I-Hydroxypropyl methylcellulose (HPMC) iyi-polymer encibilika emanzini evame ukusetshenziswa, esetshenziswa kakhulu kwezemithi, izimonyo, ukudla nezimboni, ikakhulukazi ekulungiseni ama-gel. Izakhiwo zayo ezingokomzimba nokuziphatha kokuhlakazeka kunomthelela omkhulu ekusebenzeni kahle kwezinhlelo zokusebenza ezahlukene. Ukushisa kwe-gelation yejeli ye-HPMC kungenye yezakhiwo zayo ezibalulekile zomzimba, ezithinta ngokuqondile ukusebenza kwayo emalungiselelweni ahlukahlukene, njengokukhululwa okulawulwayo, ukwakheka kwefilimu, ukuzinza, njll.
1. Isakhiwo kanye nezakhiwo ze-HPMC
I-HPMC i-polymer encibilika emanzini etholwe ngokwethula izinto ezimbili ezingaphansi, i-hydroxypropyl ne-methyl, kuhlaka lwamathambo engqamuzana ye-cellulose. Ukwakheka kwayo kwamangqamuzana kuqukethe izinhlobo ezimbili zama-substituent: i-hydroxypropyl (-CH2CHOHCH3) ne-methyl (-CH3). Izinto ezifana nokuqukethwe okuhlukile kwe-hydroxypropyl, idigri ye-methylation, nezinga le-polymerization kuzoba nomthelela obalulekile ekuncibilikeni, ekuziphatheni kwe-gelling, nasezimpahleni zemishini ze-HPMC.
Ezixazululweni ezinamanzi, i-AnxinCel®HPMC yenza izixazululo ze-colloidal ezizinzile ngokwenza amabhondi e-hydrogen nama-molecule wamanzi futhi ixhumane nohlaka lwamathambo olusekelwe ku-cellulose. Uma indawo yangaphandle (efana nezinga lokushisa, amandla e-ionic, njll.) ishintsha, ukusebenzisana phakathi kwama-molecule e-HPMC kuzoshintsha, okuholela ekugezeni.
2. Incazelo kanye nezici ezithonya lokushisa kwe-gelation
Izinga lokushisa le-Gelation (I-Gelation Temperature, T_gel) libhekisela emazingeni okushisa lapho isisombululo se-HPMC siqala ukuguquka ukusuka oketshezini kuya kokuqinile lapho izinga lokushisa lesisombululo likhuphuka lifinyelela ezingeni elithile. Kuleli zinga lokushisa, ukunyakaza kwamaketanga emolekyuli e-HPMC kuzovinjelwa, kwakhe uhlaka lwenethiwekhi olunezinhlangothi ezintathu, okuholela entweni efana nejeli.
Ukushisa kwe-gelation ye-HPMC kuthinteka yizici eziningi, enye yezinto ezibaluleke kakhulu okuqukethwe kwe-hydroxypropyl. Ngaphezu kokuqukethwe kwe-hydroxypropyl, ezinye izici ezithinta izinga lokushisa le-gel zihlanganisa isisindo samangqamuzana, ukugxila kwesisombululo, inani le-pH, uhlobo lwe-solvent, amandla e-ionic, njll.
3. Umphumela wokuqukethwe kwe-hydroxypropyl kukushisa kwejeli ye-HPMC
3.1 Ukwanda kokuqukethwe kwe-hydroxypropyl kuholela ekwenyukeni kwezinga lokushisa lejeli
Izinga lokushisa le-gelation le-HPMC lihlobene eduze nezinga lokushintshwa kwe-hydroxypropyl ku-molecule yayo. Njengoba okuqukethwe kwe-hydroxypropyl kukhula, inani lezinto ezifakwe esikhundleni se-hydrophilic kuchungechunge lwamangqamuzana e-HPMC liyakhula, okuholela ekusebenzisaneni okuthuthukisiwe phakathi kwe-molecule namanzi. Lokhu kusebenzisana kubangela ukuthi amaketanga e-molecular anwebe nakakhulu, ngaleyo ndlela anciphise amandla okuxhumana phakathi kwamaketanga e-molecular. Ngaphakathi kwebanga elithile lokuhlushwa, ukwandisa okuqukethwe kwe-hydroxypropyl kusiza ekuthuthukiseni izinga le-hydration futhi kukhuthaze ukuhlelwa okuhlangene kwamaketanga wamangqamuzana, ukuze isakhiwo senethiwekhi sakheke ekushiseni okuphezulu. Ngakho-ke, izinga lokushisa le-gelation ngokuvamile liyakhuphuka ngokukhuphuka kwe-hydroxypropyl ngokuqukethwe okwandayo.
