Izinga lei-hydroxypropyl methylcellulose (HPMC)ingahlolwa ngezinkomba eziningi. I-HPMC iphuma ku-cellulose esetshenziswa kabanzi embonini yokwakha, yemithi, yokudla nezimonyo, futhi ikhwalithi yayo ithinta ngqo ukusebenza komkhiqizo.
1. Ukubukeka nosayizi wezinhlayiyana
Ukubonakala kwe-HPMC kufanele kube yimpushana emhlophe noma emhlophe e-amorphous. Ikhwalithi ephezulu ye-HPMC powder kufanele ibe nezinhlayiya ezifanayo, akukho agglomeration, futhi akukho ukungcola kwamanye amazwe. Ubukhulu nokufana kwezinhlayiya kuthinta ukuncibilika kwayo kanye nokuhlakazeka kwayo. I-HPMC enezinhlayiya ezinkulu kakhulu noma ezihlanganisiwe ayiphazamisi kuphela ukunyibilika, kodwa ingase futhi ibangele imiphumela engalingani yokuhlakazeka ezinhlelweni zangempela. Ngakho-ke, usayizi wezinhlayiyana ezifanayo yisisekelo sokuhlola ikhwalithi yayo.
2. Ukuncibilika kwamanzi nezinga lokuncibilika
Ukuncibilika kwamanzi kwe-HPMC kungenye yezinkomba zayo ezibalulekile zokusebenza. I-HPMC yekhwalithi ephezulu incibilika ngokushesha emanzini, futhi isisombululo esincibilikisiwe kufanele sibe sobala futhi sifane. Ukuhlolwa kokuncibilika kwamanzi kungahlulelwa ngokwengeza inani elithile le-HPMC emanzini kanye nokubheka ukuthi ingancibilika ngokushesha futhi yakhe isixazululo esizinzile. Ukuqedwa okuhamba kancane noma isisombululo esingalingani kungase kusho ukuthi ikhwalithi yomkhiqizo ayihlangabezani nezinga.
3. Izici ze-viscosity
I-viscosity ye-HPMC ingenye yemingcele ebalulekile yokuhlola ikhwalithi yayo. I-viscosity yayo emanzini ngokuvamile iyanda ngokwanda kwesisindo sayo samangqamuzana. Indlela evamile yokuhlola i-viscosity ukusebenzisa i-viscometer ejikelezayo noma i-viscometer ukukala amanani we-viscosity wezixazululo zokugxila okuhlukile. Ngokuvamile, i-HPMC yekhwalithi ephezulu kufanele ibe ne-viscosity ezinzile, futhi ukuguqulwa kwe-viscosity nokwanda kokugxila kufanele kuhambisane nomthetho othile. Uma i-viscosity ingazinzile noma ingaphansi kwebanga elijwayelekile, kungase kusho ukuthi isakhiwo sayo samangqamuzana asizinzile noma iqukethe ukungcola.
4. Okuqukethwe umswakama
Umswakamo ku-HPMC uzophinde uthinte ikhwalithi yayo. Umswakama owedlulele ungase ubangele ukuthi ibumbe noma yonakale ngesikhathi igcinwa. Izinga lokuqukethwe komswakamo ngokuvamile kufanele lilawulwe ku-5%. Izindlela zokuhlola ezifana nendlela yokomisa noma indlela ye-Karl Fischer ingasetshenziswa ukunquma okuqukethwe komswakama. Ikhwalithi ephezulu ye-HPMC inomswakama ophansi futhi ihlala yomile futhi izinzile.
5. Inani le-pH lesisombululo
Inani le-pH lesisombululo se-HPMC lingaphinda libonise ikhwalithi yalo. Ngokuvamile, inani le-pH lesisombululo se-HPMC kufanele libe phakathi kuka-6.5 no-8.5. Izixazululo ezine-asidi ngokweqile noma ezine-alkaline ngokweqile zingase zibonise ukuthi umkhiqizo uqukethe izingxenye zamakhemikhali ezingcolile noma uphathwe amakhemikhali ngendlela engafanele phakathi nenqubo yokukhiqiza. Ngokuhlolwa kwe-pH, ungakwazi ukuqonda ngokunembile ukuthi ikhwalithi ye-HPMC iyahlangabezana yini nezidingo.
6. Okuqukethwe ukungcola
Okuqukethwe ukungcola kwe-HPMC kuthinta ngokuqondile ukusebenza kwayo, ikakhulukazi emkhakheni wezokwelapha nokudla, lapho okuqukethwe kokungcola okungafanelekile kungase kuholele emikhiqizweni engaphephile noma imiphumela engemihle. Ukungcola kuvame ukufaka izinto zokusetshenziswa ezingaphendulwanga ngokuphelele, amanye amakhemikhali, noma ukungcola okukhiqizwa phakathi nenqubo yokukhiqiza. Okuqukethwe ukungcola ku-HPMC kungatholwa ngezindlela ezifana ne-high-performance liquid chromatography (HPLC) noma i-gas chromatography (GC). I-HPMC yekhwalithi ephezulu kufanele iqinisekise okuqukethwe okuphansi kokungcola futhi ihlangabezane namazinga afanelekile.
