Ikhwalithi yeI-Hydroxypropyl methylcellulose (HPMC)ingahlolwa ngezinkomba eziningi. I-HPMC iyisisulu esisetshenziselwa ukwakha kabanzi ekwakhiweni, emithini, ekudleni nasezimbonini zezimonyo, futhi ikhwalithi yayo ithinta ngqo ukusebenza komkhiqizo.
1. Ukubukeka nobukhulu bezinhlayiyana
Ukuvela kwe-HPMC kufanele kube yimpuphu emhlophe noma ye-amorphous emhlophe. I-HPMC esezingeni eliphezulu ye-HPMC i-powder kufanele ibe nezinhlayiyana ezifanayo, akukho okuhlanganisiwe, futhi akukho ukungcola kwangaphandle. Ubukhulu nokufana kwezinhlayiya kuthinta i-solubility yayo nokuhlakazeka kwayo. I-HPMC enezinhlayiya ezinkulu kakhulu noma ezinama-aggggerated azithintanga nje kuphela i-soubity, kepha futhi ingadala imiphumela yokuhlakazwa okungalingani kuzinhlelo zokusebenza zangempela. Ngakho-ke, usayizi we-Uniform Particle uyisisekelo sokuhlola ikhwalithi yalo.
2. I-solubility yamanzi kanye nezinga lokuchithwa
I-solubity yamanzi ye-HPMC ingenye yezinkomba zayo ezibalulekile zokusebenza. I-HPMC esezingeni eliphakeme iyancibilikisa ngokushesha emanzini, futhi isixazululo esincibilikisiwe kufanele sibe sobala nomfaniswano. Ukuhlolwa kwe-solubity yamanzi kungahlulelwa ngokungeza inani elithile le-HPMC emanzini nokubheka ukuthi ingancibilika ngokushesha futhi yakha isisombululo esizinzile. Ukuchithwa okunciphile noma isixazululo esingalingani kungasho ukuthi ikhwalithi yomkhiqizo ayihlangabezani nezinga.
3. Izici ze-Viscosity
I-viscosity ye-HPMC ingenye yamapharamitha abalulekile wokuhlola ikhwalithi yawo. Ukubonakala kwalo emanzini kuvame ukukhuphuka ngokwanda kwesisindo sayo samangqamuzana. Indlela ejwayelekile yokuhlola i-viscosity ukusebenzisa i-vezcometer ejikelezayo noma i-visecometer ukukala amanani we-viscosity wezixazululo zokugxila okuhlukile. Ngokuvamile, i-HPMC esezingeni eliphakeme kufanele ibe nokubonakala okuzinzile, futhi ukuguquguquka okuguqukayo ngokwanda kokuhlushwa kufanele kuhambisane nomthetho othile. Uma i-viscosity ingazinzile noma ngaphansi kwebanga elijwayelekile, kungasho ukuthi isakhiwo salo se-molefanelar asizinzile noma sinokungcola.
4. Okuqukethwe umswakama
Okuqukethwe umswakama ku-HPMC kuzothinta nekhwalithi yayo. Umswakama owedlulele ungabangela ukubumba noma ukuwohloka ngesikhathi sokugcina. Izinga lokuqukethwe komswakama kufanele livame ukulawulwa ngaphakathi kwama-5%. Izindlela zokuhlola ezinjengendlela yokomisa noma indlela ye-Karl Fischer zingasetshenziswa ukuthola okuqukethwe umswakama. I-HPMC esezingeni eliphakeme inokuqukethwe komswakama okuphansi futhi kuhlala komile futhi kuyazinza.
5 Inani lekhambi lekhambi
Ivelu ye-PH yesisombululo se-HPMC nayo ingabonisa ikhwalithi yayo. Ngokuvamile, inani le-PH lesisombululo se-HPMC kufanele libe phakathi kuka-6.5 no-8.5. Izisombululo ze-Acidic noma ngokweqile zingakhombisa ukuthi umkhiqizo uqukethe izingxenye zamakhemikhali ezingezona noma aziphathwa ngendlela engafanele ngesikhathi senqubo yokukhiqiza. Ngokuhlola i-PH, ungaqonda kahle ukuthi ikhwalithi ye-HPMC ihlangabezana nezidingo.
6. Okuqukethwe ukungcola
Okuqukethwe kokungcola kwe-HPMC kuthinta ngqo ukusebenza kwayo, ikakhulukazi emkhakheni wezokwelapha nokudla, lapho okuqukethwe okungafaneleki okungekho emthethweni kungaholela emikhiqizweni engaphephile noma emiphumeleni engemihle. Ukungcola kuvame ukufaka izinto zokwakha ezingahleliwe ezingahle zisebenze, amanye amakhemikhali, noma ama-contanature akhiqizwa ngesikhathi sokukhiqiza. Okuqukethwe kokungcola ku-HPMC kungatholwa ngezindlela ezifana ne-chromatography ephezulu ye-chromatography (HPLC) noma i-chromatography yegesi (GC). I-HPMC esezingeni eliphakeme kufanele iqinisekise okuqukethwe okuvuthayo futhi ihlangabezane namazinga afanele.
