I-HPMC (Hydroxypropyl Methylcellulose) iyinqwaba futhi i-stabilizer evame ukusetshenziswa ezintweni zokwakha, izimbobo, amakhamishini nokudla. I-HPMC 15 CPS isho ukuthi i-viscosity yayo iyi-15 centipoise, okuyibanga eliphansi lokubona.
1. Khulisa ukugxila kwe-HPMC
Indlela eqondile futhi ephumelelayo yokwandisa i-viscosity ye-HPMC ukwandisa ukugxila kwayo kwikhambi. Lapho ingxenye enkulu ye-HPMC inyuka, ukubonakala kwesixazululo nakho kuzokwanda. Umnyombo wale ndlela ukuthi i-HPMC yandisa i-viscosity yesisombululo ngokwakha isakhiwo senethiwekhi enezici ezintathu. Njengoba inani lama-molekyuli le-HPMC kwikhambi liyanda, ubuningi kanye namandla enhlaka yenethiwekhi kuzokhula futhi, ngaleyo ndlela kwandise ukubonwa kwesixazululo. Kodwa-ke, kunomkhawulo wokwandisa ukugxila. Ukuhlushwa okuphezulu kakhulu kwe-HPMC kuzodala ukuthi uketshezi lwekhambi lunciphe, futhi lungathinta nokusebenza kwalo kwizicelo ezithile, njengokusebenza nokusebenza.
2. Lawula izinga lokushisa lesisombululo
Ukushisa kunethonya elihle ekubolekeni nasekuboneni kwe-HPMC. Emazingeni okushisa aphansi, ukubonakala kwesisombululo se-HPMC kuphakeme; Ngesikhathi emazingeni okushisa aphezulu, i-viscosity yesisombululo se-HPMC izokwehla. Ngakho-ke, wehlisa izinga lokushisa lesisombululo ngendlela efanele ngesikhathi sokusetshenziswa kungakhulisa ukubonakala kwe-HPMC. Kumele kuqashelwe ukuthi i-solubility ye-HPMC kwikhambi ihlukile emazingeni okushisa ahlukahlukene. Ngokuvamile kulula ukuhlakaza emanzini abandayo, kepha kuthatha isikhathi esithile sokuncibilika ngokuphelele. Iyancibilikisa ngokushesha emanzini afudumele, kepha ukubonakala kuphansi.
3. Shintsha inani le-pH le-solvent
I-viscosity ye-HPMC nayo iyazwela inani le-PH lekhambi. Ngaphansi kwezimo ezingathathi hlangothi noma eziseduze, i-viscosity yekhambi le-HPMC liphezulu kakhulu. Uma inani le-PH lekhambi liphambuka ekungathathi hlangothi, i-viscosity ingancipha. Ngakho-ke, ukubonwa kwesixazululo se-HPMC kungandiswa ngokulungisa kahle inani le-PH lekhambi (ngokwesibonelo, ngokungeza i-buffer noma umlawuli wesisekelo se-acid-base). Kodwa-ke, ekusebenzeni kwangempela, ukulungiswa kwenani le-PH kufanele kuqaphele kakhulu, ngoba izinguquko ezinkulu zingadala ukonakaliswa kwe-HPMC noma ukonakaliswa kokusebenza.
4. Khetha i-solvent efanelekile
I-solubity kanye ne-viscosity ye-HPMC ezinhlelweni ezahlukahlukene ze-solvent zihlukile. Yize i-HPMC isetshenziswa kakhulu kwizixazululo zamanzi, ukwengezwa kwezinye ze-solvents ze-organic (njenge-ethanol, i-isopropanol, njll. Isibonelo, inani elincane le-organic solvent linganciphisa ukuphazanyiswa kwama-molecule amanzi ku-HPMC, ngaleyo ndlela kwandise ukubonwa kwesixazululo. Ngokusebenza okuthile, kuyadingeka ukukhetha izixazululo ezifanele ze-organic ngokuya ngohlelo lokusebenza langempela.
I-5. Sebenzisa izinsizakusebenza zokuqina
Kwezinye izimo, ezinye izinsiza zokuqina zingangezwa ku-HPMC ukufeza umphumela wokwanda kwe-viscosity. Ingculazi esetshenziswa kaningi ifaka i-Xanthan Gum, iGum Gum, i-Carbomer, njll. Lezi izengezo zisebenzisana nama-molecule we-HPMC ukwakha isixazululo. Isibonelo, i-Xanthan Gum iyi-polysaccharide yemvelo enomphumela oqinile wokuqina. Uma isetshenziswa nge-HPMC, lokhu kungakha umphumela wokuvumelanisa futhi kukhuphule kakhulu ukubonakala kohlelo.
