I-Hydroxypropyl Methylcellulose (HPMC) iyinhlangano eguquguqukayo esetshenziswa kabanzi kwizimboni ezahlukahlukene, kufaka phakathi ama-Pharmaceuticals, izimonyo, ukudla nokwakha. Ikhono layo lokukha ama-gels, amafilimu, kanye nezixazululo kwenza kube yigugu kuzinhlelo zokusebenza eziningi. I-Hydration ye-HPMC isinyathelo esibalulekile ezinqubweni eziningi, ngoba inika amandla i-polymer ukukhombisa izakhiwo ezifiselekayo.
1. Ukuqonda HPMC:
I-HPMC iyisisulu se-cellulose futhi ihlelwe ngokwelapha iselula nge-oxylene oxide ne-methyl chloride. Kuboniswa yi-solubility yayo yamanzi kanye nekhono lokwenza ama-gels asobala, abuyiswa abukeki. Izinga le-hydroxypropyl kanye ne-methoxyls substiles lithinta izakhiwo zalo, kufaka phakathi i-solubity, ukuhlakanipha nokuziphatha kwe-gelation.
2. Ukubaluleka kwe-hydration:
I-Hydration ibalulekile ukuvula ukusebenza kwe-HPMC. Lapho i-HPMC inama-hydrate, idonsa amanzi nokudumba, okuholela ekwakhekeni kwesixazululo se-viscous noma i-gel, ngokuya ngokuhlushwa kanye nemibandela. Lesi simo se-hpdrate sinika amandla i-HPMC ukwenza imisebenzi yayo ehlosiwe, njengokuqina, ukucekelwa phansi, ukwakha amafilimu, nokuxhasa izidakamizwa.
3. Izindlela ze-hydration:
Kunezindlela eziningi ze-hpdrating hpmc, kuya ngohlelo lokusebenza kanye nomphumela owufunayo:
a. Ukuhlakazwa kwamanzi okubandayo:
Le ndlela ifaka ukusabalalisa i-HPMC powder emanzini abandayo ngenkathi ivusa ngobumnene.
Ukusabalaliswa kwamanzi okubandayo kukhethwa ukuvimbela ukuqina futhi kuqinisekisa i-hydration efanayo.
Ngemuva kokuhlakazeka, ikhambi livame ukuvunyelwe ukwenza ama-hydrate ngaphezulu ngaphansi kokuphazamiseka okumnene ukufeza i-viscosity oyifunayo.
b. Ukuhlakazwa kwamanzi okushisayo:
Ngale ndlela, i-HPMC powder ihlakazeka emanzini ashisayo, imvamisa emazingeni okushisa angaphezu kwama-80 ° C.
Amanzi ashisayo asiza i-hydration esheshayo nokuchithwa kwe-HPMC, okuholele ekukhaleni okucacile.
Ukunakekelwa kumele kuthathwe ukugwema ukufudumeza ngokweqile, okungadalula i-HPMC noma kubangele ukwakheka kwenqwaba.
c. Ukungathathi hlangothi:
Ezinye izinhlelo zingabandakanya ukungathathi hlangothi izixazululo ze-HPMC nge-Alkaline Agents enjengeSodium Hydroxide noma i-Potassium Hydroxide.
Ukungathathi hlangothi kuguqula i-PH yesisombululo, esingathonya i-viscosity kanye ne-gelation Properties ye-HPMC.
d. SOLVENT EXCHANGE:
I-HPMC nayo ingahle ihlanjululwe yi-solvent Exchange, lapho ihlakazeka khona ku-solvent engenakuphikwa njenge-ethanol noma i-methanol bese ishintshana ngamanzi.
I-Solvent Exchange ingaba wusizo kwizicelo ezidinga ukulawulwa okuqondile ku-hydration nokuvunywa.
e. I-Pre-hydration:
I-Pre-hydration ifaka ukufaka i-HPMC emanzini noma i-solvent ngaphambi kokuyifaka ekwakhiweni.
Le ndlela iqinisekisa i-hydration ephelele futhi ingazuzisa ukufeza imiphumela engaguquki, ikakhulukazi ekwakhiweni okuyinkimbinkimbi.
