Ukufundwa okuhlobene ekhaya nakwamanye amazwe lapho kulungiswa amakhambi e-Exechyxypropylllylyl Methylcellulose (HPMC) Emuva kwamuva kwabuyekezwa, futhi akwazi ukufingqwa, amalungiselelo aqinile futhi alawulwayo okukhishwa, amalungiselelo we-capsule, i-gelatin yakamuva Izicelo emkhakheni wezakhi ezintsha ezifana nezindlela zokunamathela kanye nama-bioasesives. Ngenxa yomehluko esisindoni esilinganayo se-molecular kanye nokubonakala kwe-HPMC, inezimpawu kanye nokusetshenziswa kwe-emulsation, ukunamathela, ukuqina, ukubonwa okuvuselelayo, ukumisa ukugcinwa kwefilimu kanye nokwakheka kwefilimu. Kusetshenziswa kabanzi kumalungiselelo emithi futhi kuzodlala indima enkulu emkhakheni wamalungiselelo. Ngokutadisha okujulile kwezakhiwo zayo kanye nokwenza ngcono ubuchwepheshe bokwenziwa, i-HPMC izosetshenziswa kabanzi ocwaningweni lwamafomu amasha wethayela nezinhlelo ezintsha zokulethwa kwezidakamizwa, ngaleyo ndlela zithuthukisa ukuthuthukiswa okuqhubekayo kokwakheka.
hydroxypropyl methylcellulose; amalungiselelo amakhambi; ama-exepaceuticals ekhemisi.
Ama-Execipieetient ekhemisi awona kuphela isisekelo sezinto ezibonakalayo zokwakhiwa kwezidakamizwa eziluhlaza, kodwa futhi ahlobene nobunzima benqubo yokulungiselela, ikhwalithi yezidakamizwa, ukuqina, ukuphepha, imodi yezokwelapha, ukusebenza kahle kwezempilo, kanye nokuthuthuka kwemitholampilo kanye nokuthuthuka okusha Amafomu wethamo nemizila emisha yokuphatha. kuhlobene kakhulu. Ukuvela kwe-Exessient entsha yezemithi kuvame ukukhuthaza ukuthuthuka kwekhwalithi yokulungiselela kanye nokuthuthukiswa kwamafomu amasha umthamo. I-Hydroxypropyl Methylcellulose (HPMC) ingenye ye-Excipietietietieticals ethandwa kakhulu ekhaya nakwamanye amazwe. Ngenxa yesisindo sayo esihlukile se-molecular kanye nokubonakala, inemisebenzi yokufaka, ukubopha, ukuqina, ukuqina, ukumisa, nokumisa nokuhlangana. Izici kanye nokusebenzisa njengokufana nokuhlangana kanye nokwakheka kwamafilimu kusetshenziswa kabanzi kubuchwepheshe bezemithi. Le ndatshana ibukeza ngokuyinhloko ukusetshenziswa kwe-hydroxypropyllym methylcellulose (HPMC) ekwakhiweni eminyakeni yamuva.
1.Izici eziyisisekelo ze-HPMC
I-Hydroxypropyl Methyl Cellulose (HPMC), ifomula yamangqamuzana i-C8H15O8- (C10 H18O6) i-N- C8H15o8, kanye ne-Portative Molecular material, okuyingxenye ye-POLYHYDROXYPRYPROPPYPRYPROPPYPYPY yeselula. Ingakhiqizwa ngezindlela ezimbili: eyodwa ukuthi i-methyl cellulose yebanga elifanele iphathwa ngo-Naoh bese ephendula nge-oxylene oxide ngaphansi kokushisa okuphezulu kanye nengcindezi ephezulu. Isikhathi sokuphendula kumele sigcine isikhathi eside ngokwanele ukuvumela i-methyl ne-hydroxypropyl ukwakha amabhondi e-ether ixhumeke kwindandatho ye-anhydroglucose yeselula, futhi ingafinyelela ngezinga elifunekayo; Okunye ukwelapha i-lictric yekotoni noma i-file ye-solip nge-caustic soda, bese uphendula nge-methane e-cherleated ne-propelene oxide ngokulandelana, bese uyihlaziya futhi. , okuchotshozwa kube yimpuphu enhle futhi efanayo noma imifino.
Umbala walo mkhiqizo umhlophe ku-Milky White, ophuphumayo futhi onganambitha, futhi ifomu liyimpuphu ye-granular noma ye-fibrous egeleza kalula. Lo mkhiqizo ungachithwa emanzini ukuze wakhe isixazululo esimhlophe se-Milky White Colloidal nge-viscosity ethile. I-Sol-Gel InterconVersion Penomenon ingenzeka ngenxa yokushintsha kwezinga lokushisa kwesisombululo ngokuhlushwa okuthile.
