I-Hydroxylopyolin (HPMC) iyi-polymer esetshenziswe kabanzi embonini yezemithi futhi iyifomula ebalulekile. Isetshenziswa ikakhulukazi njenge-adhesive emthanjeni oqinile (njengamathebulethi, amaphilisi nezinhlayiya), i-viscosity ethuthukisiwe ejenti kanye nokubola.
Ekulungiseleleni izidakamizwa, ukuchithwa kwezithako ezisebenzayo kubalulekile ukudonsa nokukhiqiza umphumela wokwelashwa. Kodwa-ke, ukuchithwa kwezithako ezisebenzayo kungavinjelwa ifomula. Ngakho-ke, kubalulekile ukuqonda ukukhishwa kokuqothuka kwe-HPMC kwifomethi yezidakamizwa ngoba kuthinta ukusebenza kohlobo lomthamo.
Indlela yokuqothula ye-HPMC
I-US Pharmacy (I-USP) ihlele indlela yokuhlola i-HPMC eqeda. Le ndlela imvamisa ifaka ukusetshenziswa kwemishini yokuchithwa, eyilingatha futhi ilinganise ukusongela kohlobo lomthamo endaweni ephakathi nendawo ephakathi nendawo ephakathi nendawo. Ukuhlolwa kubandakanya ukubeka umthamo kubhasikidi noma i-paddle, bese ubhasikidi noma i-paddle ujikeleze esitsheni esiqukethe okuphakathi nendawo.
I-solubity medium kumele ikhethwe ngokuya ngokusetshenziswa okulindelekile komthamo (njenge-gastric noma amathumbu). IMISEBENZI EMISELWE I-SOLUBLILE medium ye-HPMC ifaka phakathi amanzi, phosphate buffer solution kanye nojusi we-gastric we-simulation (SGF) noma i-analog yamathumbu fluid (SIF).
Ukuze uqinisekise ukuphindaphindeka nokunemba, amapharamitha wokuhlola kumele ahlelwe, njengejubane lokujikeleza, izinga lokushisa, nokuqeda ivolumu ephakathi nendawo kanye nesikhathi sesampula. Ngemuva kwalokho sebenzisa indlela efanele yokuhlaziya ukuhlaziya isixazululo sesampula esitholwe ngezikhathi ezithile ezihlukile ukunquma inani lokuchithwa kwe-HPMC.
Izindlela zokuvimbela lapho wenza izivivinyo zokuncibilika kwe-HPMC
1. Ukukhetha okulungile okuqediwe: Ukukhethwa kwe-Disolving Commor kususelwa ekusetshenzisweni okulindelekile kwefomu lomthamo. Ukukhetha ukuqothuka okufanele kubaluleke kakhulu ngoba kuzothinta ukusebenza kokuqothuka kwe-HPMC.
2. Ukuqinisekisa kahle indlela ye-solubity: Ukuqinisekisa indlela yokubhidliza ukuqinisekisa ukuthi kufanelekile futhi kubalulekile ukufeza izidingo ze-ejensi yokulawula. Ukuqinisekiswa kufanele kufake ukuqina nokuphindaphindwa kwesilinganiso.
I-3. Ukumiswa okwenziwe ngamapharamitha wokuhlola: amapharamitha wokuhlola, njengejubane lokujikeleza, izinga lokushisa, kanye nevolumu ephakathi echithiwe ithinta umphumela wokuhlolwa kokuqothula. Ngakho-ke, la mapharamitha kumele aqine ukuqinisekisa ukuvela kabusha nokuhlaziywa okunembile.
4 Naka amaphuzu wesikhathi nama-sampling ukuze uqinisekise ukuthi isampula liqoqwe ngesikhathi esihlangene.
I-5. Indlela yokuhlaziya: Khetha indlela yokuhlaziya ukuze ihlaziywe izoqinisekiswa, futhi kufanele ibe nokuzwela okufanele, ukukhetha nokunemba.
Ngamafuphi, ukuhlolwa okuchithwa kwe-HPMC kuyithuluzi elibalulekile ekuthuthukisweni kwezidakamizwa kanye nefomula yezidakamizwa. Ilebhu yekhwalithi yokulawula yekhwalithi yenziwa njalo ukuqinisekisa ukukhishwa okulungile kwezithako ezisebenzayo, futhi umuthi uphephile futhi uyasebenza. Iphutha ngendlela efanelekile yokuhlola kungaholela ekungaqondini kanye nezitatimende zamanga ekusebenzeni kwezidakamizwa. Ngakho-ke, kubalulekile ukulandela amazinga nezinyathelo zokuvimbela ngesikhathi sokuvinjwa.
Isikhathi sePosi: Jun-29-2023