IHydroxypropyl methylcellulose (HPMC) iyi-semi-synthetic, inert, i-polymer engenabuthi encibilika emanzini esetshenziswa kabanzi ezimbonini ezifana nemithi, ukudla, izimonyo nezinto zokwakha. Ubudlelwano phakathi kwesisindo sayo samangqamuzana kanye ne-viscosity kunomthelela omkhulu ekusebenzeni kwayo ezinhlelweni ezahlukahlukene.
1. Izakhiwo ze-Solubility kanye nokwenziwa kwefilimu
I-viscosity ye-HPMC ithinta ngokuqondile ukuncibilika kwayo emanzini. I-HPMC ene-viscosity ephansi ingancibilika emanzini ngokushesha futhi yakhe isixazululo esisobala nesifanayo, esilungele izinhlelo zokusebenza ezidinga ukuhlakazeka okusheshayo, njengeziphuzo ezisheshayo noma imithi esheshayo. I-HPMC ene-viscosity ephakeme idinga isikhathi eside sokuhlakazeka, kodwa inganikeza ukujiya kanye namandla angcono uma yenza ifilimu, ngakho ifanelekela ukumbozwa kwethebhulethi, ifilimu yokuvikela kanye nempahla ye-matrix ekulungiseleleni ukukhishwa okuqhubekayo.
2. Ukuzinza nokunamathela
I-HPMC ene-viscosity ephakeme ngokuvamile inokuqina okuqinile nokunamathela. Isibonelo, uma isetshenziswa njenge-thickener yosimende noma imikhiqizo esekwe ku-gypsum ezintweni zokwakha, i-viscosity ephakeme i-HPMC ingathuthukisa kakhulu ukugcinwa kwayo kwamanzi kanye nokumelana nokucwila, kusize ukunweba isikhathi sokwakha nokunciphisa ukuqhekeka. Embonini yezemithi, i-HPMC ene-viscosity ephezulu isetshenziselwa ukulawula izinga lokukhishwa kwezidakamizwa. Ukunamathela kwayo okuphezulu kuvumela umuthi ukuthi ukhululwe kancane kancane emzimbeni futhi uthuthukise i-bioavailability yomuthi.
3. Ukumiswa kanye ne-emulsification
Izinguquko ku-viscosity nazo zithinta ukumiswa kanye nezakhiwo ze-emulsification ze-HPMC. Ngenxa yochungechunge lwayo lwamamolekyuli amafushane, i-HPMC ene-viscosity ephansi ifanele ukusetshenziswa njenge-ejenti elengayo. Ingamisa ngokuphumelelayo izingxenye ezingancibiliki emithini enguketshezi futhi ivimbele imvula. I-HPMC ene-viscosity ephezulu ingakha isakhiwo senethiwekhi esinamandla esixazululweni ngenxa yochungechunge lwamangqamuzana olude, ngakho-ke yenza kangcono ekuzinzeni kwama-emulsions nokumiswa futhi ingagcina ukufana isikhathi eside.
4. I-Rheology kanye nezakhiwo zesicelo
Izakhiwo ze-rheological ze-HPMC nazo ziyisici esibalulekile esithinteka yi-viscosity. Izixazululo ze-HPMC ezine-viscosity ephansi zibonisa uketshezi olungcono, kulula ukufutha futhi zifakwe, futhi zivame ukusetshenziswa emikhiqizweni yokunakekelwa kwesikhumba nopende. Isixazululo se-HPMC esine-viscosity ephezulu sisebenza njengoketshezi olungezona olwase-Newtonian futhi sinezici zokunciphisa i-shear. Lesi sici senza i-HPMC ene-viscosity ephezulu iphatheke kalula ngaphansi kwezimo eziphakeme zokugunda, kuyilapho igcina i-viscosity ephezulu ngaphansi kwezimo ezimile, ngaleyo ndlela ithuthukise ukwakheka kwefilimu nokuzinza komkhiqizo.
5. Izibonelo zohlelo lokusebenza
Inkambu yezemithi: I-HPMC ene-viscosity ephansi (efana no-50 cps) ivamise ukusetshenziselwa ukumboza amaphilisi akhishwa ngokushesha ukuze kuqinisekiswe ukukhululwa ngokushesha kwezidakamizwa, kuyilapho i-HPMC ene-viscosity ephezulu (efana no-4000 cps) isetshenziselwa amaphilisi akhishwa njalo ukulungisa isilinganiso sokukhululwa kwezidakamizwa.
Inkundla yokudla: Eziphuzweni ezisheshayo, i-HPMC ene-viscosity ephansi ingancibilika ngokushesha ngaphandle kokuhlangana; emikhiqizweni ebhakiwe, i-HPMC ene-viscosity ephezulu ingathuthukisa umthamo wamanzi wokubamba inhlama futhi ithuthukise ukunambitheka kanye nezakhiwo ezimanzi zemikhiqizo ebhakiwe.
Inkambu yokwakha: Kuma-putty kanye nama-coatings, i-HPMC ene-viscosity ephansi isiza ukwakhiwa futhi ithuthukise ukusebenza kahle komsebenzi; kuyilapho i-HPMC ene-viscosity ephezulu ithuthukisa ukujiya nokumelana ne-sag ye-coating.
I-viscosity ye-HPMC iyipharamitha eyinhloko enquma ukusebenza kwayo ezinhlelweni zokusebenza. I-viscosity ephansi I-HPMC ivamise ukusetshenziswa lapho ukuhlakazeka okusheshayo nokugeleza kuyadingeka, kuyilapho i-viscosity ephezulu i-HPMC inenzuzo kakhulu ezinhlelweni ezidinga ukunamathela okuphezulu, ukwakheka kwefilimu okuhle nokuzinza. Ngakho-ke, ukukhetha i-HPMC ene-viscosity efanele kubalulekile ukuze kuthuthukiswe ukusebenza kwayo emikhakheni ehlukahlukene.
Isikhathi sokuthumela: Jul-08-2024