I-Hydroxypropyl methylcellulose (HPMC)isetshenziswa njengenye yezinto ezisiza kakhulu kwezemithi ekhaya naphesheya. I-HPMC ingasetshenziswa njenge-ejenti yokwakha ifilimu, i-adhesive, i-ejenti yokukhululwa okuqhubekayo, i-ejenti yokumiswa, i-emulsifier, i-ejenti ehlakazayo, njll.
Ama-excipients emithi ayingxenye ebalulekile yamalungiselelo emithi, futhi indima yabo ukuqinisekisa ukuthi izidakamizwa zihanjiswa ngokukhetha ezicutshini ngendlela ethile kanye nenqubo, ukuze izidakamizwa zikhishwe emzimbeni ngesivinini nesikhathi esithile. Ngakho-ke, ukukhethwa kwezinto ezisizayo ezifanelekile kungenye yezinto ezibalulekile zomphumela wokwelapha wamalungiselelo emithi.
1 Izakhiwo ze-HPMC
I-HPMC inezici eziningi abanye abasizi abangenazo. Inoncibilika kahle kakhulu emanzini abandayo. Uma nje yengezwe emanzini abandayo futhi inyakaziswa kancane, ingancibilika ibe yisixazululo esisobala. Ngokuphambene nalokho, empeleni ayincibiliki emanzini ashisayo angaphezu kuka-60E futhi ingancibilika kuphela. Ingabe i-non-ionic cellulose ether, isixazululo sayo asinayo i-ionic charge, kanye nosawoti wensimbi noma ama-ionic organic compounds, ukuze kuqinisekiswe ukuthi i-HPMC ayiphenduli nezinye izinto zokusetshenziswa ekulungiseni inqubo yokukhiqiza. Ngokuphikisana nokuzwela okuqinile, kanye nokwanda kwesakhiwo samangqamuzana wezinga lokushintshwa, ukulwa nokuzwela kuyathuthukiswa, kusetshenziswa i-HPMC njengezidakamizwa ezisizayo, ngokuhlobene nokusetshenziswa kwezinye izidakamizwa zendabuko (isitashi, i-dextrin, impuphu kashukela) izidakamizwa, izinga lesikhathi esisebenzayo lizinzile. Ine-inertia ye-metabolic. Njengezinto ezisizayo zemithi, ayikwazi ukuguqulwa noma ukumuncwa, ngakho-ke ayihlinzeki ngamakholori emithini nasekudleni. Inokusebenza okuyingqayizivele kwenani eliphansi le-calorific, imithi engenawo usawoti kanye ne-non-allergenic nokudla okudingekayo kubantu abanesifo sikashukela. I-HPMC izinze kakhulu ku-asidi ne-alkali, kodwa uma idlula i-pH2~11 futhi ingaphansi kwezinga lokushisa eliphezulu noma isikhathi sokulondoloza sinde, i-viscosity izoncipha. Isixazululo esine-aqueous sinikeza umsebenzi ongaphezulu futhi siveza ukungezwani kwendawo okumaphakathi kanye namanani wokungezwani phakathi kobuso. Ine-emulsification esebenzayo ohlelweni lwezigaba ezimbili futhi ingasetshenziswa njengesiqinisi esisebenzayo kanye ne-colloid evikelayo. Isixazululo se-Aqueous sinezakhiwo ezinhle kakhulu zokwakha ifilimu futhi siyinto enhle yokuhlanganisa amaphilisi namaphilisi. Ifilimu eyakhiwe yiyo ayinambala futhi iqinile. Ipulasitiki yayo nayo ingandiswa ngokungeza i-glycerol.
2.Ukusetshenziswa kwe-HPMC ekukhiqizeni ithebhulethi
2.1 Yenza ngcono ukuhlakazwa
Ukusebenzisa isixazululo se-ethanol se-HPMC noma isisombululo samanzi njenge-ejenti yokumanzisa i-granulation, ukuze kuthuthukiswe ukuqedwa kwamaphilisi, umphumela uyamangalisa, futhi ucindezelwe ubulukhuni befilimu bungcono, ukubukeka okubushelelezi. Ukunyibilika kwethebhulethi ye-Renimodipine: ukunyibilika kwe-adhesive kwaba ngu-17.34% no-28.84% lapho okunamathelayo kungu-40% ethanol, 5% polyvinylpyrrolidone (40%) isixazululo se-ethanol, 1% sodium dodecyl sulfate (40%) isixazululo se-ethanol, 3% HP 10% isitashi uginindela, 3% HPMC isixazululo, 5% HPMC isixazululo, ngokulandelana. 30.84%, 75.46%, 84.5%, 88%. Izinga lokuncibilika lamaphilisi e-piperic acid: lapho okunamathelayo kungu-12% ethanol, 1% HPMC(40%) isixazululo se-ethanol, 2% HPMC(40%) isixazululo se-ethanol, 3% HPMC(40%) isixazululo se-ethanol, izinga lokuchithwa ngu-80.94% , 86.23%, 90.45%, 99.88%, ngokulandelana. Izinga lokuqedwa kwamaphilisi e-Cimetidine: lapho okunamathelayo bekuyi-10% isitashi slurry kanye nesixazululo se-ethanol esingu-3% se-HPMC (40%), izinga lokuchithwa lalingu-76.2% no-97.54%, ngokulandelana.
Kusukela kudatha engenhla, kungabonakala ukuthi isixazululo se-ethanol kanye nesisombululo se-aqueous se-HPMC sinomthelela wokuthuthukisa ukuqedwa kwezidakamizwa, okuwumphumela wokumiswa kanye nomsebenzi ongaphezulu we-HPMC, ukunciphisa ukungezwani okungaphezulu phakathi kwesixazululo kanye izidakamizwa eziqinile, okwandisa umswakama, okuvumela ukuqedwa kwezidakamizwa.
2.2 Thuthukisa ikhwalithi yokunamathela
I-HPMC njengezinto zokwakha ifilimu, uma kuqhathaniswa nezinye izinto zokwakha ifilimu (i-acrylic resin, i-polyethylene pyrrolidone), inzuzo enkulu kakhulu ukuncibilika kwayo kwamanzi, ayidingi izinyibilikisi eziphilayo, ukusebenza okuphephile, okulula. FuthiI-HPMCinezinhlobonhlobo zokucaciswa kwe-viscosity, ukukhetha okufanele, ikhwalithi yefilimu yokugqoka, ukubukeka kungcono kunezinye izinto. Amaphilisi e-Ciprofloxacin hydrochloride angamaphilisi amhlophe angenalutho anezinhlamvu ezizinhlangothi ezimbili. Lawa maphilisi e-coating yefilimu emincane anzima, ngokusebenzisa ukuhlolwa, ukukhetha i-viscosity ye-50 mpa # s ye-plasticizer encibilikayo emanzini, anganciphisa ukucindezeleka kwangaphakathi kwefilimu encane, ithebhulethi yokugqoka ngaphandle kwebhuloho / ukujuluka 0, 0, 0, 0 / orange uwoyela ocwebile/ukwazi ukungena, 0/uqhekeko, njengenkinga yekhwalithi, ukwakheka kwefilimu ewuketshezi, ukunamathela okuhle, nokuletha unqenqema lwamagama ngaphandle kokuvuza, kuyafundeka, Uhlangothi olulodwa elikhanyayo, elihle. Uma kuqhathaniswa noketshezi olujwayelekile lokumboza, lesi sidakamizwa silula futhi sinengqondo, futhi izindleko ziyancipha kakhulu.
Isikhathi sokuthumela: Apr-25-2024