I-Hydroxypropyl methylcellulose (HPMC)Ingabe i-ether ye-annoinic cellulose enokwakha amafilimu, ukunamathela, ukuqina nokuqina kanye nokukhishwa kwezindawo ezilawulwayo, futhi kusetshenziswa kabanzi embonini yezemithi. Njenge-Execipieint yezemithi, i-ComCinCel®HPMC ingasetshenziswa kumathebulethi, amaphilisi, amalungiselelo okukhulula okuqhubekayo, amalungiselelo we-ophthalmic nezinhlelo zokulethwa kwezidakamizwa eziphezulu.
1. Izakhiwo ze-physicochemical ze-HPMC
I-HPMC iyinto eyenziwe nge-polymer ye-polymetic etholwe yi-methylating kanye ne-hydroxypropylating yemvelo yemvelo, nge-solubity enhle kakhulu yamanzi kanye nokuqina. I-solubenity yayo ayithinteki kangako ngokushisa nenani le-PH, futhi ingavuvukala emanzini ukwakha isixazululo se-viscous, esiza ukukhishwa kwezidakamizwa ezilawulwayo. Ngokusho kwe-viscosity, i-HPMC ingahlukaniswa izigaba ezintathu: Ukubonakaliswa okuphansi (ama-viscosity aphansi (ama-vispusity aphakathi (ama-viscosity aphakathi (ama-viscosity aphezulu (ama-4000-100000 MPA), afanele izidingo ezahlukahlukene zokulungiselela.
2. Ukusetshenziswa kwe-HPMC kumalungiselelo emithi
2.1 Isicelo kumathebulethi
I-HPMC ingasetshenziswa njenge-binder, ukuqhekeka, ukunamathela impahla kanye nezinto zokukhishwa kwamathambo ezilawulwayo ezibhebheni.
I-Binder:I-HPMC ingasetshenziswa njenge-binder ku-granution emanzi noma kunhloli okomile ukuthuthukisa amandla ezinhlayiyana, ukuqina kwethebhulethi kanye nokuqina kwezidakamizwa.
Ukuqhekeka:I-Vissusity ephansi i-HPMC ingasetshenziswa njengokuqhekeka ukukhuthaza ukuhlukaniswa kwethebhulethi nokukhulisa izinga lokuchithwa kwezidakamizwa ngemuva kokuvuvukala ngenxa yokumuncwa kwamanzi ngenxa yokumuncwa kwamanzi.
I-Coating Material:I-HPMC ingenye yezinto eziphambili ze-tablet coating, ezingathuthukisa ukubukeka kwezidakamizwa, zimboze ukunambitheka okubi kwezidakamizwa, futhi zingasetshenziswa kuma-plagizer noma amafilimu okuhlanganiswa namafilimu ngamapulasitiki.
Izinto zokukhishwa ezilawulwayo: I-High-Viscutity HPMC ingasetshenziswa njengezinto zamathambo zokubambezela ukukhishwa kwezidakamizwa futhi ifinyelele ukukhishwa okuqinile noma okulawulwayo. Isibonelo, i-HPMC K4M, i-HPMC K15M ne-HPMC K100M zivame ukusetshenziselwa ukulungiselela amaphilisi wokukhishwa alawulwayo.
2.2 Isicelo kumalungiselelo eCapsule
I-HPMC ingasetshenziselwa ukukhiqiza ama-caplule atholakala ngezitshalo ukuze asuse ama-gelatin caplule, alungele imifino nabantu abangahle basebenzise amaphilisi athathwe izilwane. Ngaphezu kwalokho, i-HPMC ingasetshenziselwa ukugcwalisa ama-caplule e-liquid noma ama-semisolid ukwenza ngcono ukuqina nokukhululwa kwezimpawu zezidakamizwa.
2.3 Isicelo kumalungiselelo we-ophthalmic
I-HPMC, njengengxenye eyinhloko yezinyembezi zokufakelwa, ingakhulisa ukubonakala kwamaconsi wamehlo, yandise isikhathi sokuhlala sezidakamizwa endaweni ye-ocular, futhi ithuthukise ama-bioavailability. Ngaphezu kwalokho, i-HPMC nayo ingasetshenziswa ukulungiselela ama-gels wamehlo, amafilimu wamehlo, njll., Ukuthuthukisa umphumela okhethekile wokukhishwa kwezidakamizwa zamehlo.
2.4 Isicelo kumalungiselelo wokulethwa kwezidakamizwa aphezulu
ICECCINCELX ®PPMC inezakhiwo ezinhle ezenziwe ngefilimu kanye nokuqina, futhi kungasetshenziswa ukulungiselela ama-transdermal patches, ama-gels nokhilimu. Isibonelo, ezinhlelweni zokulethwa kwezidakamizwa zeTransdermal, i-HPMC ingasetshenziswa njengezinto ze-matrix ukwandisa izinga lokungena kwezidakamizwa futhi kwandise isikhathi sesenzo.
2.5 Isicelo ku-Oral Liquid Nokumiswa
I-HPMC ingasetshenziswa njengomuntu omkhulu futhi i-Stabilizer ukuthuthukisa izakhiwo zesimbozo sokwenza uketshezi lomlomo nokumiswa, zivikele izinhlayiya eziqinile ekuxazululeni, futhi zithuthukise ukufana kanye nokuqina kwezidakamizwa.
2.6 Isicelo kumalungiselelo wokuphefumula
I-HPMC ingasetshenziswa njengenkampani yenethiwekhi yama-enalers owomile wempuphu (i-DPIS) ukuthuthukisa uxhaso kanye nokungafani kwezidakamizwa, kwandise izinga lezidakamizwa, futhi ngaleyo ndlela zithuthukise umphumela wokwelapha.
I-3. Izinzuzo ze-HPMC kumalungiselelo wokukhulula okuqhubekayo
I-HPMC inezimpawu ezilandelayo njenge-exepipued ekhethekile yokuxhashazwa:
I-Solubility Emihle Yamanzi:Ingavushelwa amanzi ngokushesha ukuze yakhe isithiyo sejeli futhi alawule isilinganiso sokukhishwa kwezidakamizwa.
I-BioCmation enhle:Okungabi nanobuthi futhi kungacasuli, kungabingelwa ngumzimba womuntu, futhi kunendlela ecacile ye-metabolic.
Ukuzivumelanisa nezimo okuqinile:Ilungele izinhlobo ezahlukene zezidakamizwa, kufaka phakathi izidakamizwa ezingenamanzi kanye nezidakamizwa ze-hydrophobic.
Inqubo Elula:Ilungele izinqubo ezahlukahlukene zokulungiselela ezifana nokuthenjiswa okuqondile nokuthambekela emanzi.
Njenge-Execipieint ebalulekile yezemithi,I-HPMCisetshenziswa kabanzi emikhakheni eminingi efana namathebulethi, amaphilisi, amalungiselelo we-ophthalmic, amalungiselelo aphezulu, njll. Ngokuzayo, ukuthuthukiswa okuqhubekayo kobuchwepheshe bokulungiselela amakhambi, ubukhulu besicelo seCedinCel®hpmc buzokwanda, bahlinzeke imboni yezemithi ngezinketho ze-excipie ezisebenzayo neziphephile.
Isikhathi sePosi: Feb-08-2025