I-Hydroxypropyl methylcellulose, eyaziwa ngokuthi i-HPMC, iyindlela esetshenziswa kabanzi yekhemisi nesengezo sokudla. Ngenxa ye-solubility yayo enhle kakhulu, amandla okubopha kanye nezakhiwo ezenziwe ngefilimu, zisetshenziswe kabanzi embonini yezemithi. I-HPMC nayo isetshenziswa kakhulu embonini yokudla njengomuntu omkhulu, i-emulsifier ne-stabilizer. Ubumsulwa be-HPMC bubaluleke kakhulu kwizimboni zezemithi nezokudla njengoba kuthinta ukusebenza kahle nokuphepha komkhiqizo. Lo mbhalo uzoxoxa ngokuzimisela kobumsulwa be-HPMC nezindlela zalo.
Ayini ama-HPMCS?
I-Hydroxypropylmetylcellellellellellulose (HPMC) yi-cellulose ether etholakala ku-methylcellulose. Isisindo sayo samangqamuzana singu-10,000 kuya ku-1 000 000 000, futhi yimpuphu emhlophe noma emhlophe, engenamsindo futhi engenamkhawulo. I-HPMC iyancibilika kalula emanzini, futhi iyancibilika kwezinye izixazululo ze-organic njenge-ethanol, i-Butanol naseChloroform. Inezakhiwo ezithile ezihlukile njengokugcinwa kwamanzi, ukuqina kanye nekhono elibophayo, elenza lilungele izimboni zezemithi nokudla.
Ukuzimisela kobumsulwa be-HPMC
Ubumsulwa be-HPMC buxhomeke ezicini ezimbalwa ezifana nezinga lokufakwa esikhundleni (DS), umswakama okuqukethwe nokuqukethwe komswakama. I-DS imele inani lamaqembu ama-hydroxyl afakwe esikhundleni samaqembu we-hydroxypropyl ku-molecule ye-cellulose. Izinga eliphakeme lokufaka esikhundleni senyusa i-solubity ye-HPMC futhi ithuthukise ikhono elakhiwa amafilimu. Ngakolunye uhlangothi, izinga eliphansi lokufaka esikhundleni lalizophumela ekunciphiseni kwe-soubelity kanye nezakhiwo ezingezinhle zefilimu.
Indlela yokuzimisela ehlangene ye-HPMC
Kunezindlela eziningi zokuthola ubumsulwa be-HPMC, kufaka phakathi umphumela we-acid-base, ukuhlaziya okuyisisekelo, i-chptography ephezulu ye-chromatography (HPLC), kanye ne-infrared spectroscopy (IR). Nayi imininingwane yendlela ngayinye:
Ukuthathwa kwesisekelo se-acid-base
Indlela isuselwa ekuphendukeni okungathathi hlangothi phakathi kwamaqembu a-acidic kanye ayisisekelo ku-HPMC. Okokuqala, i-HPMC ichithwe kwi-solvent kanye nevolumu eyaziwayo ye-acid noma isizinda solution of ukujeziswa owaziwayo. Ukuthathwa kwenziwa kwaze kwenziwa kuze kube yilapho i-PH ye-Neutral Point. Ukusuka kwinani le-acid noma isisekelo esidliwayo, izinga lokufaka esikhundleni semali lingabalwa.
Ukuhlaziywa Kwamanye
Ukuhlaziywa okuyisisekelo kulinganisa amaphesenti wento ngayinye ekhona empumputhe, kufaka phakathi ikhabhoni, i-hydrogen, kanye no-oxygen. Izinga lokufakwa esikhundleni kungabalwa kusuka kwisamba sento ngayinye ekhona kwisampula ye-HPMC.
I-Chromatography ephezulu yokusebenza kwe-chromatography (HPLC)
I-HPLC iyindlela yokuhlaziya esetshenziswa kabanzi ehlukanisa izingxenye zengxube ngokususelwa ekuxhumaneni kwazo ngezigaba ezimile neziselula. Ku-HPMC, izinga lokufakwa esikhundleni kungabalwa ngokulinganisa isilinganiso se-hydroxypropyl kumaqembu we-methyly kwisampula.
I-infrared spectroscopy (IR)
I-infrared Spectroscopy iyindlela yokuhlaziya ilinganisa ukumuncwa noma ukudluliswa kwemisebe ye-infrared ngesampula. I-HPMC ineziqongo ezihlukile zokutholwa kweHydroxyl, i-methylyproppyl, ezingasetshenziswa ukuthola izinga lokufaka esikhundleni.
Ubumsulwa be-HPMC bubalulekile emikhakheni yezemithi nokudla, futhi ukuzimisela kwayo kubalulekile ukuqinisekisa ukuphepha nokusebenza kahle komkhiqizo wokugcina. Izindlela eziningana ziyatholakala ukunquma ubumsulwa be-HPMC, kufaka phakathi Ukuthathwa kwe-acid-base, ukuhlaziya okusemthethweni, i-HPLC, ne-IR. Indlela ngayinye inezinzuzo zayo nobunzima bayo futhi ingakhethwa ngokuya ngezidingo ezithile zohlelo lokusebenza. Ukugcina ukuhlanzeka kwe-HPMC, kufanele kugcinwe endaweni eyomile, epholile kude nokukhanya kwelanga nakwezinye izinto ezingcolile.
Isikhathi sePosi: Aug-25-2023