7. Ukungafihli kanye nokuzinza kwesixazululo
Ukudluliswa kwesixazululo se-HPMC futhi kuyinkomba yekhwalithi evame ukusetshenziswa. Isixazululo esinokukhanya okuphezulu nokuzinza ngokuvamile sisho ukuthi i-HPMC inobumsulwa obuphezulu futhi inokungcola okumbalwa. Isixazululo kufanele sihlale sicacile futhi sisobala phakathi nokugcinwa isikhathi eside, ngaphandle kwemvula noma imfucumfucu. Uma isixazululo se-HPMC siginqika noma siba nesiphithiphithi ngesikhathi sokulondoloza, sibonisa ukuthi singaqukatha izingxenye eziningi ezingaphenduliwe noma ukungcola.
8. Ukuzinza kwe-thermal kanye nezinga lokushisa lokubola okushisayo
Ukuhlolwa kokuzinza kwe-thermal ngokuvamile kwenziwa ngokuhlaziywa kwe-thermogravimetric (TGA). I-HPMC kufanele ibe nokusimama okuhle kokushisa futhi akufanele ibole emazingeni okushisa okusebenza avamile. I-HPMC enezinga lokushisa eliphansi lokubola okushisayo izohlangabezana nokuwohloka kokusebenza ezinhlelweni zezinga lokushisa eliphezulu, ngakho ukuzinza okuhle kokushisa kuyisici esibalulekile sekhwalithi ephezulu ye-HPMC.
9. Ukugxilisa isixazululo kanye nokungezwani kwendawo
Ukungezwani okungaphezulu kwesixazululo se-HPMC kungathinta ukusebenza kwayo kwesicelo, ikakhulukazi embotsheni nasezintweni zokwakha. Ikhwalithi ephezulu ye-HPMC inokushuba okuphansi kwendawo ngemuva kokuhlakazeka, okusiza ukuthuthukisa ukuhlakazeka kwayo kanye noketshezi emithonjeni yezindaba ehlukene. Ukuqina kwayo kwendawo kungahlolwa imitha yokucindezela komhlaba. Isixazululo esifanelekile se-HPMC kufanele sibe nokungezwani kwendawo ephansi futhi ezinzile.
10. Ukuzinza nokugcinwa
Ukuzinza kwesitoreji se-HPMC kungaphinda kubonise ikhwalithi yayo. I-HPMC yekhwalithi ephezulu kufanele ikwazi ukugcinwa ngokuzinza isikhathi eside ngaphandle kokuwohloka noma ukuwohloka kokusebenza. Lapho kwenziwa ukuhlolwa kwekhwalithi, ukuzinza kwayo kungahlolwa ngokugcina amasampula isikhathi eside nokuhlola ukusebenza kwawo njalo. Ikakhulukazi ezindaweni ezinomswakama ophezulu noma izinguquko ezinkulu zokushisa, i-HPMC yekhwalithi ephezulu kufanele ikwazi ukulondoloza izakhiwo ezinzile ngokomzimba namakhemikhali.
11. Ukuqhathaniswa kwemiphumela yokuhlolwa namazinga emboni
Okokugcina, enye yezindlela ezinembile zokunquma ikhwalithi ye-HPMC ukuyiqhathanisa namazinga omkhakha. Kuya ngenkundla yesicelo (efana nokwakhiwa, umuthi, ukudla, njll.), amazinga ekhwalithi we-HPMC ahlukile. Lapho ukhetha i-HPMC, ungabhekisela kumazinga afanelekile nezindlela zokuhlola futhi uhlanganise imiphumela yokuhlola ukuze wahlulele ngokuphelele ikhwalithi yayo.
Ukuhlolwa kwekhwalithi yeI-HPMCidinga ukucabangela izici eziningi, okuhlanganisa ukubukeka, ukuncibilika, i-viscosity, okuqukethwe ukungcola, inani le-pH, okuqukethwe komswakama, njll. Ngochungechunge lwezindlela zokuhlola ezijwayelekile, ikhwalithi ye-HPMC ingahlulelwa ngokunembile. Ngezidingo zezinkambu ezihlukene zohlelo lokusebenza, ezinye izinkomba zokusebenza ezithile zingadinga futhi ukunakwa. Ukukhetha imikhiqizo ye-HPMC ehlangabezana nezindinganiso ezifanele kungaqinisekisa ikhwalithi nokuzinza komkhiqizo wokugcina.
Isikhathi sokuthumela: Dec-19-2024