Njengamanje, izinto zokusetshenziswa ezivuthiwe zezitshalo zamaphilisi wezitshalo ziyi-hydroxypropyllylloser methylcellulose (HPMC) kanye ne-pundulan, kanye ne-hydroxypropyl starch nayo isetshenziswa njengezinto zokwakha.
Kusukela ekuqaleni kwa-2010s,I-HPMCKusetshenziswe embonini yokukhiqiza yezitshalo yaseChina CAPSULE, futhi ngokususelwa ekusebenzeni kwayo okuhle, ama-HPMC azenzile amaphilisi ahlala endaweni eqinile emakethe ye-capsule, ekhombisa ukufunwa okuqinile eminyakeni eyishumi edlule.
Ngokusho kwemininingwane yezimboni, ngo-2020, ivolumu yokuthengisa yasekhaya yama-caplule angenazigidi ezingama-200 izoba ngamaphilisi angama-200 ayizigidi eziyizinkulungwane zezigidi zama-HPMC ahlanganiswe), okubandakanya ama-accound athengiswayo), okuvela kwa-4.2% ngaphezulu konyaka we-2019.%. Imboni yezemithi yezemithi i-93.0% yokusetshenziswa kwama-HPMC capsule eChina, kanye nokukhula kwemikhiqizo yemikhiqizo yokunakekelwa kwempilo ishayela ukuthengiswa kwama-HPMC caplule.
Kusuka ku-2020 kuya ku-2025, i-CAGR ye-HPMC capsule enama-gelling agents kulindeleke ukuthi ibe ngu-6.7%, okuphakeme kunesilinganiso sokukhula kwama-gelatin caplule. Ngaphezu kwalokho, isidingo sama-HPMC capsule emikhiqizweni yezokunakekelwa kwempilo yasekhaya ephakeme kunalokho embonini yezemithi.I-HPMCAma-capsule angasiza ngezinselelo ezinikezwa ngomuthi futhi ahlangane okuthandwa yiziko kanye nokudla kwabathengi emhlabeni jikelele. Yize isidingo samanje sama-HPMC capsule asephansi kakhulu kunaleso sama-gelatin caplule, izinga lokukhula liphezulu liphakeme kunaleso lamaphilisi we-gelatin.
1) ukwakheka kwe-ekhreji kanye nenqubo, ngaphandle kwe-ejenti ye-gelling; Kungcono ukulekelela, ukuziphatha okungaguquki kwemidiya ehlukene, kungathinteki ngamandla we-PH kanye ne-Ionic, futhi kuhlangabezana nezidingo ze-pharmacopoeia zamazwe amakhulu nezifunda;
2) kokuqukethwe okubuthakathaka kwe-alkaline, thuthukisa ama-bioavailability futhi uthuthukise ukusebenza kwefomu lomthamo;
3) Ukuvela kuhle, futhi izinqumo zombala ziningi.
I-capsule ethambile kungukuhlelwa kwamafutha noma ukumiswa okusekelwe kuwoyela ku-capsule igobolondo, futhi ukwakheka kwezinhlanzi okusheshayo, okumiswe izinhlanzi, njll Kulezi zinsuku, ama-caplule athambile anezici ezahlukahlukene ezinjengezimpawu ezihlanganisiwe, ezingahlazikazi, ze-osmotic, ukukhishwa okuqhubekayo, nama-suppopositories athambile asevele emakethe. I-Showell ethambile ye-capsule yakhiwa nge-colloid ne-auxiliary addristives. Phakathi kwazo, ama-colloids anjenge-gelatin noma i-gum yemifino yizinto eziphambili, futhi ikhwalithi yazo ithinta ngqo ukusebenza kwamakhabethe athambile. Isibonelo, i-Capsule Shell Vule, ukunamathela, ukufuduka kwezinto ezibonakalayo, ukuhlukaniswa okuhamba kancane, nokuchithwa kwama-caplule athambile kwenzeka ngesikhathi sezinkinga zokugcina njengokungatholi kuhlobene nakho.
Njengamanje, iningi lezinto zokwenziwa ze-capsule zamaphayimu athambile amasha athambile ezweni lami liyi-gelatin yezilwane, kodwa ngokunikwa kabusha nokusetshenziswa okulula kwezinto ezithambile ze-gelatin anezinkinga ze-alldehyde zesikhathi esifushane njenge Inqubo yokucwilisa i-gelatin inomthelela omkhulu ekuvikelweni kwemvelo. Ngaphezu kwalokho, kunenkinga yokuqina ebusika, enomthelela omubi kwikhwalithi yokulungiselela. Kanye nemifino gum caplule ethambile inomthelela omncane endaweni ezungezile. Ngokuqubuka okulandelanayo kwezifo ezithathelanayo zezilwane ezivela emhlabeni wonke, umphakathi wamazwe omhlaba uqhubeka ukhathazekile ngokuphepha kwemikhiqizo yezilwane. Uma kuqhathaniswa namaphilisi wezilwane we-gelatin, ama-caplule ezitshalo anezinzuzo ezinhle kakhulu ngokuya ngokusebenza, ukuphepha, ukuqina kanye nokuvikelwa kwemvelo.
Enezelelahydroxypropyl methylcelluloseukunisela nokuhlakazeka ukuze uthole ikhambi a; engeza i-ejenti ye-gelling, ama-coabulant, ipulasitiki, i-opacifier kanye nombala wamanzi futhi ahlakazekele ukuthola isixazululo b; Hlanganisa izixazululo A no-B, nokushisa kuze kufike ku-90 ~ 95 ° C, uvuse futhi ugcine ukufudumala ngo-0.5 ~ 2h, upholile phansi kuya ku-55 ~ 70 ° C, gcina ufudumele futhi umele ufudumele ukuthola i-glue;
Ungayithola kanjani ngokushesha i-glue ketshezi, inqubo ejwayelekile ukushisa kancane ku-kettle yesikhathi eside,
Abanye abakhiqizi badlula ngokushesha ngesigayo se-colloid nge-glue yamakhemikhali
Isikhathi sePosi: APR-25-2024