(1) Isingeniso se-HPMC
I-Hydroxypropyl Methylcellulose (HPMC) iyinhlangano ebalulekile ye-celvulosic ether esetshenziswa kabanzi ezihlanzisweni, izinto zokwakha, ukudla, umuthi kanye nezinye izinkambu. Ngokuhlanza izingubo zokuhlanza, i-HPMC isetshenziswa njengesikhulu ukuhlinzeka ngokuqina okuhle ukumiswa kanye ne-solubity, ukuthuthukisa ukunamathela kanye nokugeza okusebenzayo kokuhlanza izingubo. Kodwa-ke, ukufezekisa ukubonwa okuphelele kwe-HPMC ekuhlanzeni izingubo, okudingeka kucatshangwe izici eziningi, kufaka phakathi uhlobo, umthamo, izimo zokuqothula, ukwengeza ukulandelana, njll. Kwe-HPMC.
(2) Izici ezithinta i-hpmc viscosity
1. Izinhlobo namamodeli we-HPMC
Isisindo samangqamuzana kanye nesilinganiso sokufaka esikhundleni (i-methoxy ne-hydroxypropyls Okungena esikhundleni) se-HPMC sithinta ngqo i-viscosity yayo yokuvuleka kanye ne-solibity. Izinhlobo ezahlukene ze-HPMC zine-viscosity ehlukile. Ukukhetha imodeli ye-HPMC evumelana nezidingo zakho zokuhlanza izingubo zokuhlanza kubalulekile. Ngokuvamile, ama-HPMC aphezulu we-molecular anikela nge-viscosities aphezulu, ngenkathi ama-HPMC we-molecular aund HPMC ahlinzeka nge-viscosities ephansi.
2. Imithamo ye-HPMC
Inani le-HPMC linomthelela omkhulu ekuboneni. Imvamisa, i-HPMC ingezwa ngamanani phakathi kuka-0.5% no-2% kokuhlanza izingubo. Umthamo ophansi kakhulu ngeke afeze umphumela oyifunayo wokuqina, ngenkathi umthamo omkhulu kakhulu ungaholela ezinkingeni ezinjengobunzima ekuqothulweni nasekuxubeni okungalingani. Ngakho-ke, umthamo we-HPMC udinga ukulungiswa ngokuya ngezidingo ezithile nemiphumela yokuhlola ukuze uzuze i-viscosity efanele.
3. Izimo zokuqothula
Izimo zokuqothula ze-HPMC (lokushisa, ivelu ye-PH, ijubane lokuvuselela, njll.) Iba nomthelela obalulekile ekubonisweni kwayo:
Ukushisa: I-HPMC inciphisa kancane kancane emazingeni okushisa aphansi kepha inganikeza ama-viscosities aphezulu. Inciphisa ngokushesha emazingeni okushisa aphezulu kepha inokubona okuphansi. Kunconywa ukuncibilikisa i-HPMC phakathi kuka-20-40 ° C ukuqinisekisa ukuqina kwayo nokubonakala.
I-PH: I-HPMC yenza kahle ngaphansi kwezimo zokungathathi hlangothi. Amanani we-PH adlulele (acidi a-acidic noma ane-alkaline) angabhubhisa ukwakheka kwe-HPMC futhi anciphise ukubonakala kwawo. Ngakho-ke, ukulawula inani le-PH yohlelo lokuhlanza izingubo phakathi kuka-6-8 kusiza ukugcina ukuqina nokuvunywa kwe-HPMC.
Isivinini esishukumisayo: Ijubane lokuvuselela elifanele lingakhuthaza ukuchithwa kwe-HPMC, kepha ukuvuselelwa ngokweqile kungaletha ama-bubble futhi kuthinte ukufana kwesixazululo. Ngokuvamile kunconywa ukusebenzisa isivinini esihamba kancane futhi esishukumisayo ukuqeda ngokuphelele i-HPMC.
4. Faka i-oda
I-HPMC yakha kalula ama-agglomerates ngesisombululo, okuthinta ukuchithwa kwayo nokusebenza kwe-viscosity. Ngakho-ke, i-oda lapho i-HPMC yengezwa khona ibalulekile:
Ukuxuba kwangaphambili: Hlanganisa i-HPMC nabanye amapontshi owomile ngokulinganayo bese kancane kancane kancane ubangeze emanzini, okungavimba ukwakheka kwama-clumps futhi kusiza ukuncibilikisa ngokulinganayo.