Ngenxa yomehluko kokuqukethwe kwalezi zinto ezimbili ezakhiweni ze-methoxy ne-hydroxypropyl, izinhlobo ezahlukene zemikhiqizo zivele. Ngokugxila okuthile, izinhlobo ezahlukahlukene zemikhiqizo zinezici ezithile. I-Viscosity kanye ne-Thermal Gelation lokushisa, ngakho-ke yiba nezakhiwo ezihlukile futhi lungasetshenziselwa izinhloso ezihlukile. I-Pharmacopoeia yamazwe ahlukahlukene inemithetho ehlukene kanye nezethulo zemodeli: I-European Pharmacopoeia isuselwa kumabanga ahlukahlukene we-viscosities ahlukile kanye nama-degree ahlukile wokufaka izinombolo zemikhiqizo ethengiswa emakethe, futhi iyunithi yi- "MPA s ". In the US Pharmacopoeia, 4 digits are added after the generic name to indicate the content and type of each substituent of hydroxypropyl methylcellulose, such as hydroxypropyl methylcellulose 2208. The first two digits represent the approximate value of the methoxy group. Amaphesenti, amadijithi amabili okugcina amele amaphesenti asondele eHydroxypropyl.
I-Hydroxyproppropyllose ye-Calocan i-methylcellulose ine-3 chungechunge, okungukuthi uchungechunge lwe-E, c uchungechunge nochungechunge lwe-k, uchungechunge ngalunye lunamamodeli ahlukahlukene ongakhetha kuwo. I-E Serin isetshenziswa kakhulu njengezimbobo zefilimu, ezisetshenziselwa ukuhlanganiswa kwethebhulethi, amakholethi avaliwe wethebhulethi; E, F Uchungechunge lusetshenziswa njenge-viscosifiers futhi ukhiphe ama-ejenti wokubuyisa amalungiselelo okugcina amalungiselelo we-ophthalmic, ama-ejenti asolayo, amaphilisi kanye nama-bunders ama-granule; I-K uchungechunge lwe-K lusetshenziswa kakhulu njengokukhululwa okuvinjelwe kanye nezinto zokulungiselela ama-matrix we-hydrophilic we-gelrophilic gel kumalungiselelo wokukhulula kancane futhi olawulwayo.
Abakhiqizi basekhaya ikakhulukazi bafaka iFuzhou 2 Chemical Factory, i-Huzhou Food and Chemical Co, Ltd, i-Sichuan Luzhou Pharmaceutical Actories Ifektri, i-Hubei jinxian chemical Fekrace, Ltd, Shandong Liacheng Ahuaa Pharmaceutical Co ., Ltd., Izitshalo zamakhemikhali ze-Xi'an Huian, njll.
2.Izinzuzo ze-HPMC
I-HPMC isibe ngenye ye-Exessient esetshenziswa kakhulu yezemithi ekhaya nakwamanye amazwe, ngoba i-HPMC inezinzuzo ezingenazo ezinye izinto ezithi azinayo.
2.1 I-solubity yamanzi ebandayo
Incibilika emanzini abandayo ngaphansi kwama-40 ℃ noma ama-70% e-ethanol, ngokuyisisekelo incwajana emanzini ashisayo angenhla kwama-60 ℃, kepha angakwazi.
2.2 I-Memight Invert
I-HPMC uhlobo lwe-ether olungeyona eye-moulvu
2.3 Ukuqina
Kuzinzile ku-acid ne-alkali, futhi kungagcinwa isikhathi eside phakathi kwe-PH 3 no-11 ngaphandle koshintsho olukhulu ekuboneni. Isixazululo samanzi se-HPMC sinomphumela we-anti-mbutha futhi sigcina ukuqina okuhle kwentokozo ngesikhathi sokugcina isikhathi eside. Ama-Executieints Ezemithi asebenzisa i-HPMC anokuqina okungcono kwekhwalithi kunaleyo esebenzisa ama-excipients wendabuko (njenge-dextrin, isitashi, njll.).
2.4 Ukuguqulwa kwe-Viscocity
Ukutholwa okuhlukile kwe-viscosives ye-HPMC kungahlanganiswa ngezilinganiso ezihlukile, futhi ukubonakala kwalo kungashintshwa ngokuya ngomthetho othile, futhi kunobudlelwano obuhle obuqondile, ngakho-ke ingxenye ingakhethwa ngokuya ngezidingo.
I-2.5 metabolic inertness
I-HPMC ayimuzwanga noma ihlanjululwe emzimbeni, futhi ayinikezi ukushisa, ngakho-ke kungukulungiswa kwamakhambi kwezemithi. 2.6 Ukuphepha kuthathwa njengokucatshangwa ukuthi i-HPMC iyinto engeyona enobuthi futhi engacasuli, umthamo obulalayo wasendulo wegundane ngu-5 G · 2, kanye nomthamo obulalayo wasendulo wamagundane ngu-5. 2 G: KG - 1. Umthamo wansuku zonke awunangozi emzimbeni womuntu.
3.Ukusetshenziswa kwe-HPMC ekwakhiweni
3.1 Njenge-film coating impahla kanye nezinto zokwakha amafilimu
Usebenzisa i-HPMC njenge-tablet yethebhulethi ehlanganiswe ngefilimu, ithebhulethi ehlanganisiwe ayinazo izinzuzo ezisobala ekushayeleni ukunambitheka nokubukeka okuqhathaniswa namathebhulethi anoshukela, kepha ubulukhuni bawo, ukumunwa komswakama. , ukuzuza kwesisindo nezinye izinkomba ezisezingeni eliphakeme zingcono. Ibanga eliphansi le-viscosity yalo mkhiqizo lisetshenziswa njengezinto zokuhlanganisa amafilimu ezingenamanzi zamathebulethi kanye namaphilisi, futhi ibanga eliphakeme le-vivecosity lisetshenziswa njengezinto zokuhlangana zefilimu ze-organic solvent amasistimu, imvamisa ekuqoqweni okungu-2% kuya ku-20 kuye kwangu-20 %.
