I-Hydroxypropylmethylcellellelcelcellellulose (HPMC) iyinhlangano eguquguqukayo esetshenziswa kabanzi emikhakheni ehlukahlukene ngenxa yezakhiwo zayo ezihlukile. Le compound iyindlela etholwa yi-cellulose, i-polymer yemvelo etholakala ezindongeni zeseli zezitshalo. Ukuhlanganiswa kwe-HPMC kubandakanya ukwelapha i-cellulose nge-propelene oxide ukwethula amaqembu we-hydroxypropyl kanye ne-methyl chloride ukwethula amaqembu we-methyl. I-polymer ephumayo ibonisa uhla olubanzi lwezakhiwo zomzimba nangamakhemikhali, okwenza lilungele ukusetshenziswa ekwenzeni imithi, ukwakhiwa, kokudla kanye nezinye izimboni.
Isakhiwo se-1.Chical nokwakheka:
I-Hydroxypropyl methylcellulose iyi-polymer ye-semi-zokwenziwa enesakhiwo esiyinkimbinkimbi samakhemikhali. Umgogodla we-polymer uqukethe i-cellulose, uchungechunge oluqondile lwama-molecule kashukela axhumeke ama-β-1,4-glycosidic bond. Iqembu le-hydroxypropyl sethulwa ngokufaka esikhundleni se-hydroxyl group (-OH) neqembu lePropell, kanti iqembu le-methyl liyethulwa ngendlela efanayo. Izinga lokufaka esikhundleni (DS) limelela inani eliphakathi le-hydroxypropyl kanye namaqembu we-methyl ngamunye uphiko lwe-glucose futhi athinta i-solubity, ukuhlakanipha kanye nezakhiwo ezishisayo ze-polymer.
2. I-Solubity:
Enye yezinto ezihlukile ze-HPMC ngokuziphatha kwayo kokuchithwa. Kuyancibilika kuwo womabili lamanzi abandayo nawashisayo, ahlinzeka ngezinzuzo ezihlukile ezinhlobonhlobo zezicelo. I-Solubity ingashintshwa ngokulungisa izinga lokufakwa esikhundleni kanye nesisindo se-polymer. Le mpahla yenza i-HPMC ibe ngumuntu omuhle kakhulu ngezinhlelo zokukhishwa kwezidakamizwa ezilawulwayo, lapho izinga lokuchithwa lidlala indima ebalulekile eKinetics Yezidakamizwa.
3. I-Viscosity:
I-Hydroxypropylm methylcellulose itholakala kumazinga ahlukahlukene okubona, kuya ngezinto ezifana nesisindo se-molecular, degree yokufaka esikhundleni, nesixazululo. I-viscosity yezixazululo ze-HPMC Ivumela ukuthi isetshenziswe ezinhlelweni eziningi zezimboni, kufaka phakathi amakhambi emithi, njengabakhulu befomu lama-dosage awuketshezi, kanye nezinto zokwakha amafilimu zezimbali.
4 Ukusebenza okwenziwe ngefilimu:
Amandla akha amafilimu we-HPMC abucayi kuzinhlelo zokusebenza ezinjengezimbobo zezidakamizwa, lapho isetshenziselwa ukuhlinzeka ngongqimba lokuvikela ukufihla ukunambitheka kwezidakamizwa, ukulawula ukukhishwa kwezidakamizwa, nokwenza ngcono ukuqina. Amafilimu we-HPMC acacile futhi avumelana nezimo, futhi izakhiwo zawo angenziwa ngendlela yokulungisa ukugxilwa kwe-polymer, isisindo se-molecular kanye nokuqukethwe kwepulasitiki.
5 Ukusebenza okushisayo:
IHydroxypropyllylylyl methylcellulose ikhombisa ukuqina okuhle okushisayo ngaphakathi kwebanga elithile lokushisa. Izakhiwo ezishisayo zithintwa yizici ezinjengezinga lokufakwa esikhundleni, isisindo se-molecular, kanye nokuba khona kwepulasitiki. Lezi zakhiwo zenza i-HPMC ilungele izinhlelo zokusebenza lapho ukuqina okushisayo kubalulekile, njengokulungiselela ukwakheka okubucayi komakhemikhali.
