I-Hydroxypropyl Methylcellulose (HPMC) ne-Hypromellose kuyinto efanayo, futhi imigomo ivame ukusetshenziswa ngokushintshana. Lawa ngamagama ayinkimbinkimbi ezinhlobo ezijwayelekile zama-polymers asuselwa ku-cellulose anezinhlobonhlobo zezicelo ezimbonini ezahlukahlukene kufaka phakathi ama-Pharmaceuticals, ukudla nezimonyo.
Isakhiwo se-1.Chical nokwakheka:
I-Hydroxypropylmetylcellellellellellulose (HPMC) ukuguqulwa kwe-cellulose, i-polymer yemvelo etholakala ezindongeni zeseli zezitshalo. Isakhiwo samakhemikhali se-HPMC sitholakala ngethula ama-hydroxypropyl kanye namaqembu we-methyl ngesisekelo se-cellulose. I-Hydroxypropyl gerop yenza ukuncibilika okwengeziwe emanzini, futhi iqembu le-methyl lithuthukisa ukuqina kwalo futhi linciphisa ukuvumelanisa kwalo.
2. Inqubo Yokukhiqiza:
Ukukhiqizwa kwe-hydroxypropyllllylyll methylcellose kuhilela ukwelapha i-cellulose nge-oxylene oxide ukwethula amaqembu we-hydroxypropys bese kuthi nge-methyl chloride ukwengeza amaqembu we-methyl. Izinga lokufakwa esikhundleni (DS) le-hydroxypropyl kanye ne-methyl lingashintshwa ngesikhathi senqubo yokukhiqiza, okuholela kumabanga ahlukene we-HPMC anezakhiwo ezahlukahlukene.
3. Izakhiwo ezibonakalayo:
I-HPMC imhlophe ku-powder emhlophe kancane, ingenamphundla futhi ayinambitha. Izakhiwo zayo ezibonakalayo, njengokusobala kanye ne-solubility, kuncike ngezinga lokufakwa esikhundleni kanye nesisindo se-polymer. Ngaphansi kwezimo ezijwayelekile, kuncibilika kalula emanzini, kwakha ikhambi elisobala nelingenamibala.
4. Izinjongo zokwelashwa:
Enye yezinhlelo zokusebenza eziphambili ze-HPMC isembonini yezemithi. Isetshenziswa kabanzi njenge-excipieint yezemithi futhi idlala izindima ezahlukahlukene kumalungiselelo emithi. I-HPMC ivame ukutholakala ku-Oral Solid DOSAGE amafomu afana namathebulethi, amaphilisi, namaphilisi. Isebenza njenge-binder, ukuqhelelana, ne-ejenti yokukhishwa elawulwa, okufaka isandla ekuqineni okuphelele kanye nokuvunyelwa komuthi.
I-5. Indima kumalungiselelo wokukhishwa alawulwayo:
Amandla we-HPMC azokwakha ama-gels kuzixazululo zamanzi enza ukuba kubalulekile ekunikezelweni kwezidakamizwa ezilawulwayo. Ngokuhlukahlukana kwezakhiwo ze-viscosity kanye ne-gel-ekwakheni, ososayensi abakhethwayo bangalawula isilinganiso sokukhishwa kwezithako ezisebenzayo, ngaleyo ndlela bathole isenzo sezidakamizwa esisezingeni eliphakeme neside.
6. Isicelo embonini yokudla:
Embonini yokudla, i-HPMC isetshenziswa njengesikhulu, i-stabilizer kanye ne-emulsifier. Kuthuthukisa ukuthungwa kokudla okuhlukahlukene, kufaka phakathi amasoso, amasobho nemikhiqizo yobisi. Ngokwengeziwe, i-HPMC isetshenziswa ekubhaka kwamahhala-gluten-free ukuthuthukisa ukwakheka kanye nezakhiwo ezinomswakama wemikhiqizo engenama-gluten-free.
7. Izinto zokwakha nezakhayo:
I-HPMC isetshenziswa embonini yezokwakha emikhiqizweni efana nama-tile anamathela, ama-porsters asuselwa ku-cyment kanye nezinto zokwenziwa ze-gypsum. Kuthuthukisa ukuqina, ukugcinwa kwamanzi kanye nezindawo ezinamathela kwale mikhiqizo.
8. Izimonyo kanye nemikhiqizo yokunakekelwa komuntu siqu:
I-Hypromellose nayo isithako esivamile kwezimonyo nezimonyo zokunakekelwa komuntu. Isetshenziswa kumakhilimu, ama-lotions nama-shampoos ngenxa yezakhiwo zayo zokuqina nokuzinza. Ngokwengeziwe, kuyasiza ukuthuthukisa ukuthungwa okuphelele futhi uzizwe ngomkhiqizo.
9. I-Film coating ekheni:
I-HPMC isetshenziswa kabanzi embonini yezemithi yokuhlanganiswa kwamathebulethi. Amathebhulethi ahlanganiswe ngamafilimu anikela ngokubukeka okuthuthukile, ukunambitha ukuhlikihla nokuvikelwa ekuvikelekeni kwezemvelo. Amafilimu we-HPMC ahlinzeka ngenhlanganisela ebushelelezi futhi eyunifomu, ethuthukisa ikhwalithi ephelele yomkhiqizo wezidakamizwa.
13. Isiphetho:
I-Hydroxypropylm methylcellulose (HPMC) kanye ne-Helpromellose abhekisele ku-polymer esekwe kwiseli enezicelo ezahlukahlukene kuma-Pharmaceuticals, ukudla, izimonyo kanye nokwakha. Izakhiwo zayo ezihlukile, njenge-solubity, ukuqina kanye nokuqina kwe-biodeGreatability, zinomthelela ekusetshenzisweni kwayo okubanzi. Ukuguquguquka okuhlukahlukene kwe-HPMC emikhakheni ehlukene kuqokomisa ukubaluleka kwayo njengento esebenza ngemisebenzi eminingi, futhi kuqhubeke kabushaUkusesha kanye nentuthuko kungathola izinhlelo zokusebenza ezengeziwe ngokuzayo.
Lokhu kubuka konke okuphelele kuhlose ukuhlinzeka ngokuqonda okuningiliziwe kwe-hydroxypropyllyllose methylcellulose kanye ne-hypromeellose, ukucacisa ukubaluleka kwazo emikhakheni ehlukahlukene, futhi kucacise iqhaza labo ekubumbeni imikhiqizo eminingi kanye nokwakheka.
Isikhathi sePosi: DEC-21-2023