Ngabe i-HPMC ingancibilikisa emanzini ashisayo?

I-HPMC (HYDROXYPROPYL Methylcellulose)I-polymer eyenziwe nge-aon-ionic eyedwa esetshenziswa kabanzi kwezokwelapha, ukudla, ukwakha, ukumbona kanye nezinye izimboni. Ngokuthi i-HPMC ingancibilikisa emanzini ashisayo, izici zayo zokululube kanye nomphumela wokushisa ngokuziphatha kwayo kokuchithwa kudinga ukucatshangelwa.

Ukubuka konke kwe-HPMC Solbility

I-HPMC ine-solubility yamanzi enhle, kepha isimilo saso sokuchithwa sihlobene kakhulu nokushisa kwamanzi. Ngokuvamile, i-HPMC ingahlakazeka kalula futhi ichithwe emanzini abandayo, kepha ibonisa izici ezihlukile emanzini ashisayo. I-solubity ye-HPMC emanzini abandayo ithinteka ikakhulukazi ngenxa yesakhiwo sayo samangqamuzana kanye nohlobo olungafani. Lapho i-HPMC ihlangana namanzi, amaqembu e-hydrophilic (anjenge-hydroxylropyl) kuma-molecule awo azokwakha izibopho zama-hydrogen anama-molecule wamanzi, okwenza kancane kuvuvukale futhi kuncibilike kancane kancane. Kodwa-ke, izici ze-solubity ze-HPMC zihlukile emanzini emazingeni okushisa ahlukahlukene.

I-Solubity ye-HPMC emanzini ashisayo

I-solubity ye-HPMC emanzini ashisayo incike ebangeni lokushisa:

Izinga lokushisa eliphansi (0-40 ° C): I-HPMC ingadonsa amanzi kancane kancane futhi ivuvukale, futhi ekugcineni yakha isixazululo esibonakalayo noma esibonakalayo se-viscous. Izinga lokuchithwa lihamba kancane emazingeni okushisa aphansi, kepha i-gelation akwenzeki.

Ukushisa okuphakathi (40-60 ° C): I-HPMC ivuvukala kuleli banga lokushisa, kepha ayichithi ngokuphelele. Esikhundleni salokho, yakha kalula ama-agglomerates noma ukumiswa, okuthinta ukufana kwesixazululo.

Izinga lokushisa eliphakeme (ngaphezulu kwe-60 ° C): I-HPMC izokwehlukaniswa kwesigaba emazingeni okushisa aphezulu, kuboniswe njenge-gelacition noma izulu, okwenza kube nzima ukuncibilikisa. Ngokuvamile, lapho izinga lokushisa lamanzi lidlula i-60-70 ° C, ukunyakaza okushisayo kwe-HPMC I-Chain Check iyaqina, futhi ukuncipha kwalo kuyancipha, futhi kungagcina sekuvele kwakha ijeli noma i-thovitate.

Izakhiwo ze-Thermogel ze-HPMC

I-HPMC inezindawo ezijwayelekile ze-thermogel, okungukuthi, yakha ijeli emazingeni okushisa aphezulu futhi ingavunyelwa kabusha emazingeni okushisa aphansi. Le mpahla ibaluleke kakhulu kwizicelo eziningi, njenge:

Imboni yezokwakha: I-HPMC isetshenziswa njengesikhulu sodaka kasimende. Ingagcina umswakama omuhle ngesikhathi sokwakha futhi sikhombise indawo yokushisa ephezulu yokunciphisa ukulahleka kwamanzi.

Amalungiselelo amakhemikhali: Uma isetshenziswa njengezinto zokuhlanganisa ezibhebheni, izakhiwo zayo zokubhebhana zidinga ukucatshangelwa ukuze kuqinisekiswe ukuthi i-solubity enhle.

Imboni yokudla: I-HPMC isetshenziswa njengomuntu omkhulu kanye ne-emulsifier kokunye ukudla, futhi i-gelation yayo eshisayo isiza ukuqina kokudla.

Ungayiqeda kanjani i-HPMC kahle?

Ukuze ugweme i-HPMC ekwakheni i-gel emanzini ashisayo futhi yehluleka ukuncibilikisa ngokulinganayo, izindlela ezilandelayo zivame ukusetshenziswa:

Indlela yokuhlakazwa kwamanzi ebandayo:

Okokuqala, ngokulinganayo usabalalisa i-HPMC emanzini abandayo noma emanzini okushisa asekamelweni ukuze ambeke ngokugcwele bese uyivuthela.

Khulisa kancane kancane amazinga okushisa ngesikhathi sokuvuselelwa ukuze uqhubeke nokuqeda i-HPMC.

Ngemuva kokuthi ichithwe ngokuphelele, izinga lokushisa lingakhuphuke ngokufanele ukusheshisa ukwakheka kwesixazululo.

Indlela Eshisayo Yokuphangwa Kwamanzi:

Okokuqala, sebenzisa amanzi ashisayo (cishe ama-80-90 ° C) ukusabalalisa ngokushesha i-HPMC ukuze kwakhiwe isendlalelo sokuvikela i-insoluble ebusweni bayo ukuvikela ukwakheka okusheshayo kwezigaxa ezinamathelayo.

Ngemuva kokupholisa ekushiseni kwegumbi noma wengeza amanzi abandayo, kancane kancane i-HPMC incibilikisa ukwenza isixazululo esifanayo.

Indlela yokuxuba eyomile:

Hlanganisa i-HPMC nezinye izinto ezi-soluble (ezifana noshukela, isitashi, i-manitol, njll.) Bese engeza amanzi ukunciphisa i-agglomeration futhi uthuthukise ukuchithwa okufanayo.

I-HPMCayikwazi ukuncibilika ngqo emanzini ashisayo. Kulula ukwakha i-gel noma i-tycicate ekushiseni okuphezulu, okunciphisa i-solubity yayo. Indlela enhle yokuqothula ukuyisatshalaliswa emanzini abandayo kuqala noma ngaphambi kokusakazeka ngamanzi ashisayo bese uphola ukuthola isisombululo esilinganayo nesizinzile. Kuzinhlelo zokusebenza ezisebenzayo, khetha indlela efanele yokuqothula ngokuya ngezidingo zokuqinisekisa ukuthi i-HPMC isebenza kahle.