I-HPMC (HYDROXYPROPYL Methylcellulose)Ama-Capsule angenye yezinto ezivame ukusetshenziswa kwe-capsule emithini yanamuhla kanye nezithasiselo zokudla. Isetshenziswa kabanzi embonini yezemithi kanye nomkhakha womkhiqizo wezokunakekelwa kwempilo, futhi ithandeka ngabasebenza imifino neziguli ezinama-allergies ngenxa yezithako zalo zesitshalo. I-HPMC capsule kancane incibilikisa kancane kancane epheshana esiswini ngemuva kokufakwa, ngaleyo ndlela likhipha izithako ezisebenzayo kuzo.
1. Ukubuka konke kwe-HPMC capsule isikhathi sokuqothula
Isikhathi sokuchithwa kwama-HPMC capsule sivame phakathi kwemizuzu eyi-10 kuye kwengama-30, ebika ngokukhulu ukushuba kodonga lwe-capsule, inqubo yokulungiselela, uhlobo lokuqukethwe kwe-capsule, kanye nezinto zezemvelo. Uma kuqhathaniswa namaphilisi we-gelatin wendabuko, izinga lokuchithwa kwama-HPMC caplule kancane kancane, kepha kusengaphakathi kohlu olumukelekile lwepheshana lesisu lomuntu. Ngokuvamile, izidakamizwa noma izakhi zomzimba zingadedelwa ngokushesha futhi zidonswe ngemuva kokuthi i-capsule ichithwe, iqinisekisa ukungatholakali kwe-bioavailebility yezithako ezisebenzayo.
2. Izici ezithinta izinga lokuchithwa kwama-HPMC caplule
Ivelu ye-PH kanye nokushisa
Ama-HPMC capsule ane-soubelity engcono ezindaweni ezine-acidic nakungathathi hlangothi, ukuze zikwazi ukuncibilika ngokushesha esiswini. Inani le-PH yesisu livame phakathi kuka-1.5 no-3.5, futhi le ndawo ye-acid isiza ama-HPMC capsules aqhekeke. Ngasikhathi sinye, izinga lokushisa lomzimba elijwayelekile lomzimba womuntu (37 ° C) lingakhuthaza ukuchithwa okusheshayo kwama-caplule. Ngakho-ke, endaweni ye-acid yesisu, ama-hpmc caplule ajwayele ukuncibilika ngokushesha futhi akhulule okuqukethwe kwawo.
I-HPMC capsule udonga ubukhulu nobuningi
Ubukhulu be-capsule Wall buthinta ngokuqondile isikhathi sokuqothula. Izindonga ezibanzi ze-capsule zithatha isikhathi esithe xaxa ukuncibilikisa ngokuphelele, ngenkathi izindonga ze-capsule ezincanyana zincibilikisa ngokushesha. Ngaphezu kwalokho, ubuningi be-HPMC capsule buzothinta futhi izinga lokuchithwa kwalo. Ama-capsule we-denser azothatha isikhathi eside ukudiliza esiswini.
Uhlobo nohlobo lokuqukethwe
Izithako ezilayishwe ngaphakathi kwe-capsule nazo zinomphumela othile kwizinga lokuchitheka. Isibonelo, uma okuqukethwe kunama-acidic noma ancibilikayo, i-capsule izoncibilika ngokushesha esiswini; Ngenkathi ezinye izithako ezinamafutha, kungathatha isikhathi eside ukugqama. Ngaphezu kwalokho, izinga lokuchithwa kwezinto eziyimpuphu noketshezi lihlukile. Ukusatshalaliswa kokuqukethwe koketshezi kuyunifomu okwengeziwe, okulungele ukuhlukaniswa okusheshayo kwama-HPMC caplule.
Usayizi we-capsule
I-HPMCAma-Capsule wemininingwane ehlukile (njenge-No. 000, Cha. 00, Cha. 0, njll. 0, njll. 0, njll. Ngokuvamile, ama-caplule amancane athatha isikhathi esifushane sokuncibilika, ngenkathi amaphilisi amakhulu anezindonga eziwugqinsi nokuqukethwe okuningi, ngakho-ke athatha isikhashana ukuncibilikisa.
Inqubo yokulungiselela
Ngesikhathi senqubo yokukhiqiza yama-HPMC caplule, uma kusetshenziswa amapulasitiki noma ezinye izithako zengezwa, izici zokuchithwa kwama-caplule zingashintshwa. Isibonelo, abanye abakhiqizi bengeza i-glycerin yemifino noma ezinye izinto ku-HPMC ukuthuthukisa ukuqina kwamakhompiyutha, kungathinta izinga lokuqhekeka kwama-caplule ngezinga elithile.
