Umphumela wokuqukethwe kwe-hydroxypropyl ku-HPMC GEL lokushisa

I-Hydroxypropyl methylcellulose (HPMC) Ingabe i-polymer evame ukusetshenziswa kwamanzi, esetshenziswa kabanzi kumakhamishini, izimonyo, ukudla kanye nezinkundla zezimboni, ikakhulukazi lapho kulungiswa ama-gels. Izakhiwo zayo ezibonakalayo nokuziphatha kokuqothula kunomthelela omkhulu ekusebenzeni kahle kwezicelo ezihlukile. The gelation temperature of HPMC gel is one of its key physical properties, which directly affects its performance in various preparations, such as controlled release, film formation, stability, etc.

1. Ukwakheka kanye nezakhiwo ze-HPMC

I-HPMC iyi-polymer esoluniwe yamanzi etholwe ukwethula ukufaka esikhundleni kwababili, i-hydroxypropyl kanye ne-methyl, ku-cellulose moleculale skeleton. Isakhiwo saso samangqamuzana siqukethe izinhlobo ezimbili zokufakazela okufakiwe: I-Hydroxypropyl (-ch2chohchch3) ne-methyl (-ch3). Izici ezinjengokuqukethwe okuhlukile kwe-hydroxypropyl, izinga le-methylation, kanye ne-degree of polymerization kuzoba nomthelela obalulekile kwi-solubity, ekuziphatheni kwama-gelling, kanye nezindawo zemishini ze-HPMC.

Ezixazululweni ze-aqueve, i-ComCinCel®hpmpmc yakha izixazululo ezizinzile ze-colloidal ngokwakha ama-hydrogen bond ngama-molecule wamanzi nokuxhumana ne-skeleton esekelwe ku-cellulose. Lapho imvelo yangaphandle (efana nokushisa, amandla ama-ionic, njll.) Izinguquko, ukuxhumana phakathi kwama-molecule we-HPMC kuzoshintsha, okuholela ekuvinjelweni.

2. Ukuchazwa kanye nokuthonya izici zokushisa kwe-gelation

Ukushisa kwe-Gelation (izinga lokushisa le-gelation, i-t_gel) kubhekisa emazingeni okushisa lapho ikhambi le-HPMC liqala ukuguqulwa kusuka ku-liquid kuqinile lapho izinga lokushisa lesisombululo likhuphuka libe sezingeni elithile. Kuleli lokushisa, ukunyakaza kwamaketanga ama-molecular ama-hpmc kuzonqunyelwa, kwakha isakhiwo senethiwekhi enezici ezintathu, okuholela entweni enjenge-gel-efana.

Amazinga okushisa we-gelation we-HPMC athintwa yizici eziningi, esinye sezinto ezibaluleke kakhulu okuqukethwe kwe-hydroxypropyl. Ngaphezu kokuqukethwe kwe-hydroxypropyl, ezinye izinto ezithinta izinga lokushisa le-gel zifaka isisindo se-molecular, ukugxila kwesixazululo, ivelu ye-PH, i-solvent, i-ionic amandla, njll.

3. Umphumela wokuqukethwe kwe-hydroxypropyl ku-HPMC GEL lokushisa

3.1 Ukwanda kokuqukethwe kwe-hydroxypropyl kuholela ekwandeni kokushisa kwe-gel

Amazinga okushisa we-gelation we-HPMC ahlobene kakhulu nezinga le-hydroxypropylylyls e-molecule yayo. Njengoba okuqukethwe kwe-hydroxypropyl kukhuphuka, inani lama-hydrophilic afaka esikhundleni se-hpmc chain chain chain, okuholela ekuxhumaneni okuthuthukisiwe phakathi kwe-molecule namanzi. Lokhu kuxhumana kubangela ukuthi amaketanga ama-molelisar ukwelula okunye, ngaleyo ndlela anciphise amandla okusebenzisana phakathi kwamaketanga amamolekyuli. Ngaphakathi kwebanga elithile lokuhlushwa, ukwandisa okuqukethwe kwe-hydroxypropyl kusiza ukuthuthukisa izinga le-hydration futhi kuthuthukisa ukuhlelwa kwamaketanga amamolekyuli, ukuze isakhiwo senethiwekhi singakhiwa endaweni yokushisa ephakeme. Ngakho-ke, izinga lokushisa le-gelation livame ukukhuphuka nge-hydroxypropyl likhuphuka ngokuqukethwe okukhulayo.

