(1) Isingeniso ku-HPMC
IHydroxypropyl Methylcellulose (HPMC) iyi-ether ebalulekile ye-nonionic cellulose esetshenziswa kakhulu ezintweni zokuhlanza, izinto zokwakha, ukudla, imithi kanye neminye imikhakha. Kumshini wokuwasha izingubo, i-HPMC isetshenziswa njengesigxivizo ukuze inikeze ukuzinza okuhle kakhulu kokumiswa nokuncibilika, ithuthukisa ukunamathela kanye nomthelela wokuwasha okokuwasha izingubo. Nokho, ukuze kuzuzwe i-viscosity ephelele ye-HPMC kumshini wokuwasha izingubo, izici eziningi zidinga ukucatshangelwa, okuhlanganisa uhlobo, umthamo, izimo zokuhlakazwa, ukulandelana kokwengezwa, njll. kwe-HPMC.
(2) Izinto ezithinta i-HPMC viscosity
1. Izinhlobo namamodeli we-HPMC
Isisindo samangqamuzana nezinga lokushintsha (i-methoxy ne-hydroxypropyl substitution) ye-HPMC ithinta ngqo i-viscosity yayo kanye nezakhiwo zokuncibilika. Izinhlobo ezahlukene ze-HPMC zinezigaba ezihlukene ze-viscosity. Ukukhetha imodeli ye-HPMC evumelana nezidingo zakho zokwenza okokuhlanza izingubo kubalulekile. Ngokuvamile, ama-HPMC anesisindo samangqamuzana aphezulu ahlinzeka ngama-viscosity aphezulu, kuyilapho ama-HPMC esisindo esiphansi se-molecular ahlinzeka ngama-viscosity aphansi.
2. Umthamo we-HPMC
Inani le-HPMC linomthelela omkhulu ku-viscosity. Ngokuvamile, i-HPMC yengezwa ngamanani aphakathi kuka-0.5% no-2% ezintweni zokuhlanza izingubo. Umthamo ophansi kakhulu ngeke uzuze umphumela ofisa ukujiya, kuyilapho umthamo ophakeme kakhulu ungase uholele ezinkingeni ezinjengobunzima bokuhlakazeka kanye nokuxuba okungalingani. Ngakho-ke, umthamo we-HPMC udinga ukulungiswa ngokuya ngezidingo ezithile kanye nemiphumela yokuhlola ukuze kuzuzwe i-viscosity efanele.
3. Izimo zokuhlakazwa
Izimo zokuhlakazeka ze-HPMC (izinga lokushisa, inani le-pH, isivinini esinyakazayo, njll.) zinomthelela obalulekile ku-viscosity yayo:
Izinga lokushisa: I-HPMC incibilika kancane emazingeni okushisa aphansi kodwa inganikeza ama-viscosity aphezulu. Incibilika ngokushesha emazingeni okushisa aphezulu kodwa ine-viscosity ephansi. Kunconywa ukuncibilikisa i-HPMC phakathi kuka-20-40°C ukuze kuqinisekiswe ukuzinza nokubonakala kwayo.
I-pH: I-HPMC isebenza kahle kakhulu ngaphansi kwezimo ezingathathi hlangothi. Amanani e-pH edlulele (ane-asidi kakhulu noma ane-alkaline kakhulu) angacekela phansi ukwakheka kwe-HPMC futhi anciphise ukubukeka kwayo. Ngakho-ke, ukulawula inani le-pH yesistimu yokuwasha izingubo phakathi kuka-6-8 kusiza ukugcina ukuzinza nokubonakala kwe-HPMC.
Isivinini esishukumisayo: Isivinini esishukumisayo esifanelekile singakhuthaza ukuqedwa kwe-HPMC, kodwa ukunyakazisa ngokweqile kungase kungenise amabhamuza futhi kuthinte ukufana kwesixazululo. Ngokuvamile kuyanconywa ukusebenzisa isivinini esinensayo futhi esinyakazayo ukuhlakaza ngokugcwele i-HPMC.
4. Engeza i-oda
I-HPMC yakha kalula ama-agglomerate esixazululweni, okuthinta ukuhlakazeka kwayo nokusebenza kwe-viscosity. Ngakho-ke, ukuhleleka i-HPMC yengezwa ngayo kubalulekile:
Ukuxuba ngaphambilini: Hlanganisa i-HPMC nezinye izimpushana ezomile ngokulinganayo bese uzifaka kancane kancane emanzini, okungavimbela ukwakheka kwezigaxa futhi kusize ukuncibilika ngokulinganayo.
