I-HPMC (i-Hydroxypropyl Methylcellulose) iyinto esetshenziswa ngamanzi polymer impahla esetshenziswa kabanzi emikhakheni yokwakha, amakhambi, ukudla namakhemikhali nsuku zonke. Inokuqina okuhle, i-emulsation, i-Film-yakha, i-colloid evikelayo nezinye izakhiwo. Ku-Emulsion Systems, i-HPMC ingalawula ukubonakala kwe-emulsion ngezindlela ezahlukahlukene.
1. Isakhiwo samangqamuzana se-HPMC
I-viscosity ye-HPMC ithintwa kakhulu ngesisindo sayo samangqamuzana kanye nezinga lokufaka esikhundleni. Ubukhulu besisindo se-molecular, ukukhuphuka kwesixazululo sekhambi; Futhi izinga lokufakwa esikhundleni (okungukuthi, izinga lokufaka esikhundleni se-hydroxypropyl kanye namaqembu we-methoxy) lithinta i-solubity kanye ne-viscosity Properties ye-HPMC. Ngokukhethekile, ukukhuphuka kwesilinganiso sokufaka esikhundleni, okungcono i-solubility yamanzi ye-HPMC, futhi i-viscosity inyuka ngokufanele. Abakhiqizi bavame ukuhlinzeka ngemikhiqizo ye-HPMC enezinsimbi ezihlukile zama-molecular kanye namadigri wokufaka esikhundleni ukuze ahlangabezane nezidingo zezicelo ezahlukahlukene.
2. Sebenzisa okuhlushwa
Ukuhlushwa kwe-HPMC kwisixazululo samanzi kungenye yezinto ezibalulekile ezithinta i-viscosity. Ngokuvamile, kukhuphuka ukugcwaliseka kwe-HPMC, kukhula kakhulu isixazululo. Kodwa-ke, i-viscosity yezinhlobo ezahlukahlukene ze-HPMC ekuhlolweni okufanayo ingahluka kakhulu. Ngakho-ke, kuzinhlelo zokusebenza ezingokoqobo, kuyadingeka ukuthi ukhethe ukugcwaliswa okufanele kwe-HPMC Solution ngokuya ngezidingo ezithile zekasi. Isibonelo, kuzinhlelo zokusebenza zokwakha, ukugcwaliseka kwe-HPMC kuvame ukulawulwa phakathi kuka-0,1% no-1% ukuhlinzeka ngokufaneleka okufanelekile nokusebenza kokwakha.
3. Indlela yokuchithwa
Inqubo yokuchithwa kwe-HPMC nayo inomthelela obalulekile ekubonisweni kokugcina. I-HPMC kulula ukuhlakazeka emanzini abandayo, kepha izinga lokuchithwa lihamba kancane; Incibilikisa ngokushesha emanzini ashisayo, kepha kulula kakhulu ukuba ne-agglomerate. Ukuze ugweme ukuhlukaniswa kwe-agglomeration, indlela yokungezwa kancane kancane ingasetshenziswa, okungukuthi, okokuqala engeza kancane kancane i-HPMC kumanzi abandayo ukusakazeka, bese kushisa kuze kukhanye ngokuphelele. Ngaphezu kwalokho, i-HPMC ingahle futhi ihlelwe ngamanye ama-powders owomile bese ingezwa emanzini ukuncibilikisa ukuthuthukisa ukusebenza kahle kanye nokuqina kwento yokubona.
4. Ukushisa
Ukushisa kunomthelela omkhulu ekubonakaleni kwezixazululo ze-HPMC. Ngokuvamile, i-viscosity yesisombululo se-HPMC iyancipha njengoba izinga lokushisa lenyuka. Lokhu kungenxa yokuthi izinga lokushisa elikhuphukayo lizokwenza buthaka ubuhlobo be-hydrogen phakathi kwama-molecule, okwenza i-HPMC i-auch ake ushelelezi kalula, ngaleyo ndlela anciphise ukubonwa kwesixazululo. Ngakho-ke, kuzinhlelo zokusebenza ezidinga i-viscosity ephezulu, izixazululo ze-HPMC zivame ukusetshenziswa emazingeni okushisa aphansi. Isibonelo, ezisetshenzisweni zezemithi, izixazululo ze-HPMC zivame ukusetshenziswa ekushiseni kwegumbi ukuqinisekisa ukuqina kanye nokusebenza kahle komuthi.
5 Inani le-PH
I-viscosity yesisombululo se-HPMC nayo iyathinteka ngenani le-PH. I-HPMC inokuvunywa okuphezulu kakhulu ngaphansi kwezimo ezingathathi hlangothi nezingathathi hlangothi, ngenkathi i-viscosity izokwehla kakhulu ngaphansi kwezimo eziqinile ze-acidic noma ze-alkali. Lokhu kungenxa yokuthi amanani we-PH aphezulu azobhubhisa ukwakheka kwamangqamuzana kwe-HPMC futhi anciphise umphumela wawo wokuqina. Ngakho-ke, kuzinhlelo zokusebenza ezisebenzayo, inani le-PH lekhambi lidinga ukulawulwa futhi ligcinwe ngaphakathi kohlu oluzinzile lwe-HPMC (imvamisa ph 3-11) ukuqinisekisa umphumela wayo wokuqina. Isibonelo, kuzinhlelo zokusebenza zokudla, i-HPMC ivame ukusetshenziswa ekudleni okune-acidic okufana ne-yogurt nejusi, kanye nokubona okuhle okungatholakala ngokulungisa inani le-PH.
6. Ezinye izengezo
Ku-Emulsion Systems, i-viscosity ye-HPMC nayo ingashintshwa ngokungeza abanye abakhulu noma izixazululo. Isibonelo, engeza inani elifanele likasawoti we-inorganic (njenge-sodium chloride) lingakhulisa ukubonakala kwesisombululo se-HPMC; Ngenkathi ungeza izilonge ze-organic njenge-ethanol zinganciphisa ukubonana kwayo. Ngaphezu kwalokho, lapho isetshenziswa ngokuhlanganiswa nabanye abakhulu (njenge-Xanthan Gum, i-Carbomer, njll.), I-viscomer kanye nokuqina kwe-emulsion nakho kungathuthukiswa kakhulu. Ngakho-ke, ekwakhiweni kwefomula yangempela, izengezo ezifanele zingakhethwa njengoba kudingeka ukwandisa i-viscosity kanye nokusebenza kwe-emulsion.
I-HPMC ingathola ukulawula okuqondile kwe-emulsion viscosity ngesakhiwo sayo samangqamuzana, ukugxila kokusetshenziswa, indlela yokuchithwa, izinga lokushisa, inani lezengezo kanye nezithasiselo. Kuzinhlelo zokusebenza ezisebenzayo, lezi zinto zidinga ukubhekwa ngokuphelele ukuze ukhethe uhlobo lwe-HPMC olufanele kanye nezimo zokusebenzisa ukufezekisa umphumela ofanele wokuqina. Ngokwakheka kwefomula yesayensi nokulawulwa kwenqubo, i-HPMC ingadlala indima ebalulekile emikhakheni yokwakha, amakhambi, ukudla namakhemikhali nsuku zonke, ihlinzeka ukusebenza okuhle kakhulu kanye nesipiliyoni somsebenzisi.
Isikhathi sePosi: Jul-17-2024