Ilungiswa kanjani i-hydroxyethyl cellulose?

I-Hydroxyethyl celluloseiyingxenye ebalulekile ye-cellulose. Ngenxa yobuhle bemithombo yempahla eningi eluhlaza, evuselelekayo, ebolayo, engenabuthi, i-biocompatibility enhle, kanye nesivuno esikhulu, ucwaningo lwayo kanye nokusetshenziswa kwayo kudonse ukunaka okukhulu. . Inani le-viscosity liyinkomba yokusebenza ebaluleke kakhulu ye-hydroxyethyl cellulose. Kuleli phepha, i-hydroxyethyl cellulose enevelu ye-viscosity ngaphezu kwe-5×104mPa·s kanye nenani lomlotha elingaphansi kuka-0.3% lilungiswe ngendlela ye-liquid-phase synthesis method ngokusebenzisa i-alkalization kanye ne-etherification inqubo yezinyathelo ezimbili.

Inqubo ye-alkalization inqubo yokulungiselela i-alkali cellulose. Kuleli phepha, izindlela ezimbili ze-alkalization zisetshenziswa. Indlela yokuqala ukusebenzisa i-acetone njenge-diluent. I-cellulose impahla eluhlaza isekelwe ngokuqondile ekuhlanganiseni okuthile kwesisombululo samanzi se-sodium hydroxide. Ngemva kokwenziwa kwe-basification reaction, i-ejenti ye-etherifying iyengezwa ukuze yenze ngokuqondile ukusabela kwe-etherification. Indlela yesibili ukuthi impahla eluhlaza ye-cellulose yenziwa i-alkali kusisombululo esinamanzi se-sodium hydroxide ne-urea, futhi i-alkali cellulose elungiswe ngale ndlela kufanele incinywe ukuze kukhishwe i-lye eyeqile ngaphambi kokusabela kwe-etherification. I-alkali cellulose elungiselelwe ngezindlela ezahlukene yahlaziywa nge-infrared spectroscopy kanye ne-X-ray diffraction. Ngokwezakhiwo zemikhiqizo elungiselelwe ukusabela kwe-etherification, indlela yokukhetha inqunywa.

Ukuze kunqunywe inqubo engcono kakhulu yokuhlanganiswa kwe-etherification, indlela yokusabela ye-antioxidant, i-lye ne-glacial acetic acid ekuphenduleni kwe-etherification yahlaziywa kuqala. Bese ubumba uhlelo lokuhlola lokusabela kwesici esisodwa, thola izici ezinomthelela omkhulu ekusebenzeni kwe-hydroxyethyl cellulose elungisiwe, bese usebenzisa i-viscosity yesisombululo samanzi esingu-2% somkhiqizo njengenkomba yereferensi. Imiphumela yokuhlola ibonisa ukuthi izici ezifana nenani elikhethiwe le-diluent, inani le-ethylene oxide eyengeziwe, isikhathi se-alkalization, izinga lokushisa nesikhathi sokusabela kokuqala, izinga lokushisa kanye nesikhathi sokusabela kwesibili konke kunethonya elikhulu ekusebenzeni kwe-alkalization. umkhiqizo. Isikimu sokuhlola se-orthogonal esinezici eziyisikhombisa namazinga amathathu sadwetshwa, futhi ijika lomthelela elithathwe emiphumeleni yokuhlola lingahlaziya ngokubonakalayo izici eziyinhloko nesesibili kanye nomthelela wesici ngasinye. Ukuze kulungiswe imikhiqizo enamanani aphezulu e-viscosity, kwakhiwe isikimu sokuhlola esithuthukisiwe, futhi uhlelo olufanele lokulungiselela i-hydroxyethyl cellulose ekugcineni lwanqunywa ngemiphumela yokuhlola.