I-HPMC enokuqukethwe okuphezulu kwe-hydroxypropyl (okufana ne-HPMC K15M) ivamise ukukhombisa izinga lokushisa eliphezulu le-gelation ekugxiliseni okufanayo kune-AnxinCel®HPMC enokuqukethwe kwe-hydroxypropyl ephansi (njenge-HPMC K4M). Lokhu kungenxa yokuthi okuqukethwe okuphezulu kwe-hydroxypropyl kwenza kube nzima kakhulu ukuthi ama-molecule asebenzisane futhi akhe amanethiwekhi emazingeni okushisa aphansi, edinga amazinga okushisa aphakeme ukuze anqobe lokhu kufakwa kwamanzi futhi akhuthaze ukusebenzisana kwama-intermolecular ukwakha isakhiwo senethiwekhi esinezinhlangothi ezintathu. .
3.2 Ubudlelwano phakathi kokuqukethwe kwe-hydroxypropyl nokugxila kwesixazululo
Ukugxila kwesixazululo nakho kuyisici esibalulekile esithinta izinga lokushisa le-gelation le-HPMC. Ezixazululweni eziphezulu ze-HPMC, ukusebenzisana kwe-intermolecular kunamandla, ngakho-ke izinga lokushisa le-gelation lingase libe phezulu ngisho noma okuqukethwe kwe-hydroxypropyl kuphansi. Emazingeni aphansi, ukusebenzisana phakathi kwama-molecule e-HPMC akunamandla, futhi ikhambi kungenzeka ukuthi lijiyile emazingeni okushisa aphansi.
Lapho okuqukethwe kwe-hydroxypropyl kwanda, nakuba i-hydrophilicity ikhula, izinga lokushisa eliphakeme lisadingeka ukuze kwakhiwe ijeli. Ikakhulukazi ngaphansi kwezimo eziphansi zokuhlushwa, izinga lokushisa le-gelation likhuphuka kakhulu. Lokhu kungenxa yokuthi i-HPMC enokuqukethwe okuphezulu kwe-hydroxypropyl inzima kakhulu ukuheha ukusebenzisana phakathi kwamaketanga e-molecular ngokushintsha kwezinga lokushisa, futhi inqubo ye-gelation idinga amandla ashisayo engeziwe ukuze inqobe umphumela we-hydration.
3.3 Umthelela wokuqukethwe kwe-hydroxypropyl kunqubo ye-gelation
Ngaphakathi kohlu oluthile lokuqukethwe kwe-hydroxypropyl, inqubo ye-gelation ilawulwa ukuxhumana phakathi kwe-hydration namaketanga wamangqamuzana. Uma okuqukethwe kwe-hydroxypropyl ku-molecule ye-HPMC kuphansi, i-hydration ibuthakathaka, ukusebenzisana phakathi kwama-molecule kunamandla, futhi izinga lokushisa eliphansi lingakhuthaza ukwakheka kwejeli. Lapho okuqukethwe kwe-hydroxypropyl kuphakeme, i-hydration ithuthukiswa kakhulu, ukusebenzisana phakathi kwamaketanga amangqamuzana kuba buthaka, futhi izinga lokushisa le-gelation liyakhula.
Okuqukethwe okuphezulu kwe-hydroxypropyl kungase futhi kuholele ekwandeni kwe-viscosity yesisombululo se-HPMC, ushintsho ngezinye izikhathi okwandisa izinga lokushisa lokuqala kwe-gelation.
Okuqukethwe kwe-Hydroxypropyl kunomthelela omkhulu ekushiseni kwe-gelationI-HPMC. Njengoba okuqukethwe kwe-hydroxypropyl kwanda, i-hydrophilicity ye-HPMC iyanda futhi ukusebenzisana phakathi kwamaketanga amangqamuzana kuba buthaka, ngakho-ke izinga lokushisa layo le-gelation ngokuvamile liyakhuphuka. Lesi simo singachazwa ngendlela yokusebenzisana phakathi kwe-hydration namaketanga wamangqamuzana. Ngokulungisa okuqukethwe kwe-hydroxypropyl ye-HPMC, ukulawulwa okunembile kwezinga lokushisa kwe-gelation kungafinyelelwa, ngaleyo ndlela kuthuthukiswe ukusebenza kwe-HPMC kwezemithi, ukudla nezinye izinhlelo zokusebenza zezimboni.
Isikhathi sokuthumela: Jan-04-2025