Isetshenziswa kanjani i-Hypromellose (HPMC) kumathebulethi e-matrix akhululiwe?

Embonini yezemithi, i-hypromellose (I-HPMC, METHOCEL™) ingasetshenziswa njenge-filler, i-binder, i-polymer yokugqoka ithebhulethi kanye ne-excipient key ukulawula ukukhishwa kwezidakamizwa. I-Hypromellose isetshenziswe kumaphilisi iminyaka engaphezu kwengu-60 futhi iyisakhi esiyinhloko esisetshenziswa kakhulu kumaphilisi e-hydrophilic gel matrix.

Izinkampani eziningi ezenza imithi zisebenzisa i-hypromellose ukuze zikhishwe izidakamizwa ezilawulwayo, ikakhulukazi ekwakhekeni kwethebhulethi ye-hydrophilic gel matrix. Uma kukhulunywa ngemikhiqizo ye-hypromellose, ungahle uzibuze ukuthi ungayikhetha kanjani - ikakhulukazi uma ufuna okuthile okunelebula okunobungane futhi okuzinzile ukuze kumakethwe kumakhasimende akho. Kulo mhlahlandlela, sizokhuluma ngezinto ezibalulekile okudingeka uzazi nge-hypromellose.

Iyini i-hypromellose?

I-Hypromellose, eyaziwa nangokuthii-hydroxypropyl methylcellulose (HPMC), i-polymer esetshenziswa njenge-excipient yezemithi ukulawula ukukhishwa kwezidakamizwa kumaphilisi e-oral hydrophilic gel matrix.

I-Hypromellose i-semi-synthetic material etholakala ku-cellulose, i-polymer eningi kakhulu ngokwemvelo. Ezinye zezakhiwo zayo ezivamile zihlanganisa:

. encibilika emanzini abandayo

. engancibiliki emanzini ashisayo

. I-Nonionic

. I-soluble ngokukhethekile kuma-organic solvents

. Ukuguqulwa, izakhiwo zejeli ezishisayo

. I-Hydration kanye ne-viscosity ngaphandle kwe-pH

. I-surfactant

. non-toxic

. Ukunambitha nokuhogela kuthambile

. Ukumelana nama-enzyme

. I-pH (2-13) ububanzi bokuqina

. Ingasetshenziswa njenge-thickener, i-emulsifier, i-binder, i-rate regulator, ifilimu yangaphambili

Iyini i-Hydrophilic Gel Matrix Tablet?

Ithebhulethi ye-Hydrophilic gel matrix iyifomu lomthamo elingalawula ukukhishwa kwesidakamizwa kuthebhulethi isikhathi eside.

Ukulungiswa kwethebhulethi ye-Hydrophilic gel matrix:

. uma kuqhathaniswa elula

. Idinga kuphela okokusebenza okujwayelekile kokucindezela ithebhulethi

. Vimbela ukulahlwa komthamo wezidakamizwa

. Akuthintwa ubulukhuni bethebhulethi noma amandla okucindezela

. Ukukhishwa kwezidakamizwa kungalungiswa ngokuya ngenani lama-excipients nama-polymers

Ukusetshenziswa kwe-hypromellose kumaphilisi e-hydrophilic gel-matrix kuthole ukugunyazwa okubanzi kokulawula, futhi i-hypromellose isebenziseka kalula futhi inomlando omuhle wokuphepha, okuye kwaboniswa izifundo eziningi. IHypromellose isibe yisinqumo esingcono kakhulu sezinkampani ezenza imithi ukuthuthukisa nokukhiqiza amaphilisi akhishwa isikhathi eside.

Izinto Ezithinta Ukukhishwa Kwezidakamizwa Kumathebhulethi e-Matrix:

Uma udizayina ithebulethi yokukhishwa okunwetshiwe, kunezici ezimbili eziyinhloko okufanele zicatshangelwe: ukwakheka nokucutshungulwa. Kukhona nezinto ezincane okufanele zicatshangelwe lapho kunqunywa ukwakheka nokukhishwa kwephrofayili yomkhiqizo wokugcina womuthi.

Ifomula:

Izici ezibalulekile okufanele zicatshangelwe ekuthuthukisweni kwangaphambi kwesikhathi:

1. I-Polymer (uhlobo lokufaka esikhundleni, i-viscosity, inani nosayizi wezinhlayiyana)

2. Izidakamizwa (usayizi wezinhlayiyana nokuncibilika)

3. Ama-ejenti okugcwalisa (i-solubility kanye nomthamo)

4. Amanye ama-excipient (ama-stabilizer namabhafa)

Ubuciko:

Lezi zici zihlobene nendlela umuthi okhiqizwa ngayo:

1. Izindlela zokukhiqiza

2. Usayizi Wethebhulethi kanye Nomumo

3. Amandla ethebhulethi

4. imvelo pH

5. Ifilimu enamathela

Asebenza kanjani ama-skeleton chips:

Amaphilisi e-Hydrophilic gel matrix angalawula ukukhululwa kwezidakamizwa ngesendlalelo sejeli, okuhlanganisa izindlela ezimbili zokusabalalisa (izithako ezisebenzayo ezincibilikayo) kanye nokuguguleka (izithako ezisebenzayo ezingancibiliki), ngakho-ke i-viscosity ye-polymer inethonya elikhulu kuphrofayela yokukhululwa. Ngokusebenzisa i-hypromellose, izinkampani ezithaka imithi zingasebenzisa ubuchwepheshe bethebhulethi ye-hydrophilic gel matrix ukulungisa iphrofayili yokukhululwa komuthi, ukuhlinzeka ngesilinganiso esisebenza kahle kakhulu nokuthobelana kwesiguli okungcono, ngaleyo ndlela kunciphise umthwalo wemithi ezigulini. Indlela yokuphuza umuthi kanye ngosuku impela ingcono kunesipiliyoni sokuthatha amaphilisi amaningi izikhathi ezimbalwa ngosuku.