I-Hydroxypropyl methylcellulose (HPMC)iyinhlanganisela ye-polymer encibilikayo evame ukusetshenziswa emanzini, esetshenziswa kabanzi kwezemithi, ukudla, izinto zokwakha, izimonyo neminye imikhakha. I-HPMC inezici ezinhle zokuncibilika kanye ne-viscosity futhi ingakha isisombululo esizinzile se-colloidal, ngakho-ke idlala indima ebalulekile ezinhlelweni eziningi. Ukuze unikeze ukudlala okuphelele ekusebenzeni kwe-HPMC, indlela elungile yokuqedwa ibaluleke kakhulu.
1. Indlela yokuchithwa kwamanzi okushisa okujwayelekile
I-HPMC ingancibilika emanzini abandayo, kodwa ngokuvamile amakhono athile ayadingeka ukugwema ukuhlangana kwayo. Ukuze uthuthukise umphumela wokuqedwa, izinyathelo ezilandelayo zingasetshenziswa:
Isinyathelo 1: Engeza i-HPMC emanzini
Ezingeni lokushisa legumbi, qala ufafaze i-HPMC ngokulinganayo endaweni yamanzi ukuze ugweme ukuthela inani elikhulu le-HPMC emanzini ngesikhathi esisodwa. Ngenxa yokuthi i-HPMC iyinhlanganisela ye-polymer, ukwengeza ngokuqondile inani elikhulu le-HPMC kuzoyibangela ukuthi imunce amanzi futhi ivuvuke ngokushesha emanzini ukuze yakhe into efana nejeli.
Isinyathelo sesi-2: Ukuhlanganisa
Ngemva kokungeza i-HPMC, qhubeka ugovuza ngokulinganayo. Ngenxa yokuthi i-HPMC inezinhlayiya ezinhle, izokhukhumala ngemva kokumunca amanzi ukuze yakhe into efana nejeli. Ukuhlanganisa kusiza ukuvikela i-HPMC ukuthi ingahlangani ibe yizigaxa.
Isinyathelo sesi-3: Yima uphinde uqhubekise
Uma i-HPMC ingancibilikisiwe ngokuphelele, ikhambi lingashiywa ukuze lime isikhashana bese liqhubeka linyakaza. Ngokuvamile izoncibilika ngokuphelele emahoreni ambalwa.
Le ndlela ifanele izikhathi lapho ukushisisa kungadingeki, kodwa kuthatha isikhathi eside ukuqinisekisa ukuthi i-HPMC incibilike ngokuphelele.
2. Indlela yokuchithwa kwamanzi ashisayo
I-HPMC incibilika ngokushesha emanzini afudumele, ngakho-ke ukushisa izinga lokushisa kwamanzi kungasheshisa kakhulu inqubo yokuhlakazwa. Izinga lokushisa elivame ukusetshenziswa lamanzi okufudumeza lingu-50-70℃, kodwa izinga lokushisa eliphezulu kakhulu (elingaphezu kuka-80℃) lingabangela i-HPMC ukuthi yehlise izinga, ngakho-ke izinga lokushisa lidinga ukulawulwa.
Isinyathelo 1: Ukushisa amanzi
Shisisa amanzi aze afike ku-50℃ futhi uwagcine engashintshi.
Isinyathelo sesi-2: Engeza i-HPMC
Fafaza i-HPMC kancane emanzini ashisayo. Ngenxa yezinga lokushisa eliphezulu lamanzi, i-HPMC izoncibilika kalula, yehlise ukuhlangana.
Isinyathelo sesi-3: Ukuhlanganisa
Ngemuva kokungeza i-HPMC, qhubeka ugoqa isixazululo esinamanzi. Inhlanganisela yokushisisa nokunyakazisa ingakhuthaza ukuqedwa ngokushesha kwe-HPMC.
Isinyathelo sesi-4: Gcina izinga lokushisa futhi uqhubeke ugqugquzela
Ungagcina izinga lokushisa elithile futhi uqhubeke ushukumisa kuze kube yilapho i-HPMC ichitheka ngokuphelele.
3. Indlela Yokuhlakaza Utshwala
I-HPMC ingancibilika hhayi emanzini kuphela, kodwa nakwezinye izincibilikisi zotshwala (njenge-ethanol). Inzuzo enkulu yendlela yokuchithwa kotshwala ukuthi ingathuthukisa ukunyibilika nokuhlakazeka kwe-HPMC, ikakhulukazi kumasistimu anamanzi amaningi.
Isinyathelo 1: Khetha isincibilikisi sotshwala esifanele
Izinyibilikisi zotshwala ezifana ne-ethanol ne-isopropanol zivame ukusetshenziselwa ukuncibilikisa i-HPMC. Ngokuvamile, isisombululo se-ethanol esingu-70-90% sinomphumela ongcono ekuhlakazeni i-HPMC.
Isinyathelo sesi-2: Ukuqedwa
Fafaza kancane i-HPMC kusincibilikisi sotshwala, ugovuze ngenkathi ungeza ukuze uqinisekise ukuthi i-HPMC ihlakazeke ngokugcwele.
