Izakhiwo ze-HPMC nezicelo

I-HPMC ibizwa ngokuthi yi-hydroxypropyllylylym methylcellulose.

Umkhiqizo we-HPMC ukhetha kakhulu ukotini wekotini njengezinto ezingavuthiwe futhi zenziwa ngokuthezeka okukhethekile ngaphansi kwezimo ze-alkali. Yonke inqubo iqedwa ngaphansi kwezimo ze-GMP kanye nokuqapha okuzenzakalelayo, ngaphandle kwezithako ezisebenzayo njengezitho zezilwane kanye namafutha.

Izakhiwo ze-HPMC:

Umkhiqizo we-HPMC ayi-ether engeyona eye-moulvu umsebenzi, ukucaca okuphezulu nokusebenza okuzinzile. I-HPMC inezindawo zejeli eshisayo, isixazululo samanzi omkhiqizo sifuthelwa ukwakha imvula ye-gel, bese sichithwa ngemuva kokupholisa, ukucaciswa okuhlukile kokushisa kwe-gel ye-GEL yehlukile. Ukushintshwa kwe-Solubity nge-viscosity, kwehlisa i-viscosity, kukhuphuka kakhulu i-solubity, ukucaciswa okuhlukile kwe-HPMC kunomehluko othile kwizakhiwo zayo, i-HPMC emanzini ayithintwa yinani le-PH. Ubukhulu bezinhlayiyana: Izinga lokuphasa le-100 Mesh likhulu kune-100%. Ubuningi be-Bulk: 0.25-0.70g / (imvamisa cishe ngo-0.5g /), amandla athile adonsela phansi 1.26-1.31. Ukushisa kwe-Discoloration: 190-200 ℃, lokushisa le-carbonization: 280-300 ℃. Ukungezwani komhlaba: 42-56dyn / cm ngesisombululo esingamanzi esingu-2%. Ngokukhuphuka kokuqukethwe kwe-methoxyl, iphuzu lejeli lehlile, i-soubelity yamanzi yanda, futhi umsebenzi ongaphezulu wanda. I-HPMC inezimpawu zokuqina, usawoti, okuqukethwe okuphansi komlotha, ukugcinwa kwamanzi, ukuqina kwamanzi, ukumelana okuhle kwefilimu kanye nokumelana okuningana ku-enzyme, isabalalelo kanye nokubumbana.

Izicelo ze-HPMC:

1. I-Tablet Coating: I-HPMC esetshenziswe njengezinto ezihlanganisiwe zefilimu ezilungiselelweni eziqinile, ingakha ifilimu eqinile, ebushelelezi futhi enhle, ukusetshenziswa kwe-2% -8%. Ngemuva kokuhlanganisa, ukuqina kwe-ejenti ukuKhanya, ukushisa kanye nomswakama kuyanda; Akunambitha futhi aphulukile, kulula ukuthatha, kanye ne-hpmc pigment, i-sunscreen, ama-lubrics nokunye ukuhambisana okuhle kwezinto zokwakha. Ukuhlanganiswa okujwayelekile: Amanzi noma ama-30-80% e-ethanol ukuncibilikisa i-HPMC, ngesisombululo esingu-3-6%, engeza izithako ezishubile (ezifana: i-castor lamafutha -80, i-PEGC, PEC400, i-talc, njll.).

2. I-EnterIC-soluble coating ihlukanise: ngaphezulu kwamathebulethi kanye nama-granules, i-HPMC coating isetshenziswa okokuqala njengesendlalelo se-lolation esingezansi, bese ihlanganiswa nesendlalelo se-hpmcp excuble soluble. Ifilimu le-HPMC lingathuthukisa ukuqina kwe-ejenti ye-Exeble-seluble-soluble coating kwisitoreji.

I-3. Ukulungiselela Ukukhishwa Okuqhubekayo: Kusetshenziswa i-HPMC njengomenzeli odubula i-pores

4. I-ejenti yokuqina kanye nokuzivikela okunama-colloid wokuzivikela kanye namaconsi esweni

I-5. Adhesive: I-HPMC njengokuhlushwa okujwayelekile okujwayelekile kwe-2% -5%, esetshenziselwa ukuthuthukisa ukuqina kwe-hydrophobic adhesive, ukuhlanganiswa okuvame ukusetshenziswa kwe-0.5-1.5%.

6. Ukulibala i-ejenti, i-ejenti yokukhishwa elawulwa kanye ne-ejenti yokumiswa. Umenzeli wokumiswa: umthamo ojwayelekile we-ejenti yokumiswa ngu-0.5-1,5%.

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8. Isetshenziswa kwezimonyo ngezimonyo njengezinhloso, ama-emulsifiers, ama-ejenti akha amafilimu, njll.