1. Izici eziyisisekelo ze-HPMC
I-Hydroxypropyl methylcellulose (HPMC)Ingabe i-aintic cellulose ether esetshenziswa kabanzi ezintweni zokwakha, umuthi, ukudla, izimonyo kanye nezinye izimboni. Izakhiwo zayo ezihlukile ze-physicochemical, njengokuhlaselwa, ukuqina, amafilimu nokwenziwa kwezakhiwo ze-gelation kanye ne-thermal, kwenze kube yisithako esingukhiye ezihlolweni eziningi zezimboni. Ukushisa kungenye yezinto eziphambili ezithinta ukusebenza kwe-HPMC, ikakhulukazi ngokuya nge-solubity, i-viscosity, ukuqina okushisayo kanye nokuqina okushisayo.
2. Umphumela Wokushisa Kokubilika kwe-HPMC
I-HPMC iyi-polymer encibilike kakhulu, futhi inguquko yayo yokuzishisa ngokushisa:
Isimo sokushisa esiphansi (Amanzi abandayo): I-HPMC iyancibilika kalula emanzini abandayo, kepha izomunca amanzi futhi ivuvukele lapho kuqala ukuxhumana namanzi ukuze wakhe izinhlayiya ze-gel. Uma kushukumisa ukushukumisa akwanele, ama-limps angakha. Ngakho-ke, kuvame ukunconyelwa ukwengeza i-HPMC kancane ngenkathi kuvusa ukukhuthaza ukuhlakazeka okufanayo.
Ukushisa okuphakathi (20- 40 ℃): Kuleli banga lokushisa, i-HPMC ine-soubelity enhle nokubonakala okuphezulu, futhi ilungele izinhlelo ezahlukahlukene ezidinga ukuqina noma ukuzinza.
Ukushisa okuphezulu (ngaphezulu kwama-60 ° C): I-HPMC ithambekele ekwenzeni i-gel eshisayo yokushisa okuphezulu. Lapho izinga lokushisa lifinyelela izinga lokushisa elithile lejeli, ikhambi lizoba oppaque noma lihlanganise, lithinta umphumela wohlelo lokusebenza. Isibonelo, ekwakheni izinto ezifana nodaka noma i-putty powder, uma izinga lokushisa lamanzi liphezulu kakhulu, i-HPMC kungenzeka ingachithwa ngempumelelo, ngaleyo ndlela ithinta ikhwalithi yokwakha.
I-3. Umphumela wokushisa ku-HPMC Viscosity
I-Viscosity ye-HPMC ithintwe kakhulu izinga lokushisa:
Ukunyuka kokushisa, ukwehla kwe-viscosity: I-viscosity yesisombululo se-HPMC imvamisa inciphisa ngokushisa okuzayo. Isibonelo, ukubonwa kwesisombululo esithile se-HPMC kungahle kube ngo-20 ° C, kuyilapho ku-50 ° C, ukubonakala kwayo kuzokwehla kakhulu.
Ukushisa kuyancipha, i-viscosity itholakele: Uma isixazululo se-HPMC sesipholile ngemuva kokushisa, ukubonakala kwayo kuzokululama ngokwengxenye, kepha kungenzeka kungakwazi ukubuyela esimweni sokuqala.
I-HPMC ye-HPMC ehlukile amamafu aphatha ngendlela ehlukile: I-High-Viscutity HPMC ezwela kakhulu izinguquko zokushisa, ngenkathi i-HPMC ephansi inokushintshashintsha okuncane kokushintshashintsha lapho izinga lokushisa lishintsha. Ngakho-ke, kubaluleke kakhulu ukukhetha i-HPMC nge-viscosity efanelekile ezimweni ezihlukile zohlelo.
I-4. Umphumela wokushisa kwe-gelation ye-HPMC ye-HPMC
Isici esibalulekile se-HPMC yi-gelation eshisayo, okungukuthi, lapho izinga lokushisa liphuma liye ezingeni elithile, isixazululo saso sizophenduka ibe yi-gel. Lokhu kushisa kuvame ukubizwa ngokuthi izinga lokushisa le-gelation. Izinhlobo ezahlukahlukene ze-HPMC zinamazinga okushisa ahlukene we-gelation, ngokuvamile phakathi kuka-50-80 ℃.