6. Shintsha izinga lokufaka esikhundleni se-HPMC
I-viscosity ye-HPMC ihlobene ne-degree yokufaka esikhundleni samaqembu awo we-methoxy ne-hydroxypropopoxy. Izinga lokufakwa esikhundleni lithinta i-solubility yalo kanye nokubonakala kwesixazululo. Ngokukhetha i-HPMC enamazinga ahlukene wokufaka esikhundleni, i-viscosity yesixazululo ingashintshwa. Uma kukhethwa i-HPMC ephakeme ye-HPMC, umkhiqizo onokuqukethwe okuphezulu kwe-methoxy kungakhethwa, ngoba okuqukethwe okuphezulu kwe-methoxy, okunamandla kwe-hydrophobicity ye-HPMC, kanye nokubonakala ngemuva kokuqothuka kuphakeme kakhulu.
7. Nweba isikhathi sokuqothula
Isikhathi lapho i-HPMC inciphisa izothinta khona ukuhlakanipha kwayo. Uma i-HPMC ingachinjiswa ngokuphelele, i-viscosity yesisombululo ngeke ifinyelele esimweni esifanele. Ngakho-ke, ukunweba isikhathi esifanele sokuqothula isikhathi se-HPMC emanzini ukuqinisekisa ukuthi i-HPMC igcwele ama-hydrate ingakhulisa ngempumelelo ukubonwa kwesixazululo sayo. Ikakhulu lapho ukuncibilika emazingeni okushisa aphansi, inqubo yokuqothula i-HPMC ingahle ithambeze, futhi ukunweba isikhathi kubalulekile.
8. Shintsha izimo ze-shear
I-viscosity ye-HPMC nayo ihlobene ne-Shear Force ifakwa ngaphansi kokusetshenziswa. Ngaphansi kwezimo eziphakeme eziphakeme, i-viscosity yesisombululo se-HPMC izokwehla okwesikhashana, kepha lapho ama-shear eyeka, i-viscosity izolulama. Ngezinqubo ezidinga ukwanda kokubonakala, amandla e-shear lapho kufakwa khona isixazululo kungancishiswa, noma kungasetshenziswa ngaphansi kwezimo eziphansi zokuthola amandla aphezulu.
9. Khetha isisindo se-molecular esilungile
Isisindo se-molecular se-HPMC sithinta ngqo ukubonakala kwaso. I-HPMC ngesisindo esikhulu samangqamuzana yakha isakhiwo senethiwekhi esikhudlwana kwikhambi, okuphumela ekubonakaleni okuphezulu. Uma udinga ukwandisa i-viscosity ye-HPMC, ungakhetha imikhiqizo ye-HPMC ngesisindo esiphakeme se-molecular. Yize i-HPMC 15 CPS ingumkhiqizo ophansi we-viscosity, i-viscosity ingandiswa ngokukhetha isisindo esiphakeme kakhulu somkhiqizo ofanayo.
10. Cabanga ngezici zezemvelo
Izici zezemvelo ezifana nomswakama nengcindezi nazo zingaba nomthelela othile ekubonakaleni kwesisombululo se-HPMC. Emvelweni ophezulu womswakama, i-HPMC ingadonsa umswakama ovela emoyeni, okwenza ukuba ukubonakala kwayo kunciphe. Ukuze ugweme lokhu, izimo zezemvelo zokwenziwa noma indawo yokusebenzisa zingalawulwa kahle ukuze imvelo yomile futhi isengcindezi efanelekile yokulondolozwa kwesisombululo se-HPMC.
Kunezindlela eziningi zokwandisa i-viscosity yesisombululo se-HPMC 15 CPS, okubandakanya ukugxila okwandayo, okulawulwa kokushisa, ukuguqula i-aids ethambekele, ukhetha i-degree efanelekile yokufaka esikhundleni kanye nesisindo se-molecular, njll. Indlela ethize okufanele ikhethwe incike ekusetshenzisweni kwangempela isimo nezidingo zenqubo. Ekusebenzeni kwangempela, kuvame ukudingekile ukuze ucabangele ngokugcwele izici eziningi futhi wenze izinguquko ezinengqondo kanye nokwenza kahle ukuze kuqinisekiswe ukusebenza okuhle kakhulu kwesisombululo se-HPMC kuzinhlelo ezithile.
Isikhathi sePosi: Oct-16-2024