Njengamanje, izinto ezisetshenziswayo ezivuthiwe zamaphilisi ezitshalo ikakhulukazi i-hydroxypropyl methylcellulose (HPMC) kanye ne-pudulan, kanti isitashi se-hydroxypropyl siphinde sisetshenziswe njengezinto zokusetshenziswa.
Kusukela ekuqaleni kwawo-2010,I-HPMCisetshenziswe embonini yokukhiqiza i-capsule yezitshalo zaseShayina, futhi ngokusekelwe ekusebenzeni kwayo okuhle, amaphilisi angenalutho e-HPMC athathe indawo ngokuqinile emakethe yama-capsule, abonisa isidingo esinamandla ekukhuphukeni kweminyaka eyishumi edlule.
Ngokwemininingwane yezimboni, ngo-2020, umthamo wokuthengisa wasekhaya wamaphilisi aqinile angenalutho uzoba amaphilisi acishe abe yizigidi eziyizinkulungwane ezingama-200 (izimboni zemithi nemikhiqizo yezempilo zihlangene), lapho umthamo wokuthengisa wamaphilisi e-HPMC uzoba cishe amaphilisi ayizigidi eziyizinkulungwane eziyi-11.3 (kuhlanganise nokuthunyelwa kwamanye amazwe) , inyuke ngo-4.2% ngonyaka wezi-2019. %, okulinganiselwa ku-5.5%. Imboni engeyona eyemithi yenza u-93.0% wokusetshenziswa kwamaphilisi e-HPMC e-China, futhi ukukhula kwemboni yemikhiqizo yokunakekelwa kwezempilo kuqhuba ukuthengiswa kwamaphilisi e-HPMC.
Kusukela ngo-2020 kuya ku-2025, i-CAGR yamaphilisi e-HPMC anama-gelling agents kulindeleke ukuthi ibe ngu-6.7%, ephakeme kunezinga lokukhula lika-3.8% lamaphilisi e-gelatin. Ngaphezu kwalokho, isidingo samaphilisi e-HPMC embonini yemikhiqizo yokunakekelwa kwezempilo yasekhaya siphezulu kunaleso embonini yezemithi.I-HPMCamaphilisi angasiza kokubili ngezinselele zencwadi kadokotela futhi amukele izintandokazi zamasiko nezokudla zabathengi emhlabeni jikelele. Nakuba isidingo samanje samaphilisi e-HPMC sisephansi kakhulu kunaleso samaphilisi e-gelatin, izinga lokukhula kwesidingo liphezulu kunaleso samaphilisi e-gelatin.
1) Ukwakhiwa okuphumelelayo kanye nenqubo, ngaphandle kwe-ejenti ye-gelling; inokuncibilika okungcono, ukuziphatha okungaguquki kokuhlakazeka emithonjeni yezindaba ehlukene, engathinteki nge-pH namandla e-ionic, futhi ihlangabezana nezidingo ze-pharmacopoeia zamazwe amakhulu nezifunda;
2) Ngokuqukethwe kwe-alkaline ebuthakathaka, thuthukisa i-bioavailability futhi uthuthukise ukulungiselelwa kwefomu lomthamo;
3) Ukubukeka kuhle, futhi ukukhetha kombala kuningi kakhulu.
I-Soft capsule iyilungiselelo elakhiwe ngokuvala uwoyela noma ukumiswa okusekelwe kuwoyela kugobolondo le-capsule, futhi umumo walo uyindilinga, omise okwe-olive, omise okwenhlanzi encane, omise okweconsi, njll. Ibonakala ngokuncibilika noma ukumisa izithako ezisebenzayo ku amafutha, anokuqala okusheshayo kwesenzo kanye ne-bioavailability ephezulu kunokwenza isithako esisebenzayo esifanayo sibe amaphilisi, futhi asetshenziswe kabanzi ekulungiseni imikhiqizo yokunakekelwa kwezempilo nemithi. Namuhla, amaphilisi athambile anezici ezihlukile ezifana ne-enteric-coated, chewable, futha ye-osmotic, ukukhishwa okuqhubekayo, nama-suppositories athambile asevele emakethe. Igobolondo le-capsule elithambile lakhiwe izithasiselo ze-colloid nezisizayo. Phakathi kwazo, ama-colloids afana ne-gelatin noma i-gum yemifino yizici eziyinhloko, futhi izinga labo lithinta ngokuqondile ukusebenza kwama-capsules athambile. Isibonelo, ukuvuza kwegobolondo le-capsule, ukunamathela, ukufuduka kwezinto ezibonakalayo, ukuhlakazeka kancane, kanye nokuhlakazeka kwama-capsules athambile kwenzeka ngesikhathi sokugcina Izinkinga ezifana nokungahambisani nazo zihlobene nakho.
Njengamanje, izinto eziningi ze-capsule yama-capsules athambile emithi ezweni lami yi-gelatin yezilwane, kodwa ngokuthuthukiswa okujulile kanye nokusetshenziswa kwama-capsules athambile we-gelatin, ukushiyeka kwayo kanye nokushiyeka kuye kwagqama kakhulu, njengemithombo eyinkimbinkimbi yezinto zokusetshenziswa, kanye nokusabela okulula okuxhumanisa okuphambanayo nezinhlanganisela ze-aldehyde Izinkinga zekhwalithi njengesikhathi esifushane sokugcina kanye “nemfucumfucu emithathu” ekhiqizwa inqubo yokucwenga i-gelatin inomthelela omkhulu ekuvikelweni kwemvelo. Ngaphezu kwalokho, kuphinde kube nenkinga yokuqina ebusika, okunomthelela omubi ekulungiseni izinga. Futhi ama-capsules athambile we-gum yemifino anomthelela omncane endaweni ezungezile. Ngokuqubuka okulandelanayo kwezifo ezithathelwanayo zemvelaphi yezilwane emhlabeni wonke, umphakathi wamazwe ngamazwe ukhathazeka kakhulu ngokuphepha kwemikhiqizo yezilwane. Uma kuqhathaniswa namaphilisi e-gelatin ezilwane, amaphilisi ezitshalo anezinzuzo ezivelele mayelana nokusebenziseka, ukuphepha, ukuzinza, nokuvikelwa kwemvelo.
Engezai-hydroxypropyl methylcelluloseukuchelela nokuhlakaza ukuze kutholwe isixazululo A; engeza i-gelling agent, i-coagulant, i-plasticizer, i-opacifier ne-colorant emanzini futhi uhlakaze ukuze uthole isisombululo B; hlanganisa izixazululo A no-B, bese ushisa kufika ku-90 ~ 95 ° C, ugovuze futhi uhlale ufudumele ku-0.5 ~ 2h, uphole kuze kufike ku-55 ~ 70 ° C, hlala ufudumele futhi ume ukuze ukhiphe amagwebu ukuze uthole ingcina;
Ungaluthola kanjani ngokushesha uketshezi lweglue, inqubo ejwayelekile ukushisa kancane kugedlela lokuphendula isikhathi eside,
Abanye abakhiqizi badlula ngokushesha emshinini we-colloid ngeglue yamakhemikhali
Isikhathi sokuthumela: Apr-25-2024