Ake sixoxe ngeHydroxypropylylylykl methyl celluloseI-HPMCnokuthi ungalinganisa kanjani ukubonakala kwayo. I-viscosity lapha ibhekisela ekubonakaleni okusobala, okuyinkomba ebalulekile ye-hydroxypropylylylylylylylyl.
Standard. Izindlela ezijwayelekile zokulinganisa zilinganiswa ukujikeleza okujikelezayo, ukulinganiswa kwe-capillary viscosity kanye nokulinganiswa kwe-viscosity. Indlela yokuzimisela ye-hydroxypropylylylylylylylylylylyllllose yayinama-capillary adhesion.
Indlela yokuzimisela degree, usebenzisa i-UCHS Visecometer. Imvamisa ukuzimisela kwesixazululo kuyisisombululo esingamanzi esingu-2%, ifomula yile: v = kdt. V ukubonwa e-MPA. s no-k is visecometer njalo.
D ubuntu ekushiseni okuhlala njalo kanye ne-T yisikhathi kusuka phezulu kuya phansi ngokusebenzisa i-viscometer ngemizuzwana. Le ndlela yokusebenza iyinkimbinkimbi ngokwengeziwe, uma kunendaba yokungena ngaphakathi.
Amagama kulula ukudala amaphutha, kunzima ukukhomba ikhwalithi ye-hydroxypropylylylylylylylylylylylyl. Manje kuvame ukusetshenziswa ukukala ukubonakala kwe-rotary visecometer, ukusetshenziswa okujwayelekile eChina.
Ifomula ye-NDJ-1 Viscometer iyi-η = kα. I-η viscosity, nase-MPA. S, k ngu-coefficient we-viscometer, kanye ne-α ukufundwa kwe-pointer ye-viscometer.
I-Hydroxypropyllykylm methyl cellulose 2% Indlela yokuhlola ye-viscosity:
1, le ndlela ilungele ukunqunywa kokubonakala okunamandla koketshezi olungelona neNewTonian (isixazululo se-polymer, ukumiswa, isixazululo sokuhlakazeka kwe-emulsion noma isixazululo esisebenzayo, njll.).
2. Izinsimbi kanye Nemishini
2.1 I-Rotary Viscometer (NDJ-1 ne-NDJ-4 kudingeka yi-Chinese Pharmacopoeia)
2.2 Ukushisa kwamanzi okushisa kwamanzi okushisa okushisa okungajwayelekile 0.10c
2.3 Izinga lokushisa lokushaya amagoli ngu-0,20c, aqinisekiswe ngezikhathi ezithile.
2.4 Ama-Templeency Meter Pericometers asebenzisa izindlela zokuqinisa imvamisa (njenge-NDJ-1 ne-NDJ-4) zizogcinwa. Ukunemba kwe-1%. A
Isampula ye-OG ibisindwa ngokunembile bese ifakwa emgodini owomile, ongama-400ml amade. Engeza cishe i-100ml yamanzi ashisayo angama-80-90 degree bese uvuse i-10min ukuze uhlukanise
Ngokusobala uhlakaze, uvuse futhi ungeze amanzi abandayo abe ngu-400ml asonke. Okwamanje, vusa ngokuqhubekayo nge-30min ukwenza ikhambi le-2% (W / W), bese ulifaka esiqandisini sokugeza kweqhwa ukuze upholile kuze kube yilapho amafomu anciphile phansi.
Khipha bese ufaka ithangi lokushisa elihlala njalo ukuze ugcine izinga lokushisa eliphakathi liye ku-20 ℃ 0.1 ℃.
3.1 Ukufakwa kwensimbi nokusebenza kwensimbi kuzokwenziwa ngokuya ngemiyalo yokusebenza yensimbi, futhi i-rotor efanelekile ne-rotor izokhethwa ngokuya ngobubanzi be-viscocity lomkhiqizo ohloliwe kanye nezinhlinzeko ze-pharmacopoeia ngaphansi kombhalo we umphumela
Isivinini sokujikeleza.
3.2 Lungisa izinga lokushisa lamanzi okushisa njalo ngokuya ngokunqunywa ngaphansi kwento ngayinye yezidakamizwa.
3.3 Umkhiqizo wokuhlola ubekwe esitsheni esichazwe yithuluzi, futhi i-angle yokuphambuka (a) yalinganiswa ngokomthetho ngemuva kwemizuzu engama-30 yokushisa okungapheli. Cisha imoto bese uyiqala kabusha ukuze uzimisele futhi
Umehluko phakathi kwamanani ashiwo akufanele weqe ama-3%, ngaphandle kwalokho kufanele kwenziwe isilinganiso sesithathu.
3.4 Bala inani elishoyo lezivivinyo ezimbili ngokuya ngefomula ukuthola i-viscosity enamandla yomkhiqizo ohloliwe.
4. Qopha futhi ubale
4.1 Qopha imodeli ye-Routary Viscometer, inombolo ye-rotor nesivinini esisetshenzisiwe, i-Viscometer Constant njalo (k 'value), izinga lokushisa elilinganisiwe, nesilinganiso ngasinye. Inani.
Ifomula yokubala ye-4.2
I-Viscosity enamandla (MPA "S) = ka lapho i-K i-Viscometer ihlala ilinganiswa ngoketshezi olujwayelekile lokubonakala olwaziwayo kanye ne-anglection angle
Isikhathi sePosi: APR-25-2024