I-HPMC (i-hydroxypropyl methylcellulose) iyimpahla ye-polymer encibilika emanzini esetshenziswa kabanzi emkhakheni wokwakha, wezokwelapha, wokudla kanye namakhemikhali ansuku zonke. Inokuqina okuhle, i-emulsification, ukwakheka kwefilimu, i-colloid evikelayo nezinye izakhiwo. Ezinhlelweni ze-emulsion, i-HPMC ingakwazi ukulawula i-viscosity ye-emulsion ngezindlela ezihlukahlukene.
1. Isakhiwo samangqamuzana e-HPMC
I-viscosity ye-HPMC ithinteka kakhulu isisindo sayo samangqamuzana kanye nezinga lokushintshwa. Isisindo samangqamuzana sikhulu, ukuphakama kwe-viscosity yesisombululo; kanye nezinga lokushintsha (okungukuthi, izinga lokushintshwa kwe-hydroxypropyl kanye namaqembu e-methoxy) lithinta ukuncibilika kanye nezakhiwo ze-viscosity ze-HPMC. Ngokukhethekile, ukuphakama kwezinga lokushintsha, kungcono ukuncibilika kwamanzi kwe-HPMC, futhi i-viscosity iyanda ngokufanele. Abakhiqizi bavamise ukuhlinzeka ngemikhiqizo ye-HPMC ngezisindo zamangqamuzana ahlukene namadigri okushintsha ukuze kuhlangatshezwane nezidingo zezinhlelo zokusebenza ezahlukene.
2. Sebenzisa ukugxilisa ingqondo
Ukugxila kwe-HPMC kusisombululo esinamanzi kungenye yezinto ezibalulekile ezithinta i-viscosity. Ngokuvamile, ukuphakama kwe-HPMC kuphezulu, i-viscosity enkulu yesisombululo. Kodwa-ke, i-viscosity yezinhlobo ezahlukene ze-HPMC ekugxilweni okufanayo ingahluka kakhulu. Ngakho-ke, ekusetshenzisweni okungokoqobo, kuyadingeka ukukhetha ukuhlushwa okufanele kwesisombululo se-HPMC ngokuya ngezidingo ezithile ze-viscosity. Isibonelo, ezinhlelweni zokusebenza zokwakha, ukugxilwa kwe-HPMC kuvame ukulawulwa phakathi kuka-0.1% no-1% ukuze kuhlinzekwe nge-viscosity efanelekile yokusebenza nokusebenza kokwakha.
3. Indlela yokuhlakaza
Inqubo yokuqedwa kwe-HPMC nayo inomthelela obalulekile ku-viscosity yokugcina. I-HPMC kulula ukuyihlakaza emanzini abandayo, kodwa izinga lokuchithwa lihamba kancane; iyancibilika ngokushesha emanzini ashisayo, kodwa kulula ukuhlanganisa. Ukuze ugweme ukuhlangana, indlela yokwengeza kancane kancane ingasetshenziswa, okungukuthi, qala kancane kancane wengeze i-HPMC emanzini abandayo ukuze uhlakaze, bese ushisa futhi ugovuze kuze kuncibilike ngokuphelele. Ngaphezu kwalokho, i-HPMC ingaphinda ixutshwe nezinye izimpushana ezomile bese ifakwa emanzini ukuze incibilike ukuze kuthuthukiswe ukusebenza kahle kokuhlakazeka kanye nokuzinza kwe-viscosity.
4. Izinga lokushisa
Izinga lokushisa linomthelela omkhulu ku-viscosity yezixazululo ze-HPMC. Ngokuvamile, i-viscosity yesisombululo se-HPMC iyancipha njengoba izinga lokushisa likhuphuka. Lokhu kungenxa yokuthi izinga lokushisa elikhuphukayo lizokwenza buthaka ukuhlangana kwe-hydrogen phakathi kwama-molecule, okwenza iketango lamangqamuzana e-HPMC lishelele kalula, ngaleyo ndlela kunciphise i-viscosity yesixazululo. Ngakho-ke, ezinhlelweni ezidinga i-viscosity ephezulu, izixazululo ze-HPMC zivame ukusetshenziswa emazingeni okushisa aphansi. Isibonelo, ekusetshenzisweni kwemithi, izixazululo ze-HPMC zivame ukusetshenziswa ekamelweni lokushisa ukuze kuqinisekiswe ukuzinza nokusebenza komuthi.
5. inani le-pH
I-viscosity yesisombululo se-HPMC nayo ithintwa inani le-pH. I-HPMC ine-viscosity ephezulu kakhulu ngaphansi kwezimo ezingathathi hlangothi nezine-asidi ebuthakathaka, kuyilapho i-viscosity izokwehla kakhulu ngaphansi kwezimo eziqinile ze-asidi noma ze-alkaline. Lokhu kungenxa yokuthi amanani e-pH eyeqisayo azobhubhisa ukwakheka kwamangqamuzana e-HPMC futhi enze buthaka umphumela wawo wokujiya. Ngakho-ke, ekusetshenzisweni okungokoqobo, inani le-pH lesixazululo lidinga ukulawulwa futhi ligcinwe ngaphakathi kwebanga elizinzile le-HPMC (imvamisa i-pH 3-11) ukuze kuqinisekiswe umphumela wayo wokujiya. Isibonelo, ekusetshenzisweni kokudla, i-HPMC ivamise ukusetshenziswa ekudleni okune-asidi okufana neyogathi nejusi, futhi i-viscosity efanelekile ingatholwa ngokulungisa inani le-pH.
6. Ezinye izithasiselo
Kuzinhlelo ze-emulsion, i-viscosity ye-HPMC ingabuye ilungiswe ngokungeza ezinye izingqimba noma izincibilikisi. Isibonelo, ukwengeza inani elifanele likasawoti we-inorganic (njenge-sodium chloride) kungakhuphula i-viscosity yesisombululo se-HPMC; kuyilapho ukwengeza izincibilikisi eziphilayo ezifana ne-ethanol kunganciphisa i-viscosity yayo. Ngaphezu kwalokho, uma isetshenziswa ngokuhlanganiswa namanye ama-thickeners (njenge-xanthan gum, i-carbomer, njll.), i-viscosity nokuzinza kwe-emulsion kungathuthukiswa kakhulu. Ngakho-ke, ekwakhiweni kwefomula yangempela, izithasiselo ezifanele zingakhethwa njengoba kudingeka ukuze kuthuthukiswe i-viscosity nokusebenza kwe-emulsion.
I-HPMC ingafinyelela ukulawula okunembile kwe-emulsion viscosity ngokusebenzisa isakhiwo sayo samangqamuzana, ukugxila kokusetshenziswa, indlela yokuhlakazeka, izinga lokushisa, inani le-pH kanye nezithasiselo. Ezinhlelweni ezingokoqobo, lezi zici zidinga ukucatshangelwa ngokugcwele ukuze kukhethwe uhlobo olufanele lwe-HPMC nezimo zokusetshenziswa ukuze kuzuzwe umphumela ofanele wokujiya. Ngokuklanywa kwefomula yesayensi nokulawula inqubo, i-HPMC ingadlala indima ebalulekile emkhakheni wezokwakha, ezemithi, ukudla namakhemikhali ansuku zonke, inikeze ukusebenza okuhle kakhulu nolwazi lomsebenzisi.
Isikhathi sokuthumela: Jul-17-2024