Izakhiwo ze-high-viscosity elungiselelwei-hydroxyethyl cellulosezahlaziywa futhi zahlolwa, okuhlanganisa ukunqunywa kwe-viscosity, okuqukethwe komlotha, ukudluliswa kokukhanya, okuqukethwe umswakama, njll., ngokusebenzisa i-infrared spectroscopy, i-nuclear magnetic resonance, i-gas chromatography, i-X-ray diffraction, ukuhlaziywa kwe-thermogravimetric-differential thermal kanye nezinye izindlela zokulinganisa ziyasetshenziswa. ukuhlaziya kanye nezimpawu zokwakheka komkhiqizo, ukufana okubambele, idigri yokushintsha i-molar, I-crystallinity, ukuzinza kwe-thermal, njll. Izindlela zokuhlola zibhekisela kumazinga we-ASTM.

I-Hydroxyethyl cellulose, okuphuma ku-cellulose ebalulekile, idonse ukunaka ngenxa yobuningi bezinsiza zayo zezinto ezingavuthiwe, ezivuselelekayo, ezibolayo, ezingenabuthi, ezihambelana ne-biocompatible, kanye nesivuno esikhulu. I-viscosity ye-hydroxyethyl cellulose iyinkomba ebaluleke kakhulu yokusebenza kwayo. I-viscosity ye-cellulose ye-hydroxyethyl elungiselelwe ingaphezulu kwe-5 × 104mPa · s, futhi okuqukethwe komlotha kungaphansi kuka-0.3%.

Kuleli phepha, i-high-viscosity hydroxyethyl cellulose yalungiswa nge-liquid-phase synthesis method ngokusebenzisa i-alkalization kanye ne-etherification. Inqubo ye-alkalization ukulungiswa kwe-alkali cellulose. Khetha ezindleleni ezimbili ze-alkalization. Enye ukuthi impahla ye-cellulose i-alkali ngokuqondile ne-acetone njenge-diluent kusisombululo se-aqueous sodium hydroxide, bese ibhekana nokusabela kwe-etherification nge-ejenti e-etherifying. Okunye ukuthi impahla ye-cellulosic i-alkali kusisombululo se-aqueous sodium hydroxide kanye ne-urea. I-alkali eyengeziwe ku-cellulose ye-alkali kufanele isuswe ngaphambi kokusabela. Kuleli phepha, ama-cellulose e-alkali ahlukahlukene acwaningwa nge-infrared spectroscopy kanye ne-X-ray diffraction. Ekugcineni, indlela yesibili yamukelwa ngokuya ngezakhiwo zemikhiqizo ye-etherification.

Ukuze kunqunywe izinyathelo zokulungiselela i-etherification, indlela yokusabela ye-antioxidant, i-alkali ne-glacial acetic acid ngesikhathi sokudla yafundwa. Izici ezithinta ukulungiswa kwe-hydroxyethyl cellulose zanqunywa ukuhlolwa kwesici esisodwa. Ngokusekelwe ku-viscosity value yomkhiqizo ku-2% yesisombululo samanzi. Imiphumela yokuhlola ibonisa ukuthi ivolumu ye-diluent, inani le-ethylene oxide, isikhathi se-alkalization, izinga lokushisa kanye nesikhathi sokubuyiselwa kwamanzi okuqala nokwesibili kunethonya elikhulu ekusebenzeni komkhiqizo. Indlela yezinto eziyisikhombisa namazinga amathathu yamukelwa ukuze kutholwe indlela engcono kakhulu yokulungiselela.

Sihlaziya izakhiwo ezilungiselelwei-hydroxyethyl cellulose, okuhlanganisa i-viscosity, umlotha, ukudluliswa kokukhanya, umswakama, njll. Ukulingiswa kwesakhiwo, i-homogeneity esikhundleni, i-molarity esikhundleni, icrystallinity kanye nokuzinza kwe-thermal kwaxoxwa ngakho nge-infrared, i-nuclear magnetic resonance, i-gas chromatography, i-X-ray diffraction, i-DSC ne-DAT, kanye izindlela zokuhlola zamukele izindinganiso ze-ASTM.