Ukuswakama: Ngaphambi kokwengeza i-HPMC emshinini wokuwasha izingubo, ungaqale uwumanzise ngamanzi abandayo amancane, bese ufaka amanzi ashisayo ukuze uwancibilikise. Lokhu kungathuthukisa ukusebenza kahle kokuqedwa kanye ne-viscosity ye-HPMC.
(3) Izinyathelo zokuthuthukisa i-viscosity ye-HPMC
1. Idizayini yefomula
Khetha imodeli efanelekile ye-HPMC kanye nomthamo ngokusekelwe ekusetshenzisweni kokugcina kanye nezimfuneko zokuhlanza izingubo. Izihlanzi zokuhlanza izingubo ezisebenza kahle kakhulu zingadinga i-HPMC ene-viscosity ephezulu, kuyilapho imikhiqizo yokuhlanza evamile ingase ikhethe i-HPMC ene-viscosity emaphakathi kuya ephansi.
2. Ukuhlolwa kokuhlola
Yenza ukuhlolwa kweqoqo elincane elabhorethri ukubona umthelela wayo ku-viscosity yesihlanzi sempahla ngokushintsha umthamo, izimo zokuhlakazeka, ukuhleleka kokwengezwa, njll. kwe-HPMC. Rekhoda amapharamitha nemiphumela yokuhlolwa ngakunye ukuze uthole inhlanganisela engcono kakhulu.
3. Ukulungiswa kwenqubo
Sebenzisa izindlela zokupheka ezingcono kakhulu zaselabhorethri futhi ucubungule izimo kulayini wokukhiqiza futhi uzilungisele ukukhiqizwa kwenani elikhulu. Ukuqinisekisa ukusatshalaliswa okufanayo kanye nokuhlakazwa kwe-HPMC ngesikhathi senqubo yokukhiqiza ukuze kugwenywe izinkinga ezifana nezigaxa nokuhlakazeka okungekuhle.
4. Ukulawulwa kwekhwalithi
Ngezindlela zokuhlola ikhwalithi, ezifana nokulinganisa i-viscometer, ukuhlaziya usayizi wezinhlayiyana, njll., ukusebenza kwe-HPMC kumshini wokuwasha izingubo kuyagadwa ukuze kuqinisekiswe ukuthi ifinyelela i-viscosity elindelwe kanye nomthelela wokusetshenziswa. Yenza ukuhlolwa kwekhwalithi okuvamile futhi ulungise ngokushesha izinqubo namafomula uma izinkinga zitholakala.
(4) Imibuzo evame ukubuzwa nezisombululo
1. Ukuqedwa kahle kwe-HPMC
Izizathu: Izinga lokushisa elingalungile lokuhlakaza, isivinini esinyakazayo esisheshayo noma esinensa kakhulu, ukuhleleka okungalungile kokwengeza, njll.
Isixazululo: Lungisa izinga lokushisa lokuncibilika libe ngu-20-40°C, sebenzisa isivinini esinensayo futhi esinyakazayo, futhi wandise ukulandelana kokwengeza.
2. I-HPMC viscosity ayikho ezingeni
Izizathu: Imodeli ye-HPMC ayifanelekile, umthamo ayanele, inani le-pH liphezulu kakhulu noma liphansi kakhulu, njll.
Isixazululo: Khetha imodeli efanelekile ye-HPMC nomthamo, bese ulawula ivelu ye-pH yesistimu yokuhlanza izingubo phakathi kuka-6-8.
3. Ukwakhiwa kwe-clump ye-HPMC
Isizathu: I-HPMC yengezwe ngqo kusixazululo, izimo zokuchithwa okungafanele, njll.
Isixazululo: Sebenzisa indlela yokuhlanganisa ngaphambilini, qala uhlanganise i-HPMC nezinye izimpushana ezomile, bese uyifaka kancane kancane emanzini ukuze incibilike.
Ukuze kuzuzwe i-viscosity ephelele ye-HPMC kumshini wokuwasha izingubo, izici ezifana nohlobo, umthamo, izimo zokuhlakazeka, nokuhleleka kokwengezwa kwe-HPMC zidinga ukucatshangelwa ngokugcwele. Ngokuklanywa kwefomula yesayensi, ukuhlolwa kokuhlola kanye nokulungiswa kwenqubo, ukusebenza kwe-viscosity ye-HPMC kungenziwa ngcono ngempumelelo, ngaleyo ndlela kuthuthukiswe umphumela wokusetshenziswa nokuncintisana kwemakethe yesihlanzi sezingubo.
Isikhathi sokuthumela: Jul-08-2024