Ensimini yezemithi, i-sodium carboxyylcelcellulose (CMC) ne-hydroxypropyllylylyll methylcellulose (HPMC) yimidlalo emibili esetshenziswa amakhemikhali enezinto ezahlukene zamakhemikhali nemisebenzi.
Ukwakheka kwamakhemikhali nezakhiwo
I-CMC iyi-cellulose etholwa ngamanzi okutholwe okutholwe ngokuguqula ingxenye yamaqembu e-hydroxyl ama-cellulose kumaqembu e-carboxymethyl. I-solubility yamanzi nokubonakala kwe-CMC kuncike ekuthatheni esikhundleni sayo sokufakwa esikhundleni kanye nesisindo se-molecular, futhi kuvame ukuziphatha njenge-ejenti enhle futhi esondelana.
I-HPMC itholakala ngokufaka ingxenye yamaqembu e-hydroxyl apulazilikazi nge-methyl kanye ne-hydroxypropyl. Uma kuqhathaniswa ne-CMC, i-HPMC ine-soubity ebanzi, ingachithwa emanzini abandayo nawemvu ashisayo, futhi ibonisa ukubonakala okuzinzile ngamanani ahlukile we-PH. I-HPMC ivame ukusetshenziswa njengefilimu yangaphambili yefilimu, enamathela, isikhulu kanye ne-ejenti yokukhishwa elawulwa emikhakheni.
Inkambu yesicelo
Izibhebhe
Ekwenziweni kwamathebulethi, i-CMC isetshenziswa ikakhulukazi njengokuqhekeka nokunamathela. Njengokuqhekeka, i-CMC ingadonsa amanzi nokudumba, ngaleyo ndlela kukhuthaza ukuhlukaniswa kwamathebulethi futhi kwandise izinga lokukhishwa kwezidakamizwa. Njenge-binder, i-CMC ingakhulisa amandla emishini yamathebulethi.
I-HPMC isetshenziswa ikakhulukazi njenge-ejenti yokukhishwa yefilimu futhi elawulwayo kumathebulethi. Ifilimu eyakhiwa yi-HPMC inamandla amahle kakhulu okwenziwa ngomshini futhi igqoke ukumelana, okungavikela umuthi ethonyeni lendawo yangaphandle. Ngasikhathi sinye, izakhiwo ezakha amafilimu ze-HPMC nazo zingasetshenziswa ukulawula isilinganiso sokukhishwa kwesidakamizwa. Ngokushintsha uhlobo kanye nomthamo we-HPMC, ukukhishwa okuqhubekayo noma umphumela wokukhishwa olawulwayo ungatholakala.
Amaphilisi
Ekulungiseleleni kwe-capsule, i-CMC ayisetshenziswa kangako, kuyilapho i-HPMC isetshenziswa kabanzi, ikakhulukazi ekukhiqizweni kwama-caplule zemifino. Amagobolondo we-capsule wendabuko anwetshwa kakhulu nge-gelatin, kepha ngenxa yenkinga yemithombo yezilwane, i-HPMC isiphenduke ezinye izinto ezingezona ezingokwehlukile. I-capsule Shell eyenziwe nge-HPMC ayigcini ngokune-biocomtic kuphela, kepha futhi ihlangabezana nezidingo zabantu abasebenza imifino.
Ukulungiselela uketshezi
Ngenxa yezakhiwo zayo zokuqina ezinhle kakhulu kanye nokumiswa, i-CMC isetshenziswa kabanzi kumalungiselelo we-liquid njengezixazululo zomlomo, amaconsi wamehlo namalungiselelo aphezulu. I-CMC ingakhuphula i-viscosity yamalungiselelo awuketshezi, ngaleyo ndlela yenza ngcono ukumiswa kanye nokuqina kwezidakamizwa nokuvimbela ukuqunjelwa kwezidakamizwa.
Ukusetshenziswa kwe-HPMC kumalungiselelo we-liquid kugxile kakhulu kubakhulu kanye nama-emulsifers. I-HPMC ingahlala iqinile ngaphezu kobubanzi be-PH futhi ingahambelana nezidakamizwa ezahlukahlukene ngaphandle kokuthinta ukusebenza kwezidakamizwa. Ngaphezu kwalokho, izakhiwo ezakha amafilimu ze-HPMC nazo zisetshenziswa kumalungiselelo we-topical, njengethonya elakhiwe ngefilimu emaconsi eso.
Amalungiselelo okukhishwa alawulwayo
Ngamalungiselelo okukhishwa alawulwayo, ukusetshenziswa kwe-HPMC kuvelele ikakhulukazi. I-HPMC iyakwazi ukwakha inethiwekhi ye-gel, futhi isilinganiso sokukhishwa kwesidakamizwa singalawulwa ngokulungisa ukugxila nokwakheka kwe-HPMC. Le mpahla isetshenziswe kabanzi kumathebulethi okukhishwa komlomo kanye nezimila. Ngokuphambene, i-CMC ayisetshenziswa kangako kumalungiselelo wokukhishwa alawulwayo, ikakhulukazi ngoba isakhiwo se-gel IT asizinzile njenge-HPMC.
Ukuqina kanye ukuhambisana
I-CMC inokuqina okungafanele kumanani ahlukile we-PH futhi ithinteka kalula ngezindawo ze-acid-base. Ngaphezu kwalokho, i-CMC inokuhambisana okungekuhle nezithako ezithile zezidakamizwa, ezingadala ukwelashwa kwezidakamizwa noma ukwehluleka.
I-HPMC ikhombisa ukuqina okuhle ngaphezu kwebanga le-PH, alithinteki kalula nge-acid-base, futhi linokuhambisana okuhle kakhulu. I-HPMC ingahambisana nezithako eziningi zezidakamizwa ngaphandle kokuthinta ukuqina kanye nokusebenza kahle kwesidakamizwa.
Ukuphepha kanye nemigomo
Kokubili i-CMC ne-HPMC kubhekwa njengokuphepha okuphephile kwezemithi Kodwa-ke, ngesikhathi sokusebenzisa, i-CMC ingadala ukungahambi kahle komzimba noma ukungakhululeki kwesisu, ngenkathi i-HPMC iyanda kakhulu.
I-CMC ne-HPMC zinezinzuzo zazo ezisetshenziswayo zemithi. I-CMC ithatha isikhundla esibalulekile kumalungiselelo owuketshezi ngenxa yezakhiwo zayo ezihamba phambili kanye nokumiswa, ngenkathi i-HPMC isetshenziswe kabanzi kumathebulethi, ama-caplule namalungiselelo wokukhishwa alawulwa ngenxa yezakhiwo zayo ezinhle kakhulu zefilimu nezolawulwa. Ukukhethwa kwamalungiselelo emithi kufanele kususelwe kwizakhiwo eziqondene nezidakamizwa kanye nezidingo zokulungiswa, ukucubungula kahle izinzuzo nokubi kokubili, nokukhetha i-Excipient elungele kakhulu.
Isikhathi Sokuposa: Jul-19-2024