UZhang Jixing et al. Sebenzisa indlela ye-FUNDA YOKUVULA UKWAZI UKWAZI UKUZEZA I-PREPIX ADEAMANI nge-HPMC njenge-Coating Coating. Ukuthatha i-HPMC eyakha amafilimu, inani le-polyvinyl alcohol no-polyethylene glycol njengezinto zokuphenya, amandla ashukumisayo kanye nokuvunyelwa kwefilimu le-coating kuyinkomba yokuhlola, kanye nobudlelwano phakathi kokuhlolwa Inkomba kanye nezinto zokuhlola zichazwa yimodeli yezibalo, kanye nenqubo efanelekile yokwakha ekugcineni iyatholakala. Ukusetshenziswa kwayo kungukuhlakanipha kwe-Agent Hydroxypropyll (HPMCE5) I-11.88 g, i-polyvinyl alcohol 24.12 g, futhi amandla okumiswa okumiswa yi-coatizer kanye nokuqina kwamandla wefilimu afinyelela umphumela omuhle kakhulu . UZhang Yuan uthuthukise inqubo yokulungiselela, wasebenzisa i-HPMC njenge-binder ukufaka esikhundleni se-starch slurry, futhi washintsha amaphilisi we-jiahua kumasheke awo, athuthukise amaphilisi awo, okulula ukugcwala, amaphilisi okuvalwa kanye nezinye izinkinga, Ngcono ukuqina kwethebhulethi. Inqubo eyakheka kahle yanqunywa ngokuhlolwa kwe-orthogonal, okungukuthi, ukugxila okumnandi kwakungu-2% HPMC ngesisombululo esingu-70% se-ethanol ngesikhathi sokuhlanganiswa, kanye nesikhathi esishukumisayo ngesikhathi senqwaba. Imiphumela amathebhulethi ahlanganiswe ama-jiahua alungiselelwe yinqubo entsha kanye nemicrosoft kadokotela kwathuthukiswa kakhulu ngokubukeka, isikhathi sokuqhekeka kanye nobulukhuni obuyisisekelo kunaleyo ekhiqizwa yinqubo yokuqala kadokotela, futhi izinga elifanelekile lamathebhulethi ahlanganiswe amafilimu athuthukiswa kakhulu. kufinyelelwe ngaphezulu kwama-95%. ULiang Meiyi, uLu Xaooi, njll. Futhi wasebenzisa i-hydroxypropyllym methylcellulose njengezinto ezenziwe ngefilimu zokulungiselela ithebhulethi ye-patinae colon pole tablet kanye ne-matrine colon poweture, ngokulandelana. kuthinta ukukhishwa kwezidakamizwa. I-Huang Yunran elungiselelwe amaphilisi we-COLOC COLOC e-COLOCE COLOC, futhi isebenzisa i-HPMC kwikhambi le-coating yengqimba yokuvuvukala, nengxenye yalo enkulu kwakungu-5%. Kungabonakala ukuthi i-HPMC ingasetshenziswa kabanzi kuhlelo lokulethwa kwezidakamizwa okuhloswe ngalo.
IHydroxypropyllylyl Methylcellulose akuyona nje impahla enhle kakhulu yamafilimu, kepha futhi ingasetshenziswa njengento eyakha amafilimu ekwakhiweni kwamafilimu. Wang wongshun njll. Kwenzelwe umuthi wokubhalwa kwe-zicorice ye-zicorice ye-zicorice ne-aminolexanol ngomlomo wefilimu, ngokuguquguquka, ukufana, ukucaciswa, i-hpmc 0,1 g, g g ye I-Propellene Glycol ihlangabezana nezidingo zokukhishwa kancane nokuphepha, futhi ingasetshenziswa njengokwakheka kwefilimu eyinhlanganisela.
3.2 njenge-binder nokuqhekeka
Ibanga eliphansi lokubona kulo mkhiqizo lingasetshenziswa njenge-binder nokuqhekeka kwamathebulethi, amaphilisi kanye nama-granule, kanye nebanga eliphakeme le-viscosity lingasetshenziswa kuphela njenge-binder. Umthamo uyahlukahluka ngamamodeli ahlukile nezidingo. Ngokuvamile, umthamo we-binder yamathebhulethi e-granung owomile yi-5%, kanye nomthamo we-binder yamathebhulethi anamanzi ama-2%.