4. Izici ezithinta i-hydration:
Kunengqondo eziningana zithonya i-hpdration ye-HPMC:
a. Ubukhulu bezinhlayiyana: I-HPMC egayiwe kahle i-hpmc powder hydrate kalula kunezinhlayiya ezihlanganayo ngenxa yendawo ekhuphukayo engaphezulu.
b. Ukushisa: Amazinga okushisa aphezulu ngokuvamile asheshisa i-hydration kepha angaba nomthelela ekuboneni kwe-viscosity nokuziphatha kwe-gelation ye-HPMC.
c. I-PH: I-PH ye-hydration medium ingathinta isimo se-ionization se-HPMC ye-HPMC futhi ngenxa yalokho ngenxa yalokho ama-kinetics awo we-hydration kanye nezakhiwo ze-rheological.
d. Ukuxuba: Ukuxuba okulungile noma ukuguga kubalulekile nge-hydration efanayo kanye nokuhlakazwa kwezinhlayiya ze-HPMC kwi-solvent.
e. Ukuhlushwa: Ukuhlushwa kwe-HPMC ku-hydration medium kuthonya i-viscosity, amandla we-gel, nezinye izakhiwo zesisombululo esiphumela noma ijeli.
5. Izicelo:
I-HYDRACT HPMC ithola izinhlelo zokusebenza ezahlukahlukene kuyo yonke imboni ehlukahlukene:
a. Ukwehlukaniswa Kwezemithi: Ku-Tablet Coatings, Matric alawulwa ngokulawulwa, izixazululo ze-Ophthalmic, kanye nokumiswa.
b. Imikhiqizo yokudla: Njengomkhulu, i-Stabilizer, noma i-ejenti eyakha amafilimu kusoso, ukugqoka, imikhiqizo yobisi, kanye ne-confectionery.
c. I-COSMETICS: Kukhilimu, ama-lotion, ama-gels, kanye nezinye izinhlobo zokuguqulwa kwe-viscosity kanye ne-emulsation.
d. Izinto zokwakha: Emikhiqizweni esekwe ku-CETEM, izinamathiseli, kanye nama-version ukwenza ngcono ukuzokwenza, ukugcinwa kwamanzi, kanye nokunamathela.
6. Ukulawulwa kwekhwalithi:
I-hydration ephumelelayo ye-HPMC ibalulekile ekusebenzeni komkhiqizo nokuvumelana. Izindlela zokulawula ezisezingeni eliphezulu zingafaka:
a. Ukuhlaziywa kobukhulu bezinhlayiyana: Ukuqinisekisa ukufana kokusatshalaliswa kosayizi wezinhlayiyana ukwenza kahle ama-hydration kinetics.
b. Ukulinganiswa kwe-Viscosity: Ukuqapha okubonakalayo ngesikhathi sokuthola i-hydration ukufeza ukuvumelana okudingayo ngohlelo lokusebenza okuhlosiwe.
c. Ukuqapha kwe-PH: Ukulawula i-PH ye-hydration medium ukwandisa i-hydration futhi kuvikele ukonakala.
d. Ukuhlolwa kwe-Microscopic: Ukuhlolwa okubukwayo kwamasampula anama-hydrate ngaphansi kwesibonakhulu ukuze ahlole ukuhlakazeka kwezinhlayiyana nobuqotho.
7. Isiphetho:
I-Hydration iyinqubo eyisisekelo ekuhlanganiseni izakhiwo ze-HPMC ngezinhlelo ezahlukahlukene. Ukuqonda izindlela, izici, kanye nezindlela zokulawula ikhwalithi ezihambisana ne-hydration kubalulekile ekwakheni ukusebenza komkhiqizo kanye nokuqinisekisa ukungaguquguquki ekwakhiweni. Ngokusebenzisa i-hydration ye-HPMC, abacwaningi namakhemikhali bangavula amandla aso aphelele kuzo zonke izimboni eziningi, ukushayela okusha kanye nentuthuko yomkhiqizo.
Isikhathi Sokuthumela: Mar-04-2024