I-Hydroxypropyl methylcellulose (HPMC)I-polymer esetshenziswayo esetshenziswayo ye-polymer esetshenziswayo, esetshenziswe kabanzi emithi yezemithi, ukudla, izinto zokwakha, izimonyo kanye nezinye izinkambu. I-HPMC ine-solubity enhle kanye nezimpawu ze-viscosity futhi ingakha isixazululo esizinzile se-colloidal, ngakho-ke idlala indima ebalulekile kwizicelo eziningi. Ukuze unikeze ukudlala okugcwele ekusebenzeni kwe-HPMC, indlela efanele yokuqothula ibaluleke kakhulu.
1. Indlela ejwayelekile yokuchithwa kwamanzi okuchithwa kwamanzi
I-HPMC ingachithwa emanzini abandayo, kepha imvamisa amakhono athile ayadingeka ukugwema ukuhlangana kwawo. Ukuze uthuthukise umphumela wokuchitheka, lezi zinyathelo ezilandelayo zingasetshenziswa:
Isinyathelo 1: Faka i-HPMC ukuze amanzi
Emazingeni okushisa asekamelweni, okokuqala fafaza i-HPMC ngokulinganayo endaweni yamanzi ukugwema ukuthela inani elikhulu le-HPMC emanzini ngasikhathi sinye. Ngoba i-HPMC iyingxenye ye-polymer, ngokungezwa ngokuqondile inani elikhulu le-HPMC elizolibangela ukuthi lidonse amanzi futhi livunguswe ngokushesha emanzini ukuze kwakheke into efana nejeli.
Isinyathelo 2: Vuselela
Ngemuva kokungeza i-HPMC, gcina uvuse ngokulinganayo. Ngoba i-HPMC inezinhlayiya ezinhle, izokhula ngemuva kokuthola amanzi okuthola into efana ne-gel. I-Stiring isiza ukuvikela i-HPMC kusuka ku-agglomerating ibe ama-clumps.
Isinyathelo 3: Yima futhi uqhubeke
Uma i-HPMC ingachinjiswa ngokuphelele, ikhambi lingashiywa ukuze lime isikhashana bese liqhubeka livusa. Imvamisa ichithwe ngokuphelele kungakapheli amahora ambalwa.
Le ndlela ilungele izikhathi lapho ukufudumeza kungadingeki, kepha kuthatha isikhathi eside ukuqinisekisa ukuthi i-HPMC ichithwa ngokuphelele.
2. Indlela eshisayo yokuchithwa kwamanzi
I-HPMC iyancibilikisa ngokushesha emanzini afudumele, ngakho-ke ukufudumeza izinga lokushisa kwamanzi kungasheshisa kakhulu inqubo yokuqothula. Amazinga okushisa asetshenziswa ngokuvamile asetshenziswayo angama-50-70 ℃, kepha aphezulu kakhulu okushisa (okufana kakhulu nama-80 ℃) kungadala ukuthi i-HPMC ihlehlise, ngakho-ke izinga lokushisa lidinga ukulawulwa.
Isinyathelo 1: Ukushisa Amanzi
Shisisa amanzi acishe abe ngu-50 ℃ futhi ugcine njalo njalo.
Isinyathelo 2: Faka i-HPMC
Fafaza i-HPMC kancane emanzini ashisayo. Ngenxa yokushisa kwamanzi okuphezulu, i-HPMC izoncibilika kalula, inciphise i-agglomeration.
Isinyathelo 3: Kuvuselelwa
Ngemuva kokungeza i-HPMC, qhubeka uvusa isisombululo esinamanzi. Inhlanganisela yokushisa nokuvuselela ingakhuthaza ukuchithwa okusheshayo kwe-HPMC.
Isinyathelo 4: Gcina izinga lokushisa bese uqhubeka uvuselelwa
Ungagcina izinga lokushisa elithile bese uqhubeka uvuselelwa kuze kube yilapho i-HPMC ichithwa ngokuphelele.
3. Indlela yokuqothula yotshwala
I-HPMC ingancishiswa hhayi emanzini kuphela, kodwa futhi nasezinhlelweni ezithile zotshwala (njenge-ethanol). Inzuzo eyinhloko yendlela yokuchithwa kotshwala ukuthi ingathuthukisa i-solubility kanye nokuhlakazwa kwe-HPMC, ikakhulukazi ezinhlelweni ezinokuqukethwe kwamanzi okuphezulu.
Isinyathelo 1: Khetha i-solvent efanelekayo yotshwala
I-Alcohol Solvents enjenge-ethanol ne-isopropanol kuvame ukusetshenziselwa ukuncibilikisa i-HPMC. Ngokuvamile, isixazululo se-70-90% esiThanol sinomphumela ongcono ekuqedeni i-HPMC.
Isinyathelo 2: Ukuchithwa
Shayela kancane i-HPMC ku-solul solvent, uvuse ngenkathi unezela ukuqinisekisa ukuthi i-HPMC ihlakazeka ngokuphelele.