I-LI Houtao et al ihlolwe i-Binder of Thidazole Amathebhulethi. I-8% PolyvinylPyrrolidone (PVP-K30), isiraphu engu-40%, i-10% isitashi slurry, 2.0% i-hydroxypropylllm methylcellulosek (hpmck4m), i-50% ethanol yaphenywa njengoba kubhekwe amaphilisi we-tinidazole nakho. Ukulungiselela amaphilisi we-tinidazole. Ukushintshwa kokushintsha kwamathebhulethi asobala nangemva kokuhlanganiswa kwe-coating kuqhathaniswa, kanye nokushiswa, ubunzima, umkhawulo wesikhathi sokuncipha kanye nezinga lokuchithwa kwezibhebhelo ezingezona ezinikezwayo Imiphumela amaphilisi alungiselelwe ngu-2.0% we-hydroxypropyllllyryryls ayecwebezela, futhi isilinganiso sokushiswa kwezicucu asitholi ukukhishwa okunqenqemeni kanye ne-phenomenon yamakhosi, nangemva kokugoba, ukubukeka kwethebhulethi bekukuhle. Ngakho-ke, amaphilisi we-tidazole alungiselelwe nge-2.0% HPMC-K4 no-50% eThanol njengoba kusetshenziswa amabhinde. UGuan Shihai wafunda inqubo eyakheka yamathebhulethi okuthatha amacala, wahlola amathebhulethi, wahlola ama-adhesives, futhi wahlola ama-ethanol angama-50%, ama-10% ama-ethanol kanye nama-50% ama-ethanol solution anokuxineka, bushelelezi, kanye nokuvuvukala njengezinkomba zokuhlola. , 5% CMC-NE kanye ne-15% HPMC solution (5 MPA s). Imiphumela amashidi elungiselelwe ngu-50% e-ethanol, i-15% isitashi unamathisele, 10% PVP 50% Isixazululo se-Ethanol kanye no-5% CMC-NA babenendawo ebushelelezi, kodwa ubunzima obuphansi nobunzima, obungakwazi ukubhekana nezidingo zokuhlanganisa; I-15% HPMC Solution (ama-5 MPA S), ingaphezulu lethebhulethi libushelelezi, ukubalwa kwethebhulethi kuyafaneleka, futhi ukuxinana kuhle, okungahlangabezana nezidingo zokuhlanganisa. Ngakho-ke, i-HPMC (5 MPA s) yakhethwa njenge-adhesive.
3.3 Njengama-ejenti okumisa eceleni
Ibanga eliphakeme le-viscosity lalo mkhiqizo lisetshenziswa njenge-ejenti yokumisa ukulungiselela ukulungiswa kokulungiswa koketshezi. Inokumiswa okuhle okulandelayo, kulula ukuguqula kabusha, ayinamatheli odongeni, futhi inezinhlayiya ezinhle zokufakelwa. Umthamo ojwayelekile ngu-0,5% kuya ku-1.5%. Iculo tian et al. Kusetshenziswe izinto ezisetshenziswayo ze-polymer (i-hydroxypropylm methylcellose, sodium carboxymethylcelcellellulose, ipolidone, i-xanthan gum, i-methylcellulose, njll.) Njengabakhiqizi abamisa ama-racecadotril. ukumiswa ngokomile. Ngokulinganiswa kwevolumu ye-sediment yokumiswa okuhlukile, inkomba yokuvuselela kabusha, kanye ne-Rheology, ukuqondiswa kokumiswa kanye nokumiswa kwe-microscopic morphology kwaqashelwa, kanye nokuqina kwezinhlayiya zezidakamizwa ngaphansi kokuhlolwa okusheshisiwe nakho kwaphenywa. Imiphumela ukumiswa okusomile okulungiselelwe nge-2% HPMC njengoba umenzi osomisayo enenqubo elula nokuqina okuhle.
Uma kuqhathaniswa ne-methyl cellulose, i-hydroxypropylykl methyl cellulose inezimpawu zokwakha isixazululo esicacile, futhi kuphela inani elincane kakhulu lezinto ezingekho emthethweni ezikhona, ngakho-ke i-HPMC isetshenziswa futhi njenge-ejenti elisamisayo kumalungiselelo wokumisa ama-opthalmic. Liu jie et al. wasebenzisa i-HPMC, i-hydroxypropyl celtulose (HPC), i-Carbomer 940, i-polyethylene glycol (i-sodium hyalurolate (ha) kanye nenhlanganisela ye-HA / HPMC njengama-ejenti ahlukile ukumiswa okuhlukile kokumiswa kwe-ciclovir ophthalmic, ubukhulu bevolumu, ubukhulu bezinhlayiyana zikhethwe njengezinkomba zokuhlola ukusekela umhlinzeki osombisa kahle kakhulu. Imiphumela ikhombisa ukuthi ukumiswa kwe-acyclovir ophthalmic okulungiselelwe ngu-0.05% ha kanye no-0.05% HPMC njenge-ejenti okumisiwe, isilinganiso sevolumu sedimentiment singu-0.998, ubukhulu bezinhlayiyana buhle, futhi ukulungiswa kocansi okuzinzile kuyanda.
3.4 Njenge-blocker, i-ejenti yokukhishwa ehamba kancane nelawulwa ne-ejenti eyakha i-pore
Ibanga eliphezulu le-viscosity kulo mkhiqizo lisetshenziselwa ukulungiswa kwamathebulethi we-hydrophilic gel matrix amathebulethi okukhishwa kwama-hydrophilic, ama-blockers kanye nama-ejenti alawulwa alawulwa ama-matrix ahlanganisiwe amaphilisi we-matrix, futhi anomphumela wokubambezeleka kwezidakamizwa. Ukuhlushwa kwayo kungu-10% kuya ku-80%. Amamaki okuvusa okuphansi asetshenziswa njengama-porogens amalungiselelo wokukhipha okugcinayo noma wokukhishwa. Umthamo wokuqala odingekayo wezokwelapha wazokwelapha amaphilisi anjalo angafinyelelwa ngokushesha, bese kuba nomphumela wokukhululwa okuqhubekayo noma okulawulwa yigazi, futhi okuhlushwa izidakamizwa ezisebenzayo zegazi kuyagcinwa emzimbeni. . I-Hydroxypropyllykyl methylcellulose igcwele ama-hydrate ukwakha ungqimba lwejeli lapho lihlangana namanzi. Indlela yokukhishwa kwezidakamizwa kusuka kuthebhulethi ye-matrix ikakhulukazi ifaka phakathi ukuguquguquka kwe-gel ungqimba kanye nokuguguleka kwe-gel ungqimba. UJung Bo Shim et al elungiselelwe amaphilisi weCarvedilol asuswayo akhethekile nge-HPMC njengezinto ezisetshenziselwa ukukhishwa.