Umswakama kanye nezimo zokugcina
Ama-HPMC capsule azwela umswakama kanye nezimo zokugcina. Uma kugcinwe endaweni yokushisa eyomile noma ephezulu, ama-caplule angaba brittle, ngaleyo ndlela eshintsha izinga lokuchitheka esiswini somuntu. Ngakho-ke, ama-HPMC caplule ajwayele ukugcinwa emazingeni okushisa aphansi nendawo eyomile ukuqinisekisa ukuqina kwezinga labo lokuchithwa kanye nekhwalithi.
I-3. Inqubo yokuqothula ye-HPMC capsule
Inqubo yokuchithwa kwama-HPMC capsule ngokuvamile ahlukaniswe izigaba ezintathu:
Isigaba sokuqala sokufakwa kwamanzi Ingaphezulu le-capsule limanzi bese liqala kancane kancane ukuthambisa. Njengoba ukwakheka kwama-HPMC capsule anezinga elithile lokumuncwa kwamanzi, lesi sigaba sivame ngokushesha.
Ukuvuvukala kwesigaba sokuvuvukala kanye ne-diliregration: Ngemuva kokuthola amanzi, udonga lwe-capsule kancane kancane ukuze wakhe ungqimba lwe-gelatinous. Lesi sendlalelo sibangela ukuthi i-capsule iphinde ihlukaniswe, futhi okuqukethwe kuvezwa futhi kwakhishwa. Lesi sigaba sinquma izinga lokuchithwa kwe-capsule futhi futhi liyisihluthulelo sokukhishwa kwezidakamizwa noma izakhi zomzimba.
Qedela Isigaba Sokuchithwa: Njengoba ukuhlukaniswa kwengqondo kuqhubeka, i-capsule ichithwa ngokuphelele, okuqukethwe kukhululwe ngokuphelele, futhi kungadotshwa ngumzimba womuntu. Imvamisa kungakapheli imizuzu eyi-10 kuye kwengama-30, ama-HPMC caplule angaqedela inqubo ekuqhekekeni ukuze aqede ukuchithwa.
Inqubo yokulungiselela
Ngesikhathi senqubo yokukhiqiza yama-HPMC caplule, uma kusetshenziswa amapulasitiki noma ezinye izithako zengezwa, izici zokuchithwa kwama-caplule zingashintshwa. Isibonelo, abanye abakhiqizi bengeza i-glycerin yemifino noma ezinye izinto ku-HPMC ukuthuthukisa ukuqina kwamakhompiyutha, kungathinta izinga lokuqhekeka kwama-caplule ngezinga elithile.
Umswakama kanye nezimo zokugcina
Ama-HPMC capsule azwela umswakama kanye nezimo zokugcina. Uma kugcinwe endaweni yokushisa eyomile noma ephezulu, ama-caplule angaba brittle, ngaleyo ndlela eshintsha izinga lokuchitheka esiswini somuntu. Ngakho-ke, ama-HPMC caplule ajwayele ukugcinwa emazingeni okushisa aphansi nendawo eyomile ukuqinisekisa ukuqina kwezinga labo lokuchithwa kanye nekhwalithi.
I-3. Inqubo yokuqothula ye-HPMC capsule
Inqubo yokuchithwa kwama-HPMC capsule ngokuvamile ahlukaniswe izigaba ezintathu:
Isigaba sokuqala sokufakwa kwamanzi Ingaphezulu le-capsule limanzi bese liqala kancane kancane ukuthambisa. Njengoba ukwakheka kwama-HPMC capsule anezinga elithile lokumuncwa kwamanzi, lesi sigaba sivame ngokushesha.
Ukuvuvukala kwesigaba sokuvuvukala kanye ne-diliregration: Ngemuva kokuthola amanzi, udonga lwe-capsule kancane kancane ukuze wakhe ungqimba lwe-gelatinous. Lesi sendlalelo sibangela ukuthi i-capsule iphinde ihlukaniswe, futhi okuqukethwe kuvezwa futhi kwakhishwa. Lesi sigaba sinquma izinga lokuchithwa kwe-capsule futhi futhi liyisihluthulelo sokukhishwa kwezidakamizwa noma izakhi zomzimba.
Qedela Isigaba Sokuchithwa: Njengoba ukuhlukaniswa kwengqondo kuqhubeka, i-capsule ichithwa ngokuphelele, okuqukethwe kukhululwe ngokuphelele, futhi kungadotshwa ngumzimba womuntu. Imvamisa kungakapheli imizuzu eyi-10 kuye kwengama-30, ama-HPMC caplule angaqedela inqubo ekuqhekekeni ukuze aqede ukuchithwa.
Isikhathi sePosi: Nov-07-2024