IHydroxypropyl methyl cellulose ne-carboxymethyl cellulose sodium ingaxutshwa

I-Hydroxypropyl methyl cellulose (HPMC) kanye ne-carboxymethyl cellulose sodium (CMC) yizinto ezimbili eziphuma ku-cellulose ezisetshenziswa kabanzi ezimbonini ezahlukahlukene ngenxa yezakhiwo nokusebenza kwazo okuhlukile. Ngenkathi zombili zingama-polymers asekelwe ku-cellulose, ziyahluka ngesakhiwo sawo samakhemikhali kanye nezakhiwo, okuwenza afanelekele ukusetshenziswa okuhlukile. Nokho, kwezinye izimo, zingaxutshwa ukuze kuzuzwe izici ezithile zokusebenza noma ukuthuthukisa izici ezithile zomkhiqizo wokugcina.

IHydroxypropyl methyl cellulose (HPMC), eyaziwa nangokuthi i-hypromellose, i-non-ionic cellulose ether etholakala ku-cellulose ye-polymer yemvelo. Ihlanganiswa ngokusabela kwe-alkali cellulose nge-propylene oxide ne-methyl chloride. I-HPMC isetshenziswa kakhulu kwezemithi, izinto zokwakha, imikhiqizo yokudla, nezimonyo ngenxa yezakhiwo zayo ezinhle kakhulu zokwakha ifilimu, ukuqina, ukubopha, kanye nezindawo zokugcina amanzi. I-HPMC itholakala kumabanga ahlukahlukene anamazinga ahlukene e-viscosity, okuvumela ukusetshenziswa kwayo ezinhlobonhlobo zezinhlelo zokusebenza.

Ngakolunye uhlangothi, i-carboxymethyl cellulose sodium (CMC) iphuma emanzini e-anionic cellulose etholakala ngokusabela kwe-cellulose nge-sodium hydroxide ne-chloroacetic acid. I-CMC yaziwa ngomthamo wayo ophezulu wokugcina amanzi, ikhono lokujiya, izakhiwo zokwakha ifilimu, nokuzinza ezinhlobonhlobo zezimo ze-pH. Ithola izinhlelo zokusebenza emikhiqizweni yokudla, kwezemithi, kwezimonyo, kwezindwangu, nasekukhiqizeni amaphepha ngenxa yokuguquguquka kwayo kanye nokuhambisana kwayo nezinto eziphilayo.

Ngenkathi i-HPMC ne-CMC zabelana ngezinto ezithile ezijwayelekile njengokuncibilika kwamanzi nekhono lokwenza ifilimu, ziphinde zibonise izici ezihlukile ezizenza zifanelekele izinhlelo zokusebenza ezithile. Isibonelo, i-HPMC ikhethwa ekwenziweni kwemithi njengamaphilisi namaphilisi ngenxa yezakhiwo zayo zokukhishwa okulawulwayo kanye nokuhambisana nezithako ezisebenzayo zemithi. Ngakolunye uhlangothi, i-CMC ivamise ukusetshenziswa emikhiqizweni yokudla efana namasoso, okokugqoka, nezinto ezibhakwayo njenge-ejenti yokujiya kanye nesiqinisi.

Ngaphandle komehluko wazo, i-HPMC ne-CMC zingaxutshwa ndawonye ekwakhiweni okuthile ukuze kuzuzwe imiphumela ye-synergistic noma ukuthuthukisa izici ezithile. Ukuhambisana kwe-HPMC ne-CMC kuncike ezintweni ezimbalwa ezifana nesakhiwo sazo samakhemikhali, isisindo samangqamuzana, izinga lokushintshwa, kanye nezici ezifiswayo zomkhiqizo wokugcina. Uma kuhlanganiswe ndawonye, ​​i-HPMC ne-CMC ingabonisa izakhiwo ezithuthukisiwe zokujiya, ukubopha, nokwenza ifilimu uma kuqhathaniswa nokusebenzisa noma iyiphi i-polymer iyodwa.

Ukusetshenziswa okukodwa okujwayelekile kokuxuba i-HPMC ne-CMC kusekwakheni amasistimu okulethwa kwezidakamizwa asuselwa ku-hydrogel. Ama-Hydrogel ayizakhiwo zenethiwekhi ezinezinhlangothi ezintathu ezikwazi ukumunca futhi zigcine amanzi amaningi, okuwenza afanelekele izinhlelo zokusebenza ezilawulwayo zokukhishwa kwezidakamizwa. Ngokuhlanganisa i-HPMC ne-CMC ngezilinganiso ezifanele, abacwaningi bangalungisa izakhiwo zama-hydrogel njengokuziphatha kokuvuvukala, amandla emishini, kanye ne-kinetics yokukhishwa kwezidakamizwa ukuze kuhlangatshezwane nezidingo ezithile.

Okunye ukusetshenziswa kokuxuba i-HPMC kanye ne-CMC kulungiselelwa upende osekelwe emanzini kanye nama-coatings. I-HPMC kanye ne-CMC zivame ukusetshenziswa njengezishintshisi ezijiyayo kanye nezilungisi ze-rheology kupende osuselwe emanzini ukuze kuthuthukiswe izakhiwo zohlelo lwazo, njengokuxubha, ukumelana nokucwila, nokumelana ne-spatter. Ngokulungisa isilinganiso se-HPMC ku-CMC, abenzi befomula bangafinyelela i-viscosity oyifunayo kanye nokuziphatha kokugeleza kopende kuyilapho begcina ukuzinza nokusebenza kwawo ngokuhamba kwesikhathi.

Ngaphezu kwemithi nezingubo zokumboza, izingxube ze-HPMC ne-CMC nazo zisetshenziswa embonini yokudla ukuze kuthuthukiswe ukuthungwa, ukuqina, kanye nokuzwakala komlomo kwemikhiqizo ehlukahlukene yokudla. Isibonelo, i-HPMC ne-CMC kuvame ukungezwa emikhiqizweni yobisi efana neyogathi no-ayisikhilimu njengeziqinisi ukuvimbela ukuhlukana kwesigaba futhi kuthuthukiswe ukukhilimu. Ezimpahleni ezibhakwayo, i-HPMC ne-CMC zingasetshenziswa njengezifudumezi zenhlama ukuze kuthuthukiswe izakhiwo zokuphatha inhlama futhi kwandise impilo yeshalofu.

kuyilapho i-hydroxypropyl methyl cellulose (HPMC) kanye ne-carboxymethyl cellulose sodium (CMC) kuyizinto ezimbili ezihlukene eziphuma ku-cellulose ezinezakhiwo ezihlukile kanye nezinhlelo zokusebenza, zingaxutshwa ndawonye ekwakhekeni okuthile ukuze kuzuzwe imiphumela ye-synergistic noma ukuthuthukisa izici ezithile. Ukuhambisana kwe-HPMC ne-CMC kuncike ezintweni ezahlukahlukene ezifana nesakhiwo sazo samakhemikhali, isisindo samangqamuzana, kanye nezici ezifiselekayo zomkhiqizo wokugcina. Ngokukhetha ngokucophelela isilinganiso nenhlanganisela ye-HPMC ne-CMC, abakhi bangakwazi ukuhlanganisa izici zokwakheka kwabo ukuze bahlangabezane nezimfuneko ezithile kwezemithi, okokuhlanganisa, imikhiqizo yokudla, nezinye izimboni.