7. Ukusobala nokuqina kwesisombululo
Ukudluliselwa kwekhambi le-HPMC nakho kuyinkomba yekhwalithi evame ukusetshenziswa. Isixazululo esinokubonakala okuphezulu nokuqina sivame ukusho ukuthi i-HPMC inobumsulwa obuphezulu futhi inokungcola okumbalwa. Isixazululo kufanele sihlale sicacile futhi sisobala ngesikhathi sokugcina isikhathi eside, ngaphandle kwemvula noma i-turbidity. Uma isixazululo se-HPMC sinetha noma siba turmid ngesikhathi sokugcina, kukhombisa ukuthi ingaqukatha izingxenye ezingaphenduki noma ukungcola.
8. Ukuqina okushisayo kanye nokushisa okuvumayo
Ukuhlolwa kokuqina okushisayo kuvame ukwenziwa ukuhlaziywa kwe-thermogravimetric (TGA). I-HPMC kufanele ibe nokuqina okuhle okushisayo futhi akufanele ibole kumazinga okushisa ajwayelekile wesicelo. I-HPMC ene-Thermal Dealrongonition lokushisa eliphansi lizohlangabezana nokuwohloka kokusebenza ezihlelweni zokushisa okuphezulu, ngakho-ke ukuqina okuhle okushisayo kuyisici esibalulekile se-HPMC esezingeni eliphakeme.
9. Isixazululo sokuhlushwa kanye nokungezwani komhlaba
Ukungezwani kwe-surface yekhambi le-HPMC kungathinta ukusebenza kwayo kohlelo lokusebenza, ikakhulukazi ezitsheni nasezintweni zokwakha. I-HPMC esezingeni eliphakeme inokungezwani okuphansi komhlaba ngemuva kokuchithwa, okusiza ukuthuthukisa ukungafani kwayo kanye noxhaso emithonjeni ehlukene. Ukungezwani kwayo okungaphezulu kungahlolwa ngemitha yengxabano. Isixazululo esifanelekile se-HPMC kufanele sibe nokungezwani okuqinile futhi okuzinzile komhlaba.
10. Ukuqina nokugcinwa
Ukuqina kwesitoreji kwe-HPMC kungakhombisa nekhwalithi yayo. I-HPMC esezingeni eliphakeme kufanele ikwazi ukugcinwe ngokukhethekile isikhathi eside ngaphandle kokuwohloka noma ukonakaliswa kokusebenza. Lapho uqhuba ukuhlolwa kwekhwalithi, ukuqina kwayo kungahlaziywa ngokugcina amasampula isikhathi eside futhi uhlole ukusebenza kwawo njalo. Ikakhulu ezindaweni ezinomswakama ophezulu noma izinguquko ezinkulu zokushisa, i-HPMC esezingeni eliphakeme kufanele ikwazi ukugcina izakhiwo ezizinzile zomzimba nezamakhemikhali.
11. Ukuqhathaniswa kwemiphumela yokuhlola ngamazinga wezimboni
Ekugcineni, enye yezindlela ezinembile kakhulu zokuthola ikhwalithi ye-HPMC ukuyiqhathanisa namazinga embonini. Kuya ngomkhakha wohlelo lokusebenza (njengokwakha, umuthi, ukudla, njll.), Amazinga ekhwalithi we-HPMC ahlukile. Lapho ukhetha i-HPMC, ungabheka amazinga afanele nezindlela zokuhlola futhi uhlanganise imiphumela yokuhlola ukuze ahlulele ngokuphelele ikhwalithi yawo.
Ukuhlolwa kwekhwalithi yeI-HPMCIzidingo zokucabanga ngezinto eziningi, okubandakanya ukubukeka, ukuzunguzela, okuqukethwe okunokuvuselelwa, okuqukethwe okungcolile, inani le-PH, okuqukethwe umswakama, ikhwalithi ye-HPMC ingahlulelwa ngokwengeziwe. Ngezidingo zezinkundla ezihlukile zohlelo lokusebenza, ezinye izinkomba zomsebenzi ezithile nazo zingadinga ukunakekelwa. Ukukhetha imikhiqizo ye-HPMC ehlangabezana namazinga afanele angaqinisekisa ikhwalithi nokuqina komkhiqizo wokugcina.
Isikhathi Seposi: Dece-19-2024