Izici ze-HPMC Nemisebenzi

I-Hydroxypropyl Methylcellulose (HPMC) iyi-polymer esebenzayo enezicelo ezibanzi ezimbonini ezahlukahlukene ezinjengezemithi, ukwakhiwa, ukudla, izimonyo, njll. Izakhiwo zayo ezahlukahlukene emikhiqizweni eminingi. Nakhu ukuhlola okujulile kwe-HPMC:

1. Izici ze-HPMC:

Isakhiwo samakhemikhali: I-HPMC isuselwa ku-cellulose, i-polymer yemvelo etholakala ezitshalweni. Ihlanganiswe ngokushintsha amakhemikhali ngokuguqula iselula nge-propelllene oxide ne-methyl chloride. Izinga lokufaka esikhundleni se-hydroxypropyl kanye namaqembu we-methoxy anquma izakhiwo zalo.

I-Solubinity: I-HPMC iyancibilika emanzini ngaphezu kwebanga lokushisa elibanzi. I-solubinity incike ngezinga lokufakwa esikhundleni kanye nesisindo se-polymer. Amazinga aphezulu aphezulu aholela ekukhulisweni kwamanzi.

I-Viscosity: I-HPMC ikhombisa indlela yokuziphatha eshintshashintshayo noma ukuncipha okunciphisayo, okusho ukuthi ukubonakala kwayo kuncipha ngaphansi kwengcindezi ye-shear. I-viscosity yezixazululo ze-HPMC ingashintshwa ngokulungiswa kwamapharamitha anjengesisindo samangqamuzana, izinga lokufaka esikhundleni, kanye nokuhlushwa.

Ukwakheka kwamafilimu: Amafilimu we-HPMC acacile futhi avumelana nezimo lapho akhishwe kwisixazululo. Izakhiwo zefilimu zingashintshwa ngokulungisa ukugxilwa kwe-polymer kanye nokuba khona kwamapulasitiki.

Ukuqina okushisayo: I-HPMC inokuqina okuhle okushisayo, ngamazinga okushisa okubola ngokuvamile ngenhla kwama-200 ° C. Lokhu kwenza ilungele izindlela ezahlukahlukene zokucubungula, kufaka phakathi ukukhishwa okushisayo okushisayo nokubumba okushisayo.

I-Hydrophicility: Ngenxa yemvelo yayo ye-hydrophilic, i-HPMC ingakwazi ukumunca futhi igcinwe amanani amakhulu amanzi. Le mpahla inenzuzo kuzinhlelo zokusebenza ezinjengokulethwa kwezidakamizwa ezilawulwayo kanye ne-ejenti yokuqina ezinhlelweni zamashele.

Ukuvumelana: I-HPMC iyahambisana nezinye izinto zokwenziwa, kufaka phakathi amanye ama-polymers, amapulasitiki, nezithako ezisebenzayo zemithi (API). Lokhu kuhambisana kuvumela amasistimu ayinkimbinkimbi azokwakhiwa ngezinto ezenziwe ngezifiso.

Izakhiwo ezingezona eze-ionic: I-HPMC iyi-polymer engeyona eye-ionic, okusho ukuthi ayiphathi noma iyiphi imali kagesi. Le mpahla inciphisa ukusebenzisana kwezinhlobo ezikhokhiswayo ekwakhekeni futhi ithuthukisa ukuqina kwayo kwisixazululo.

Imisebenzi ye-2.HPMC:

Ama-Binders: Ngokuya kwethebhulethi, i-HPMC isebenza njenge-binder, ukukhuthaza ukunamathela phakathi kwezinhlayiya nokwandisa amandla okusebenza kwethebhulethi. Kuyasiza futhi amaphilisi ahlukaniswe ngemuva kokuthola.

I-Film coating: I-HPMC isetshenziswa kabanzi njenge-ejenti ye-coating yefilimu yamathebulethi kanye nama-caplule. Kwakha umfaniswano wokuhlobana, ovikelayo ohlanganisa ukunambitheka nephunga lesidakamizwa, kuthuthukisa ukuqina, futhi kusiza ukugwinya.

