Kokubili i-hydroxypropyll methylcellose kanye hydroxyethyl cellulose kukhona iselula

I-Hydroxypropyl methylcellulose (HPMC)kanye ne-hydroxyyethyl cellulose (HEC) yimibhalo emibili ebalulekile yeselula esetshenziswe kabanzi kwizimboni ezahlukahlukene ngenxa yezakhiwo zazo ezihlukile. Ngenkathi bobabili basuselwa ku-cellulose, banazo izinhlaka zamakhemikhali ezihlukile futhi babonisa izici ezahlukahlukene kanye nezicelo.

1. Isingeniso ku-Cellulose Derivatives:
I-Cellulose iyi-polysaccharide yemvelo etholakala ezindongeni zamaseli ezitshalo, ezinamaketanga aqondile ama-glucose amayunithi axhumeke yi-β (1 → 4) amabhondi e-glycosidic. I-Celsulose Derivatives itholakala ngokuguqula amakhemikhali ukuze athuthukise izakhiwo ezithile noma angenise ukusebenza okusha. I-HPMC ne-HEC kuyizinto ezimbili ezinjalo ezisetshenziswe kakhulu ezimbonini ezisukela emikhakheni ekwakheni.

2. Synthesis:
I-HPMC ihlanganiswe ngokuphendula i-cellulose nge-propelene oxide ukwethula amaqembu we-hydroxypropyl futhi ngemuva kwalokho i-methyl chloride ukwethula amaqembu we-methyl. Lokhu kuphumela ekufakwe esikhundleni samaqembu e-hydroxyl ku-cellulose chain, kuthela umkhiqizo nge-solubity ethuthukisiwe kanye nezakhiwo ezenziwe ngefilimu.

Ngakolunye uhlangothi, i-HEC, ikhiqizwa ngokuphendula i-cellulose nge-ethylene oxide ukufaka amaqembu we-hydroxyethyl. Izinga lokufakwa esikhundleni (DS) kuzo zombili i-HPMC ne-HEC zingalawulwa ngokulungisa izimo zokuphendula, zithinta izakhiwo zazo ezifana nokuvunywa, ukuzibandakanya nokuziphatha kwe-gelation.

3. Isakhiwo samakhemikhali:
I-HPMC ne-HEC ihlukile ezinhlotsheni zamaqembu afakiwe anamathiselwe kwi-cellulose backbone. I-HPMC iqukethe zombili i-hydroxypropyl kanye namaqembu we-methyl, ngenkathi i-hec iqukethe amaqembu we-hydroxyethyl. Lokhu kufakazelwa kufaka phakathi izici ezihlukile ekususweni ngakunye, kuthonya ukuziphatha kwabo kuzicelo ezahlukahlukene.

4. Izakhiwo ezibonakalayo:
Kokubili i-HPMC ne-HEC kungama-polymers ancibilikayo anezinkinga ezinezici ezinhle kakhulu zokuqina. Kodwa-ke, zibonisa umehluko ekubonakaleni, umthamo we-hydration, kanye nekhono elenza ifilimu. I-HPMC imvamisa inokubona okuphezulu okuqhathaniswa ne-HEC ekugxiliseni okufanayo, okwenza kube lula ukuthola izinhlelo zokusebenza ezidinga ukuqina okukhulu.

Ngokwengeziwe, ama-HPMC akha amafilimu acacile futhi ahlangana kakhulu ngenxa yokufakwa esikhundleni kwe-methyl, kanti u-Hec udale amafilimu aguquguqukayo. Lo mehluko ezizakhisweni zefilimu wenza i-derivative ngayinye efanelekile ukuthola izinhlelo ezithile kuma-Pharmaceuticals, imikhiqizo yokunakekelwa komuntu, kanye nezimboni zokudla.

5. Izicelo:
5.1 Imboni Yezemithi:
Kokubili i-HPMC ne-HEC kusetshenziswa kabanzi ekwakhiweni kwemithi njengezixhumanisi, izinhlanzi, kanye nama-ejenti amafilimu. Bathuthukisa ubuqotho bethebhulethi, balawule ukukhishwa kwezidakamizwa, futhi bathuthukise umlomo ngokwakha uketshezi. I-HPMC ilindelwe izifundo ezisetshenziselwa ukukhishwa ngenxa yamazinga ayo ahamba kancane, ngenkathi i-hec ivame ukusetshenziswa kuzixazululo ze-ophthalmic kanye nokhilimu othosiwe ngenxa yokucaca kwayo kanye nokuhambisana namanzi akhona.

5.2 Imboni yezokwakha:
Embonini yezokwakha,I-HPMCna-I-HECbaqashwa njengezengezo ngezinto zokwakha amasimende, ezinjengezidakamizwa, ama-grouts, kanye nama-render. Bathuthukisa ukusebenza, ukugcinwa kwamanzi, kanye nokunamathela, okuholela ekusebenzeni okuthuthukile nokuqina komkhiqizo wokugcina. I-HPMC ivame ukuthandwa umthamo wayo ophakeme wokugcina amanzi, okunciphisa ukuqhekeka futhi kuthuthukise ukusetha isikhathi.

5.3 Imikhiqizo Yokunakekelwa Kwakho:
Zombili izinto zokutholwa zithola izinhlelo zokusebenza emikhiqizweni yokunakekelwa komuntu siqu ezifana nama-shampoos, ama-lotion, kanye nokhilimu njengama-ejenti akhuthazayo, ama-emulsifiers, kanye nokuqina. I-HEC idlulisela ukuthungwa okubushelelezi futhi okucwebezelayo ekwakhiweni, okwenza kube lufanele imikhiqizo yokunakekelwa kwezinwele kanye nokhilimu wesikhumba. I-HPMC, ngezakhiwo zayo eziphakeme zefilimu, isetshenziswa kuma-sunscreens kanye nokwakhiwa kwezimonyo ezidinga ukumelana kwamanzi nokugqoka okuhlala isikhathi eside.

5.4 Imboni yokudla:
Embonini yokudla, i-HPMC ne-HEC kusebenza njengama-ejenti okuqina, abaqinisi, kanye nama-texturizer emikhiqizweni ehlukahlukene kufaka phakathi amasoso, ukugqoka kanye nama-dessert. Bathuthukisa i-moundfeel, bavikele i-syneresis, futhi bathuthukise izimfanelo zokuzwa izinto zokudla. I-HPMC ivame ukuthandwa ngokucacelwa kwayo nokuqina kokushisa, okwenza kube lula ukuthi izinhlelo ezidinga ama-gels asobala nama-emulsions azinzile.

6. Isiphetho:
I-Hydroxypropyl Methylcellulose (HPMC) neHydroxyEthyl celtulose (HEC) yi-cellulose derivativeves enezinto ezihlukile zamakhemikhali, izakhiwo kanye nezicelo. Ngenkathi bobabili benikela ngezindawo ezinhle kakhulu zokuqina kanye nefilimu, zibonisa umehluko ekubonakaleni, ukucaciswa kwamafilimu, nokuziphatha kwe-hydration. Ukuqonda lokhu kwehluka kubalulekile ekukhetheni okususelwa kokutholakala kwezicelo ezithile kuzo zonke izimboni ezinjengezemithi, ukwakhiwa, ukunakekelwa komuntu siqu nokudla. Njengoba ucwaningo luyaqhubeka nokuqhubekisela phambili, ukuguqulwa okuthe xaxa kanye nokusetshenziswa kwezinsizakusebenza ze-cellulose derivatives kulindeleke, kufaka isandla ekuphawuleni kwawo okuqhubekayo emikhakheni ehlukahlukene yezimboni.