6. I-BioCOMTIL:
Emasimini ezempi kanye ne-biomedical, i-BIOCATIAL ukucatshangelwa okubalulekile kwezinto ezisetshenziswa ezinhlelweni zezidakamizwa. I-Hydroxypropyllylylylykly ngokuvamile ibhekwa njengephephile futhi ine-biocomtic enhle. Kusetshenziswa kabanzi ekwakhekeni kwamafomu we-dosage yomlomo, izixazululo ze-ophthalmic nezinhlelo zokunikezwa kwezidakamizwa ezilawulwayo.
7. Ukugcinwa kwamanzi kanye nezakhiwo ezihlanganayo:
Amandla we-HPMC okugcina ama-water kanye nezixazululo ezikhuthele enza ukuba baluleke ngezinto zokwakha ezinjengemikhiqizo esekwe ku-monce. Kulezi zicelo, i-HPMC isebenza njenge-ejenti yokugcina amanzi, ukwenza ngcono ukucubungula kanye nokuvimbela ukoma kwangaphambi kokuqukethwe. Izakhiwo ezijikelezayo zisetshenziswa futhi emikhiqizweni yokudla ehlukahlukene ukuze uthuthukise ukuthungwa kanye nomlomo.
8. Ukulethwa kwezidakamizwa okulawulwa:
Enye yezicelo ezibalulekile ze-Hydroxypropylllylylyly methylcellulose ekwakhekeni kwezinhlelo zokukhishwa kwezidakamizwa ezilawulwayo. I-polymer's solubility, i-viscosity, kanye nezakhiwo ezenziwe ngefilimu zisiza ukukhishwa kwezidakamizwa, okwenza ukulethwa kwezidakamizwa okuqhubekayo nokubhekiswe. Lokhu kuzuzisa ikakhulukazi ukwenza ngcono ukuhambisana kweziguli kanye nokunciphisa imiphumela emibi ehambisana nokukhishwa kwezidakamizwa okusheshayo.
9. Ukuqina ngaphansi kwezindawo ezihlukile ze-Ph:
I-HPMC ikhombisa ukuqina kobubanzi be-PH, okwenza ukuthi ilungele ukwakheka okudinga ukuqina ngaphansi kwezimo ze-acidic noma ze-alkali. Le mpahla inenzuzo emikhakheni ngoba ukwakhiwa kwezidakamizwa kungahlangabezana nezimo ezahlukahlukene ze-Ph epheshana lesisu.
10. Izakhiwo ze-Rheological:
Ukuziphatha kwe-rheological kwezixazululo ze-HPMC kubalulekile ukuthola izinhlelo zokusebenza lapho kuvela khona izindawo zokugeleza, njengasekuhlelweni kwezimbozo, ukunamathela namajeli. Izakhiwo ze-Rheological zingalinganiswa ngokulungisa ukugxilisa ingqondo kanye ne-molecular ye-HPMC ukufezekisa izici zokugeleza ezidingekayo ukuze ulawule ama-E.
I-Hydroxypropyllylylyl vele yaba yi-polymer ebaluleke kakhulu kwizimboni ezahlukahlukene ngenxa yenhlanganisela yayo eyingqayizivele ye-soubity, i-viscosity, ikhono elakha amafilimu kanye nokubi. Ukusebenza kwayo kwayo kwenza kufanelekile ukuthola izinhlelo ezahlukahlukene, kusuka kumakhamishini kanye nezinto zokwakha kuya kokudla nezimonyo. Njengoba abaphenyi bayaqhubeka nokuhlola ukwakheka okusha kanye nezicelo, izakhiwo ze-hydroxypropyllllylylylylylylylyllose kuzofaka isandla entuthukweni emikhakheni ehlukahlukene, kuqinisekiswe ukubaluleka kwayo okuqhubekayo ezintweni zesayensi kanye nezimboni.
Isikhathi sePosi: Jan-10-2024