I-Hydroxypropyl methylcellulose (HPMC)isetshenziswa njengomunye wabaningi be-excipietietieticals enkulu kakhulu ekhaya nakwamanye amazwe. I-HPMC ingasetshenziswa njenge-ejenti yokwakha amafilimu, ukunamathela, i-ejenti yokukhishwa okuqhubekayo, i-ejenti yokumiswa, i-emulsifier, i-ejenti ehlukanisayo, njll.
Ama-Execipieetietietietietical Exechipuents ayingxenye ebalulekile yamalungiselelo emithi, kanye nendima yawo ukuqinisekisa ukuthi izidakamizwa zihanjiswa izicubu ngendlela ethile nenqubo, ukuze izidakamizwa zikhishwe emzimbeni ngesivinini esithile nangesikhathi esithile. Ngakho-ke, ukukhethwa kwama-Excipients afanelekile kungenye yezinto ezibalulekile zezokwelapha zokwelapha amakhambi.
1 Izakhiwo ze-HPMC
I-HPMC inezimpawu eziningi ezingenazo ezinye izinto zenjabulo. Ine-solubility yamanzi enhle kakhulu emanzini abandayo. Uma nje ingezwe emanzini abandayo futhi ivuswe kancane, ingancibilika kwikhambi elisobala. Ngokuphambene nalokho, ngokuyisisekelo kuncibilika emanzini ashisayo ngenhla kwe-60e futhi kungahlukana kuphela. Ingabe i-ether ye-cellulose engeyona eye-ionic, isixazululo saso asinalo imali ekhokhwayo, nosawoti wensimbi noma amakhompiyutha we-onic organic, ukuze aqinisekise ukuthi i-HPMC ayisebenzi nezinye izinto eziluhlaza enqubweni yokukhiqiza ukulungisa. Ngokuzwela okuqinile, futhi ngokwanda kwesakhiwo samangqamuzana esinqunyelwe esikhundleni sokufakwa esikhundleni, ukuzwela okulwa nakho kuyathuthuka, kusetshenziswa izidakamizwa ezinamanyala, isitabane, i-sugad powder), ikhwalithi yesikhathi esisebenzayo sizinzile kakhulu. Ine-metabolic inertia. Njengezinto ezisetshenziswayo zezemithi, akunakulinganiswa noma kuthathwe, ngakho-ke akukunikezeli amakhalori kwezokwelapha nokudla. Inokusebenza okuhlukile kwenani eliphansi le-calorific, umuthi ongenawo usawoti futhi ongewona owokuhle kanye nokudla okudingekayo ngabantu abanesifo sikashukela. I-HPMC iyenzile kakhulu i-acid ne-alkali, kepha uma idlula i-PH2 ~ 11 futhi ifakwa ngaphansi kwamazinga okushisa aphezulu noma isikhathi sokugcina kukude, i-viscosity izoncishiswa. Isixazululo samanzi sinikeza umsebenzi ongaphezulu futhi siveza ukungezwani okulinganiselayo kwezingxabano kanye namanani wokungezwani kwezingcingo. Ine-emulsation ephumelelayo kusistimu yesigaba ezimbili futhi ingasetshenziswa njenge-stabilizer ephumelelayo ne-colloid evikelayo. Isixazululo samanzi sinezakhiwo ezinhle kakhulu zefilimu eyakha futhi ziyinto enhle yokuhlangana yamathebulethi namaphilisi. Ifilimu eyakhiwa yi-Colourless futhi linzima. Ipulasitiki yayo nayo ingakhula ngokungeza i-glycerol.
2.Ukukusiza kwe-HPMC ekukhiqizeni ithebhulethi
2.1 Thuthukisa ukuqedwa
Kusetshenziswa isixazululo se-HPMC e-Ethanol noma ikhambi elinamanzi njenge-ejenti enamanzi yokuthambekela, ngokwenza ngcono ukuchithwa kwamathebulethi, umphumela uyamangalisa, futhi ucindezelwe kubulukhuni befilimu bungcono, ukubukeka bushelelezi. I-Solubity yeThebhulethi yeRenimodipine: I-solubity of adhesive yayingu-17.34% no-28.84% lapho isixazululo se-ethanol esingu-40%), i-3% i-HPMC ichithwe ku-10% isixazululo sesitayela, i-5% HPMC, 5% Isixazululo se-HPMC, ngokulandelana. I-30.84%, 75.46%, 84.5%, 88%. Izinga lokuchithwa kwamathebulethi e-piperic acid: Lapho ukunamathela kuyi-12% ethanol, 1% HPMC (40%) Isixazululo se-Ethanol, ama-80%), ama-80.45%, 90.88%, ngokulandelana. Izinga lokuchithwa kwamathebulethi e-CICETIDINE: Lapho ukunamathela bekungu-10% starch slurry kanye ne-3% hpmc (40%) HPMC (40%) Isixazululo se-Ethanol, izinga lokuchithwa lalingu-76.2% no-97.54%, ngokulandelana.
Ukusuka kwidatha engenhla, kungabonakala ukuthi isixazululo se-ethanol kanye nekhambi lamanzi le-HPMC linomphumela wokwenza ukungcoliswa kwezidakamizwa, okuwumsebenzi ongaphezulu we-HPMC, okunciphisa umswakama oqinile, okukhulisa umswakama wezidakamizwa.
2.2 Thuthukisa ikhwalithi ye-coating
I-HPMC njengezinto zokwakha amafilimu, uma iqhathaniswa nezinye izinto zokwakha amafilimu (i-acrythen resin, i-polyethylene pyrlolidone), inzuzo enkulu kunazo zonke i-solubity yayo yamanzi, awudingi izixazululo ze-organic, ukusebenza okuphephile, okulula. Na-I-HPMCInezincazelo ezahlukahlukene ze-viscosity, ukukhetha okufanele, ikhwalithi yefilimu ehlanganayo, ukubukeka kungcono kunezinye izinto zokwakha. Amaphilisi we-ciprofloxacin hydrochloride amaphilisi amhlophe acwebezelayo anezincazelo ezinamacala ahlangene. Lawa maphilisi ama-coating amafilimu anzima, ngokuhlolwa, ukhetha i-viscosity yama-mpla angama-50 # s we-clisticle yefilimu, i-admealial film, i-adhealion admealing, i-adhesion anchesionity adree ngaphandle kokuvuza, okuhle, okukodwa. Uma kuqhathaniswa noketshezi lwezinhlangothi zendabuko, lo mbhalo ulula futhi unengqondo, futhi izindleko zincishiswe kakhulu.
Isikhathi sePosi: APR-25-2024