I-Hydroxypropyl Methylcellulose (HPMC) iyi-polymer yokwenziwa eyenziwe ngesandla esetshenziswa kabanzi kwizimboni eziningi, ikakhulukazi ensimini yezemithi. I-HPMC isiphenduke i-Excipoint ebaluleke kakhulu kumalungiselelo emithi ngenxa yokuthambisa kwayo, okungeyona ubuthi kanye nezakhiwo ezinhle kakhulu zomzimba nezamakhemikhali.
(1) Izici eziyisisekelo ze-HPMC yebanga lemithi
I-HPMC iyi-ether engeyona eye-celvule elungiselelwe ukusabela kwe-cellulose ene-propelene oxide kanye ne-methyl chloride ngaphansi kwezimo ze-alkali. Isakhiwo saso samakhemikhali esiyingqayizivele sinikeza i-HPMC i-solubility enhle kakhulu, ukuqina, ukuhlanza ifilimu kanye nokufaka izakhiwo. Okulandelayo ezinye izici ezibalulekile ze-HPMC:
Ukuzinikela kwamanzi kanye nokuncika kwe-PH: I-HPMC iyancibilika emanzini abandayo futhi yakha isixazululo esibonakalayo esibonakalayo. I-viscosity yesixazululo sayo ihlobene nokuhlushwa kanye nesisindo samangqamuzana, futhi inokuqina okuqinile ku-ph futhi ingahlala isitebele ezindaweni ezine-acidic nase-alkali.
Izakhiwo ze-Thermogel: I-HPMC ibonisa izakhiwo ezihlukile ze-thermogel lapho zifudumeza. Kungakha ijeli lapho kufuthelwa emazingeni okushisa athile bese kubuyela esimweni se-liquid ngemuva kokupholisa. Le mpahla ibaluleke ikakhulukazi kumalungiselelo wokukhulula izidakamizwa.
I-BioCOMTIMITILibility kanye ne-non-Fooxicity: Njengoba i-HPMC iyisisulu se-cellulose futhi ayikhokhisi futhi ngeke isabele nezinye izithako, inokuthambekela okuhle kakhulu futhi ngeke kuthathwe emzimbeni. Kuyinto engeyona eye-excipient.
(2) Ukusetshenziswa kwe-HPMC emithini
I-HPMC isetshenziswa kabanzi embonini yezemithi, ukumboza izinkambu eziningi njengemithi yomlomo, yezihloko nezijova. Izikhombisi-ndlela zayo eziphambili zimi kanjena:
1. Indwangu eyakha ifilimu ezibhebheni
I-HPMC isetshenziswa kabanzi kwinqubo yokuhlangana yamathebulethi njengezinto ezakha amafilimu. I-tablet coating ayikwazi ukuvikela kuphela izidakamizwa ethonyeni lemvelo yangaphandle, njengomswakama nokukhanya, kepha futhi zimboze iphunga elibi nokunambitha izidakamizwa, ngaleyo ndlela kuthuthukise ukulandelwa kwezidakamizwa. Ifilimu eyakhiwa yi-HPMC inokumelana namanzi okuhle namandla, okungadlulisela ngempumelelo impilo yeshelufu yezidakamizwa.
Ngasikhathi sinye, i-HPMC nayo ingasetshenziswa njengengxenye eyinhloko yolwelwesi olulawulwa ngokulawulwa kokukhiqizwa kwamathebulethi okukhishwa nokulawulwa okulawulwayo. Izakhiwo zayo ze-Thermal Gel zivumela izidakamizwa ukuthi zikhishwe emzimbeni ngesilinganiso sokukhishwa kwangaphambili, ngaleyo ndlela sizuze umphumela wokwelashwa kwezidakamizwa okudala. Lokhu kubaluleke kakhulu ekwelapheni izifo ezingamahlalakhona, njengezidingo zemithi zesikhathi eside zeziguli ezinesifo sikashukela kanye nomfutho wegazi ophakeme.
2. Njengomenzeli ophelelwe amandla
I-HPMC isetshenziswa kabanzi njenge-ejenti yokukhishwa okulondoloziwe kumalungiselelo wezidakamizwa omlomo. Ngoba ingakha ijeli emanzini kanti ungqimba lwejeli luncibilika kancane njengoba kukhululwa isidakamizwa, kungalawula ngempumelelo isilinganiso sokukhishwa kwesidakamizwa. Lolu hlelo lokusebenza lubaluleke kakhulu ezidakamizweni ezidinga ukukhishwa kwezidakamizwa okuthatha isikhathi eside, njenge-insulin, ama-antidepressants, njll.
