I-Hydroxypropyllylylykl methylcellulose demodel umehluko

I-Hydroxypropyl methylcellulose (HPMC)Ingabe isakhiwo esiguquguqukayo esisetshenziswa ezimbonini ezahlukahlukene, kufaka phakathi ama-Pharmaceuticals, ukudla, izimonyo kanye nokwakha. Izakhiwo zayo kanye nezicelo ziyahlukahluka ngokuya ngesakhiwo sayo samangqamuzana, esingashintshwa ukuze sivumelane nezidingo ezithile.

Isakhiwo samakhemikhali:

I-HPMC iyisisulu se-cellulose, i-polymer yemvelo etholakala ezitshalweni.
I-Hydroxypropyls kanye ne-methyl substiturents zinamathiselwe emaqenjini ama-hydroxyl we-cellulose backbone.
Isilinganiso salokhu kufakazelwa esikhundleni salokhu kufakazelwa kwe-HPMC, njenge-solubity, i-gelation kanye nekhono elenza ifilimu.

Ukufakwa esikhundleni (DS):

I-DS isho inombolo ephakathi yamaqembu aphezulu ngeyunithi ye-glucose e-cellulose backbone.
Amanani aphezulu we-DS aphumela ekukhuphukeni kwe-hydrophility, i-solubility, kanye namandla okugcina.
I-Low DS HPMC iyazinza kakhulu futhi inokumelana kangcono nomswakama, okwenza kube lula ukuthola izinhlelo zokusebenza ezintweni zokwakha.

Isisindo se-Molecular (MW):

Isisindo samangqamuzana sithinta i-viscosity, amandla akha amafilimu, kanye nezakhiwo zemishini.
Isisindo esiphakeme se-molecular HPMC ngokuvamile sinokubonakala okuphezulu kanye nezakhiwo ezingcono zefilimu, okwenza zilungele ukusetshenziswa ekwakhiweni kwamakhemikhali okwenziwe ngezikhathi.
Izinhlobo eziphansi ze-molecular izinsimbi zikhethwa ngezicelo lapho kufunwa khona okuphansi nokuchithwa okusheshayo, njengasekuhlotsheni nasezinamathitsheni.

Usayizi wezinhlayiyana:

Ubukhulu bezinhlayiyana buthonya i-powder flow proveties, izinga lokuchithwa, kanye nokufana ekwakhiweni.
Ubungako obuhle bezinhlayiyana i-HPMC bahlakazeka kalula ezixazululweni zamanzi, okuholela ekuthini i-hydration esheshayo kanye nokwakheka kwejeli.
Izinhlayiya ze-COARSER zinganikeza izimo ezingcono zokugeleza ezixukwini ezomile kodwa zingadinga izikhathi ezinde ze-hydrative.

Ukushisa kwe-Gelation:

Ukushisa kwe-gelation kubhekisele emazingeni okushisa lapho izixazululo ze-HPMC zibhekene nenguquko yesigaba esigabeni esivela kwikhambi.
Amazinga aphezulu aphezulu kanye nezinsimbi zamangqamuzana zivame ukuholela emazingeni okushisa aphansi we-gela.
Ukuqonda izinga lokushisa lokushisa kubalulekile ekwakheni izinhlelo zokulethwa kwezidakamizwa ezilawulwayo kanye nasekukhiqizweni kwama-gels ngezicelo ze-topical.

Izakhiwo ezishisayo:

Ukuqina okushisayo kubalulekile kuzinhlelo zokusebenza lapho i-HPMC ifakwa khona ukushisa ngesikhathi sokucubungula noma ukugcinwa.
I-DS HPMC ephezulu ye-DS HPMC ingakhombisa ukuqina okuphansi okushisayo ngenxa yokuba khona kokunye okubonakalayo okwengeziwe.
Amasu wokuhlaziywa okushisayo afana nokuhlukaniswa kwe-calorimetry ehlukile (DSC) kanye nokuhlaziywa kwe-thermogravimetric (TGA) kusetshenziselwa ukuhlola izakhiwo ezishisayo.

Ukuzijabulisa nokuziphatha okuvuvukala:

Ukuziphatha kokuzimela nokuvuvukala kuncike ku-DS, isisindo samangqamuzana, kanye namazinga okushisa.
Izinhlobo eziphakeme ze-DS kanye nama-molecular isisindo ahlukahlukene abonisa i-solubility enkulu nokuvuvukala emanzini.
Ukuqonda ukuhlukunyezwa nokuziphatha okuvuvukala kubalulekile ekuklameni izinhlelo zokulethwa kwezidakamizwa ezilawulwayo kanye nokwenza ama-hydrogels afaka izicelo ze-biomedical.

Izakhiwo ze-Rheological:

Izakhiwo ze-Rheological ezinjengokuvuleka, ukuncipha kokuziphatha okunciphisayo, futhi i-viscoeliasticity ibalulekile kwizicelo ezahlukahlukene.
I-HPMCIzixazululo zibonisa indlela yokuziphatha ye-Pseudoplastic, lapho ukubonakala kwehla khona ngezinga elikhulayo le-Shear.
Izakhiwo ze-Rheological ze-HPMC zithonya ukucubungulwa kwalo ezimbonini ezinjengokudla, izimonyo kanye nemithi.

Umehluko phakathi kwamamodeli ahlukahlukene wesiqu se-HPMC kusuka ekuhlukahlukani kwesakhiwo samakhemikhali, ukufakwa esikhundleni, isisindo se-molecular, amazinga okushisa we-gelal, i-solubity, indlela yokuvuvutha, kanye nezakhiwo ze-rheloging. Ukuqonda lo mehluko kubalulekile ekukhetheni i-HPMC efanelekile yokuhlukahluka kwezicelo ezithile, ezisukela ekuthini kungukuqanjwa kwemithi ezintweni zokwakha.