Ukulungisa isixazululo se-Hydroxypropyl Methylcellulose (HPMC) kuyinqubo eyisisekelo ezimbonini zemithi nezokudla. I-HPMC iyi-polymer evame ukusetshenziswa ekwakhiweni kokumboza ngenxa yezakhiwo zayo ezinhle kakhulu zokwakha ifilimu, ukuzinza, nokuhambisana nezithako ezisebenzayo ezahlukahlukene. Izixazululo zokumboza zisetshenziselwa ukudlulisa izendlalelo zokuvikela, ukulawula amaphrofayili okukhululwa, nokuthuthukisa ukubukeka nokusebenza kwamaphilisi, amaphilisi, namanye amafomu omthamo oqinile.
1. Izinto ezidingekayo:
IHydroxypropyl Methylcellulose (HPMC)
I-solvent (imvamisa amanzi noma ingxube yamanzi notshwala)
I-Plasticizer (uyazikhethela, ukuthuthukisa ukuguquguquka kwefilimu)
Ezinye izithasiselo (ongakukhetha, njengama-colorants, ama-opacifiers, noma ama-anti-tacking agents)
2. Izisetshenziswa ezidingekayo:
Ukuxuba isitsha noma isitsha
I-stirrer (imishini noma kazibuthe)
Ibhalansi yesisindo
Umthombo wokushisisa (uma kudingeka)
Sieve (uma kunesidingo ukususa izigaxa)
imitha ye-pH (uma ukulungiswa kwe-pH kuyadingeka)
Imishini yokuphepha (amagilavu, izibuko, ijazi laselabhu)
3. Inqubo:
Isinyathelo 1: Ukukala Izithako
Linganisa inani elidingekayo le-HPMC usebenzisa ibhalansi yokukala. Inani lingahluka kuye ngokuthi i-concentration oyifunayo yesisombululo se-coating kanye nobukhulu be-batch.
Uma usebenzisa i-plasticizer noma ezinye izithasiselo, linganisa amanani adingekayo futhi.
Isinyathelo sesi-2: Ukulungiswa Kwencibilika
Nquma uhlobo lwe-solvent oluzosetshenziswa ngokusekelwe kuhlelo lokusebenza kanye nokuhambisana nezithako ezisebenzayo.
Uma usebenzisa amanzi njengesincibilikisi, qinisekisa ukuthi anobumsulwa obuphezulu futhi okungcono ahlanjululwe noma akhishwe.
Uma usebenzisa ingxube yamanzi notshwala, thola isilinganiso esifanele ngokusekelwe ekuncibilikeni kwe-HPMC kanye nezici ezifiswayo zesixazululo sokumboza.
Isinyathelo sesi-3: Hlanganisa
Beka isitsha sokuxuba ku-stirrer bese wengeza i-solvent.
Qala ukunyakazisa i-solvent ngesivinini esimaphakathi.
Yengeza kancane kancane impushana ye-HPMC esikalilwe ngaphambilini kusincibilikisi esinyakazayo ukuze ugweme ukunqwabelana.
Qhubeka ugqugquzela kuze kube yilapho impushana ye-HPMC ihlakazwa ngokufanayo ku-solvent. Le nqubo ingase ithathe isikhathi esithile, kuye ngokugxila kwe-HPMC nokusebenza kahle kwemishini enyakazayo.
Isinyathelo sesi-4: Ukushisisa (uma kudingeka)
Uma i-HPMC ingancibiliki ngokuphelele ekamelweni lokushisa, ukufudumeza okuthambile kungase kudingeke.
Shisisa ingxube ngenkathi ugqugquzela kuze kube yilapho i-HPMC ichitheka ngokuphelele. Qaphela ukuthi ungashisi ngokweqile, njengoba izinga lokushisa elidlulele lingehlisa isithunzi i-HPMC noma ezinye izingxenye zesixazululo.
Isinyathelo sesi-5: Ukwengezwa kwePlasticizer nezinye Izithako (uma zikhona)
Uma usebenzisa i-plasticizer, yengeze kwisisombululo kancane kancane ngenkathi uvuselela.
Ngokufanayo, engeza noma yiziphi ezinye izithasiselo ozifisayo njengama-colorants noma ama-opacifiers kulesi sigaba.
Isinyathelo sesi-6: Ukulungiswa kwe-pH (uma kunesidingo)
Hlola i-pH yesisombululo sokumboza usebenzisa imitha ye-pH.
Uma i-pH ingaphandle kwebanga elifunekayo ngenxa yezizathu zokuzinza noma zokuhambisana, yilungise ngokungeza amanani amancane ezixazululo ezine-acidic noma eziyisisekelo ngokufanele.
Gcoba ikhambi kahle ngemva kokuhlanganisa ngakunye bese uhlola kabusha i-pH kuze kube yilapho izinga olifunayo lifinyelelwa.
Isinyathelo sesi-7: Ukuhlanganiswa Kokugcina Nokuhlola
Uma zonke izingxenye zengezwe futhi zixutshwe kahle, qhubeka ugoqa imizuzu embalwa ukuze uqinisekise i-homogeneity.
Yenza noma yiziphi izivivinyo zekhwalithi ezidingekayo ezifana nokulinganisa i-viscosity noma ukuhlola okubonakalayo kwanoma yiziphi izimpawu ze-particle noma ukuhlukaniswa kwesigaba.
Uma kudingeka, dlulisa isixazululo ngesisefo ukuze ususe noma yiziphi izigaxa ezisele noma izinhlayiya ezingancibilikisiwe.
Isinyathelo sesi-8: Isitoreji Nokupakisha
Dlulisa isixazululo esilungisiwe sokumboza se-HPMC ezitsheni ezifanele zokugcina, okungcono kakhulu amabhodlela engilazi ye-amber noma iziqukathi zepulasitiki ezisezingeni eliphezulu.
Lebula iziqukathi ngolwazi oludingekayo njengenombolo yeqoqo, usuku lokulungiselela, ukugxilisa ingqondo, nezimo zokugcinwa.
Gcina ikhambi endaweni epholile, eyomile evikelekile ekukhanyeni nasebuswakameni ukuze ugcine uzinzo kanye nempilo yeshelufu.
4. Amathiphu Nokucatshangelwa:
Ngaso sonke isikhathi landela izinqubo ezinhle zaselabhorethri neziqondiso zokuphepha lapho uphatha amakhemikhali nezinto zokusebenza.
Gcina ukuhlanzeka kanye nobunyumba kuyo yonke inqubo yokulungiselela ukuze ugweme ukungcola.
Hlola ukuhambisana kwesisombululo sokumboza ne-substrate ehlosiwe (amaphilisi, amaphilisi) ngaphambi kokufaka isicelo esikhulu.
Yenza izifundo zokuzinza ukuze uhlole ukusebenza kwesikhathi eside nezimo zokugcina zesisombululo sokumboza.
Bhala inqubo yokulungiselela futhi ugcine amarekhodi ngezinjongo zokulawula ikhwalithi nokuhambisana nemithetho.
Isikhathi sokuthumela: Mar-07-2024