Isinyathelo sesi-3: Ukuma nokunyakazisa
Inqubo yokuncibilikisa isincibilikisi sotshwala i-HPMC iyashesha uma kuqhathaniswa, futhi ngokuvamile ithatha amaminithi ambalwa ukufeza ukuqedwa okuphelele.
Indlela yokuchithwa kotshwala ngokuvamile isetshenziswa ezimeni zohlelo ezidinga ukuqedwa ngokushesha kanye nokuqukethwe kwamanzi aphansi.
4. Indlela yokuncibilika okuxubile okuncibilikisa amanzi
Kwesinye isikhathi i-HPMC ichithwa ngengxube yengxenye ethile yamanzi nesincibilikisi. Le ndlela ifaneleka ikakhulukazi ezimweni lapho i-viscosity yesisombululo noma izinga lokuqedwa lidinga ukulungiswa. Ama-solvents ajwayelekile afaka i-acetone, i-ethanol, njll.
Isinyathelo 1: Lungiselela ikhambi
Khetha isilinganiso esifanele sesincibilikisi namanzi (isb. 50% amanzi, 50% isincibilikisi) nokushisa okufike ezingeni lokushisa elifanele.
Isinyathelo sesi-2: Engeza i-HPMC
Ngenkathi ushukumisa, engeza kancane i-HPMC ukuze uqinisekise ukuqedwa okufanayo.
Isinyathelo sesi-3: Okunye ukulungisa
Njengoba kudingekile, ingxenye yamanzi noma i-solvent inganyuswa ukuze kulungiswe ukunyibilika kanye ne-viscosity ye-HPMC.
Le ndlela ifanele izikhathi lapho izincibilikisi zemvelo zengezwa ezixazululweni ezinamanzi ukuze kuthuthukiswe izinga lokuqedwa noma ukulungisa izakhiwo zesixazululo.
5. Indlela yokuchithwa kwe-Ultrasonic
Ngokusebenzisa umphumela we-oscillation we-high-frequency oscillation we-ultrasound, indlela yokuchithwa kwe-ultrasonic-assisted ingasheshisa inqubo yokuqedwa kwe-HPMC. Le ndlela ifaneleka kakhulu amanani amakhulu e-HPMC adinga ukuchithwa ngokushesha, futhi inganciphisa inkinga ye-agglomeration engenzeka ngesikhathi sokunyakaziswa kwendabuko.
Isinyathelo 1: Lungiselela ikhambi
Engeza i-HPMC enanini elifanele lamanzi noma isixazululo esixutshwe yi-solvent yamanzi.
Isinyathelo sesi-2: Ukwelashwa kwe-ultrasonic
Sebenzisa i-ultrasonic cleaner noma i-ultrasonic dissolver futhi uyiphathe ngokuvumelana namandla amisiwe nesikhathi. Umphumela we-oscillation we-ultrasound ungasheshisa kakhulu inqubo yokuqedwa kwe-HPMC.
Isinyathelo sesi-3: Hlola umphumela wokuqedwa
Ngemuva kokwelashwa kwe-ultrasonic, hlola ukuthi isixazululo sihlakazwe ngokuphelele. Uma kunengxenye engancibilikisiwe, ukwelashwa kwe-ultrasonic kungenziwa futhi.
Le ndlela ifanele izinhlelo zokusebenza ezidinga ukuqedwa okuphumelelayo nokushesha.
6. Ukwelashwa ngaphambi kokuqedwa
Ukuze ugwemeI-HPMCi-agglomeration noma ubunzima bokuncibilika, ezinye izindlela zokwelapha ngaphambi kwesikhathi zingasetshenziswa, njengokuxuba i-HPMC nenani elincane lezinye izincibilikisi (njenge-glycerol), ukuyomisa kuqala, noma ukumanzisa i-HPMC ngaphambi kokwengeza isincibilikisi. Lezi zinyathelo zokwelapha kusengaphambili zingathuthukisa ngempumelelo ukunyibilika kwe-HPMC.
Ziningi izindlela zokuncibilikisa i-HPMC. Ukukhetha indlela efanelekile yokuhlakaza kungathuthukisa kakhulu ukusebenza kahle kokuqedwa kanye nekhwalithi yomkhiqizo. Indlela yokuchithwa kwezinga lokushisa kwegumbi ifaneleka endaweni ethambile, indlela yokuncibilika kwamanzi ashisayo ingasheshisa inqubo yokuqedwa, futhi indlela yokuchithwa kotshwala kanye nendlela yokuhlakaza okuxubile okuxubene namanzi e-solvent ifaneleka ukuhlakazwa ngezidingo ezikhethekile. I-ultrasonic-assisted dissolution method iyindlela ephumelelayo yokuxazulula ukuqedwa ngokushesha kwenani elikhulu le-HPMC. Ngokwezidingo ezithile zohlelo lokusebenza, ukukhethwa okuguquguqukayo kwendlela efanelekile yokuhlakaza kungaqinisekisa ukusebenza okuhle kakhulu kwe-HPMC emikhakheni ehlukene.
Isikhathi sokuthumela: Dec-19-2024