Emkhakheni wokwenza imithi, i-sodium carboxymethylcellulose (CMC) ne-hydroxypropyl methylcellulose (HPMC) yizinto ezimbili ezisetshenziswa kakhulu ezisiza ekwelashweni ezinezakhiwo nemisebenzi yamakhemikhali ehlukene.
Isakhiwo samakhemikhali kanye nezakhiwo
I-CMC iphuma ku-cellulose encibilika emanzini etholwe ngokuguqula ingxenye yamaqembu e-hydroxyl e-cellulose abe amaqembu e-carboxymethyl. Ukunyibilika kwamanzi kanye ne-viscosity ye-CMC kuncike ezingeni layo lokushintsha kanye nesisindo samangqamuzana, futhi ngokuvamile iziphatha njenge-thiener enhle ne-ejenti elengayo.
I-HPMC itholakala ngokushintsha ingxenye yamaqembu e-hydroxyl ye-cellulose ngamaqembu e-methyl kanye ne-hydroxypropyl. Uma kuqhathaniswa ne-CMC, i-HPMC inokunyibilika okubanzi, ingancibilika emanzini abandayo nashisayo, futhi ibonise i-viscosity ezinzile ngamavelu e-pH ahlukene. I-HPMC ivamise ukusetshenziswa njengefilimu yangaphambili, enamathelayo, ejiya kanye ne-ejenti yokukhululwa elawulwayo kwezemithi.
Inkambu yohlelo lokusebenza
Izibhebhe
Ekukhiqizeni amaphilisi, i-CMC isetshenziswa kakhulu njenge-disintegrant kanye ne-adhesive. Njenge-disintegrant, i-CMC ingakwazi ukumunca amanzi futhi ivuvuke, ngaleyo ndlela ikhuthaze ukuhlakazeka kwamaphilisi futhi ikhulise izinga lokukhululwa kwezidakamizwa. Njengesibophezelo, i-CMC ingathuthukisa amandla omshini wamathebulethi.
I-HPMC isetshenziswa kakhulu njenge-ejenti yokukhululwa yefilimu yangaphambili futhi elawulwayo kumathebulethi. Ifilimu eyakhiwe yi-HPMC inamandla amahle kakhulu emishini nokumelana nokugqoka, okungavikela umuthi ethonyeni lendawo yangaphandle. Ngesikhathi esifanayo, izakhiwo zefilimu ze-HPMC zingasetshenziswa futhi ukulawula izinga lokukhululwa komuthi. Ngokulungisa uhlobo nesikali se-HPMC, ukukhululwa okuqhubekayo noma umphumela olawulwayo wokukhululwa ungafinyelelwa.
Amaphilisi
Ekulungiseni i-capsule, i-CMC isetshenziswa kancane, kuyilapho i-HPMC isetshenziswa kakhulu, ikakhulukazi ekukhiqizeni amaphilisi emifino. Amagobolondo e-capsule endabuko enziwa kakhulu nge-gelatin, kodwa ngenxa yenkinga yemithombo yezilwane, i-HPMC isiphenduke enye into efanelekile. Igobolondo le-capsule elenziwe nge-HPMC aligcini nje ngokuba ne-biocompatibility enhle, kodwa futhi lihlangabezana nezidingo zabantu abadla imifino.
Amalungiselelo oketshezi
Ngenxa yezakhiwo zayo ezinhle kakhulu zokuqina nokumiswa, i-CMC isetshenziswa kabanzi ekulungiseleleni uketshezi njengezixazululo zomlomo, amaconsi iso kanye namalungiselelo asezindaweni. I-CMC ingakhuphula i-viscosity yamalungiselelo oketshezi, ngaleyo ndlela ithuthukise ukumiswa nokuzinza kwezidakamizwa futhi ivimbele ukubola kwezidakamizwa.
Ukusetshenziswa kwe-HPMC ekulungiseleleni uketshezi kugxile kakhulu kuma-thickeners nama-emulsifiers. I-HPMC ingahlala izinzile phezu kwebanga elibanzi le-pH futhi ingahambisana nezinhlobonhlobo zemithi ngaphandle kokuthikameze ukusebenza ngempumelelo kwemithi. Ukwengeza, izakhiwo zefilimu ze-HPMC nazo zisetshenziswa ekulungiseleleni ama-topical, njengomphumela wokuvikela wokwenza ifilimu kumaconsi iso.
Amalungiselelo okukhishwa okulawulwayo
Kumalungiselelo okukhishwa okulawulwayo, ukusetshenziswa kwe-HPMC kugqame kakhulu. I-HPMC iyakwazi ukwenza inethiwekhi yejeli, futhi izinga lokukhululwa lomuthi lingalawulwa ngokulungisa ukugxila kanye nesakhiwo se-HPMC. Lesi sakhiwo sisetshenziswe kabanzi kumathebulethi akhishwa ngomlomo akhishwa njalo kanye nama-implants. Ngokuphambene, i-CMC isetshenziswa kancane kumalungiselelo okukhishwa okulawulwayo, ikakhulukazi ngenxa yokuthi ukwakheka kwejeli eyakhayo akuzinzile njenge-HPMC.
Ukuzinza nokuhambisana
I-CMC inozinzo olungeluhle kumanani e-pH ahlukene futhi ithintwa kalula izindawo ezine-acid-base. Ngaphezu kwalokho, i-CMC ayihambisani kahle nezithako ezithile zezidakamizwa, ezingase zidale ukuna kwezidakamizwa noma ukwehluleka.
I-HPMC ikhombisa ukuzinza okuhle ebangeni le-pH elibanzi, ayithinteki kalula isisekelo se-asidi, futhi inokuhambisana okuhle kakhulu. I-HPMC ingahambisana nezithako eziningi zezidakamizwa ngaphandle kokuphazamisa ukuzinza nokusebenza komuthi.
Ukuphepha nemithethonqubo
Kokubili i-CMC ne-HPMC zithathwa njengezisiza eziphephile zemithi futhi zigunyazwe ukuthi zisetshenziselwe amalungiselelo emithi ngama-pharmacopoeias nama-ejensi alawulayo emazweni ahlukahlukene. Nokho, ngesikhathi sokusetshenziswa, i-CMC ingase ibangele ukungezwani okuthile noma ukungakhululeki kwesisu, kuyilapho i-HPMC ingavamile ukubangela ukusabela okungekuhle.
I-CMC ne-HPMC zinezinzuzo zazo ezinhlelweni zemithi. I-CMC ithatha isikhundla esibalulekile ekulungiseleleni uketshezi ngenxa yezakhiwo zayo ezinhle kakhulu zokujiya nokumiswa, kuyilapho i-HPMC isetshenziswe kabanzi kumaphilisi, amaphilisi kanye namalungiselelo okukhishwa okulawulwayo ngenxa yezakhiwo zayo ezinhle kakhulu zokwakha ifilimu nokukhishwa okulawulwayo. Ukukhethwa kwamalungiselelo emithi kufanele kusekelwe ezakhiweni ezithile zomuthi kanye nezidingo zokuwulungiselela, kucatshangelwa kabanzi izinzuzo nezinkinga zakho kokubili, nokukhetha osizayo ofaneleka kakhulu.
Isikhathi sokuthumela: Jul-19-2024