Embonini yezemithi, i-hypromeellose (I-HPMC, I-Melomel ™) ingasetshenziswa njengofler, i-Binder, i-Pology coating polymer kanye nokhiye we-pussient ukulawula ukukhishwa kwezidakamizwa. I-Hypromellose isetshenziswe kumathebulethi iminyaka engaphezu kwengu-60 futhi iyisihluthulelo se-Expeapuint esetshenziswa kakhulu kumathebulethi we-hydrophilic gel matrix.
Izinkampani eziningi zemithi zisebenzisa i-Hypromellose ngokukhishwa kwezidakamizwa okulawulwayo, ikakhulukazi ukwakheka kwethebhulethi ye-hydrophilic gel matrix. Uma kukhulunywa ngemikhiqizo ye-Hypromellose, ungahle uzibuze ukuthi ungakwenza kanjani ukukhetha - ikakhulukazi uma ufuna okuthile okunobungane futhi okuqhubekayo ukumaketha kumakhasimende akho. Kulesi siqondisi, sizokhuluma ngezinto ezibalulekile okudingeka wazi nge-Hypromellose.
Kuyini i-Hypromellose?
I-Hypromellose, eyaziwa nangokuthiI-Hydroxypropyl methylcellulose (HPMC), i-polymer esetshenziswa njenge-excipietical yekhamishini ukulawula ukukhishwa kwezidakamizwa kusuka kumathebulethi we-oral hydrophilic gel matrix.
I-Hypromellose iyinto eyenziwe ngezinto ezengeziwe ezisuselwa ku-cellulose, i-polymer eningi kakhulu ngokwemvelo. Ezinye zezakhiwo zayo ezivamile zifaka phakathi:
. incibilika emanzini abandayo
. insoluble emanzini ashisayo
. -Ngezwani
. Ukukhetha ukuncibilika ku-organic solvents
. Ukuhlekisa, Izakhiwo zeGemal Gel
. I-Hydration kanye ne-Viscosity ezimele ye-PH
. Unqenqema
. non-anobuthi
. Ukunambitheka nokunuka kuyimnene
. Ukumelana ne-enzyme
. ph (2-13) Ububanzi obuhle
. Ingasetshenziswa njengoMkhulu, i-Emulsifier, i-Binder, i-Rate Regulator, ifilimu langaphambili
Iyini ithebhulethi ye-gerrophilic gel matrix?
I-Hydrophilic Gel Matrix Tablet iyifomu lomthamo elingalawula ukukhishwa kwezidakamizwa kwithebhulethi isikhathi eside.
Ukulungiselela i-Hydrophilic Gel Matrix Ithebhulethi Ukulungiselela:
. kulula kakhulu
. Idinga kuphela imishini yokucindezela yethebhulethi ejwayelekile
. Vimbela Ukulahlwa Kwe-Dose Dose Dose
. Ayithinteki kubulukhuni bethebhulethi noma amandla okucindezela
. Ukukhishwa kwezidakamizwa kungashintshwa ngokuya ngenani le-excipients nama-polymers
Ukusetshenziswa kwe-Hypromellose kumathebulethi weHydrophilic Gel-Matrix athole ukuvunywa okubanzi okulawulayo, futhi i-Hypromellose kulula ukuyisebenzisa futhi inerekhodi elihle lokuphepha, eliboniswe yizifundo eziningi. I-Hypromellose isiphenduke isinqumo esihle kakhulu ezinkampanini ezenza imithi ukuthuthukisa nokukhiqiza amaphilisi wokukhishwa okuqhubekayo.
Izici ezithinta ukukhishwa kwezidakamizwa ezibhebheni ze-matrix:
Lapho uklama ithebhulethi ekhishwa yisikhathi, kunezici ezimbili eziphambili okufanele zicatshangelwe: ukwakheka nokucutshungulwa. Kukhona nezinto ezingaphansi okufanele zicatshangelwe lapho zinquma ukwakhiwa nokukhishwa kwephrofayili yomkhiqizo wezidakamizwa wokugcina.
Ifomula:
Izici ezibalulekile okufanele uzicabangele ukuthuthuka kwangaphambili:
1. I-Polymer (Uhlobo lokufaka esikhundleni, i-viscosity, inani kanye nosayizi wezinhlayiyana)
2. Izidakamizwa (usayizi wezinhlayiyana kanye ne-solubity)
3
4
Craft:
Lezi zinto zihlobene nokuthi umuthi wakhiwa kanjani:
1. Izindlela zokukhiqiza
2. Ubukhulu be-tablet nesimo
3. I-Tablet Force
4. Imvelo ye-PH
I-5. I-film coating
Ama-skeleton chips asebenza kanjani:
Amathebulethi we-Hydrophilic Gel Matrix angalawula ukukhishwa kwezidakamizwa nge-gel ungqimba, kufaka phakathi izindlela ezimbili zokuphazamiseka (izithako ezisebenzayo) kanye nokuguguleka (izithako ezisebenzayo ze-insoluble), ngakho-ke i-viscosity ye-polymer inethonya elikhulu kwiphrofayili yokukhishwa. Kusetshenziswa i-Hypromellose, izinkampani ezenza imithi zingasebenzisa ubuchwepheshe bethebhulethi ye-Hydrophilic Gel Matrix ukulungisa iphrofayili yokukhishwa kwesidakamizwa, ukuhlinzeka ngemithamo ephumelelayo kanye nokulandela umkhawulo wesiguli kangcono, ngaleyo ndlela kunciphise umthwalo wemithi ezigulini. Indlela yokuthatha umuthi kanye ngosuku ingcono kunesipiliyoni sokuthatha amaphilisi amaningi izikhathi eziningana ngosuku.
Isikhathi sePosi: APR-25-2024