Emvelweni yesisu, i-gel ungqimba lwe-HPMC ingalawula isilinganiso sokukhishwa kwesidakamizwa, ukugwema ukukhishwa ngokushesha kwesidakamizwa ngesikhathi esifushane, ngaleyo ndlela kunciphise imiphumela emibi nokwandisa ukusebenza kahle. Le mpahla ekhishwa okuqhubekayo ilungele ukwelashwa kwezidakamizwa ezidinga ukugxila kwezidakamizwa ezizinzile zegazi, njengezidakamizwa, izidakamizwa ezilwa nama-anti-, njll.
3. Njenge-binder
I-HPMC ivame ukusetshenziswa njenge-binder kwinqubo yokukhiqiza yethebhulethi. Ngokungeza i-HPMC kuzinhlayiya zezidakamizwa noma ama-powders, uketshezi lwalo kanye nokunamathela kungathuthukiswa, ngaleyo ndlela kuthuthukise umphumela wokucindezela namandla wethebhulethi. Ukungabi nobuthi kanye nokuqina kwe-HPMC kwenza kube yi-binder ekahle kumathebulethi, ama-granules kanye nama-caplule.
4. Njengomkhulu kanye ne-stabilizer
Uma amalungiselelo e-liquid, i-HPMC isetshenziswa kabanzi njengomuntu omkhulu futhi i-stabilizer ku-uquid ohlukahlukene ngomlomo, amaconsi wamehlo kanye nokhilimu othosiwe. Impahla yayo yokuqina ingakhuphula i-viscosity yezidakamizwa eziwuketshezi, gwema ukuhlukaniswa kwezidakamizwa noma kwezulu, futhi uqinisekise ukuhanjiswa okufanayo kwezithako zezidakamizwa. Ngasikhathi sinye, i-shortity kanye ne-moisturing Properties ye-HPMC ikuvumela ukuthi inciphise ngempumelelo ukungakhululeki kwamehlo ngamaconsi esweni futhi ivikele amehlo ekucasuleni kwangaphandle.
I-5. Isetshenziswa kuma-caplule
Njenge-cellulose ethathwe izitshalo, i-HPMC inokunye ukuqina okuhle, okwenza kube yinto ebalulekile yokwenza ama-caplule wezitshalo. Uma kuqhathaniswa namaphilisi endabuko we-gelatin wesintu, ama-hpmc caplule anokuqina okungcono, ikakhulukazi ezindaweni zokushisa eziphakeme nasezindaweni eziphakeme zomswakama, futhi akulula ukuzidela noma ukuncibilikisa. Ngaphezu kwalokho, ama-HPMC capsule alungele imifino neziguli ezingezwani ne-gelatin, zandisa ubukhulu bokusetshenziswa kwezidakamizwa ze-capsule.
(3) Ezinye izinhlelo zezidakamizwa ze-HPMC
Ngaphezu kwezinhlelo zokusebenza ezingenhla zezidakamizwa ezingenhla, i-HPMC nayo ingasetshenziswa kwamanye amafomu athile wezidakamizwa. Isibonelo, ngemuva kokuhlinzwa kwe-Ophthalmic, i-HPMC isetshenziswa ngamaconsi wamehlo njenge-lubricant ukunciphisa ukuxabana ebusweni be-eyeball futhi kukhuthaze ukululama. Ngaphezu kwalokho, i-HPMC ingabuye isetshenziswe kuma-ointry nama-gels ukukhuthaza ukumuncwa kwezidakamizwa futhi kuthuthukise ukusebenza kwezidakamizwa zasendaweni.
Ibanga le-HPMC le-Pharmaceutical Ibanga libamba iqhaza elibalulekile kumalungiselelo wezidakamizwa ngenxa yezakhiwo zalo ezinhle kakhulu zenyama nangamakhemikhali. Njenge-Exessietieint yekhemisi eminingi esebenzayo, i-HPMC ayikwazi ukwenza ngcono ukuqina kwezidakamizwa futhi ilawule ukukhishwa kwezidakamizwa, kepha futhi ithuthukise okuhlangenwe nakho kwezidakamizwa futhi yandise ukulandelwa kwezidakamizwa. Ngokuthuthuka okuqhubekayo kobuchwepheshe bezemithi, inkambu yesicelo ye-HPMC izoba nkulu futhi idlale indima ebaluleke kakhulu ekuthuthukisweni kwezidakamizwa okuzayo.
Isikhathi Seposi: I-Sep-19-2024