Isinyathelo 3: Ukuma nokuvusa
Inqubo yotshwala i-solvent eqeda i-HPMC ishesha kakhulu, futhi kuvame ukuthatha imizuzu embalwa ukufeza ukuqedwa ngokuphelele.
Indlela yokuqothula yotshwala ivame ukusetshenziswa kwizimo zohlelo lokusebenza ezidinga ukuchithwa ngokushesha kanye nokuqukethwe kwamanzi okuphansi.
4. Indlela yokuqothula amanzi ahlanganisiwe
Kwesinye isikhathi i-HPMC ichithwa engxenyeni yengxenye ethile yamanzi futhi i-solvent. Le ndlela ilungele ikakhulukazi izimo lapho i-viscosity yesixazululo noma izinga lokuchithwa kudinga ukulungiswa. Izixazululo ezijwayelekile zifaka i-acetone, ethanol, njll.
Isinyathelo 1: Lungiselela ikhambi
Khetha isilinganiso esifanele se-solvent namanzi (isib. Amanzi angama-50%, ama-50% solvent) nokushisa emazingeni okushisa afanele.
Isinyathelo 2: Faka i-HPMC
Ngenkathi ivuselela, yengeza kancane kancane i-HPMC ukuqinisekisa ukuchithwa okufanayo.
Isinyathelo 3: Ukulungiswa okwengeziwe
Njengoba kudingeka, ingxenye yamanzi noma i-solvent ingandiswa ukuze kulungiswe i-solubity kanye nokubonakala kwe-HPMC.
Le ndlela ilungele izikhathi lapho kufakwa khona izixazululo ze-organic kwizisolo zamanzi ukuze zithuthukise izinga lokuchithwa noma ukulungisa izakhiwo zekhambi.
I-5
Usebenzisa umphumela we-oscillation ophakeme we-ultrasound, indlela yokuqothula esizwakala yi-ultrasonic-esizwayo ingasheshisa inqubo yokuchithwa kwe-HPMC. Le ndlela ilungele ikakhulukazi inani elikhulu le-HPMC elidinga ukuchithwa ngokushesha, futhi linganciphisa inkinga ye-agglomeation engenzeka ngesikhathi sokuvuselelwa kwendabuko.
Isinyathelo 1: Lungiselela ikhambi
Ngeza i-HPMC ngenani elifanele lamanzi noma isixazululo esihlanganisiwe samanzi.
Isinyathelo 2: Ukwelashwa kwe-Ultrasonic
Sebenzisa i-ultrasonic Cleaner noma i-ultrasonic dissolver futhi uyiphathe ngokwesikhathi esethiwe nesikhathi. Umphumela we-oscillation we-ultrasound ungasheshisa kakhulu inqubo yokuchithwa kwe-HPMC.
Isinyathelo 3: Bheka umphumela wokuchitheka
Ngemuva kokwelashwa kwe-ultrasonic, hlola ukuthi isixazululo sichithwa ngokuphelele. Uma kunengxenye enganqunyiwe, ukwelashwa kwe-ultrasonic kungenziwa futhi.
Le ndlela ilungele izinhlelo zokusebenza ezidinga ukuqondiswa okusebenzayo nokusheshayo.
6. Ukuhlekisa ngaphambi kokuchithwa
Ukuze ugwemeI-HPMCI-Agglomeration noma ubunzima bokuqedwa, ezinye izindlela zokuhlekisa zingasetshenziswa, njengokuxuba i-HPMC enenani elincane lamanye ama-sols (anjenge-glycerol), womisa i-HPMC yokuqala, noma enamanzi i-HPMC ngaphambi kokungeza i-solvent. Lezi zinyathelo zokuhlekisa zingathuthukisa ngempumelelo i-solubity ye-HPMC.
Kunezindlela eziningi zokuncibilikisa i-HPMC. Ukukhetha indlela efanelekile yokuqothula kungathuthukisa kakhulu ukusebenza kahle kanye nekhwalithi yomkhiqizo. Indlela yokuchithwa kwamazinga okushisa ilungele imvelo emnene, indlela eshisayo yokuchithwa kwamanzi ingasheshisa inqubo yokuchithwa, kanye nendlela yokuchithwa kotshwala kanye ne-solvent-water adilizwa indlela yokuchithwa kwendlela efanelekile ngezidingo ezikhethekile. Indlela yokuqothula esisize i-ultrasonic iyindlela ephumelelayo yokuxazulula ukuchithwa okusheshayo kwenani elikhulu le-HPMC. Ngokusho kwezidingo ezithile zohlelo lokusebenza, ukukhetha okuguquguqukayo kwendlela efanele yokuqothula kungaqinisekisa ukusebenza okuhle kwe-HPMC emikhakheni ehlukene.
Isikhathi Seposi: Dece-19-2024