I-Hydroxypropyllylylyly isetshenziswa kabanzi amaphilisi we-matrix akhishwe ngokuqhubekayo emithi yendabuko yaseChina, futhi izithako eziningi ezisebenzayo, izingxenye ezisebenzayo kanye namalungiselelo okukodwa wendabuko yaseChina. U-Liu Wen et al. Isebenzisa i-15% hydroxypropylll methylcellulose njengezinto ze-matrix, i-1% lactose kanye ne-5% microcrystalline celtulose njengabagibeli, futhi ilungiselele i-jingfang taohe chengq amaphilisi agcina ngokumele akhishwe. Imodeli yi-higuchi equation. Uhlelo lokuhlanganiswa kwefomula lilula, ukulungiselela kulula, futhi imininingwane yokukhishwa iqinile, ehlangabezana nezidingo ze-Chinese pharmacopoeia. Tang Gunguang et al. Kusetshenziswe ama-saponins awonke e-astragalus njengomuthi oyisibonelo, amaphilisi we-matrix alungiselelwe ama-HPMC, futhi ahlolisise izici ezithinta ukukhishwa kwezidakamizwa ezingxenyeni ezisebenzayo zemithi yendabuko yamaShayina kuma-HPMC Matrix Amathebulethi. Imiphumela njengoba umthamo we-HPMC ukhule, ukukhishwa kwe-astragalosiko kwancipha, futhi amaphesenti okukhishwa kwalesi sidakamizwa ane-Umbani enomugqa olinganayo necala lokuchithwa kwe-matrix. Kuthebhulethi ye-phpromellose HPMC Matrix, kunobudlelwano obuthile phakathi kokukhishwa kwengxenye ephumelelayo yomuthi wendabuko waseChina kanye nomthamo nohlobo lwe-HPMC, kanye nenqubo yokukhishwa ye-hpdrophilic commomer monomer iyafana nayo. I-Hydroxypropylm methylcellulose ayilungele kuphela amakhompiyutha e-hydrophilic, kepha futhi nezinto ezingezona ze-hydrophilic. I-Liu Guihua yasebenzisa i-17% hydroxypropyllyllose (hpmck15m) njengezibhebhe ze-matrix ezikhethekile, futhi ilungiselele amaphilisi we-matrix weTianshan Xueelian ngokuxhaswa nge-WET Granution and Way. Umphumela wokukhishwa okugciniwe wawusobala, futhi inqubo yokulungiselela yayizinzile futhi kungenzeka.
I-Hydroxypropyllylylyll ayifakwanga kuphela kumathebulethi ase-matrix akhishwe ekugcineni kwezithako ezisebenzayo kanye nezingxenye ezisebenzayo zemithi yendabuko yaseChina, kodwa futhi futhi esetshenziswa kakhulu emithini yendabuko yamaShayina Medicine Medicine Medicine Medicine. I-Wu Huichao et al. Isebenzisa i-20% hydroxypropylllylylylylylyll metrulose (HPMCK4M) njengendlela ye-matrix, futhi wasebenzisa indlela yokucindezela eqondile ye-matrix ukulungiselela ithebhulethi ye-Yizhi hydrophilic gel matrix engasusa ngokuqhubekayo nangamahora ayi-12. ISaponin RG1, i-GINSENESITO RB1 nePanax NotoginnEng Saponin R1 yayisetshenziswa njengezinkomba zokuhlola ukuphenya ukukhishwa eVitro, kanye ne-Equation yokukhishwa kwezidakamizwa kwahlanganiswa ukutadisha inqubo yokukhishwa kwezidakamizwa. Imiphumela yemithi yokukhishwa kwezidakamizwa evumelane ne-zero-oda i-kinetic equation kanye ne-ritger-peppas equation, lapho i-geniposide ikhishwe yi-frick devil, futhi izakhi ezintathu ePanax NotoginnEng zikhishwe yi-Skelete Erosion.
3.5 I-glue evikela i-greater njenge-colloid ne-colloid
Lapho lo mkhiqizo usetshenziswa njengesikhulu, ukugxilisa imali okujwayelekile kungu-0.45% kuya ku-1.0%. Kungakhuphula nokuqina kwe-hydrophobic glue, kwakha i-colloid evikelayo, kuvikele izinhlayiya kusuka ekuhlanganeni kanye nasekuqageleni, ngaleyo ndlela kuvimbela ukwakheka kwama-sedimentnts. Iphesenti layo elijwayelekile lokuhlushwa yi-0.5% kuya ku-1.5%.
