I-Hydroxypropyl methylcellulose (HPMC)Ingabe i-cellulose ether ebalulekile enobubanzi bezicelo, ikakhulukazi emikhakheni yokwakha, umuthi, ukudla, njll ngokuya ngezindlela ezahlukahlukene zokucubungula, i-HPMC ingahlukaniswa ngezinhlobo eziphathwayo futhi ezingalashwa.
1. Umehluko ezinhlelweni zokukhiqiza
I-HPMC engalashwa
I-HPMC engekho emthethweni ayibonisi ukwelashwa okukhethekile kwe-proating yenqubo ethile ngesikhathi sokukhiqiza, ngakho-ke i-hydrophicial kanye ne-solubity yagcinwa ngokuqondile. Lolu hlobo lwe-HPMC luvuvukala ngokushesha futhi luqala ukuncibilikisa ngemuva kokuxhumana namanzi, kukhombisa ukukhuphuka okusheshayo kokubonakala.
I-HPMC ephethwe ngaphandle
I-HPMC ephethwe ingaphezulu izoba nenqubo eyengeziwe yokuhlanganisa eyengeziwe ngemuva kokukhiqizwa. Izinto zokwelashwa ezijwayelekile ezingaphezulu komhlaba zine-acetic acid noma ezinye izinhlanganisela ezikhethekile. Ngale thile, kuzokwakhiwa ifilimu le-hydrophobic phezu kwezinhlayiya ze-HPMC. Lokhu kwelashwa kunciphisa phansi inqubo yayo yokuqothula, futhi kuvame ukudingeka ukwenza kusebenze ukuqedwa kwe-Uniform evuselelayo.
2. Umehluko kwizakhiwo ze-solubity
Izici zokuchithwa kwe-HPMC engasebenzi
I-HPMC engasebenzi kahle izoqala ukuncibilikisa ngokushesha ngemuva kokuxhumana namanzi, alungele izimo ezinezidingo eziphakeme zejubane lokuqothula. Kodwa-ke, njengoba ukuchithwa okusheshayo kuthambekele ekwakheni ama-agglomerates, isivinini sokudla kanye nokufana okuvelelayo kudingeka kulawulwe ngokucophelela.
Izici zokuchithwa kwe-HPMC ephethwe ngaphandle
Ukuhlanganiswa ebusweni bezinhlayiya ze-HPMC ephethwe yi-HPMC kuthatha isikhathi ukuncibilikisa noma ukuchitha, ngakho-ke isikhathi sokuqothula isikhathi eside, imvamisa imizuzu eminingana kuya ngaphezulu kwemizuzu engaphezu kweshumi. Lo mklamo ugwema ukwakheka kwama-agglomerates futhi kufanelekile ikakhulukazi izigcawu ezidinga ukuvuselelwa okukhulu noma okunzima kwamanzi ngesikhathi senqubo yokungezela.
3. Umehluko ezicini ze-Viscosity
I-HPMC ephethwe ingaphezulu ingadedeli i-viscosity ngokushesha ngaphambi kokuqothuka, ngenkathi i-HPMC engalashwa ingakhulisa ngokushesha ukubonwa kohlelo. Ngakho-ke, ezimweni lapho i-viscosity idinga ukuguqulwa kancane kancane noma inqubo idinga ukulawulwa, uhlobo oluphethwe ingaphezulu lunezinzuzo eziningi.
4. Umehluko ezimweni ezisebenzayo
I-HPMC ephethwe ngayo
Ilungele izigcawu ezidinga ukuchithwa okusheshayo kanye nomphumela osheshayo, njenge-capsule esheshayo ye-capsule coating endle yekhamu yezemithi noma amakhulu asheshayo embonini yokudla.
Iphinde yenze kahle kwezinye izifundo zelebhu noma ukukhiqizwa okuncane okunamandla ngokulawulwa okuqinile kokulandelana kokuphakanyiswa.
I-HPMC ephethwe ngaphandle
Kusetshenziswa kabanzi embonini yezokwakha, ngokwesibonelo, e-Drile Datar, tile anamathela, ukumboza kanye neminye imikhiqizo. Kulula ukuhlakazeka futhi azazi ama-agglomerates, alungele ikakhulukazi imibandela yokwakha eyenziwe ngomshini.
Iphinde isetshenziswe kwamanye amalungiselelo emithi adinga ukukhishwa okuqhubekayo noma izengezo zokudla ezilawula izinga lokuchitheka.
I-5. Intengo Nokugcina Umehluko
Izindleko zokukhiqiza ze-HPMC ephethwe ingaphezulu ziphakeme kancane kunalezo ezingalashwa, eziboniswa umehluko ngentengo yemakethe. Ngaphezu kwalokho, uhlobo oluphethwe ingaphezulu lunenhlanganisela evikelayo futhi lunezidingo eziphansi zomswakama kanye nokushisa kwemvelo yesitoreji, ngenkathi uhlobo olungalashwa luhlotshiswe ngokwengeziwe futhi ludinga izimo eziqinile zokugcina.
6. Isisekelo sokukhetha
Lapho ukhetha i-HPMC, abasebenzisi badinga ukubheka amaphuzu alandelayo ngokwezidingo ezithile:
Ngabe izinga lokuchithwa libalulekile?
Izidingo zesilinganiso sokukhula kwe-viscosity.
Ukuthi izindlela zokudla nezindlela zokuxuba kulula ukwakha ama-agglomerates.
Inqubo yezimboni yesicelo esiqondiwe kanye nezidingo zokusebenza zokugcina zomkhiqizo.
Iphathwe ngaphandle kwengaphezulu nangaphezuluI-HPMCbabe nezimpawu zabo. Lowo owayekade ethuthukisa ukukhululeka kokusetshenziswa nokuqina kokusebenza ngokushintsha isenzo sokuchitheka, futhi ulungele ukukhiqizwa kwezimboni ezinkulu zezimboni; Okokugcina kugcina izinga lokuqothula eliphakeme futhi kufanelekile kakhulu embonini yamakhemikhali enhle edinga izinga lokuchithwa eliphakeme. Ukukhethwa kwawo uhlobo olufanele kuhlanganiswe nesimo esithile sohlelo lokusebenza, izimo zenqubo kanye nesabelomali sezindleko.
Isikhathi sePosi: Nov-20-2024