impilo yabo eshalofini.
3. Nambitha Masking: Ezinye izidakamizwa ezifakwe kumatikuletsheni we-hydrophilic zingaba nokunambitheka okungathandeki noma iphunga. I-Ethylcellose Coation ingasebenza njengokunambitheka-imaskhi, ukuvimbela ukuxhumana ngqo kwesidakamizwa ngama-receptors okunambitha e-Oral Cavity. Lokhu kungaqhakambisa ukuhambisana kwesiguli, ikakhulukazi ezindaweni ezihamba ngezinyawo kanye ne-geriatric, ngokuhlikihla imizwa yokunambitha engathandeki.
4. Ukuqina okwenziwe ngcono ngokomzimba: Ukuhlanganiswa kwe-Ethylcellose kungathuthukisa ukuqina komzimba kwamatikuleshini ama-hydrophilic ngokunciphisa ukuthambekela kwabo ekucindezelekeni okwenziwe ngomshini, i-abrasion, kanye nokulimala okuhlobene nokuphatha. I-coating yakha igobolondo elivikelayo ezungeze i-matrix, ivimbele ukuguguleka komhlaba, ukuqhekeka, noma ukukhishwa ngesikhathi sokukhiqiza, ukupakishwa, nokuphatha.
5. Amaphrofayili wokukhishwa asetshenziswe ngokwezifiso Izakhi ezahlukahlukene zenhlamba kanye namasu okusebenzisa avumela ukuthuthukiswa kwezinto ezilondoloziwe, ezeluliwe, ezibambezelekile, noma zokwakheka okubambezelekile, noma ama-pulsatile ekhishwe enzelwe izidingo zeziguli.
6. Ukucekelwa phansi okwenziwe ngcono: I-Ethylcellose Coatings ihlinzeka ngokuqedwa komhlaba okubushelelezi futhi okufanayo kuma-hydrophilic matric, lula ukuqina ngesikhathi sokukhiqiza. Izinsizakusebenza ze-coating ekulandiseni ukwehluka kwesisindo sethebhulethi, ukwenza ngcono ukubukeka kwethebhulethi, futhi kunciphise iziphambeko zokukhiqiza njengokukhetha, ukunamathela, noma ukukhokha.
7. Ukuhambisana namanye ama-excipients: Izambatho ze-Ethylcellose ziyahambelana nohla olubanzi lwe-Execipietietietietietietics yezemithi ezisetshenziswayo ezakhiweni ze-hydrophilic, kufaka phakathi ama-filler, ama-linder, ukukhishwa, ukukhishwa kanye nokuthambisa. Lokhu kuhambisana kuvumela ukwakheka okuguquguqukayo ukwakhiwa nokwenza kahle ukusebenza komkhiqizo.

I-Ethylcellose Coating inikeza izixazululo eziguquguqukayo zokuguqula izithako zokukhishwa kwezidakamizwa, ukuvikela izithako ezisebenzayo, ukunambitheka kwama-masking, ukuthuthukisa ukuqina komzimba, kanye nokwenza ngcono ukucubungula kumakhi we-hydrophilic matrix. Lezi zinhlelo zokusebenza zifaka isandla ekuthuthukisweni kwemikhiqizo ephephile, enobuhlakani, enobungane bemithi.