IHydroxypropyl methyl cellulose njengesamukeli semithi

IHydroxypropyl methyl cellulose (HPMC)iyisakhi semithi esisebenza ngezindlela eziningi esisetshenziswa kabanzi kumafomu emithamo ahlukahlukene ngenxa yezakhiwo zayo ezihlukile. Lokhu okuphuma ku-cellulose kususelwa ku-cellulose, i-polymer eyenzeka ngokwemvelo etholakala ezitshalweni, futhi ilungiswa ngokusabela kwamakhemikhali ukuze kutholwe izici ezifiselekayo. Ekwakhekeni kwemithi, i-HPMC isebenzisa imisebenzi eminingi, okuhlanganisa i-binder, ifilimu yangaphambili, i-thickener, i-stabilizer, ne-ejenti ekhishwa isikhathi eside. Ukusetshenziswa kwayo okusabalele nokubaluleka embonini yezemithi kuqinisekisa ukuqonda okuphelele kwezakhiwo zayo, ukusetshenziswa kwayo, kanye nezinzuzo.

Izakhiwo ze-HPMC ze-solubility kanye ne-viscosity ziyenza ibe ukukhetha okuhle kakhulu kokulawula ukukhishwa kwezidakamizwa ngamafomu omthamo oqinile womlomo. Yakha i-matrix yejeli phezu kwe-hydration, engase ibambezele ukukhululwa kwesidakamizwa ngokusakazwa ngongqimba lwejeli oluvuvukele. I-viscosity yejeli incike ezicini ezifana nesisindo samangqamuzana, izinga lokushintsha, nokugxila kwe-HPMC ekwakhekeni. Ngokushintsha le mingcele, ososayensi bezokwelapha bangalungisa amaphrofayili okukhishwa kwezidakamizwa ukuze bathole imiphumela efiselekayo yokwelapha, njengokukhululwa ngokushesha, ukukhululwa okuqhubekayo, noma ukukhululwa okulawulwayo.

I-HPMC ivamise ukusetshenziswa njengesihlanganisi ekwakhiweni kwethebulethi ukuze kudluliselwe ukuhlangana nokuthuthukisa amandla omshini wamathebulethi. Njengesibophezelo, sikhuthaza ukunamathela kwezinhlayiyana kanye nokwakheka kwe-granule phakathi nenqubo yokucindezelwa kwethebhulethi, okuholela kumaphilisi anokuqukethwe kwezidakamizwa okufanayo kanye namaphrofayili wokuchithwa angaguquki. Ukwengeza, izakhiwo zefilimu ze-HPMC ziyenza ifanelekele ukumboza amaphilisi, asebenza ngezinjongo ezihlukahlukene njengokufihla ukunambitheka, ukuvikela umswakama, nokukhishwa kwezidakamizwa okushintshiwe.

Ngokungeziwe kumafomu emithamo eqinile yomlomo, i-HPMC ithola ukusetshenziswa kwezinye izithako zemithi, okuhlanganisa izixazululo ze-ophthalmic, amajeli e-topical, ama-transdermal patches, nemijovo ekhishwa okulawulwayo. Kuzixazululo ze-ophthalmic, i-HPMC isebenza njenge-ejenti ethuthukisa i-viscosity, ithuthukisa isikhathi sokuhlala sokwakheka endaweni ye-ocular futhi ithuthukisa ukumuncwa kwezidakamizwa. Kuma-gels we-topical, inikeza ukulawulwa kwe-rheological, okuvumela ukusetshenziswa okulula kanye nokungena kwesikhumba okuthuthukisiwe kwezithako ezisebenzayo.

I-HPMC-ama-patches asuselwa ku-transdermal anikezela ngohlelo olulula nolungahlanyisi lokulethwa kwezidakamizwa lokwelashwa kwesistimu noma kwendawo. I-polymer matrix ilawula ukukhishwa kwesidakamizwa esikhumbeni isikhathi eside, igcina amazinga emithi yokwelapha egazini ngenkathi inciphisa ukuguquguquka. Lokhu kunenzuzo ikakhulukazi kuzidakamizwa ezinamafasitela okwelapha amancane noma lawo adinga ukuphathwa okuqhubekayo.

I-biocompatibility ye-HPMC nokungangeni kwayo kuyenza ifanelekele ukusetshenziswa ekwakhiweni kwabazali njenge-ejenti emisiwe noma isilungisi se-viscosity. Kumijovo ekhishwa okulawulwayo, ama-microspheres e-HPMC noma ama-nanoparticles angakwazi ukuhlanganisa ama-molecule ezidakamizwa, anikeze ukukhululwa okuqhubekayo esikhathini eside, ngaleyo ndlela ehlise imvamisa yomthamo futhi athuthukise ukuthobela kwesiguli.

I-HPMC ibonisa izici zokunamathisela i-mucoadhesive, iyenze ibe wusizo ekwenziweni okuklanyelwe ukulethwa kwezidakamizwa ze-mucosal, njengamafilimu e-buccal nezifutho zamakhala. Ngokunamathela ku-mucosal surface, i-HPMC yelula isikhathi sokuhlala kwezidakamizwa, okuvumela ukumuncwa kwezidakamizwa okuthuthukisiwe kanye nokuba khona kwe-bioavailability.

I-HPMC ngokuvamile ibonwa njengephephile (GRAS) yiziphathimandla ezilawulayo ezifana ne-US Food and Drug Administration (FDA), okuyenza ifanelekele ukusetshenziswa ekwenziweni kwemithi okuhloselwe ukusetshenziswa abantu. Ukuwohloka kwayo kwemvelo kanye nemvelo engenabo ubuthi iqhubeka nokuba nomthelela ekuthandeni kwayo njengesamukeli sezemithi.

IHydroxypropyl methyl cellulose (HPMC)iyisisetshenziswa semithi esisebenza ngezindlela eziningi esinezinhlelo zokusebenza ezahlukahlukene kuwo wonke amafomu emithamo ahlukahlukene. Izakhiwo zayo eziyingqayizivele, ezihlanganisa ukuncibilika, i-viscosity, ikhono lokwenza ifilimu, kanye nokuvumelana kwe-biocompatibility, kuyenza ibe yingxenye ebaluleke kakhulu ekwakhiweni kwezidakamizwa okuhloswe ngayo ukufeza imigomo ethile yokwelapha. Njengoba ucwaningo lwezemithi luqhubeka nokuvela, i-HPMC kungenzeka ihlale iyingxenye yesisekelo ekuthuthukisweni kwezinhlelo ezintsha zokulethwa kwezidakamizwa kanye nokwenziwa.