Wang zhen et al. Sebenzisa indlela ye-L9 Orthogonal yokuhlola indlela yokuhlola indlela yokuphenya inqubo yokulungiselela yezokwelapha eyenziwe nge-Enema ye-Carbon. Izimo zenqubo ezinhle zokunqunywa kokugcina kwemithi esetshenzisiwe yekhabhoni yekhabhoni ukusebenzisa i-0.5% sodium carboxylylllllllllllllllllls methylellose methylyellulose methylellulose (hpmc iqukethe ama-methoxylll gerlulose, i-hydroxypropoxyllek, izigaba zenqubo zisiza ukuthuthukisa ukuqina kwemithi yokwelapha eyenziwe ngekhabhoni. Zhang zhiqiang et al. Uthuthukise i-levdrochlolic ebucayi ye-levdrochloride ye-ophthalmic ukulungele ukusetshenziswa nomphumela wokukhishwa okuqhubekayo, usebenzisa i-carbopol njenge-matrix ye-gel kanye ne-hydroxypropyll methylcellulose njenge-ejenti yokuqina. Umuthi Ofanele Ngokuhlola, ekugcineni uthole incwadi ephelele i-legofloxacin hydrochloride 0.1 g, i-carropol (9400) I-3 g, i-dirodium hydrogen phosphate 0.35 g, phosphoric hydrogen phosphate 0.35 g, phosphoric acid 0.45 g we-sodium chloride , 0.03 g we-Ethyl Paraben, namanzi afakiwe ekwenzeni i-100 ml. Esivivinyweni, umbhali wahlolelwa i-hydroxypropyll methylcellose methocellose uchungechunge lwenkampani ye-Colorcon enezincazelo ezihlukile (k4m, e15 lv, e55 lv, umphumela we-HPMC e50 lv njengoMkhulu. I-Shidener ye-levlocloxacin hydrochlocin hydrochloride ama-gels asheshayo.
3.6 Njenge-Capsule Material
Imvamisa, i-capsule Shell impahla yama-caplule ikakhulukazi i-gelatin. Inqubo yokukhiqiza ye-Capsule Shell ilula, kepha kukhona ezinye izinkinga nezimo ezinjengokuvikelwa kabi ekuvikelekeni komswakama kanye nezidakamizwa ezibucayi komoya-mpilo, ukuncishiswa kwezidakamizwa okuncishisiwe, nokuncishiswa kwezidakamizwa kwe-capsule Shell ngesikhathi sokugcina. Ngakho-ke, i-hydroxypropylylylyly isetshenziswa esikhundleni se-gelatin caplules yokulungiselela ama-caplule, athuthukisa ukwakheka kokwenziwa kwe-capsule kanye nomphumela wokusebenzisa, futhi kukhushulwe kakhulu ekhaya nakwamanye amazwe.
Usebenzisa i-The theophylLine njengomuthi wokulawula, i-podczeck et al. Kutholakale ukuthi izinga lokuchithwa kwezidakamizwa kwama-capsule ane-hydroxypropyllllylylyllylylylylylylylylylylylylylylylyllose amagobolondo ayemkhulu kunalokho kwamakhompiyutha e-gelatin. Isizathu sokuhlaziywa ukuthi ukuhlukaniswa kwe-HPMC kungukuhlukaniswa kwalo lonke i-capsule ngasikhathi sinye, ngenkathi ukuhlukaniswa kwe-gelatin capsule kungukuphazamiseka kwesehlakalo senethiwekhi kuqala, ngakho-ke ukuhlukaniswa kwalo lonke i-capsule, kanjalo I-HPMC capsule ilungele kakhulu ama-capsule amagobolondo ekwenziweni kokukhululwa ngokushesha. UChiwele et al. Iphinde yathola iziphetho ezifanayo futhi yaqhathanisa ukuchithwa kwe-gelatin, i-gelatin / polyethylene glycol kanye namagobolondo HPMC. Imiphumela ikhombisile ukuthi amagobolondo we-HPMC ancibilikisiwe ngokushesha ngaphansi kwezimo ezahlukahlukene ze-PH, ngenkathi amaphimbo e-gelatin athintwa kakhulu yizimo ezahlukahlukene ze-PH. Tang yue et al. Ihlolwe uhlobo olusha lwe-Capsule Shell yohlelo lwe-Low-Dose olungenalutho lwempuphu ye-inhaler inhaler system. Uma kuqhathaniswa ne-capsule Shell ye-hydroxypropyllylyll methylcellulose kanye ne-capsule Shell of gelatin, ukuqina kwe-capsule Shell kanye nezakhiwo ze-powder egoboloji ngaphansi kwezimo ezahlukahlukene kwaphenywa, futhi kwaqubuka ukuhlolwa kwezimo. Imiphumela ikhombisa ukuthi uma iqhathaniswa nama-gelatin caplule, ama-HPMC capsule amagobolondo angcono ngokuqina nokuvikelwa okuqinile, futhi abe nokuqina komswakama okunamandla, futhi ube nokuqina komswakama okuphansi, ngakho-ke i-hpmc capsule amagobolondo alungele ama-caplule wokuphefumula owomile.