Ukuthambisa: Ngaphambi kokungeza i-HPMC kwikhambi lokuhlanza izingubo zokuhlanza, ungaqala ukugcoba ngenani elincane lamanzi abandayo, bese ungeza amanzi ashisayo ukuze uwancibilike. Lokhu kungathuthukisa ukusebenza kahle nokuqothuka kwe-HPMC.
(3) Izinyathelo zokwenza kahle i-HPMC Viscosity
1. I-formula design
Khetha imodeli efanelekile ye-HPMC kanye nomthamo osuselwa ekusetshenzisweni kokuphela kanye nezidingo zokuhlanza izingubo. Ukuhlanza okusebenzayo okusebenzayo kokuhlanza izingubo zokuhlanza kungadinga ukubonwa okuphezulu kwe-HPMC, ngenkathi imikhiqizo yokuhlanza ejwayelekile ingakhetha okuphakathi kokubonakaliswa kwe-HPMC ephansi.
2. Ukuhlolwa kokuhlola
Yenza izivivinyo ezincane-ze-latch ebhularothri ukuze zibheke umthelela wayo ekuboneni kokuhlanza izingubo ngokushintsha umthamo, izimo zokuqothula, njll. I-HPMC. Qopha amapharamitha kanye nemiphumela yokuhlolwa ngakunye ukuthola inhlanganisela engcono kakhulu.
3. Inqubo yokulungiswa
Sebenzisa izindlela zokupheka ezinhle kakhulu zelebhu kanye nemibandela yokukhiqiza bese uzilungisela ukukhiqizwa okukhulu. Qinisekisa ukusatshalaliswa okufanayo kanye nokuchithwa kwe-HPMC ngesikhathi senqubo yokukhiqiza ukugwema izinkinga ezinjengezinkinga nokuchithwa kabi.
4. Ukulawulwa kwekhwalithi
Ngezindlela zokuhlola ikhwalithi, njengokulinganisa kwe-viscometer, ukuhlaziya usayizi wezinhlayiyana, njll. Yenza ukuhlolwa kwekhwalithi ejwayelekile bese ulungisa izinqubo namafomula ngokushesha uma kutholakala izinkinga.
(4) Imibuzo ebuzwa njalo nezixazululo
1. Ukuchithwa okumpofu kwe-HPMC
Izizathu: Izinga lokushisa elingafanele, lishesha kakhulu noma lihamba kancane kakhulu, i-oda lokungezwa elingafanele, njll.
Isixazululo: Lungisa izinga lokuchithwa liye ku-20-40 ° C, sebenzisa isivinini esihamba kancane futhi esishukumisayo, futhi senze lula ukulandelana okulandelayo.
2. I-HPMC Viscosity ayikho ku-standard
Izizathu: Imodeli ye-HPMC ayilungile, umthamo awenele, inani le-PH liphezulu kakhulu noma liphansi kakhulu, njll.
Isixazululo: Khetha imodeli efanelekile ye-HPMC kanye nomthamo, futhi ulawule inani le-PH yohlelo lokuhlanza izingubo phakathi kuka-6-8.
3. I-HPMC Clump ukwakheka
Isizathu: I-HPMC yengezwa ngqo kwikhambi, izimo ezingafanele zokukhumbula, njll.
Isixazululo: Sebenzisa indlela yangaphambi kokuxubana, ukuxubana kwe-HPMC yokuqala nabanye abaponsi owomile, futhi kancane kancane kwengeze emanzini ukuncibilikisa.
Ukufeza ukubonwa okuphelele kwe-HPMC ekuhlanzeni izingubo, izinto ezifana nohlobo, umthamo, izimo zokuqothula, kanye nokuhleleka kokungezwa kwe-HPMC kudingeka kubhekwe ngokufanele. Ngokwakheka kwefomula yesayensi, ukulungiswa kokuhlola kanye nokulungiswa kwenqubo, ukusebenza kwe-viscosity ye-HPMC kungalungiswa ngempumelelo, ngaleyo ndlela kuthuthukise umphumela wokusetshenziswa kanye nokuncintisana kwemakethe kokuhlanza izingubo.
Isikhathi sePosi: Jul-08-2024