Ukukhishwa okulondoloziwe: I-HPMC ingasetshenziswa ukulawula isilinganiso sokukhishwa kwezidakamizwa kusuka kumafomu wamadosi amakharmaceutical dosage. Nge-hydrating ukwakha ungqimba lwejeli, i-HPMC ingabambezela ukukhishwa kwezidakamizwa futhi inikeze imiphumela yokwelapha eqhubekayo.

I-VisCosity Modifier: ezinhlelweni zamashele, i-HPMC isebenza njengesiguquli se-viscosity noma isikhunzi. Inika amandla okugeleza kokugeleza kwe-pseudoplastic, ethuthukisa ukuqina nokusebenza kohlelo lokusebenza kokwenziwa okufana nokhilimu, ama-lotion nama-gels.

Umenzeli osomisayo: I-HPMC isetshenziselwa izinti lokumiswa kwezinhlayiya ezisetshenziswayo ekwakhiweni koketshezi. Kuvimbela ukuzinza ngokwandisa i-viscosity yesigaba esiqhubekayo nokuthuthukisa ukuhlakazeka kwezinhlayiya.

I-Emulsifier: Kumakhiwo e-Emulsion, i-HPMC iqinisa ukuxhumana phakathi kwezigaba zamafutha nezinzipho, ukuvimbela ukuhlukaniswa kwesigaba kanye nokwahlukaniswa kwe-emulsation. Kuthuthukisa ukuqina nokuqina kweshelufu kwe-lotion emikhiqizweni efana nokhilimu, amafutha kanye ne-lotions.

Ukwakheka kwe-Hydrogel: I-HPMC ingakha ama-hydrogels lapho i-hydrate, okwenza kube lusizo ekugqokeni izinxephezelo, amalensi wokuxhumana, kanye nezinhlelo zokulethwa kwezidakamizwa. Lawa ama-hydrogels anikezela indawo enomswakama yokuphulukiswa kwezilonda futhi ingalayishwa ngezidakamizwa zokulethwa kwasendaweni.

Umenzeli wokuqina: I-HPMC ivame ukusetshenziswa njenge-ejenti yokuqina emikhiqizweni yokudla efana nososo, ukugqoka kanye nama-dessert. Inika umdwebo obushelelezi futhi ithuthukisa ukunambitheka ngaphandle kokushintsha ukunambitheka noma okuqukethwe okunempilo.

Izengezo Zokwakha: embonini yezokwakha, i-HPMC isetshenziswa njenge-ejenti yokugcina amanzi kuma-majenti asuselwa kusazi kanye nama-porsis. Kuthuthukisa ukusebenziseka, ukunamathela, futhi kunciphise ukuqhekeka ngokunciphisa ukuhwamuka kwamanzi.

I-Surface Modifier: I-HPMC ingashintsha izakhiwo ezingaphezulu kwezindawo ezihlanganisiwe ezifana nephepha, izindwangu nama-ceramics. Kuthuthukisa ukuphrinta, ukunamathela kanye nezithiyo zezakhiwo zezimbali namafilimu.

I-Hydroxypropymethylcelcelcellellulose (HPMC) iyinhlangano eguquguqukayo enezabelo ezahlukahlukene nemisebenzi. I-solubility yayo, i-viscosity, ikhono elakha amafilimu kanye nokuhambisana kwenza kube yisithako esisemqoka kuzinhlelo eziningi ezisetshenziselwa izimboni. Ukusuka emikhakheni ekwakheni, ukudla kwezimonyo, i-HPMC iyaqhubeka nokudlala indima ebalulekile ekwenzeni ngcono ukusebenza komkhiqizo nekhwalithi. Njengocwaningo kanye nobuchwepheshe kusengaphambili, ukuguquguquka okuhlukahlukene kanye nokusetshenziswa kwe-HPMC kungahle kwandise, ukushayela okusha ekwakheni ukwakhiwa kanye nokuthuthukiswa komkhiqizo.