3.7 njenge-bioaphesive
Ubuchwepheshe be-Biofion Buchwepheshe busebenzisa ama-Excipients ane-BioDhesive Polymers. Ngokunamathela kwi-mucosa yemvelo, kuthuthukisa ukuqhubeka nokuqina koxhumana naye phakathi kokulungiselela kanye ne-mucosa, ukuze umuthi ukhishwe kancane futhi umunwe yi-mucosa ukufeza inhloso yokwelashwa. Kusetshenziswa kabanzi njengamanje. Ukwelashwa kwezifo zepheshana lesisu, i-vagina, i-mucosa yomlomo nezinye izingxenye.
Ubuchwepheshe be-gastrointesinal BIADHESION Technology uhlelo olusha lokulethwa kwezidakamizwa oluthuthukisiwe eminyakeni yamuva. Akugcini nje kuphela isikhathi sokuhlala samalungiselelo ezidakamizwa epheshana lesisu, kodwa futhi kuthuthukisa ukusebenza koxhumana nabo phakathi kwesidakamizwa kanye nolwelwesi lwamaseli esizeni somumo, futhi kwenza ukungeniswa kwesidakamizwa kube Amangqamuzana amancane amathumbu amathumbu athuthukiswa, ngaleyo ndlela athuthukise ama-bioavailability of the doction. Wei Keda et al. Ihlolwe i-tablet ebaluleke kakhulu ngethamo le-HPMCK4M kanye ne-Carbomer 940 njengezinto zokuphenya, futhi zisebenzisa idivaysi yokuphenya, futhi yasebenzisa idivaysi ye-Biofivion yokulinganisa ukukala amabutho aphakathi kwethebhulethi kanye nekhwalithi yekhwalithi yamanzi esikhwameni sepulasitiki. , futhi ekugcineni wakhetha okuqukethwe kwe-HPMCK40 ne-Carbomer 940 ukuba abe ngu-15 no-27,5 mg endaweni efanele kadokotela ye-NCAEBT cores, ngokulandelana, ukulungiselela ama-bioapesive methylcellulose)) kunganciphisa kakhulu ukuthuthuka ukunamathela kokulungiselela izicubu.
Amalungiselelo we-Oral Biodhesive nawo aluhlobo olusha lohlelo lokulethwa kwezidakamizwa olufundwe ngaphezulu eminyakeni yamuva. Amalungiselelo we-Oral Biodhesive angalandela umuthi engxenyeni ethintekayo ye-cavity yomlomo, engapholi isikhathi sokuhlala somuthi esidakamizwa e-mucosa yomlomo, kodwa futhi ivikela i-mucosa yomlomo. Umphumela ongcono wokwelapha kanye nokwenza ngcono izidakamizwa ama-bioavailability. Xue Xiaoyan et al. Kwenzelwe ukwakhiwa kwamathebulethi we-insulin omlomo anamathela, chitosan, carbomer 934p, hpmcypropyl methylcellulose (hpmc k392 methylcellulose (hpmc k392 methylcellulose (hpmc k392 methylcellulose (hpmc k392 methylcellulose (hpmc k392 methylcellulose (hpmc k392 methylcellulose (hpmc k392 methylcellulose (HPMC K392) kanye ne-sodium alganate njengezinto zokwakha umzimba, kanye neqhwa - ukomisa ukulungiselela i-insulin yomlomo. Ishidi elinamathela kabili elinamathela. Ithebhulethi elungiselelwe i-insulin adhesive adhesive inesakhiwo esinjengesiponji esinjenge-porous, esilungele ukukhishwa kwe-insulin, futhi inesendlalelo sokuvikela i-hydrophobic, esingaqinisekisa ukukhishwa kwesidakamizwa esingajwayelekile futhi sigweme ukulahlekelwa komuthi. Hao jifu et al. Futhi kulungiselelwe ubuhlalu obuluhlaza okwesibhakabhaka obuhlaza okwesibhakabhaka obudlabha ama-biodhesive usebenzisa i-baiji glue, i-hpmc ne-carbomer njengezinto ze-bioadive.
Kuzinhlelo zama-Vaginal Drug Delivery System, ubuchwepheshe be-biofion ubuchwepheshe futhi busetshenziswe kabanzi. Zhu yting et al. I-Carbomer esetshenzisiwe (i-CP) ne-HPMC njengezinto ezinamathela futhi i-matrix ekhishwa okuqhubekayo ukulungiselela amaphilisi we-clotrimazole biadinal anezakhiwo ezahlukahlukene nezilinganiso, futhi alinganise ukunamathela kwawo, isikhathi sokunamathela kanye nephesenti lokuvuvukala emvelweni yoketshezi lwesitho sangasese sowesifazane. , Umuthi ofanele ofanele wahlolelwa njenge-CP-HPMC1: 1, ishidi elilungiselelwe elilungiselelwe lalinokusebenza okuhle kokunamathela, futhi inqubo yayilula futhi ingenzeka.
3.8 njenge-topical gel
Njengokulungiselela okunamathelayo, i-gel inochungechunge lwezinzuzo ezinjengokuphepha, ubuhle, ukuhlanza okulula, izindleko eziphansi, inqubo elula yokulungiselela, kanye nokuhambisana okuhle nezidakamizwa. Ukuqondiswa kwentuthuko. Isibonelo, i-Transdermal Gel iyifomu elisha le-DOSAGE elifundwe ngaphezulu eminyakeni yamuva. Akukwazi kuphela ukugwema ukucekelwa phansi kwezidakamizwa epheshana lesisu futhi kunciphise ukuhlukahluka okuphezulu kokuhlushwa kwezidakamizwa, kodwa futhi sekuyinye yezinhlelo ezisebenzayo zokukhishwa kwezidakamizwa ukunqoba imiphumela emibi yezidakamizwa. .
