Izici ezithinta ukukhiqizwa kwe-viscoxypropylylylylylylylylylylylylylylylyllose

I-Hydroxypropyl methylcellulose (HPMC)Ingabe i-polymer esetshenziswe kabanzi emikhakheni ehlukahlukene, kufaka phakathi amakhambi, ukudla, ukwakhiwa kanye nezimonyo. I-viscosity yayo idlala indima ebalulekile ekusetshenzisweni kwayo. Ukuqonda izici ezithinta ukukhiqizwa kwensiza ye-HPMC kubalulekile ekwakheni ukusebenza kwayo ezimeni ezihlukile. Ngokuhlaziya ngokuphelele lezi zinto, ababambiqhaza bangakwazi ukusebenzisa kangcono izakhiwo ze-HPMC ukuze bahlangabezane nezidingo ezithile zohlelo lokusebenza.

Isingeniso:
I-Hydroxypropyl Methylcellulose (HPMC) iyinhlangano eguquguqukayo enezicelo ezisakazekile ezikweletwa izakhiwo zayo ezihlukile, kufaka phakathi i-solubinity yamanzi, ikhono elakha amafilimu, kanye ne-biocompty. Enye yamapharamitha abucayi athinta ukusebenza kwawo ukuhlakanipha. I-viscosity yezixazululo ze-HPMC ithonya ukuziphatha kwayo ezisetshenzisweni ezahlukahlukene, njengokuqina, ukugabha, amafilimu, nokukhululwa okuqhubekayo ekunikezelweni kwemithi. Ukuqonda izici ezilawula ukukhiqizwa kwe-HPMC Viscosity kubaluleke kakhulu ngokwenza kahle ukusebenza kwayo kuyo yonke imboni ehlukile.

Izici ezithinta ukukhiqizwa kwe-Viscosity ye-HPMC:

Isisindo samangqamuzana:
Isisindo samangqamuzana weI-HPMCkuthinta kakhulu ukubonakala kwayo. Ama-polymers aphezulu we-molecular ephakeme akhombisa ukubonakala okuphezulu ngenxa yokukhuphuka kweketanga. Kodwa-ke, isisindo samangqamuzana aphezulu ngokweqile singaholela ezinkingeni zokulungiselela isixazululo nokucutshungulwa. Ngakho-ke, ukukhetha uhla lwesisindo se-molecular esifanele kubalulekile ukuze kulinganiswe nezidingo zokuvuselela i-viscosity ngokucatshangelwa okusebenzayo.

Degree of substitution (DS):
Izinga lokufakwa esikhundleni lisho inani eliphakathi le-hydroxypropyl kanye ne-methoxy faka esikhundleni seyunithi ye-anhydroglucose ku-cellulose chain. Amanani aphezulu we-DS ngokuvamile aphumela ekubonakaleni okuphezulu ngenxa yokwanda kwe-hydrophicility kanye nokusebenzisana kweketanga. Kodwa-ke, ukufaka esikhundleni ngokweqile kungaholela ekunciphiseni insonhlity kanye nokuthambekela kwe-gelation. Ngakho-ke, ukwenza kahle i-DS kubalulekile ekufezeni ukubonakala okufunayo ngenkathi kugcinwa i-solubity kanye nokusebenza.

Ukugxila:
I-HPMC Viscosity ilingana ngqo nokuhlushwa kwayo kusisombululo. Njengoba ukuqunjelwa kwe-polymer kukhuphuka, inani lamaketanga we-polymer ngevolumu yeyunithi ngalinye liyakhuphuka, okuholela ekuhlolweni kwe-chain ethuthukisiwe nokuvunywa okuphezulu. Kodwa-ke, ngokugxila okuphezulu kakhulu, ukubonakala kwamandla amangalisayo noma ukwehla ngenxa yokusebenzisana kwe-polymer-polymer kanye nokwakheka kwe-gel ekugcineni. Ngakho-ke, ukwenza kahle ukugxila kubalulekile ekufezeni ukubonakala okufunayo ngaphandle kokuyekethisa ukuzinza kwesisombululo.

Lokushisa:
Ukushisa kunomthelela omkhulu ekuboniseni izixazululo ze-HPMC. Ngokuvamile, ukuhlakanipha kuyancipha ngokushisa okuthuthukile ngenxa yokuncishiswa kwe-polymer-polymer ukusebenzisana kanye nokuhamba nge-molecular molecular. Kodwa-ke, lo mphumela ungahluka ngokuya ngezinto ezifana nokuhlushwa kwe-polymer, isisindo se-molecular, kanye nokuxhumana okukhethekile okunama-solves noma izengezo. Ukuzwela okushisa kufanele kubhekwe lapho kwakhiwa imikhiqizo esekwe kwa-HPMC ukuqinisekisa ukusebenza okungaguquki ezimweni zokushisa ezihlukile.

Ph:
I-PH yesisombululo ithonya i-HPMC yokuqagela ngomphumela wayo ku-polymer solubilility kanye ne-conformation. I-HPMC ibilika kakhulu futhi ibonisa ukubonakala okuphezulu ku-acidic kancane kuya kumabanga we-pH angathathi hlangothi. Ukuphambuka kwaleli banga le-PH kungaholela ekunciphiseni i-soubity kanye ne-viscosity ngenxa yezinguquko kuhlelo lwe-polymer nokusebenzisana ngama-molecule e-solvent. Ngakho-ke, ukulondolozwa kwezimo ze-PH eziphelele kubalulekile ukuze kukhuliswe i-HPMC viscosity ngesixazululo.

Izithasiselo:
Izithasiselo ezahlukahlukene, ezinjengosawoti, ama-surfactants, kanye nama-solvents, kungathinta i-HPMC viscosity ngokuguqula izixazululo zezixazululo kanye nokuxhumana kwe-polymer-solvent. Isibonelo, usawoti angakuheha ukuthuthukiswa kwe-viscosity ngomphumela wokuphela komoya, ngenkathi ama-surfactants angathonya ukungezwani komhlaba kanye ne-polymer soubelity. I-Soalvents Cools ingaguqula i-solvent polarity futhi ithuthukise i-polymer solubility kanye ne-viscosity. Kodwa-ke, ukuhambisana kanye nokusebenzisana phakathi kwe-HPMC nezengezo kumele kuhlolwe ngokucophelela ukugwema imiphumela engafuneki ekuvulekezweni kanye nokusebenza komkhiqizo.

Ingabe i-polymer eguquguqukayo esetshenziswa kabanzi ekudleni kwemithi, kokudla, ekwakheni, kanye nezimboni zezimonyo. I-viscosity yezixazululo ze-HPMC idlala indima ebalulekile ekunqumeni ukusebenza kwayo ezinhlelweni ezahlukahlukene. Ukuqonda izici ezithinta ukukhiqizwa kwe-Viscosity ye-HPMC, kufaka phakathi isisindo se-molecular, izinga lokufaka esikhundleni, okuhlushwa, izinga lokushisa, i-ph, i-pH, pH. Ngokusebenzisa ngokucophelela lezi zinto, ababambiqhaza bangakwazi ukwenza izici ze-HPMC ukuze bahlangabezane nezidingo ezithile zohlelo lokusebenza ngempumelelo. Ukucwaninga okwengeziwe ekuxhumekeni phakathi kwalezi zinto kuzoqhubeka nokuthuthukisa ukuqonda kwethu nokusetshenziswa kwe-HPMC emikhakheni yezimboni ehlukahlukene.