Embonini yezimboni zokudla kanye nezemithi, lesi sici se-HPMC sisetshenziselwa ukulungiselela izidakamizwa ezisetshenziselwa ukukhishwa noma ama-colloids wokudla.
Kuzinhlelo zokwakha, njengosimende ongumuntu no-pedar udaka kanye ne-putty powder, i-gelation eshisayo ye-HPMC inganikeza ukugcinwa kwamanzi, kepha uma izinga lokushisa lemvelo lokwakha liphezulu kakhulu, i-gelisation ingathinta umsebenzi wokwakha.
I-5. Umphumela wokushisa kokuqina okushisayo kwe-HPMC
Isakhiwo samakhemikhali se-HPMC sizinzile ngaphakathi ebangeni lokushisa elifanele, kepha ukuvezwa kwesikhathi eside kumazinga okushisa aphezulu kungadala ukonakala.
Ukushisa okuphezulu kwesikhashana (njengokushisa okusheshayo kuya ngenhla kwe-100 ℃): Kwangathi kungaphazamisi kakhulu izakhiwo zamakhemikhali ze-HPMC, kepha kungadala ushintsho ezingxenyeni ezibonakalayo, njengokuncipha kwezakhiwo.
Ukushisa okuphezulu kwesikhathi eside (njengokushisa okuqhubekayo ngenhla kwe-90 ℃): Kungadala ukuthi uchungechunge lwamangqamuzana we-HPMC luphule, okuholela ekunciphiseni okungenakuqhathaniswa ekuboneni, okuthinta izakhiwo zalo zokuqina kanye nefilimu.
Izinga lokushisa eliphakeme kakhulu (ngaphezulu kwama-200 ℃): I-HPMC ingahle ibolile, ukukhulula izinto ezishintshashintshayo njenge-methanol ne-propanol, futhi kubangele lokho ku-carbonilise.
6. Izincomo zohlelo lokusebenza ze-HPMC ezindaweni ezihlukile zokushisa
Ukuze unikeze ukudlala okugcwele ekusebenzeni kwe-HPMC, kufanele kuthathwe izinyathelo ezifanele ngokuya ngezindawo ezihlukile zokushisa:
Endaweni yokushisa ephansi (0-10 ℃): I-HPMC iyancibilika kancane, futhi kunconyelwa ukuyikhipha ngaphambili emanzini afudumele (20- 40 ℃) ngaphambi kokusebenzisa.
Endaweni yokushisa ejwayelekile (10-40 ℃): I-HPMC inokusebenza okuzinzile futhi ilungele izinhlelo eziningi, njengezinkungu, zodaka, ukudla kanye ne-excipieticals yezemithi.
Endaweni yokushisa ephezulu (ngenhla kwe-40 ℃): Gwema ukwengeza i-HPMC ngqo ku-Lique Cartete Liquid. Kunconywa ukuyiqeda emanzini abandayo ngaphambi kokuyishisa, noma khetha i-HPMC ephezulu yokumelana ne-HPMC yokunciphisa umthelela we-gelation ye-thermal kuhlelo lokusebenza.
Izinga lokushisa linomphumela obalulekile kwi-solubity, i-viscosity, i-gertation eshisayo kanye nokuqina okushisayo kweI-HPMC. Ngesikhathi senqubo yokufaka isicelo, kuyadingeka ukuthi ukhethe kahle imodeli nendlela yokusebenzisa i-HPMC ngokuya ngezimo ezithile zokushisa ukuze uqinisekise ukusebenza kwayo okuhle. Ukuqonda ukuzwela okushisa kwe-HPMC akunakuthuthukisa ikhwalithi yomkhiqizo kuphela, kepha futhi kugweme ukulahleka okungadingekile okubangelwa izinguquko zokushisa kanye nokwenza ngcono ukusebenza kahle kokukhiqiza kanye nezinzuzo zezomnotho.
Isikhathi sePosi: Mar-28-2025