Zhu jingjie et al. wafunda umphumela wama-matric ahlukene ekukhishweni kwe-scutellarin Alcohol Gel e-Vitro, futhi wahlolelwa nge-carbomer (980nf) kanye ne-hydroxypropylylyllose methric, futhi wathola i-scutellarin efanelekile i-scutellarin. I-Gel Matrix ye-Plastids yotshwala. Imiphumela yokuhlolwa ikhombisa ukuthi 1. 0% Carbomer, 1. 5% Carbomer, 1. 0% Carbomer + 1. 0% HPMC, 1. 0% HPMC, 1. 0% HPMC, 1 . Ngesikhathi sokuhlola, kwatholakala ukuthi i-HPMC ingashintsha imodi yokukhishwa kwezidakamizwa ye-Carbomer Gel Matrix ngokufaneleka i-kinetic equation yokukhishwa kwezidakamizwa, futhi i-1.0% HPMC ingathuthukisa i-matrix ye-carbomer engu-1.0%. Isizathu kungenzeka ukuthi i-HPMC inwebeka ngokushesha, futhi ukwanda okusheshayo ekuqaleni kokuhlolwa kwenza igebe le-molecular ye-carbomer gel material, ngaleyo ndlela lisheshise isilinganiso salo sokukhishwa kwezidakamizwa. Zhao Wencui et al. I-Carbomer-934 ne-Hydroxypropyllylyll methylcellulose njengezithwali zokulungiselela i-Norfloxacin Ophthalmic Gel. Inqubo yokulungiselela ilula futhi iyenzeka, futhi ikhwalithi ivumelana ne-ophthalmic gel ye- "Chinese pharmacopoeia" (2010 edition) Izidingo zekhwalithi.
3.9 I-ENHISTION LINIBIC YOKUQHAWULA KOKUZIPHATHA KAKHULU
I-Self-MicroemulSifezetsication System (SMEDDS) uhlobo olusha lohlelo lokulethwa kwezidakamizwa, okuyingxube enobungozi, elizinzile futhi elibonakalayo elihlanganiswe nezidakamizwa, isigaba se-oyela, i-emulsifier kanye ne-emulsifier. Ukwakheka kwalolu mbono kulula, futhi ukuphepha nokuqina kuhle. Ngezidakamizwa ezincibilikezeke kabi, izinto ze-fiber-soluble polymer, njenge-HPMC, i-polyvinylpycrorone (PVP), njll. Khulisa i-solubility yezidakamizwa futhi uthuthukise ama-bioavailability.
Peng Xuan et al. ilungiselele uhlelo lokulethwa kwezidakamizwa olungapheli lwe-silibinin I-Oxyethylene hydrogenated castor Amafutha (i-cremophor ge40), i-12% caprylic capric acid polyethylene glycol glyceride (labrasol) njenge-emulsifier, no-50 mg-1 hpmc. Ukungezwa i-HPMC kuma-SSEDDS kungaphazamisa ama-Silibinin wamahhala ukuze ancibilike kuma-S-sedds futhi avimbele i-silibinin kusuka ekutholeni ngaphandle. Uma kuqhathaniswa nokwakhiwa kwendabuko kwe-microsion, inani elikhudlwana le-surfactant livame ukungezwa ukuvimbela ukubhekelwa phansi kwezidakamizwa. Ukungezwa kwe-HPMC kungagcina i-solubity ye-silibinin ekwakhiweni okuphakathi nendawo okungapheli, kunciphisa ukwamukelwa kokuzikhandla. umthamo we-ejenti.
4.Conclusion
Kungabonakala ukuthi i-HPMC isetshenziswe kabanzi emalungiseleleni ngenxa yezakhiwo zayo zomzimba, zamakhemikhali nezemvelo, kepha i-HPMC nayo inamaphutha amaningi kumalungiselelo, njengokukhishwa kwangaphambi kokuqhuma. methyl methacrylate) ukuthuthuka. Ngasikhathi sinye, abanye abacwaningi baphenya ukusetshenziswa kwe-Osmotic theory ku-HPMC ngokulungiselela amaphilisi okukhishwa kwezimoto eziqhubekayo kanye namathebulethi we-verapamil hydrochloride wokugcina ukuze aqhubeke nokufunda indlela yawo yokukhishwa. Ngamagama, abacwaningi abaningi ngokwengeziwe benza umsebenzi omningi ukuthola uhlelo olungcono lwe-HPMC ngamalungiselelo, futhi ngokutadisha okujulile kwezakhiwo zalo kanye nokwenza ngcono ubuchwepheshe bokulungiselela, kuzosetshenziswa kabanzi kumafomu amasha wethamo kanye namafomu amasha umthamo. Ecwaningweni lohlelo lwezemithi, bese lukhuthaza ukuthuthukiswa okuqhubekayo kwekhemisi.
Isikhathi sePosi: Oct-08-2022