I-HPMC enokuqukethwe okuphezulu kwe-hydroxypropyl (enjenge-HPMC K15M) kuvame ukukhombisa ukukhombisa izinga lokushisa eliphakeme kakhulu ekuhlushweni okufanayo kuneCHINCCYPROPYLS (njenge-HPMC K4M). Lokhu kungenxa yokuthi okuqukethwe okuphezulu kwe-hydroxypropyl kwenza kube nzima ngokwengeziwe ama-molekyuli ukuthi ahlanganyele futhi akha amanethiwekhi asezingeni eliphansi, edinga ukuvumelanisa okuphezulu kwe-hydrative futhi athuthukise ukusebenzelana kwenethiwekhi okunezinhlangothi ezintathu. .

3.2 ubudlelwano phakathi kokuqukethwe kwe-hydroxypropyl kanye nokuhlushwa kwesixazululo

Ukuhlushwa kwesixazululo nakho kuyinto ebalulekile ethinta izinga lokushisa le-gelation ye-HPMC. Ezixazululweni ze-HPMC eziphakeme kakhulu, ukusebenzisana kwama-intellalmolecular kunamandla, ngakho-ke izinga lokushisa le-gelation lingase liphakeme noma ngabe okuqukethwe kwe-hydroxypropp kuphansi. Ekugxilisweni okuphansi, ukusebenzisana phakathi kwama-molecule we-HPMC abuthakathaka, futhi isixazululo kungenzeka kakhulu ukuba amazinga okushisa aphansi.

Lapho okuqukethwe kwe-hydroxypropp kukhuphuka, yize i-hydrophicicity inyuka, izinga lokushisa eliphakeme lisadingeka ukwakha ijeli. Ikakhulu ngaphansi kwezimo zokuhlushwa okuphansi, izinga lokushisa le-gelation likhulisa kakhulu. Lokhu kungenxa yokuthi i-HPMC enokuqukethwe okuphezulu kwe-hydroxypropyl kunzima kakhulu ukunxenxa ukusebenzisana phakathi kwamaketanga amamolekyuli ngoshintsho lokushisa, nenqubo ye-gelation idinga amandla angeziwe we-hyrmal ukunqoba umphumela we-hydration.

3.3 Umphumela wokuqukethwe kwe-hydroxypropyl ngenqubo ye-gelation

Ngaphakathi uhla oluthile lokuqukethwe kwe-hydroxypropyl, inqubo ye-gelation ibuswa ukuxhumana phakathi kwamakhekhe ama-hydration kanye nama-molefanelar. Lapho okuqukethwe kwe-hydroxypropyl ku-molecule ye-HPMC kuphansi, i-hydration ibuthakathaka, ukuxhumana phakathi kwama-molecule kuqinile, futhi izinga lokushisa eliphansi lingakhuthaza ukwakheka kwejeli. Lapho okuqukethwe kwe-hydroxypropp kuphakeme, i-hydration ithuthukiswa kakhulu, ukuxhumana phakathi kwamaketanga ama-molefanelar kuba buthaka, futhi izinga lokushisa le-gelation likhuphuka.

Okuqukethwe okuphezulu kwe-hydroxyproppyl kungahle kuholele ekukhuphukeni kwe-viscosity yesisombululo se-HPMC, ushintsho kwesinye isikhathi olukhulisa izinga lokushisa lokushisa le-gelation.

Okuqukethwe kwe-Hydroxypropyl kunomthelela omkhulu ekushiseni kwe-gelation kweI-HPMC. Njengoba okuqukethwe kwe-hydroxypropyl kukhuphuka, i-hydrophicicity ye-HPMC inyuka futhi ukuxhumana phakathi kwamaketanga ama-molecular buble, ngakho-ke izinga lokushisa layo le-gelation livame ukukhuphuka. Le nto ingachazwa yimishini yokusebenzisana phakathi kwamaketanga we-hydration kanye nama-molefanelar. Ngokushintsha okuqukethwe kwe-hpdroxypropyl ye-HPMC, Ukulawulwa okuqondile kokushisa kwe-gelation kungatholakala, ngaleyo ndlela kube nokwenza kahle ukusebenza kwe-HPMC ekusebenzeni kwemithi, ukudla kanye nezinye izinhlelo zezimboni.